Tag: 100-200

Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines was written by Ye, Hao;Wu, Linhui;Zhang, Minrui;Jiang, Guomin;Dai, Hong;Wu, Xin-Xing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application In Synthesis of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Protocol for the analyzing of terpin hydrate in a multi-component sugar coated tablet named Pectol D by GC was written by Ha, Minh Hien;Tran, Thi Bich Ha;Bo, Nguyen Thuy Duoung. And the article was included in Tap Chi Duoc Hoc in 2006.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Anal. of terpin hydrate in multi-component sugar coated tablets namely Pectol D by UV-Vis method was not possible due to the interference of excipients. Alternatively, a GC method using a packed column of 50% di-Me 50% di-Ph polysiloxane was suggested and validated based on ASEAN Guidelines for Validation of Anal. Procedures. The method was proved to be accurate, precise and sufficiently selective. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Strategy of solution process precursors for phase change memory was written by Hwang, Jeong Min;Lee, Ji Hun;Kim, Hyo-Suk;Park, Chan Woo;Yoo, Dagyum;Park, Bo Keun;Kim, Chang Gyoun;Chung, Taek-Mo. And the article was included in Polyhedron in 2020.Formula: C6H15NO This article mentions the following:

The relation between the steric hindrance of the alpha carbon substituent group of aminoalkoxy ligand and formation of germanium telluride (GeTe) and antimony telluride (Sb₂Te₃) was elucidated. Germanium and antimony precursors were prepared using aminoalkoxide-type bidentate ligands of different sizes such as dmampH, dmapH and dmaeH. These precursor materials were further treated with bis(trimethylsilyl)telluride in hexadecane through thermal reaction and studied with powder x-ray diffraction (pXRD) to compare the formation of germanium telluride (GeTe) and antimony telluride (Sb₂Te₃) alloys which are potential precursor materials for phase change random access memory devices. While the pXRD patterns of the thermal reaction materials of compounds 2 and 3 at 190° revealed a rhombohedral phase of GeTe and tellurium, compounds 5 and 6 at 190° showed a rhombohedral phase of Sb₂Te₃ and tellurium at this temperature Probably the formation of chalcogenide alloys was more favorable when relatively less bulk ligand was used. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Formula: C6H15NO).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides was written by Sun, Xin;Lin, En-Ze;Li, Bi-Jie. And the article was included in Journal of the American Chemical Society in 2022.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Catalytic branch-selective hydrofunctionalization of feedstock α-olefins to form enantioenriched chiral compounds is a particularly attractive yet challenging transformation in asym. catalysis. Herein, an iridium-catalyzed asym. hydroalkenylation of α-olefins through directed C-H cleavage of enamides was reported. This atom-economical addition process is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter. DFT calculations reveal the origin of regio- and enantioselectivity. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of Cu(II) aminoalkoxide complexes and their unusual thermolysis to Cu(0) was written by Park, Jung Woo;Jang, Hong Suk;Kim, Minchan;Sung, Kiwhan;Lee, Sun Sook;Chung, Taek-Mo;Koo, Sangman;Kim, Chang Gyoun;Kim, Yunsoo. And the article was included in Inorganic Chemistry Communications in 2004.Formula: C6H15NO This article mentions the following:

The F free Cu(II) aminoalkoxide complexes Cu(OCMe₂CH₂NR₂)₂ (R = Me(I), Et(II)) were synthesized and characterized as a low melting solid (I) and a viscous liquid (II). The complexes are thermally decomposed at <200° to produce metallic Cu by unusual γ-H elimination reaction. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Formula: C6H15NO).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron-Catalyzed β-Alkylation of Alcohols was written by Bettoni, Leo;Gaillard, Sylvain;Renaud, Jean-Luc. And the article was included in Organic Letters in 2019.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

β-Branched alkylated alcs. have been prepared in good yields using a double-hydrogen auto-transfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcs. and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcs. (2-arylethanol and either methanol or benzyl alc.) served as hydrogen donors in this cascade process. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of Trisaccharide of Incanoside from Caryopteris incana was written by Li, Jubiao;Wang, Yanguang. And the article was included in Synthetic Communications in 2004.Formula: C6H14O6 This article mentions the following:

Trisaccharide Ph 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl-(1→2)-3,4-di-O-benzoyl-α-L-rhamnopyranosyl-(1→3)-2-O-acetyl-4,6-O-benzylidene-1-thio-β-D-glucopyranoside, the sugar core of incanosides from Caryopteris incana, was synthesized via a concise route. The key step of this route involved the preparation of decisive disaccharide acceptor from the Ph 2-acetyl-3,4-di-O-benzoyl-α-L-rhamnopyranosyl-(1→3)-2-O-acetyl-4,6-O-benzylidene-1-thio-β-D-glucopyranoside by regioselective and chemoselective deacetylation method. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies was written by Gao, Jingjing;Liu, Xiaochi;Secinti, Hatice;Jiang, Ziwen;Munkhbat, Oyuntuya;Xu, Yisheng;Guo, Xuhong;Thayumanavan, S.. And the article was included in Chemistry – A European Journal in 2018.HPLC of Formula: 60463-12-9 This article mentions the following:

Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New mol. designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9HPLC of Formula: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfuryl Fluoride Promoted Thiocyanation of Alcohols: A Practical Method for Preparing Thiocyanates was written by Zhang, Guofu;Xuan, Lidi;Zhao, Yiyong;Ding, Chengrong. And the article was included in Synlett in 2020.Safety of (2,4-Dichlorophenyl)methanol This article mentions the following:

A novel SO₂F₂-promoted thiocyanation method for the one-step synthesis of thiocyanates RCH₂SCN [R = Ph, 2-pyridyl, CH₂(CH₂)₅CH₃, etc.] through C-O bond cleavage of alcs. RCH₂OH with ammonium thiocyanate as the thiocyanating agent was developed. The method avoided the use of addnl. catalyst and a variety of (hetero)arene, alkene and aliphatic alcs. reacted with high efficiency in Et acetate under mild conditions to afford the corresponding thiocyanates RCH₂SCN in excellent to quant. yields with broad functional-group compatibility. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Safety of (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photocatalytic Dehydroxymethylative Arylation by Synergistic Cerium and Nickel Catalysis was written by Chen, Yuegang;Wang, Xin;He, Xu;An, Qing;Zuo, Zhiwei. And the article was included in Journal of the American Chemical Society in 2021.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

Under mild reaction conditions with inexpensive cerium and nickel catalysts, easily accessible free alcs. can now be utilized as operationally simple and robust carbon pronucleophiles in selective C(sp³)-C(sp²) cross-couplings. Facilitated by automated high-throughput experimentation, sterically encumbered benzoate ligands have been identified for robust cerium complexes, enabling the synergistic cooperation of cerium catalysis in the emerging metallaphotoredox catalysis. A broad range of free alcs. and aromatic halides can be facilely employed in this transformation, representing a new paradigm for the C(sp³)-C(sp²) bond construction between free alcs. and aryl halides with the extrusion of formaldehyde. Moreover, mechanistic investigations have been conducted, leading to the identification of a tribenzoate cerium(III) complex as a viable intermediate. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts