Tag: 100-200

COA of Formula: C6H15NOIn 2021 ,《Stepwise Crystallization and Induced Microphase Separation in Nucleobase-Monofunctionalized Supramolecular Poly(ε-caprolactone)》 was published in Macromolecules (Washington, DC, United States). The article was written by Li, Xing; Xu, Wenqing; Chang, Xiaohua; Zheng, Ying; Ni, Lingling; Shan, Guorong; Bao, Yongzhong; Pan, Pengju. The article contains the following contents:

End functionalization of homopolymers by noncovalent binding units is a straightforward approach to prepare supramol. polymers with a broad application scope as stimuli-responsive functional materials. Crystallization and microphase separation of end groups and polymer blocks can lead to the formation of short- and long-range ordered structures in end-functionalized supramol. polymers. Herein, we report the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramol. polymer, thymine-monofunctionalized poly(ε-caprolactone) (PCL-Thy). PCL-Thy with high end functionality and adjustable composition was synthesized by ring-opening polymerization using hydroxyl-functionalized thymine as the initiator. PCL-Thy showed a double-crystalline nature; its thymine units and PCL blocks crystallized and melted in a stepwise manner in the cooling and subsequent heating processes. The crystallization of thymine units from the melt resulted in an ordered and aligned thymine stack, which further drove the microphase separation and long-range lamellar organization of the PCL-Thy. The subsequent crystallization of PCL blocks occurred in a confined manner between the pre-existing thymine lamellae and slightly decreased the regularity of lamellar ordering. The PCL chains, which crystallized between the thymine lamellae, transformed from nonfolded to single-folded crystals upon increasing the PCL block length. This work offers important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramol. polymers. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.COA of Formula: C6H15NO

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Name: 3-PyridinemethanolIn 2019 ,《Uniform silver nanoparticles on tunable porous N-doped carbon nanospheres for aerobic oxidative synthesis of aryl nitriles from benzylic alcohols》 was published in Applied Organometallic Chemistry. The article was written by Hashemi, Alireza Nemati; Eshghi, Hossein; Lamei, Kamran. The article contains the following contents:

Tunable N-doped carbon nanospheres were prepared from sucrose as carbon source and tris(2-aminoethyl)amine (TAEA) as nitrogen source by a simple and easily reproducible method. It was demonstrated that the tunable N-doping of carbon spheres could be realized by altering the ratio of TAEA in the raw materials. The content of doped nitrogen, surface area, pore volume and pore size of carbon nanospheres were increased with the increasing of TAEA amount in the hydrothermal process. Prepared N-doped carbon nanospheres acted as solid ligand for anchoring of Ag NPs which was generated via chem. reduction of Ag ions. Benzylic alcs. and aldehydes were converted into the aryl nitriles R-CN [R = Ph, 3-pyridyl, 3-HOC6H4, etc.] by using Ag/N-CS-1 nanospheres as the catalyst and O2 as the oxidant, efficiently. This catalyst was stable and could use for 6 successful runs. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 3-Pyridinemethanol

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In 2022,Ding, Yi-Xuan; Zhu, Zhou-Hao; Chen, Mu-Wang; Yu, Chang-Bin; Zhou, Yong-Gui published an article in Angewandte Chemie, International Edition. The title of the article was 《Rhodium-Catalyzed Asymmetric Hydrogenation of All-Carbon Aromatic Rings》.Recommanded Product: 89466-08-0 The author mentioned the following in the article:

Compared with heteroarenes, homogeneous asym. hydrogenation of all-carbon aromatic rings is a longstanding challenge in organic synthesis due to the strong aromaticity and difficult enantioselective control. Herein, authors report the rhodium/diphosphine-catalyzed asym. hydrogenation of all-carbon aromatic rings, affording a series of axially chiral cyclic compounds with high enantioselectivity through desymmetrization or kinetic resolution In addition, the central-chiral cyclic compounds were also obtained by asym. hydrogenation of phenanthrenes bearing a directing group. The key to success is the introduction of chiral diphosphine ligands with steric hindrance and strong electron-donating properties. The axially chiral monophosphine ligands could be obtained by simple conversion of the hydrogenation products bearing the phosphine atom. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

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Giofre, Sabrina; Molteni, Letizia; Nava, Donatella; Lo Presti, Leonardo; Beccalli, Egle Maria published an article in 2021. The article was titled 《Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza-)Alkenols》, and you may find the article in Angewandte Chemie, International Edition.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

An oxidative Pd-catalyzed intra-intermol. dioxygenation of (aza-)alkenols were reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent-iodine compounds was compared. In particular, by using a C-6 modified pyridinyl-oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio- and diastereoselectivity was achieved. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks

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Zhang, Jin-He; Xie, Hong-Xu; Li, Yue; Wang, Kai-Ming; Song, Zhiling; Zhu, Kong-Kai; Fang, Lei; Zhang, Juan; Jiang, Cheng-Shi published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors》.Computed Properties of C7H6O3 The article contains the following contents:

In this present study, a series of novel I [R = 2,3-(OH)2, 3-OH, 3,4-(OH)2, etc.] against α-glucosidase were designed and synthesized, and their biol. activities were evaluated in vitro and in vivo. Most of the designed analogs exhibited better inhibitory activity than the marketed acarbose, especially the most potent compound I [R = 3,4-(OH)2] with an IC50 value of 9.26 ± 1.84μM. The direct binding of I [R = 3,4-(OH)2] and I [R = 3,5-(OH)2] with α-glucosidase was confirmed by fluorescence quenching experiments, and the kinetic and mol. docking studies revealed that I [R = 3,4-(OH)2] and I [R = 3,5-(OH)2] inhibited α-glucosidase in a non-competitive manner. Cytotoxicity bioassay indicated compounds I [R = 3,4-(OH)2] and I [R = 3,5-(OH)2] were non-toxic towards LO2 and HepG2 at 100μM. Furthermore, both compounds were demonstrated to have in vivo hypoglycemic activity by reducing the blood glucose levels in sucrose-treated rats. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Computed Properties of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Computed Properties of C7H6O3

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《Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a Meta-Selective Inverse Sonogashira Coupling》 was written by Porey, Sandip; Zhang, Xinglong; Bhowmick, Suman; Kumar Singh, Vikas; Guin, Srimanta; Paton, Robert S.; Maiti, Debabrata. Product Details of 89466-08-0 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

The late-stage functionalization (LSF) of pharmaceutical and agrochem. compounds by the site-selective activation of C-H bonds provides access to diverse structural analogs and expands synthetically-accessible chem. space. We report a C-H functionalization LSF strategy that hinges on the use of an alkyne linchpin to assemble conjugates of sp2-rich marketed pharmaceuticals and agrochems. with sp3-rich 3D fragments and natural products. This is accomplished through a template-assisted inverse Sonogashira reaction that displays high levels of selectivity for the meta position. This protocol is also amenable to distal structural modifications of α-amino acids. The transformation of alkyne functionality to other functional groups further highlights the applicative potential. Computational and exptl. mechanistic studies shed light on the detailed mechanism. Turnover-limiting 1,2-migratory insertion of the bromoalkyne coupling partner occurs after relatively fast C-H activation. While this insertion occurs unselectively, regioconvergence results from one of the adducts undergoing a 1,2-trialkylsilyl migration to form the alkynylated product. A heterobimetallic Pd-Ag transition structure is essential for product formation in the β-bromide elimination step.2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Product Details of 89466-08-0

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《Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)-H Activation》 was written by Park, Hojoon; Yu, Jin-Quan. Synthetic Route of C9H11NO And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Cycloaddition reactions provide an expeditious route to construct ring systems in a highly convergent and stereoselective manner. For a typical cycloaddition reaction to occur, however, the installation of multiple reactive functional groups (π-bonds, leaving group, etc.) is required within the substrates, compromising the overall efficiency or scope of the cycloaddition reaction. Here, we report a palladium-catalyzed [3 + 2] reaction that utilizes twofold C(sp3)-H activation to generate the three-carbon unit for formal cycloaddition The initial β-C(sp3)-H activation of aliphatic amide, followed by maleimide insertion, triggers a relayed, second C(sp3)-H activation to complete a formal [3 + 2] cycloaddition The key to success was the use of weakly coordinating amide as the directing group, as previous studies have shown that Heck or alkylation pathways are preferred when stronger-coordinating directing groups are used with maleimide coupling partners [e.g., N,N-dimethylpivalamide + N-(4-nitrophenyl)maleimide → I (87%, dr 6:1)]. To promote the amide-directed C(sp3)-H activation step, the use of pyridine-3-sulfonic acid ligands is crucial. This method is compatible with a wide range of amide substrates, including lactams, which lead to spiro-bicyclic products. The [3 + 2] product is also shown to undergo a reductive desymmetrization process to access chiral cyclopentane bearing multiple stereocenters with excellent enantioselectivity. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C9H11NO

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In 2019,Journal of the American Chemical Society included an article by Sun, Shang-Zheng; Romano, Ciro; Martin, Ruben. Quality Control of 5-Hexen-1-ol. The article was titled 《Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins》. The information in the text is summarized as follows:

A catalytic deaminative alkylation of unactivated olefins is described. The protocol was characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both α-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization. In the part of experimental materials, we found many familiar compounds, such as 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Quality Control of 5-Hexen-1-ol

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In 2012,Dillon, Barry R.; Roberts, Dannielle F.; Entwistle, David A.; Glossop, Paul A.; Knight, Craig J.; Laity, Daniel A.; James, Kim; Praquin, Celine F.; Strang, Ross S.; Watson, Christine A. L. published 《Development of a scaleable synthesis of a geminal dimethyl tertiary amine as an inhaled muscarinic antagonist for the treatment of COPD》.Organic Process Research & Development published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

An efficient and scaleable process for the synthesis of muscarinic antagonist, PF-3635659 (I), is described, illustrating redesign of an analog-targeted synthesis which contained a scale-limiting rhodium-activated C-H amination step. The final route includes a reproducible modified Bouveault reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodol. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 2006,Barnes, David M.; Christesen, Alan C.; Engstrom, Kenneth M.; Haight, Anthony R.; Hsu, Margaret C.; Lee, Elaine C.; Peterson, Matthew J.; Plata, Daniel J.; Raje, Prasad S.; Stoner, Eric J.; Tedrow, Jason S.; Wagaw, Seble published 《Chlorination at the 8-Position of a Functionalized Quinolone and the Synthesis of Quinolone Antibiotic ABT-492》.Organic Process Research & Development published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

The total synthesis of quinolone antibiotic ABT-492 (I) has been achieved in 67% yield over nine steps from 2,4,5-trifluorobenzoic acid. The highlights of this synthesis include a novel chemoselective chlorination at the 8-position of a highly elaborated quinolone core. In addition, a Lewis acid promoted cyclization reaction to form the quinolone heterocycle was developed which was incorporated into a one-pot, three-step cyclization/coupling/protection sequence that proceeds in 93% yield. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Category: alcohols-buliding-blocks) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Category: alcohols-buliding-blocks Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Alcohol – Wikipedia,
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