Tag: 100-200

《Effect of Molecular Weight on Viscosity Scaling and Ion Transport in Linear Polymerized Ionic Liquids》 was written by Zhao, Qiujie; Evans, Christopher M.. Electric Literature of C3H7BrOThis research focused onviscosity scaling ion transport linear polymerized ionic liquid. The article conveys some information:

A series of acrylic polymerized ionic liquids (PILs) with imidazolium cations and bis(trifluoromethylsulfonyl)imide (TFSI) anions were synthesized via reversible addition-fragmentation chain-transfer polymerization The absolute mol. weights (MWs) of PILs were determined from size exclusion chromatog. with light scattering. The d.p. (N) ranged from 15 to 254, and steady rotational rheol. indicated the zero-shear viscosity (η0) measured at a constant distance above the glass transition scales as η0 ~N1.0 for N < 92, in agreement with the theory for unentangled polymer melts. In the range from N = 92-254, we measured η0 ~N2.3 which is interpreted as a transition region. The N1.0 scaling in the unentangled regime is in contrast to the prior report of η0 ~N1.7 in polyethylene-based PILs (Macromols., 2011,44, 7719) but in agreement with a calculated η0 ~N1.1 of acrylic ammonium TFSI PILs (Macromols., 2016,49, 4557). Oscillatory shear rheol. revealed that electrostatic interactions in this system were weak enough to have no impact on delaying the onset of flow, which was supported by a lack of ion aggregation in wide-angle X-ray scattering. The polymer nanostructure was also found to be minimally influenced by the d.p. Ionic conductivity slightly decreased as MW increased but overlapped when normalized to the calorimetric glass transition temperature In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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《Design, Synthesis, Acaricidal Activity, and Mechanism of Oxazoline Derivatives Containing an Oxime Ether Moiety》 was written by Li, Yongqiang; Li, Chaojie; Zheng, Yanlong; Wei, Xingcun; Ma, Qiaoqiao; Wei, Peng; Liu, Yuxiu; Qin, Yaoguo; Yang, Na; Sun, Yufeng; Ling, Yun; Yang, Xinling; Wang, Qingmin. Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol And the article was included in Journal of Agricultural and Food Chemistry on April 9 ,2014. The article conveys some information:

Two series of novel 2,4-diphenyl-1,3-oxazolines containing an oxime ether moiety were designed and synthesized via the key intermediate N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide. The bioassay results showed that the target compounds with an oxime ether substituent at the para position of 4-Ph exhibited excellent acaricidal activity against Tetranychus cinnabarinus in the laboratory Moreover, all of the target compounds had much higher activities than etoxazole, as the ovicidal and larvicidal activities of the target compounds I-a-I-l and II-a-II-n against T. cinnabarinus were all over 90% at 0.001 mg L-1, but etoxazole gave only 30% and 40% resp. at the same concentration The activity order of compounds with regard to acaricidal activity in vivo was almost consistent with their affinity activity with sulfonylurea receptor (SUR) of Blattella germanica in vitro, hence, it was supposed that the acaricidal mechanism of action of the target compounds was that they can bind with the site of SUR and therefore inhibit chitin synthesis. Moreover, the eminent effect of the compound II-l, [2-(trifluoromethyl)benzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime], against Panonychus citri and T. cinnabarinus in the field indicated that II-l exhibited a promising application prospect as a new candicate for controlling spider mites in the field. In the experiment, the researchers used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol

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《Cu-catalyzed enantioselective alkylarylation of vinylarenes enabled by chiral binaphthyl-BOX hybrid ligands》 was written by Sakurai, Shunya; Matsumoto, Akira; Kano, Taichi; Maruoka, Keiji. Related Products of 126456-43-7This research focused onvinylarene enantioselective alkylarylation; copper chiral binaphthyl BOX hybrid ligand catalysis. The article conveys some information:

Transition-metal-catalyzed radical relay coupling reactions have recently emerged as one of the most powerful methods to achieve difunctionalization of olefins. However, there has been limited success in applying this method to asym. catalysis using an effective chiral ligand. Herein we report the Cu-catalyzed enantioselective alkylarylation of vinylarenes using alkylsilyl peroxides as alkyl radical sources. This reaction proceeds under practical reaction conditions and affords chiral 1,1-diarylalkane structures that are found in a variety of bioactive mols. Notably, a highly enantioselective reaction was accomplished by combining chiral bis(oxazoline) ligands with chiral binaphthyl scaffolds. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 126456-43-7

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Quality Control of 3-Bromopropan-1-olIn 2021 ,《Ion Specific, Thin Film Confinement Effects on Conductivity in Polymerized Ionic Liquids》 appeared in Macromolecules (Washington, DC, United States). The author of the article were Zhao, Qiujie; Bennington, Peter; Nealey, Paul F.; Patel, Shrayesh N.; Evans, Christopher M.. The article conveys some information:

Acrylate-based polymerized ionic liquids (PILs) with ammonium (Am) or imidazolium (Im) cations and tetrafluoroborate (BF4) or bis(trifluoromethanesulfonyl)imide (TFSI) anions were synthesized and spin coated onto gold interdigitated electrodes on silica to investigate nanoconfinement effects on ion transport. The film thickness ranged from 23 to 313 nm. A significant reduction of the in-plane conductivity was observed in some PIL thin films with thickness below 100 nm. Specifically, Am BF4 PIL showed the largest conductivity drop (ca. 50% difference between a 22 nm and a 261 nm film) while Im TFSI PIL showed almost no change under confinement. The difference in conductivity drop is discussed in terms of (i) differences in interfacial layer thickness by fitting a two-layer conductivity model and (ii) potential changes in glass transition temperature (Tg) under confinement, which were estimated using the Vogel-Fulcher-Tammann fits of bulk conductivities. Decreasing film thickness also caused the dielec. loss peaks to shift to lower frequency, indicating that the ion diffusion process slowed under confinement. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Quality Control of 3-Bromopropan-1-ol

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In 2022,Ongaro, Alberto; Violatto, Martina Bruna; Casarin, Elisabetta; Pellerani, Isabella; Marchini, Gloria; Ribaudo, Giovanni; Salmona, Mario; Carbone, Marco; Passoni, Alice; Gnodi, Elisa; Schiavon, Elisa; Mattarei, Andrea; Barisani, Donatella; Invernizzi, Pietro; Bigini, Paolo; Morpurgo, Margherita published an article in Nanomedicine (New York, NY, United States). The title of the article was 《The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Avidin-Nucleic-Acid-NanoASsemblies (ANANAS) possess natural tropism for the liver and, when loaded with dexamethasone, reduce clin. progression in an autoimmune hepatitis murine model. Here, we investigated the linker chem. (hydrazide-hydrazone, Hz-Hz, or carbamate hydrazide-hydrazone, Cb-Hz bond) and length (long, 5 kDa PEG, or short, 5-6 carbons) in biotin-dexamethasone conjugates used for nanoparticle decoration through in vitro and in vivo studies. All four newly synthesized conjugates released the drug at acidic pH only. In vitro, the Hz-Hz and the PEG derivatives were less stable than the Cb-Hz and the short chain ones, resp. Once injected in healthy mice, dexamethasone location in the PEGylated ANANAS outer layer favors liver penetration and resident macrophages uptake, while drug Hz-Hz, but not Cb-Hz, short spacing prolongs drug availability. In conclusion, the tight modulation of ANANAS decoration can significantly influence the host interaction, paving the way for the development of steroid nanoformulations suitable for different pharmacokinetic profiles. In the experiment, the researchers used many compounds, for example, 6-Aminohexan-1-ol(cas: 4048-33-3Category: alcohols-buliding-blocks)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Category: alcohols-buliding-blocks

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Gangireddy, Madhu Sudhana Reddy; Mantipally, Manohar; Badavath, Vishnu Nayak; Maddipati, Venkatanarayana Chowdary; Paidikondala, Kalyani; Katari, Naresh Kumar; Gundla, Rambabu published their research in Chemical Data Collections in 2021. The article was titled 《Design, synthesis and molecular docking of piperidin-4-amine linked pyrimidine derivatives as potent anticancer agents》.Synthetic Route of C6H13NO The article contains the following contents:

A series of rationally designed novel hybrid piperidin-4-amine linked pyrimidine derivatives I [R = n-propylamino, cyclobutylamino, phenylethylamino, etc.] were synthesized. Compound I [R = 3,4-dimethoxyphenylethylamino] was found to be most potent with (IC50 = 1.92μM, 60.94% inhibition), while I [R = 4-pyridylethylamino] (IC50 of 5.2μM, 66.45% inhibition), the second most potent among all, against HepG2 human liver cancer cell lines. Compounds I [R = 4-pyridylethylamino, 4-fluorophenylmethylamino] exhibited excellent inhibition percentages of 66.45 and 68.76 resp., compared to pos. control Paclitaxel (62.12%). In-silico target hunting for the potent compounds I [R = 3,4-dimethoxyphenylethylamino, 4-pyridylethylamino] revealed two possible targets, one was binding with human estrogen receptor and other one was inhibiting tubulin polymerization The mol. docking studies suggested that compounds I [R = 3,4-dimethoxyphenylethylamino, 4-pyridylethylamino] with hydrophobic group linked by an alkyl chain may facilitate free access in the Helix 12 domain (in determining potency plays a crucial role) in the human estrogen receptor’s active and also inhibiting the tubulin polymerase by binding site at α/β-tubuline interface at colchicine binding site. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Synthetic Route of C6H13NO

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In 2019,European Journal of Inorganic Chemistry included an article by Buchner, Magnus R.; Mueller, Matthias; Raymond, Onyekachi; Severinsen, Rebecca J.; Nixon, David J.; Henderson, William; Brothers, Penelope J.; Rowlands, Gareth J.; Plieger, Paul G.. COA of Formula: C6H7BO3. The article was titled 《Synthesis of a Boronic Acid Anhydride Based Ligand and Its Application in Beryllium Coordination》. The information in the text is summarized as follows:

The synthesis of a boronic acid anhydride-based ligand containing one three- and one four-coordinated B atom is presented. This ligand was successfully employed as a tridentate κ1N,κ2O-ligand in the coordination of Be chloride and both the ligand and the resulting complex were structurally characterized. While the B-element separations are within the typical range of related homo-nuclear compounds, the corresponding Be-element distances are rather long, suggesting unexpectedly high electron d. at the Be center. Incorporation of a Be atom in a six-membered ring causes no more distortion than the corresponding B atom, suggesting that analogous ligand systems could be used in B and Be coordination chem. The generated hetero-tri-nuclear complex enables the direct comparison of bond lengths and angles at Be and B atoms in similar coordination environments and can act as a monomol. model for Be borates. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3

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In 2019,European Journal of Pharmaceutical Sciences included an article by Debnath, Utsab; Mukherjee, Suprabhat; Joardar, Nikhilesh; Sinha Babu, Santi P.; Jana, Kuladip; Misra, Anup Kumar. Electric Literature of C7H6O3. The article was titled 《Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages》. The information in the text is summarized as follows:

A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55-76% yield using simple reaction condition. The synthesized compounds were evaluated for their anti-inflammatory activities based on their ability to inhibit pro-inflammatory cytokine secretion from the macrophages after stimulation with lipopolysaccharide (LPS). Three compounds appeared as promising anti-inflammatory agents. The mechanism of inflammatory activity of the potent compound 3e was further investigated using a series of biochem., mol. and microscopic techniques. Further structure activity relationship (SAR) study was carried out to validate the anti-inflammatory activities of the active compounds Our exptl. data revealed that the active moiety i.e. compound 3e majorly causes inhibition of TLR4 signaling pathway and this appears to be the novel functional attribute of this compound In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

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In 2019,Journal of the American Chemical Society included an article by Bregante, Daniel T.; Johnson, Alayna M.; Patel, Ami Y.; Ayla, E. Zeynep; Cordon, Michael J.; Bukowski, Brandon C.; Greeley, Jeffrey; Gounder, Rajamani; Flaherty, David W.. Computed Properties of C6H12O. The article was titled 《Cooperative Effects between Hydrophilic Pores and Solvents: Catalytic Consequences of Hydrogen Bonding on Alkene Epoxidation in Zeolites》. The information in the text is summarized as follows:

Hydrophobic voids within titanium silicates have long been considered necessary to achieve high rates and selectivities for alkene epoxidations with H2O2. The catalytic consequences of silanol groups and their stabilization of hydrogen-bonded networks of water (H2O), however, have not been demonstrated in ways that lead to a clear understanding of their importance. We compare turnover rates for 1-octene epoxidation and H2O2 decomposition over a series of Ti-substituted zeolite *BEA (Ti-BEA) that encompasses a wide range of densities of silanol nests ((SiOH)4). The most hydrophilic Ti-BEA gives epoxidation turnover rates that are 100 times larger than those in defect-free Ti-BEA, yet rates of H2O2 decomposition are similar for all (SiOH)4 densities. These differences cause the most hydrophilic Ti-BEA to also give the highest selectivities, which defies conventional wisdom. Spectroscopic, thermodn., and kinetic evidence indicate that these catalytic differences are not due to changes in the electronic affinity of the active site, the electronic structure of Ti-OOH intermediates, or the mechanism for epoxidation Comparisons of apparent activation enthalpies and entropies show that differences in epoxidation rates and selectivities reflect favorable entropy gains produced when epoxidation transition states disrupt hydrogen-bonded H2O clusters anchored to (SiOH)4 near active sites. Transition states for H2O2 decomposition hydrogen bond with H2O in ways similar to Ti-OOH reactive species, such that decomposition becomes insensitive to the presence of (SiOH)4. Collectively, these findings clarify how mol. interactions between reactive species, hydrogen-bonded solvent networks, and polar surfaces can influence rates and selectivities for epoxidation (and other reactions) in zeolite catalysts. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Computed Properties of C6H12O

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In 2018,Journal of the American Chemical Society included an article by Smith, Russell T.; Zhang, Xiaheng; Rincon, Juan A.; Agejas, Javier; Mateos, Carlos; Barberis, Mario; Garcia-Cerrada, Susana; de Frutos, Oscar; MacMillan, David W. C.. Computed Properties of C3H8ClNO. The article was titled 《Metallaphotoredox-Catalyzed Cross-Electrophile Csp3-Csp3 Coupling of Aliphatic Bromides》. The information in the text is summarized as follows:

A strategy for the installation of small alkyl fragments onto pharmaceutically relevant aliphatic structures has been established via metallaphotoredox catalysis. Herein, we report that tris(trimethylsilyl)silanol can be employed as an effective halogen abstraction reagent that, in combination with photoredox and nickel catalysis, allows a generic approach to Csp3-Csp3 cross-electrophile coupling. In this study, we demonstrate that a variety of aliphatic drug-like groups can be successfully coupled with a number of com. available small alkyl electrophiles, including Me tosylate and strained cyclic alkyl bromides. Moreover, the union of two secondary aliphatic carbon centers, a long-standing challenge for organic mol. construction, has been accomplished with a wide array of structural formats. Last, this technol. can be selectively merged with Csp2-Csp3 aryl-alkyl couplings to build drug-like systems in a highly modular fashion. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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