Tag: 100-200

In 2010,Krishna Reddy, V. V. R. M.; Kishore Babu, K.; Ganesh, A.; Srinivasulu, P.; Madhusudhan, G.; Mukkanti, K. published 《Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates》.Organic Process Research & Development published the findings.Application In Synthesis of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

An improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatog.-free with purity 99.3 area %.Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Related Products of 100-55-0In 2021 ,《A predictive model for additions to N-alkyl pyridiniums》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M.. The article conveys some information:

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 100-55-0

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Reference of 2,6-PyridinedimethanolIn 2022 ,《Mixed-Ligand Metal-Organic Frameworks: Synthesis and Characterization of New MOFs Containing Pyridine-2,6-dimethanolate and Benzene-1,4-dicarboxylate Ligands》 appeared in European Journal of Inorganic Chemistry. The author of the article were Mylonas-Margaritis, Ioannis; Mayans, Julia; Efthymiou, Constantinos G.; McArdle, Patrick; Papatriantafyllopoulou, Constantina. The article conveys some information:

The development of synthetic approaches towards new mixed-ligand metal organic frameworks (MOFs) was attracting considerable attention recently as they display fascinating properties due to the synergistic effect between the different ligands. Herein, the initial combination of pyridine-2,6-dimethanol (H2pdm) with benzene-1,4-dicarboxylic acid (H2bdc) provided access to three new mixed-ligand MOFs, [M3(bdc)2(Hpdm)2]n (MII = ZnII, 1; MnII, 2) and [Mn3(bdc)3(H2pdm)2]n (3). 1-3 Are the first MOFs containing H2pdm in its neutral or anionic form. 1 And 2 are isostructural 2D MOFs with a square lattice (sql) framework topol., while 3 is a 3D MOF possessing a primitive cubic (pcu) topol. Dc magnetic susceptibility measurements for 3 demonstrate antiferromagnetic interactions between the MnII ions which is a combination of intra- and intertrimer exchange pathways.2,6-Pyridinedimethanol(cas: 1195-59-1Reference of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2,6-Pyridinedimethanol

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Computed Properties of C7H6O2In 2019 ,《Nickel(II) immobilized on dithizone-boehmite nanoparticles: as a highly efficient and recyclable nanocatalyst for the synthesis of polyhydroquinolines and sulfoxidation reaction》 appeared in Journal of the Iranian Chemical Society. The author of the article were Ghorbani-Choghamarani, Arash; Moradi, Parisa; Tahmasbi, Bahman. The article conveys some information:

In this work, in the first stage, boehmite nanoparticles were easily fabricated via addition of NaOH solution to a solution of Al(NO3)3.9H2O at room temperature in water. Then, nickel-dithizone catalyst was supported on boehmite nanoparticles (Ni-dithizone@boehmite). Ni-dithizone@boehmite is a low-cost, nontoxic, and recoverable catalyst, which provides an environment friendly reaction conditions. In the second stage, catalytic activity of this catalyst was studied in the synthesis of polyhydroquinoline derivatives and selective oxidation of sulfides to sulfoxides. The reactions not require very high temperatures or inert atm. The developed heterogeneous catalyst could be easily separated by centrifugation and recycled for several runs without leaching of Nickel from the surface of the catalyst or significant loss of its catalytic activity.3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Computed Properties of C7H6O2

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Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. published an article in 2022. The article was titled 《Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis》, and you may find the article in Science (Washington, DC, United States).Synthetic Route of C6H13NO The information in the text is summarized as follows:

A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C6H13NO

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Kondo, Yuto; Kimura, Hiroyuki; Fukumoto, Chiaki; Yagi, Yusuke; Hattori, Yasunao; Kawashima, Hidekazu; Yasui, Hiroyuki published their research in Journal of Labelled Compounds and Radiopharmaceuticals in 2021. The article was titled 《Copper-mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide》.COA of Formula: C6H7BO3 The article contains the following contents:

A copper-mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel-mediated radioiodination drawbacks. The copper-mediated radiolabeling method allows radioiodination at room temperature with stable aryl boronic precursors without preparing complex starting materials or reagents and can be performed in a reaction vessel exposed to air. This method has good potential in radiochem.; however, studies on the scope of copper-mediated radioiodination through boronic precursors are insufficient. In particular, few reports have demonstrated the effect of protecting groups on radiolabeling efficiency. Therefore, the effect of the protecting group of aryl boronic acids on the copper-mediated radioiodination was investigated. In addition, this method, which does not require heating, is expected to be useful for direct radiolabeling of peptides. Thus, we attempted direct radioiodination of c(RGDyk) as an example. The resulting radioiodination method was well tolerated in various substrates and was unaffected by the pinacol ester-type protecting group. Also, c(RGDyk) was labeled with 125I via copper-mediated radioiodination using an aryl boronic acid precursor. The reaction time and yield were improved, compared with the indirect method. Furthermore, the large difference in polarity between the boronic acid precursor and the radiolabeled compound facilitated purification2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3

