Tag: 100-200

《Chromium-Catalyzed Alkylation of Amines by Alcohols》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Kallmeier, Fabian; Fertig, Robin; Irrgang, Torsten; Kempe, Rhett. HPLC of Formula: 873-75-6 The article mentions the following:

The alkylation of amines by alcs. is a broadly applicable, sustainable, and selective method for the synthesis of alkyl amines, which are important bulk and fine chems., pharmaceuticals, and agrochems. We show that Cr complexes can catalyze this C-N bond formation reaction. We synthesized and isolated 35 examples of alkylated amines, including 13 previously undisclosed products, and the use of amino alcs. as alkylating agents was demonstrated. The catalyst tolerates numerous functional groups, including hydrogenation-sensitive examples. Compared to many other alc.-based amine alkylation methods, where a stoichiometric amount of base is required, our Cr-based catalyst system gives yields higher than 90% for various alkyl amines with a catalytic amount of base. Our study indicates that Cr complexes can catalyze borrowing hydrogen or hydrogen autotransfer reactions and could thus be an alternative to Fe, Co, and Mn, or noble metals in (de)hydrogenation catalysis.(4-Bromophenyl)methanol(cas: 873-75-6HPLC of Formula: 873-75-6) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.HPLC of Formula: 873-75-6 It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Palladium oxide nanoparticles intercalated mesoporous silica for solvent free acceptorless dehydrogenation reactions of alcohols》 were Samanta, Partha Kumar; Ray, Shounak; Das, Trisha; Gage, Samuel H.; Nandi, Mahasweta; Richards, Ryan M.; Biswas, Papu. And the article was published in Microporous and Mesoporous Materials in 2019. Product Details of 100-55-0 The author mentioned the following in the article:

Aggregation-free well-dispersed palladium oxide nanoparticles intercalated into the walls of mesoporous silica (PdOMS) were prepared by using thioether groups during the sol-gel preparation of mesoporous silica. The PdOMS material was characterized by N2 adsorption-desorption, X-ray diffraction, SEM, transmission electron microscopy and UV-Vis spectroscopy. The material retains mesoporous structure with narrow pore size distribution with an average pore diameter of 6.8 nm and possesses high surface area of 683 m2g-1. The PdOMS catalyst was employed as an efficient heterogeneous catalyst in the acceptor- and oxidant-free dehydrogenation of neat alcs. to corresponding carbonyl compounds in very good to excellent yields (72-95%) at 80° under inert atm. The catalytic efficacy of PdOMS was evaluated for the acceptorless dehydrogenative coupling reactions of alcs. with o-diamino benzene and o-amino phenol to yield azole-based heterocycles. The stability of PdOMS was assessed by investigating its recyclability and reusability in the dehydrogenation of neat alc. for up to five cycles. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Product Details of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Poly[(side-on mesogen)-alt-(end-on mesogen)]: A Compromised Molecular Arrangement》 were Wang, Meng; Bao, Wei-Wei; Chang, Wen-Ying; Chen, Xu-Man; Lin, Bao-Ping; Yang, Hong; Chen, Er-Qiang. And the article was published in Macromolecules (Washington, DC, United States) in 2019. Name: 6-Aminohexan-1-ol The author mentioned the following in the article:

In recent years, sequence-controlled side-chain liquid crystal polymers (SCLCPs) have gained extensive interest because mesogenic units with different lengths and distributions can form various ordered sequences, which further endow LCP materials with diverse functions. In this manuscript, a side-chain side-on maleimide-containing monomer 2,5-bis-(4-butoxy-benzoyloxy)-benzoic acid 6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl ester (Y1801) and a side-chain end-on styrene-containing monomer 4′-[6-(4-vinyl-phenoxy)-hexyloxy]-biphenyl-4-carbonitrile (Y1802) are combined in one single macromol. chain and orderly polymerized in an alternative sequence to form an alternating copolymer Poly(Y1801-alt-Y1802). The chem. structure and alternating sequence of Poly(Y1801-alt-Y1802) are confirmed by GPC and NMR techniques. The combination of DSC, POM, and WAXS data indicates that, although the side-on homopolymer PY1801 and the end-on homopolymer PY1802 both exhibit the nematic phase, their alternating copolymer Poly(Y1801-alt-Y1802) shows an interdigitated smectic A phase, a compromised mol. arrangement instead. In addition, a strong fluorescence emission of Poly(Y1801-alt-Y1802) is observed, which might provide this novel alternating-structured liquid crystal polymer with potential applications in luminescent materials and devices. After reading the article, we found that the author used 6-Aminohexan-1-ol(cas: 4048-33-3Name: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Name: 6-Aminohexan-1-ol

