Tag: 100-200

《Tandem Use of Optical Sensing and Machine Learning for the Determination of Absolute Configuration, Enantiomeric and Diastereomeric Ratios, and Concentration of Chiral Samples》 was written by De los Santos, Zeus A.; MacAvaney, Sean; Russell, Katina; Wolf, Christian. SDS of cas: 126456-43-7 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

We have developed an optical method for accurate concentration, er, and dr anal. of amino alcs. based on a simple mix-and-measure workflow that is fully adaptable to multiwell plate technol. and microscale anal. The conversion of the four aminoindanol stereoisomers with salicylaldehyde to the corresponding Schiff base allows anal. of the dr based on a change in the UV maximum at 420 nm that is very different for the homo- and heterochiral diastereomers and of the concentration of the sample using a hypsochromic shift of another absorption band around 340 nm that is independent of the analyte stereochem. Subsequent in situ formation of CuII assemblies in the absence and presence of base enables quantification of the er values for each diastereomeric pair by CD anal. Applying a linear programming method and a parameter sweep algorithm, we determined the concentration and relative amounts of each of the four stereoisomers in 20 samples of vastly different stereoisomeric compositions with an averaged absolute percent error of 1.7%. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 126456-43-7

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《Fluorescent supramolecular mechanophores based on charge-transfer interactions》 was written by Imato, Keiichi; Yamanaka, Ryota; Nakajima, Hidekazu; Takeda, Naoya. Reference of 3-Bromopropan-1-ol And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Supramol. mechanofluorophores based on charge-transfer (CT) interactions between fluorescent pyrene and naphthalene diimide(s) with a tandem structure are newly developed and incorporated into the mid-chain of poly(ε-caprolactone)s. The fluorescence (FL) is quenched by the intramol. CT interactions even at low concentrations both in solution and in the polymer matrix, and turn-on FL is induced upon application of mech. forces. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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The author of 《Structurally Defined Molecular Hypervalent Iodine Catalysts for Intermolecular Enantioselective Reactions》 were Haubenreisser, Stefan; Woeste, Thorsten H.; Martinez, Claudio; Ishihara, Kazuaki; Muniz, Kilian. And the article was published in Angewandte Chemie, International Edition in 2016. Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol The author mentioned the following in the article:

Mol. structures of the most prominent chiral non-racemic hypervalent iodine(III) reagents to date have been elucidated for the first time. The formation of a chirally induced supramol. scaffold based on a selective hydrogen-bonding arrangement provides an explanation for the consistently high asym. induction with these reagents. As an exploratory example, their scope as chiral catalysts was extended to the enantioselective dioxygenation of alkenes. A series of terminal styrenes RCH:CH2 (R = Ph, 4-FC6H4, 4-MeO2CC6H4, 3,5-Me2C6H3, 2-naphthyl, etc.) were converted into the corresponding vicinal diacetoxylation products (S)-RCH(OAc)CH2OAc under mild conditions and provided the proof of principle for a truly intermol. asym. alkene oxidation under iodine(I/III) catalysis.(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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Related Products of 157142-48-8On November 15, 2002 ,《The role of nucleation inhibition in optical resolutions with families of resolving agents》 appeared in Angewandte Chemie, International Edition. The author of the article were Nieuwenhuijzen, Jose W.; Grimbergen, Reinier F. P.; Koopman, Carla; Kellogg, Richard M.; Vries, Ton R.; Pouwer, Kees; van Echten, Erik; Kaptein, Bernard; Hulshof, Lumbertus A.; Broxterman, Quirinius B.. The article conveys some information:

The role of nucleation inhibition during Dutch resolution (DR) of several compounds in the presence of various additives is investigated. Significant improvements in the diastereomeric excesses (de values) of the salt products are observed The overall results indicated that the nucleation inhibition and associated kinetic effects can play a role in DR leading to a second generation of DR, namely the use of small amounts of a certain family member of the resolving agent as an additive. In the experiment, the researchers used many compounds, for example, 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Related Products of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Related Products of 157142-48-8

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《Preparation and characterization of dry β-cyclodextrin-based ternary complexes of haloperidol and lactic acid for drug delivery》 was written by Chantasart, Doungdaw; Rakkaew, Prisada. SDS of cas: 54-17-1 And the article was included in Journal of Drug Delivery Science and Technology on August 31 ,2019. The article conveys some information:

This study was aimed to prepare dry β-cyclodextrin (β-CD)-based ternary complexes of haloperidol (HALO) with lactic acid for drug delivery. The influences of different media (buffers pH 3 and pH 6) and preparation methods ((freeze drying (FD) and solvent evaporation (SE)) on the HALO inclusion complexes were determined HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 exhibited higher inclusion yield than those in buffer pH 6. Furthermore, HALO/β-CD/lactic acid ternary complexes prepared via FD gave higher inclusion yield than those prepared via SE. The physicochem. properties of dry HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 were subsequently determined The interaction of HALO, β-CD and lactic acid was found and confirmed by Fourier transform IR and proton NMR. Results from differential scanning calorimetry and X-ray powder diffractometry depicted that the β-CD ternary complexes of HALO and lactic acid prepared via FD in buffer pH 3 transformed the drug from a crystalline state to an amorphous state. With significantly enhanced release of HALO from the complexes, HALO/β-CD/lactic acid ternary complexes was shown to be a promising carrier for HALO delivery. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.SDS of cas: 54-17-1

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Computed Properties of C3H7BrOIn 2019 ,《Single Chain Cationic Polymer Dot as a Fluorescent Probe for Cell Imaging and Selective Determination of Hepatocellular Carcinoma Cells》 was published in Analytical Chemistry (Washington, DC, United States). The article was written by Ozenler, Sezer; Yucel, Muge; Tuncel, Ozge; Kaya, Hakan; Ozcelik, Serdar; Yildiz, Umit Hakan. The article contains the following contents:

This letter describes formation of single chain cationic polymer dots (Pdots) made of poly[1,4-dimethyl-1-(3-((2,4,5-trimethylthiophen-3-yl)oxy)propyl)piperazin-1-ium bromide] conjugated polyelectrolyte (CPE). The single chain Pdot formation relies on a simple process which is a rapid nanophase separation between CPE solution of ethylene glycol and water. Pdots show narrow monodisperse size distribution with a 3.6 nm in diameter exhibiting high brightness and excellent colloidal and optical stability. It has been demonstrated that photoluminescent Pdots provide selective nuclear translocation to hepatocellular carcinoma cells as compared to healthy liver cells. The Pdot labeling effectively discriminates cancer cells in the coculture media. Pdots hold great promise as a luminescent probe to diagnose cancer cells in histol. and may guide surgeons during operations to precisely sep. out cancerous tissue due to augmented fluorescence brightness. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Computed Properties of C3H7BrO

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Related Products of 126456-43-7In 2020 ,《Pyridine- and Quinoline-Based Gold(III) Complexes: Synthesis, Characterization, and Application》 appeared in European Journal of Organic Chemistry. The author of the article were Reiersolmoen, Ann Christin; Fiksdahl, Anne. The article conveys some information:

Studies on gold(III) coordination of a series of prepared polydentate pyridine and quinoline based ligands are reported. Characterization (1H, 13C, 15N NMR, and XRD) of the novel gold(III) complexes, prepared in 31-98% yield, revealed different coordination ability of the pyridine and quinoline nitrogen atoms. Testing of catalytic activity in cyclopropanation of propargyl ester and styrene demonstrated that all the new ligated gold(III) complexes were catalytically active and outperformed KAuCl4. The superior activity of the particular Au(III)-pyridine-oxazole complexes may indicate de-coordination of the pyridine-N ligand as a crucial step for efficient generation of catalytic activity. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 126456-43-7

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《Synthesis and characterization of Cu-N, N’-Dicyclohexylcarbodiimide supported on CMK-3 as a novel, efficient and recoverable nanocatalyst for synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives》 was published in Reaction Kinetics, Mechanisms and Catalysis in 2020. These research results belong to Ghafouri-Nejad, Raziyeh; Hajjami, Maryam. SDS of cas: 100-83-4 The article mentions the following:

Mesoporous carbon CMK-3 was prepared using SBA-15 silica mesoporous as a hard template. Then, Cu-N, N’-Dicyclohexylcarbodiimide was supported on CMK-3 as a reusable and highly efficient nanocatalyst for the synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives This new catalyst was characterized by FT-IR spectroscopy, XRD, SEM, BET, TGA, EDX, and ICP-OES techniques. After completing reactions, the catalyst was easily separated from the reaction mixture using centrifuge and reusable five times without significant loss of their catalytic efficiency.3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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In 2017,Jagadeesh, Rajenahally V.; Murugesan, Kathiravan; Alshammari, Ahmad S.; Neumann, Helfried; Pohl, Marga-Martina; Radnik, Joerg; Beller, Matthias published 《MOF-derived cobalt nanoparticles catalyze a general synthesis of amines》.Science (Washington, DC, United States) published the findings.Application In Synthesis of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chem. research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobalt-diamine-dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atm. The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples). The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and mol. hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Application In Synthesis of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of trans-4-Aminocyclohexanol

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In 2011,Krishna Reddy, V. V. R. M.; Udaykiran, D.; Chintamani, U. S.; Mahesh Reddy, E.; Kameswararao, Ch.; Madhusudhan, G. published 《Development of an optimized process for the preparation of 1-Benzylazetidin-3-ol: an industrially important intermediate for substituted azetidine》.Organic Process Research & Development published the findings.Name: Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

A thoroughly optimized and robust process for the synthesis of 1-benzylazetidin-3-ol has been emphasized. 1-Benzylazetidin-3-ol I, has been utilized as a starting material in the com. synthesis of azetidin-3-ol hydrochloride. Synthesis of azetidin-3-ol hydrochloride involves the usage of very low cost and com. available starting material (benzylamine) and with reduced formation of di(3-chloro-2-hydroxypropyl) benzylamine significantly resulting in an economical process that allows the effective production of 1-benzyl azetidin-3-ol as well as azetidin-3-ol hydrochloride. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Name: Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Name: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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