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Marinho, Juliane Aparecida; Martins Guimaraes, Daniel Silqueira; Glanzmann, Nicolas; de Almeida Pimentel, Giovana; Karine da Costa Nunes, Izabelle; Gualberto Pereira, Henrique Marcelo; Navarro, Maribel; de Pilla Varotti, Fernando; David da Silva, Adilson; Abramo, Clarice published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization》.HPLC of Formula: 26153-38-8 The article contains the following contents:

Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains. Mol. hybridization techniques have been used as a tool in the search for new drugs and was implemented in the present study in an attempt to produce compound candidates to treat malarial infections by CQ-resistant strains. Two groups of mols. were produced from the 4-aminoquinoline ring in conjugation to hydrazones (HQ) and imines (IQ). Physicochem. and pharmacokinetic properties were found to be favorable when analyzed in silico and cytotoxicity and antiplasmodial activity were assayed in vitro and in vivo showing low cytotoxicity and selectiveness to the parasites. Candidates IQ5 and IQ6 showed important values of parasite growth inhibition in vivo on the 5th day after infection (IQ5 15 mg/kg = 72.64% and IQ6 15 mg/kg = 71.15% and 25 mg/kg = 93.7%). IQ6 also showed interaction with ferriprotoporphyrin IX similarly to CQ. The process of applying condensation reactions to yield imines is promising and capable of producing mols. with antiplasmodial activity. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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《New eugenol derivatives with enhanced insecticidal activity》 was written by Fernandes, Maria Jose G.; Pereira, Renato B.; Pereira, David M.; Fortes, A. Gil; Castanheira, Elisabete M. S.; Goncalves, M. Sameiro T.. SDS of cas: 627-18-9 And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:

Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biol. potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a Pr chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising mols. were evaluated for their impact in cell morphol., caspase-like activity, and potential toxicity towards human cells. Some mols. stood out in terms of toxicity towards insect cells, with morphol. assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products.3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

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《Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method》 was written by Bains, Amreen K.; Biswas, Ayanangshu; Adhikari, Debashis. COA of Formula: C7H7BrO And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcs. following “”borrowing hydrogen””. A one-pot, cascade C3-alkylation starting from 2-aminophenyl Et alcs., and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6COA of Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.COA of Formula: C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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《Photosensitizing and antioxidant activities of humic substances: A case study of β2-adrenoceptor agonist terbutaline》 was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2020. These research results belong to Zhou, Lei; Sleiman, Mohamad; Halladja, Sabrina; Ferronato, Corinne; Chovelon, Jean-Marc; Richard, Claire. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Humic substances (HS) play an important role in the phototransformation of micro-pollutants in surface waters and a significant part of this reactivity is often attributed to oxidant triplet excited states (3HS*). The present study aims to understand why 3HS* were found to be negligibly involved in the HS-mediated phototransformation of β2-adrenoceptor agonist terbutaline (TBL) while this chem. shows a high reactivity towards triplet 3-carboxybenzophenone (3CBP*), a typical HS model sensitizer. To clarify this apparent discrepancy, several experiments were conducted. We first confirmed that TBL can be easily oxidized by triplet riboflavin (3RF*), another sensitizer (k = (1.7 ± 0.4)x109 M-1 s-1). Afterwards, we studied the effect of TBL on the HS-mediated phototransformation of 2,4,6-trimethylphenol (TMP), chosen for its high reactivity with 3HS*. TBL was found to enhance the rate of TMP loss. This result is rationalized by postulating that (i) TMP and TBL are both oxidized by 3HS* to yield the phenoxyl radicals TMP•-H and TBL•-H, resp., and (ii) TBL•-H is further reduced by TMP which generates addnl. TMP•-H. Fitting the exptl. data gives k = (1.8 ± 0.5)x109 M-1 s-1 for the reaction between 3HS* and TBL and DFT calculations further support the conclusion that TBL•-H can be reduced by a lot of phenols. Hence, in the case of TBL, the oxidant effect of 3HS* is counterbalanced by the antioxidant properties of HS. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products, can be used to produce pesticide epoxiconazole, etc.Name: 3,5-Dihydroxybenzaldehyde

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