Tag: 100-200

《Tandem electrospray mass spectrometry of cyclic N-substituted oligo-β-(1→6)-D-glucosamines》 was written by Chizhov, Alexander O.; Gening, Marina L.; Tsvetkov, Yury E.; Nifantiev, Nikolay E.. Related Products of 54-17-1 And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:

High-resolution electrospray mass spectra (MS and MS/MS CID) of pos. ions of a series of protonated, ammoniated, and metalated mols. of cyclic N-substituted oligo-β-(1→6)- D-glucosamines differing in cycle size and N-acyl substituents were registered and interpreted. It was shown that the main type of fragmentation is a cleavage of glycosidic bonds of a cycle, and in some cases fragmentation of amide side chains is possible. If labile fragments in substituents (e.g., carbohydrate chains) are present, a decay of the cycle and an elimination of labile fragments are of comparable possibility. It was found that in some cases rearrangements with loss of an internal carbohydrate residue (IRL), or an internal part of a side chain, are feasible. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Related Products of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Related Products of 54-17-1

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《Selective photocatalytic oxidation of glycerol and 3-pyridinemethanol by nanotube/nanowire-structured TiO2 powders obtained by breakdown anodization》 was written by Cetinkaya, Sidika; Khamidov, Gofur; Ozcan, Levent; Palmisano, Leonardo; Yurdakal, Sedat. Category: alcohols-buliding-blocksThis research focused ontitanium dioxide glycerol pyridinemethanol nanotube nanowire photocatalytic oxidation; 3-pyridinemethanol; glycerol; green synthesis; heterogeneous photocatalysis; nanotube structured TiO2; selective oxidation; vitamin B3. The article conveys some information:

Nanotube/nanowire-structured TiO2 was formed on the Ti surface by an anodic oxidation method performed at different potential values (50 or 60 V) and for different times (3 or 5 h). The TiO2 photocatalysts were taken in powder form using the ultrasonic treatment from the Ti electrodes, calcined at different temperatures, and characterized by XRD and SEM techniques, and BET surface area analyses. Both the crystallinity and the size of the primary TiO2 particles increased by increasing the heat treatment temperature While all the photocatalysts heat treated up to 500°C were only in the anatase phase, the particles heat-treated at 700°C consisted of both anatase and rutile phases. The BET sp. surface area of the samples decreased drastically after heat treatment of 700°C because of partial sinterization. SEM analyses indicated that the prepared materials were structured in both nanotubes and nanowires. They were tested as photocatalysts for the selective oxidation of glycerol and 3-pyridinemethanol under UVA irradiation in water at room temperature and ambient pressure. Glyceraldehyde, 1,3-dihydroxyacetone, and formic acid were determined as products in glycerol oxidation, while the products of 3-pyridinemethanol oxidation were 3-pyridinemethanal and vitamin B3. Non-nanotube/nanowire-structured com. (Degussa P25 and Merck TiO2) photocatalysts were used for the sake of comparison. Low selectivity values towards the products obtained by partial oxidation were determined for glycerol. On the contrary, higher selectivity values towards the products were obtained (total 3-pyridinemethanal and vitamin B3 selectivity up to ca. 90%) for the photocatalytic oxidation of 3-pyridinemethanol. TiO2 photocatalysts must be highly crystalline (calcined at 700°C) for effective oxidation of glycerol, while for the selective oxidation of 3-pyridinemethanol it was not necessary to obtain a high crystallinity, and the optimal heat treatment temperature was 250°C. Glycerol and its oxidation products could more easily desorb from highly crystalline and less hydroxylated surfaces, which would justifies their higher activity. The prepared photocatalysts showed lower activity than Degussa P25, but a greater selectivity towards the products found. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0Category: alcohols-buliding-blocks)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Category: alcohols-buliding-blocks

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Singh, Nidhi; Pandey, Jaya published their research in Current Research in Green and Sustainable Chemistry in 2021. The article was titled 《DABCO catalyzed, green and efficient, one-pot multicomponent synthesis of 5-aminopyrazole-4-carbonitrile》.Name: 3-Hydroxybenzaldehyde The article contains the following contents:

This work describes an unaccustomed DABCO catalyzed synthetic approach for the synthesis of 5-Aminopyrazole-4-carbonitriles I [R1 = H, 3-OH, 4-OH, 4-Br, 4-Cl, 4-OMe; R2 = H, 3,5-(NO2)2]. A series of substituted derivatives of 5-Aminopyrazole-4-carbonitrile I was synthesized deploying this facile and efficient catalyst in green aqueous media. The reaction involves condensation of malononitrile, benzaldehydes R1C6H4CHO and phenylhydrazines such as phenylhydrazine and 3,5-dinitrophenylhydrazine, generating one-pot pyrazole products. The mechanistic chem. of synthesis encompasses Knoevenagel condensation followed by amination and superseded by intra-mol. cyclization. The synthetic route is a lucid and effective route involving green solvent and less hazardous reaction conditions. Besides this, min. reaction period, easy work-up and elimination of byproducts during synthesis, make this reaction a model reaction for pyrazole synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

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《An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer’s disease mice》 was written by Dang, Yijing; Wang, Fengyang; Li, Lingling; Lai, Yi; Xu, Zhiai; Xiong, Zhi; Zhang, Ao; Tian, Yang; Ding, Chunyong; Zhang, Wen. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, the authors disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by using a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Category: alcohols-buliding-blocks

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Recommanded Product: Azetidin-3-ol hydrochlorideIn 2021 ,《Asymmetric copper-catalyzed propargylic amination with amine hydrochloride salts》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Huang, Jian; Kong, Han-Han; Li, Si-Jia; Zhang, Rui-Jin; Qian, Hao-Dong; Li, Dan-Ran; He, Jin-Yu; Zheng, Yi-Nuo; Xu, Hao. The article conveys some information:

The highly enantioselective copper-catalyzed propargylic amination of propargylic esters with amine hydrochloride salts has been realized for the first time using copper salts with chiral N,N,P-ligands. This method features a broad substrate scope and wide functional group tolerance, generating propargylic amines in good to excellent yields with high enantioselectivities (up to 99% ee). The utility of the approach was demonstrated by late-stage functionalization of marketed pharmaceuticals. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Intermaggio, Nicholas E.; Millet, Agustin; Davis, Dali L.; MacMillan, David W. C. published an article in 2022. The article was titled 《Deoxytrifluoromethylation of Alcohols》, and you may find the article in Journal of the American Chemical Society.Product Details of 100-55-0 The information in the text is summarized as follows:

Deoxy-functionalization of alcs. represents a class of reactions that has had profound impact on modern medicine. In particular, deoxyfluorination is commonly employed as a means to incorporate high-value fluorine atoms into drug-like mols. Recently, the trifluoromethyl (CF3) group has garnered attention from medicinal chemists due to its ability to markedly improve the pharmaceutical properties of small mol. drug candidates. To date, however, there remains no general means to accomplish the analogous deoxygenative trifluoromethylation of alcs. Herein, a copper metallaphotoredox-mediated direct deoxytrifluoromethylation is reported, wherein alc. substrates are activated in situ by benzoxazolium salts for C(sp3)-CF3 bond formation. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 100-55-0

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《Newly synthesized imino-derivatives analogues of resveratrol exert inhibitory effects in breast tumor cells》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Iacopetta, Domenico; Lappano, Rosamaria; Mariconda, Annaluisa; Ceramella, Jessica; Sinicropi, Maria Stefania; Saturnino, Carmela; Talia, Marianna; Cirillo, Francesca; Martinelli, Fabio; Puoci, Francesco; Rosano, Camillo; Longo, Pasquale; Maggiolini, Marcello. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Breast cancer represents the most frequently diagnosed malignancy in women worldwide. Various therapeutics are currently used in order to halt the progression of breast tumor, even though certain side effects may limit the beneficial effects. In recent years, many efforts have been addressed to the usefulness of natural compounds as anticancer agents due to their low toxicity. Resveratrol, a stilbene found in grapes, berries, peanuts and soybeans, has raised a notable interest for its antioxidant, anti-inflammatory, and antitumor properties. Here, we report the design, the synthesis and the characterization of the anticancer activity of a small series of imino N-aryl-substituted compounds that are analogs of resveratrol. In particular, the most active compound, named 3, exhibited anti-tumor activity in diverse types of breast cancer cells through the inhibition of the human topoisomerase II and the induction of apoptotic cell death. Therefore, the abovementioned compound maybe considered as a promising agent in more comprehensive treatments of breast cancer.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Wang, Zhi-Qin; Tang, Xiao-Sheng; Yang, Zhao-Qi; Yu, Bao-Yi; Wang, Hua-Jing; Sang, Wei; Yuan, Ye; Chen, Cheng; Verpoort, Francis. Electric Literature of C6H12O. The article was titled 《Highly active bidentate N-heterocyclic carbene/ruthenium complexes performing dehydrogenative coupling of alcohols and hydroxides in open air》. The information in the text is summarized as follows:

Eight bidentate NHC/Ru complexes were designed and prepared In particular, compound I displayed extraordinary performance even in open air for the dehydrogenative coupling of alcs. and hydroxides. Notably, an unprecedentedly low catalyst loading of 250 ppm and the highest TON of 32 800 and TOF of 3200 until now were obtained. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Electric Literature of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Electric Literature of C6H12O

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In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Pang, Huan; Xu, Pingping; Li, Chonglu; Zhan, Yibei; Zhang, Zengyuan; Zhang, Wanshu; Yang, Guangfu; Sun, Yao; Li, Haibing. Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《A photo-responsive macroscopic switch constructed using a chiral azo-calix[4]arene functionalized silicon surface》. The information in the text is summarized as follows:

A photo-responsive macroscopic switch was fabricated using a chiral azo-calix[4]arene derivative (FC4AD) functionalized silicon surface and exhibited selective and reversible recognition of (1R,2S)-1-amino-2-indanol through the variation of wettability. This photo-responsive device may have wide applications in controlled release of chiral drugs and in biosensors. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2017,Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Ortiz-Frade, Luis; Klimova, Elena I. published 《Reactions of 2,3-diferrocenylcyclopropenylium salts with bis-1,4-N,O-nucleophiles: Novel synthesis, characterization, chemical and electrochemical properties of the 2-(Z-1,2-diferrocenylvinyl)- 4,5-dihydrooxazole derivatives》.Journal of Organometallic Chemistry published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A new method of synthesis of 2-(Z-1,2-diferrocenylvinyl)-4-R-5-R1-4,5-dihydrooxazoles (3a-f, R, R1 = H, Me, Ph) and (5, R-R1 = 1,2-indano); 2-(Z-1,2-diferrocenylvinyl)-4-R-5-R1-4,5-dihydrooxazol-3-ium salts (4a-f, R, R1 = H, Me, Ph) 3-H-4-R2 oxazolinium salts (4g,h, R2 = iPr, Ph) and 3-R3-4-R-5-R1 oxazolinium salts (9h-j, R3 = Me, Et, using N-R3 aminoethanols) by reactions of 1-X-2,3-diferrocenylcyclopropenylium salts (1a,b, X = OEt, 4-morpholinyl) with 1,2-amino- and 1,2-N-alkylaminoalcs. in the presence of Et3N is described. The interactions of the salts 4a,d,f and 9h-j with morpholine and piperidine results in the corresponding (E)-2-[N-2′,3′-diferrocenylacryloyl-2-(N-alkyl)amino]ethylmorpholines and piperidines FcCH:CFcCONR3CHRCHR1X (X = 4-morpholinyl, 1-piperidinyl). The characterization of the new compounds was done by IR, 1H and 13C NMR spectroscopy, mass-spectrometry, elemental anal., and X-ray diffraction studies. Electrochem. properties of the compounds 3a-d and 4a-d were investigated using cyclic square voltammetry. One adsorption process and two electrochem. processes II and III, attributed to the oxidations of the ferrocene moieties, E0′(II), E0′(III), and comproportionation constant Kcom are reported. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: alcohols-buliding-blocks

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