Tag: 100-200

Product Details of 2240-88-2On March 22, 2020, Khodja, Maroua; El Kateb, Mejda; Beji, Mohammed; Guittard, Frederic; Darmanin, Thierry published an article in Journal of Colloid and Interface Science. The article was 《Tuning nanotubular structures by templateless electropolymerization with thieno[3,4-b]thiophene-based monomers with different substituents and water content》. The article mentions the following:

Here, templateless electropolymerization is employed to produce nanotubular structures from various thieno[3,4-b]thiophene-based monomers that differ in substituent structure and size, as well as the linker connecting the thieno[3,4-b]thiophene core and substituent. The formation of densely packed vertically aligned are obtained from monomers with a pyrene substituent and when a significant amount of water (CH2Cl2 + H2O) is included in the solvent. The geometrical parameters of the nanotubes are highly dependent on the electopolymn. method. A significant amount of air is trapped within the structure of the densely packed open nanotubes obtained with Qs = 100 mC cm-2 causing an increase in water contact angle (θw) up to 82.6° (intermediate state between the Wenzel and the Cassie-Baxter state), and θw can become even more hydrophobic by further modifying the deposition method or the electrolyte. In the experiment, the researchers used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Product Details of 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Product Details of 2240-88-2

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《Mesoporous SBA-15@n-Pr-THAM-ZrO organic-inorganic hybrid: as a highly efficient reusable nanocatalyst for the synthesis of polyhydroquinolines and 2,3-dihydroquinazolin-4 (1H)-ones》 was written by Ghorbani-Choghamarani, Arash; Aghavandi, Hamid; Mohammadi, Masoud. Name: 3-HydroxybenzaldehydeThis research focused ontris hydroxymethyl aminomethane zirconium complex supported modified SBA15 preparation; polyhydroquinoline green preparation; benzaldehyde dimedone ethyl acetoacetate ammonium acetate Hantzsch zirconium catalyst; dihydroquinazolinone green preparation; aromatic aldehyde anthranilamide cyclocondensation zirconium mesoporous catalyst. The article conveys some information:

In this work, tris(hydroxymethyl)aminomethane-zirconium complex supported on modified SBA-15 (SBA-15@n-Pr-THMAM-ZrO) prepared as a novel mesoporous catalyst. The structure of this mesoporous catalyst was characterized by XRD, nitroge adsorption-desorption, TEM, TGA, EDS, ICP, X-ray mapping, and SEM techniques. Mesoporous SBA-15@n-Pr-THAM-ZrO nanocatalyst used for the synthesis of polyhydroquinolines I [Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and 2,3-dihydroquinazolin-4 (1h)-ones II [R = H, 4-Cl, 4-OMe, etc.] via Hantzsch reaction/cyclocondensation of aryl benzaldehydes with dimedone, Et acetoacetate, ammonium acetate/anthranilamide. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Name: 3-Hydroxybenzaldehyde

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Product Details of 18621-18-6In 2020 ,《Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Yamaguchi-Sasaki, Toru; Kawaguchi, Takanori; Okada, Atsushi; Tokura, Seiken; Tanaka-Yamamoto, Nozomi; Takeuchi, Tomoki; Ogata, Yuya; Takahashi, Ryo; Kurimoto-Tsuruta, Risa; Tamaoki, Tomokazu; Sugaya, Yutaka; Abe-Kumasaka, Tomoko; Arikawa, Kaho; Yoshida, Ippei; Sugiyama, Hiroyuki; Kanuma, Kosuke; Yoshinaga, Mitsukane. The article conveys some information:

The development of effective respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors against both wild-type and the D486N-mutant F protein is urgently required. We recently reported a 15-membered macrocyclic pyrazolo[1,5-a]pyrimidine derivative 4 that exhibited potent anti-RSV activities against not only wild-type, but also D486N-mutant F protein. However, NMR studies revealed that the 15-membered derivative 4 existed as a mixture of atropisomers. An optimization study of the linker moiety between the 2-position of the benzoyl moiety and the 7-position of the pyrazolo[1,5-a]pyrimidine scaffold identified a 16-membered derivative 42c with an amide linker that showed a rapid interconversion of atropisomers. Subsequent optimization of the 5-position of the pyrazolo[1,5-a]pyrimidine scaffold and the 5-position of the benzoyl moiety resulted in the discovery of a potent clin. candidate 60b for the treatment of RSV infections. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Synthetic Route of C3H8ClNOIn 2011 ,《Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Bengtsson, Christoffer; Blaho, Stefan; Saitton, David Blomberg; Brickmann, Kay; Broddefalk, Johan; Davidsson, Oejvind; Drmota, Tomas; Folmer, Rutger; Hallberg, Kenth; Hallen, Stefan; Hovland, Ragnar; Isin, Emre; Johannesson, Petra; Kull, Bengt; Larsson, Lars-Olof; Loefgren, Lars; Nilsson, Kristina E.; Noeske, Tobias; Oakes, Nick; Plowright, Alleyn T.; Schnecke, Volker; Stahlberg, Pernilla; Soerme, Pernilla; Wan, Hong; Wellner, Eric; Oester, Linda. The article conveys some information:

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to two compounds, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good phys. and in vitro ADME properties and good bioavailability. X-ray crystallog. has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both most potent compounds lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Synthetic Route of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Synthetic Route of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Category: alcohols-buliding-blocksIn 2021 ,《Strategic Synthesis of ‘Picket Fence’ Porphyrins Based on Nonplanar Macrocycles》 appeared in European Journal of Organic Chemistry. The author of the article were Norvaisa, Karolis; Yeow, Kathryn; Twamley, Brendan; Roucan, Marie; Senge, Mathias O.. The article conveys some information:

Traditional ‘picket fence’ porphyrin systems have been a topic of interest for their capacity to direct steric shielding effects selectively to one side of the macrocycle. Sterically overcrowded porphyrin systems that adopt macrocycle deformations have recently drawn attention for their applications in organo-catalysis and sensing. Here, the authors explore the combined benefits of nonplanar porphyrins and the old mol. design to bring new concepts to the playing field. The challenging ortho-positions of meso-Ph residues in dodeca-substituted porphyrin systems led to the transition to less hindered para- and meta-sites and the development of selective demethylation based on the steric interplay. Isolation of the sym. target compound [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(3,5-dipivaloyloxyphenyl)porphyrin] was investigated under two synthetic pathways. The obtained insight was used to isolate unsym. [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-nitro-5-pivaloyloxyphenyl)porphyrin]. Upon separation of the atropisomers, a detailed single-crystal X-ray crystallog. anal. highlighted intrinsic intermol. interactions. The nonplanarity of these systems in combination with ‘picket fence’ motifs provides an important feature in the design of supramol. ensembles. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks

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In 2022,Bondarenko, G. N.; Legkov, S. A.; Merekalov, A. S.; Otmakhova, O. A.; Talroze, R. V. published an article in Russian Journal of Physical Chemistry A. The title of the article was 《Molecular Structure and Donor-Acceptor Properties of β-(2,4,7-Trinitro-9-fluorenylideneaminooxy)propionic Acid Complexes with Triphenylene-Containing Systems》.Related Products of 627-18-9 The author mentioned the following in the article:

Quantum chem. calculations and FTIR spectroscopic studies show that β-(2,4,7-trinitro-9-fluorenylideneiminooxy)propionic acid (TNF-carb) can act as an electron acceptor. It stabilizes charge transfer complexes with discotic triphenylene-containing mols. Complexes TNF-carb/discotic may have different compositions (up to 1/4) and stabilize their structure via π-π interaction, but with the complementary hydrogen bonding as well. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

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Puleo, Thomas R.; Klaus, Danielle R.; Bandar, Jeffrey S. published an article in 2021. The article was titled 《Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer》, and you may find the article in Journal of the American Chemical Society.Application In Synthesis of 5-Hexen-1-ol The information in the text is summarized as follows:

A general protocol for the direct C-H etherification of N-heteroarenes is reported. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alc. substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcs. with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Application In Synthesis of 5-Hexen-1-ol

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Sietmann, Jan; Ong, Mike; Mueck-Lichtenfeld, Christian; Daniliuc, Constantin G.; Wahl, Johannes M. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ-Lactams》.Product Details of 126456-43-7 The article contains the following contents:

Asym. access to γ-lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)-1-amino-2-indanol for chiral induction. Mechanistic anal. of the key N,O-ketal rearrangement reveals a Curtin-Hammett scenario, which enables a downstream stereo induction (up to 88:12 dr) and is corroborated by spectroscopic, crystallog., and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ-lactams, including those bearing all-carbon quaternary stereocenters. In addition, the formal synthesis of drug mols. baclofen, brivaracetam, and pregabalin further demonstrates the synthetic utility and highlights the general applicability of the presented method. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Product Details of 126456-43-7

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Qiu, Yaxin; Munna, Dheeman-Roy; Wang, Fang; Xi, Juqun; Wang, Zhifeng; Wu, Defeng published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Regulating Asynchronous Deformations of Biopolyester Elastomers via Photoprogramming and Strain-Induced Crystallization》.Recommanded Product: 627-18-9 The article contains the following contents:

For shape-memory polymers (SMPs), introducing material heterogeneity is vital to tailor shape-shifting pathways. However, it is hard to reprogram the heterogeneity for both covalent networks and dynamic covalent networks after these networks are encoded. Here, photoactive coumarin derivative end-capped dangling chains were used to participate in building photoreversible polycaprolactone/poly(malic acid) networks, endowing the networks with reprogrammable heterogeneity and a capability of room-temperature storage of entropic energy. The alternations of network topol. with 365/254 nm UV irradiation and strain-induced crystallization behavior of as-prepared bio-based elastomers were studied, aiming at quant. guiding the spatiotemporal release of entropic energy to regulate asynchronous deformations. This work provides applicable methods for simplifying shaping manipulation or for diversifying shape-shifting pathways of SMPs. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 627-18-9

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Abdolmohammadi, Shahrzad; Shariati, Shahab; Mirza, Behrooz published their research in Applied Organometallic Chemistry in 2021. The article was titled 《Ultrasound promoted and Kit-6 mesoporous silica-supported Fe3O4 magnetic nanoparticles catalyzed cyclocondensation reaction of 4-hydroxycoumarin, 3,4-methylenedioxyphenol, and aromatic aldehydes》.Computed Properties of C7H6O2 The article contains the following contents:

A new effective approach to synthesize a series of 7-aryl-6H,7H-[1]benzopyrano[4,3-b][1,3]dioxolo[4,5-g][1]benzopyran-6-ones I (Ar = Ph, 3-nitrophenyl, 4-chlorophenyl, etc.) was reported using Fe3O4@SiO2@Kit-6 as heterogeneous catalyst at room temperature under ultrasonic irradiation in aqueous media. This procedure is of great value due to its short reaction time, high yields, simple processing, and the use of easily available and magnetically recyclable heterogeneous catalyst. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Computed Properties of C7H6O2

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