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In 2019,Macromolecules (Washington, DC, United States) included an article by Fu, Linxia; Yang, Jixing; Dong, Liqi; Yu, Huitao; Yan, Qinghai; Zhao, Fulai; Zhai, Fei; Xu, Yunhua; Dang, Yanfeng; Hu, Wenping; Feng, Yiyu; Feng, Wei. SDS of cas: 4048-33-3. The article was titled 《Solar Thermal Storage and Room-Temperature Fast Release Using a Uniform Flexible Azobenzene-Grafted Polynorborene Film Enhanced by Stretching》. The information in the text is summarized as follows:

Deformation-controlled solar thermal storage and release are important for thermal management of dynamic systems. However, few researchers have examined cyclic solid-state solar thermal utilization with different deformations. A uniform flexible stretchable solar thermal fuel film is presented using polynorbornene-templated azobenzene (PNB-Azo) with ring-opening metathesis polymerization and covalent grafting. This film has a high degree of isomerization and good storage stability compared to push-pull electronic interaction. At 20% strain rate, the film combines high-degree photocharging (85%), high energy d. (49.0 Wh kg-1), and high rate of heat release induced by blue light (475 nm) at room temperature Greater free volume improves isomerization and the first-order kinetic constant is increased by 1 order of magnitude. Reversible elec.-driven dynamic stretching during charging and discharging enables PNB-Azo””fingers”” to release heat more rapidly than static stretched film, resulting in a temperature increase of 1.5 °C. The result indicates that PNB-Azofilm can be used as a high-power dynamic solar heat source by controlling the deformation. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.SDS of cas: 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Rezazadeh, Sina; Devannah, Vijayarajan; Watson, Donald A. published 《Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides》.Journal of the American Chemical Society published the findings.Electric Literature of C6H13NO The information in the text is summarized as follows:

In the presence of a nickel(II) diphenyldimethylphenanthroline complex, primary, secondary, and tertiary alkyl iodides such as 3-phenyl-1-Pr iodide alkylated primary nitroalkanes such as Et 4-nitrobutanoate with potassium tert-butoxide and diethylzinc in 1,4-dioxane/MTBE to provide nitroalkanes such as Ph(CH2)3CH(NO2)(CH2)3CO2Et in 34-85% yields. Alkenes, esters, phthalimides, and protected amines, alcs., and ketones were tolerated; compound with Lewis basic groups could be prepared in improved yields with addnl. phenanthroline ligand. TEMPO inhibited the alkylation, and alkylation with cyclpropylmethyl iodide and 6-iodo-1-hexene yielded ring-opened and cyclized products, resp., implying a radical mechanism for the alkylation. The antiviral agent adapromine was prepared in two steps using this method. The structures of cis- and trans-N-(iodocyclohexyl)fluorobenzamides and cis- and trans-N-[(nitromethyl)cyclohexyl]fluorobenzamides were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2015,Karlsson, Staffan; Bergman, Rolf; Loefberg, Christian; Moore, Peter R.; Ponten, Fritiof; Tholander, Joakim; Soerensen, Henrik published 《Development of a Large-Scale Route to an MCH1 Receptor Antagonist: Investigation of a Staudinger Ketene-Imine Cycloaddition in Batch and Flow Mode》.Organic Process Research & Development published the findings.SDS of cas: 18621-18-6 The information in the text is summarized as follows:

A practical large-scale route to an MCH1 receptor antagonist, azetidinyl oxadiazole I, is described. A Staudinger β-lactam synthesis of an imine and an in situ generated ketene was utilized as a key step for the preparation of a spiro-azetidine building block. The reaction was demonstrated in both batch and flow mode and a comparison of these techniques is described. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6SDS of cas: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V.; Yakhshilikova, L. J.; Bekrenev, D. D.; Gazizov, A. S.; Burilov, A. R.; Pudovik, M. A. published their research in Russian Journal of General Chemistry on February 28 ,2022. The article was titled 《Reactions of Aminoacetals with C-Nucleophiles as a New Method for the Synthesis of Di(het)arylmethane Derivatives with a Taurine Fragment》.Synthetic Route of C8H19NO2 The article contains the following contents:

Based on the acid-catalyzed reaction of functionalized aminoacetals with C-nucleophiles, a series of new diarylmethane derivatives with a taurine fragment were synthesized. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Synthetic Route of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V.; Turmanov, R. A.; Gazizov, A. S.; Kuznetsova, E. A.; Burilov, A. R.; Pudovik, M. A. published an article in Russian Journal of Organic Chemistry. The title of the article was 《Reaction of N-(4,4-Diethoxybutyl)phosphonamides with Chloro(diphenyl)phosphine. Synthesis of 2-(Diphenylphosphoryl)pyrrolidines》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

The reaction of N-(4,4-diethoxybutyl)phosphonamides with chloro(diphenyl)phosphine in chloroform in the presence of acetic acid gave previously unknown 2-(diphenylphosphoryl)pyrrolidines, and hydrolysis of the latter afforded 2-(diphenylphosphoryl)pyrrolidine. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Category: alcohols-buliding-blocks)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis, in vitro evaluation, and molecular docking studies of benzofuran based hydrazone a new inhibitors of urease》 was written by Abdullah Al-Mohammadi, Jana; Taha, Muhammad; Rahim, Fazal; Hussain, Rafaqat; aldossary, Hanan; Khalid Farooq, Rai; Wadood, Abdul; Nawaz, Muhammad; Salahuddin, Mohammed; Mohammed Khan, Khalid; Uddin, Nizam. Product Details of 26153-38-8This research focused onurease inhibitor benzofuran hydrazone mol docking. The article conveys some information:

This work has described the synthesis of novel class (1-25) of benzofuran based hydrazone. The hybrid scaffolds (1-25) of benzofuran based hydrazone were evaluated in vitro, for their urease inhibition. All the newly synthesized analogs (1-25) were found to illustrate moderate to good urease inhibitory profile ranging from 0.20 ± 0.01 to 36.20 ± 0.70 μM. Among the series, compounds 22 (IC50 = 0.20 ± 0.01 μM), 5 (IC50 = 0.90 ± 0.01 μM), 23 (IC50 = 1.10 ± 0.01 μM) and 25 (IC50 = 1.60 ± 0.01 μM) were found to be the many folds more potent than thiourea as standard inhibitor (IC50 = 21.86 ± 0.40 μM). The elevated inhibitory profile of these analogs might be due to presence of dihydroxy and flouro groups at different position of Ph ring B attached to hydrazone skeleton. These dihydroxy and fluoro groups bearing compounds have shown many folds better inhibitory profile through involvement of oxygen of dihydroxy groups in hydrogen bonding with active site of enzymes. Various types of spectroscopic techniques such as 1H-, 13C- NMR and HREI-MS spectroscopy were used to confirm the structure of all the newly developed compounds To find SAR, mol. docking studies were performed to understand, the binding mode of potent inhibitors with active site of enzymes and results supported the exptl. data. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2019 ,《Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes》 appeared in Journal of Organometallic Chemistry. The author of the article were Gawali, Suhas Shahaji; Gunanathan, Chidambaram. The article conveys some information:

We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2]-cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene mols. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts