Tag: 100-200

《Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders》 was written by Espadinha, Margarida; Viejo, Lucia; Lopes, Ricardo M. R. M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J. V. A.; Goncalves, Lidia; Rodriguez-Franco, Maria Isabel; de los Rios, Cristobal; Santos, Maria M. M.. Product Details of 126456-43-7 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

The synthesis and pharmacol. evaluation of a new scaffold with antagonistic activity for NMDAR was reported. Specifically, a chem. library of eighteen 1-aminoindan-2-ol tetracyclic lactams was synthesized and screened as NMDAR antagonists. The compounds were obtained by chiral pool synthesis using enantiomerically pure 1-aminoindan-2-ols as chiral inductors, and their stereochem. was proven by X-ray crystallog. anal. of two target compounds Most compounds reveal NMDAR antagonism, and eleven compounds display IC50 values in a Ca2+ entry-sensitive fluo-4 assay in the same order of magnitude of memantine, a clin. approved NMDAR antagonist. Docking studies suggest that the novel compounds can act as NMDAR channel blockers since there is a compatible conformation with MK-801 co-crystallized with NMDAR channel. In addition, we show that the tetracyclic 1-aminoindan-2-ol derivatives are brain permeable and non-toxic, and we identify promising hits for further optimization as modulators of the NMDAR function. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 126456-43-7

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Alcohol – Wikipedia,
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《Novel Biodegradable Laminarin Microparticles for Biomedical Applications》 was written by Castanheira, Edgar J.; Correia, Tiago R.; Rodrigues, Joao M. M.; Mano, Joao F.. Recommanded Product: 3-Bromopropan-1-ol And the article was included in Bulletin of the Chemical Society of Japan in 2020. The article conveys some information:

Fabrication of biocompatible polymeric carriers for sustained/controlled drug-delivery have been extensively explored over the years. Furthermore, systems based on polymers from natural origins exceed conventional polymers in biocompatibility, biodegradability and cost efficiency. Polysaccharides are one of the most common biopolymers found in nature and they can achieve a high degree of complexity and fine biol. properties. Herein, is proposed a biodegradable and biocompatible microcarrier synthesized from laminarin, a low Mw marine polysaccharide based on glucose units with great biol. activity, such as immune modulation and antimicrobial properties. Within this work, controlled size microparticles were obtained from novel modifications of laminarin. Microparticles showed 40% release of fluorescein isothiocyanate-dextran (70 kDa) after 24 h and full degradability after 11 days, when in physiol. conditions. When incubated with human adipose stem and L929 cell lines (up to a microparticle concentration of 100 μg/mL) no cytotoxicity was perceived, and neither membrane or nucleus disturbance. Thus, microparticles synthesized from laminarin, proved to be a cost efficient, biocompatible and biodegradable system. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 3-Bromopropan-1-ol

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《A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish》 was written by Deng, Tao; Wang, Xiaojuan; Wu, Shengjun; Hu, Shiyou; Liu, Wei; Chen, Tongkai; Yu, Zhiqiang; Xu, Qin; Liu, Fang. Computed Properties of C6H7BO3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A new FRET probe has been prepared for ratiometric fluorescence detection of hydroxyl radicals. It has been successfully used for detecting mitochondria-localized drug activation in living cells and imaging endogenous hydroxyl radicals in zebrafish gastrointestinal (GI) tracts under normal culturing conditions. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

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Alcohol – Wikipedia,
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《Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation》 was written by Verzijl, Gerard K. M.; Hassfeld, Jorma; de Vries, Andre H. M.; Lefort, Laurent. Product Details of 126456-43-7 And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

Herein, we report the first example of the asym. hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of BET inhibitor BAY 1238097 (I). High-throughput screening in a parallel reactor enabled us to identify an efficient catalyst based on Ir and a chiral bisphosphine. An additive screening allowed significant reduction of catalyst loading. Ultimately, the hydrogenation was performed on a kilogram scale leading to the production of 27 kg of the desired product with an enantiomeric excess of 99% after crystallization In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 126456-43-7

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Alcohol – Wikipedia,
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The author of 《Synthesis and characterization of spinel FeAl2O4 (hercynite) magnetic nanoparticles and their application in multicomponent reactions》 were Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Shiri, Lotfi; Taherinia, Zahra. And the article was published in Research on Chemical Intermediates in 2019. Application of 100-83-4 The author mentioned the following in the article:

The spinel ferrite FeAl2O4 (hercynite) MNPs (magnetic nanoparticles) were applied as a reusable catalytic system for the one-pot synthesis of benzo[a]pyrano[2,3-c] phenazine and polyhydroquinoline derivatives via a multicomponent reaction under green reaction conditions. The structure of the prepared nanocatalyst has been characterized by XRD, FTIR, SEM, EDS, BET, and VSM techniques. The FeAl2O4 MNPs act as Lewis acids and offer several advantages such as high yields of products, short reaction times, and easy workup procedure. Moreover, the recycled nanocatalyst was used at least four times without significant loss of its activity. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Bera, Atanu; Sk, Motahar; Singh, Khushboo; Banerjee, Debasis. Product Details of 873-75-6. The article was titled 《Nickel-catalyzed dehydrogenative coupling of aromatic diamines with alcohols: selective synthesis of substituted benzimidazoles and quinoxalines》. The information in the text is summarized as follows:

The first nickel-catalyzed dehydrogenative coupling of primary alcs. and ethylene glycol with aromatic diamines for selective synthesis of mono- and di-substituted benzimidazoles and quinoxalines is reported. The earth-abundant, non-precious and simple NiCl2/1,10-phenanthroline system enables the synthesis of N-heterocycles releasing water and hydrogen gas as byproducts. Mechanistic studies involving deuterium labeling experiments and quant. determination of hydrogen gas evaluation were performed. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6Product Details of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Product Details of 873-75-6 It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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Alcohol – Wikipedia,
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In 2018,Hu, Fang; Yuan, Youyong; Wu, Wenbo; Mao, Duo; Liu, Bin published 《Dual-Responsive Metabolic Precursor and Light-Up AIEgen for Cancer Cell Bio-orthogonal Labeling and Precise Ablation》.Analytical Chemistry (Washington, DC, United States) published the findings.Quality Control of 3,5-Dihydroxybenzaldehyde The information in the text is summarized as follows:

Metabolic glycoengineering of unnatural glycans with bio-orthogonal chem. groups and a subsequent click reaction with fluorescent probes have been widely used in monitoring various bioprocesses. Herein, we developed a dual-responsive metabolic precursor that could specifically generate unnatural glycans with azide groups on the membrane of targeted cancer cells with high selectivity. Moreover, a water-soluble fluorescent light-up probe with aggregation-induced emission (AIE) was synthesized, which turned its fluorescence on upon a click reaction with azide groups on the cancer cell surface, enabling special cancer cell imaging with low background signal. Furthermore, the probe can generate 1O2 upon light irradiation, fulfilling its dual role as an imaging and therapeutic agent for cancer cells. Therefore, the concepts of the cancer-cell-specific metabolic precursor cRGD-S-Ac3ManNAz and the AIE light-up probe are promising in bio-orthogonal labeling and cancer-specific imaging and therapy. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Quality Control of 3,5-Dihydroxybenzaldehyde

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Alcohol – Wikipedia,
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In 2018,Ke, Bowen; Ma, Lin; Kang, Ting; He, Wei; Gou, Xueyan; Gong, Deying; Du, Lupei; Li, Minyong published 《In Vivo Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model》.Analytical Chemistry (Washington, DC, United States) published the findings.HPLC of Formula: 1195-59-1 The information in the text is summarized as follows:

As a trace element nutrient, cobalt is critical for both prokaryotes and eukaryotes. In the current study, a turn-on Cobalt Bioluminescent Probe 1 (CBP-1) for the detection of cobalt has been successfully developed based on oxidative C-O bond cleavage. This probe exhibited high selectivity and sensitivity toward cobalt over other analytes. By using CBP-1, the successful in vivo imaging of cobalt accumulation was carried out in a mouse model. Such an ability to determine cobalt in living animals provides a powerful technol. for studying the system distribution, toxic potency, and biol. effect of Co2+. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 1195-59-1

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Alcohol – Wikipedia,
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The author of 《Synthesis and identification of 1,3-oxazepine derivatives by reaction of Schiff bases with anhydride derivative of cycloheptatriene》 were Mohammad, Ham J.; Alsamarrai, Abdulmajeed S. H.; Mahmood, Rabeah T.. And the article was published in Journal of Pharmaceutical Sciences and Research in 2019. Recommanded Product: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

In this work, 1,3-oxazepine derivatives I [R = H, OH, Cl, Br; R’ = H] and I [R = H, R’ = OH; R = OH, R’ = OMe] were synthesized from reaction of Schiff bases with anhydride derivative of cycloheptatriene. Schiff bases C6H5N=C(4-R,3-R’C6H3) were prepared by the reaction of aniline with benzaldehydes at room temperature Anhydride derivative of cycloheptatriene also prepared from reaction of maleic anhydride with cycloheptatriene without using any solvent. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,International Journal of Biological Macromolecules included an article by Valiey, Ehsan; Dekamin, Mohammad G.; Alirezvani, Zahra. Name: 3-Hydroxybenzaldehyde. The article was titled 《Melamine-modified chitosan materials: An efficient and recyclable bifunctional organocatalyst for green synthesis of densely functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives》. The information in the text is summarized as follows:

An environmentally benign protocol for diversity-oriented synthesis of functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been investigated by the reaction of aryl aldehydes, Et acetoacetate, hydrazine derivatives, malononitrile and 4-hydroxycoumarin in the presence of melamine-modified chitosan (Cs-Pr-Me) materials as a reusable bifunctional organocatalyst. The Cs-Pr-Me materials were properly characterized by the Fourier transform IR (FTIR) spectroscopy, CHN elemental anal., thermal gravimetric (TGA) and derivative thermogravimetric (DTG) anal., field emission SEM (FESEM) and energy-dispersive X-ray (EDX) spectroscopy. The remarkable advantages of this green protocol are high to quant. yields of the desired products, short reaction times, wide scope, simple work-up procedure and low loading of a transition metal-free catalyst. An addnl. advantage of this bio-based organocatalyst is the ability to sep. and recycle it easily from the reaction mixture with minimal effort in subsequent runs without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts