Tag: 100-200

In 2019,ACS Biomaterials Science & Engineering included an article by Guan, Qinghua; Li, Nan; Shi, Leilei; Yu, Chunyang; Gao, Xihui; Yang, Jiapei; Guo, Yuanyuan; Li, Peiyong; Zhu, Xinyuan. Product Details of 4048-33-3. The article was titled 《Aggregation-Induced Emission Fluorophore-Based Molecular Beacon for Differentiating Tumor and Normal Cells by Detecting the Specific and False-Positive Signals》. The information in the text is summarized as follows:

Accurate and nondestructive detection of tumor-related mRNA in living cells is of great significance for tumor diagnosis. The universal technique for imaging mRNA in living cells is nucleic-acid-based fluorescent probes. However, the majority of developed nucleic-acid-based fluorescent probes were only designed to detect the targeted mRNA but could not avoid the interference arising from nuclease or other biol. matrixes, which results in inevitable false-pos. signals. To overcome this dilemma, a new aggregation-induced emission (AIE) fluorophore and the fluorescence resonance energy transfer (FRET) principle were used to establish a novel AIE fluorophore-based mol. beacon (AIE-MB). The AIE fluorophore tetraphenylethylene-quinoxaline (TPEQ) was designed by incorporating quinoxalinone with one typical AIE active luminogen tetraphenylethene (TPE), which could acquire a wide range of excitation wavelength. On this basis, the AIE-MB was designed by labeling two fluorophores: the TPEQ acceptor and an aggregation-caused quenching (ACQ) fluorophore 7-amino-4-methylcoumarin acid (AMCA) donor. On the basis of these two fluorophores, the AIE-MB could exhibit three states: weak fluorescence at primary stage, blue fluorescence (specific signal) generated by pairing with target mRNA in tumor cells, and both blue and green fluorescence (false-pos. signal) due to the endogenous degradation in normal cells. Obviously, the specific imaging for target mRNA in tumor cells and the false-pos. signal resulting from endogenous degradation in normal cells could be accurately distinguished through the different fluorescence emission. As a result, in contrast to traditional nucleic-acid-based fluorescent probes, the AIE-MB could improve the accuracy of the tumor detection by efficiently differentiating both specific and false-pos. signals, which showed potential application value in tumor diagnosis and biomedical research. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Product Details of 4048-33-3

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In 2018,Journal of the American Chemical Society included an article by Wang, Hao; Bai, Zibo; Jiao, Tangqian; Deng, Zhiqiang; Tong, Huarong; He, Gang; Peng, Qian; Chen, Gong. Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand》. The information in the text is summarized as follows:

A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated alkenes with C-H nucleophiles has been developed using a chiral monodentate oxazoline (MOXin) ligand. Various indoles react at C3 position with aminoquinoline-coupled 3-alkenamides to give γ addition products in good to excellent yield and enantioselectivity. This study represents an important advance of the development of chiral monodentate oxazoline ligands, which have been underexplored for asym. catalysis. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 1974,Okutani, Tetsuya; Kaneko, Tatsuhiko; Masuda, Katsutada published 《Azetidine derivatives. I. Synthesis o f 3-substituted azetidine derivatives》.Chemical & Pharmaceutical Bulletin published the findings.Formula: C3H8ClNO The information in the text is summarized as follows:

The azetidinols I (R = OH; R1 = Me2CH, Me3C, cyclohexyl, PhCHMe; R2 = H) were prepared by treating R1NH2 with epichlorohydrin followed by MeCN. I (R = OH, R1 = Et, R2 = H) was prepared from I (R = OH, R1 = R2 = H) and EtI. cis- and trans-I (R = OH, R1 = cyclohexyl, R2 = Ph) were prepared by bromination of PhCH:CHCH2Cl followed by treatment with cyclohexylamine. I (R = OH; R1 = Me2CH, Me3C, tert-octyl, cyclohexyl, PhCHMe, 1-adamantyl; R2 = H) were converted to I [R = MeSO3, NH2, CN, CO2H, NHC(:NH)NH2]. I [R = NHC(:NH)NH2] were antihypertensives (no data). In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Formula: C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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The author of 《Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones》 were Agrawal, Krishna C.; Booth, Barbara A.; DeNuzzo, Suzanne M.; Sartorelli, Alan C.. And the article was published in Journal of Medicinal Chemistry in 1975. Application In Synthesis of (4-Phenylpyridin-2-yl)methanol The author mentioned the following in the article:

Title compounds 4-(o-aminophenyl)- [55218-89-8], 4-(p-aminophenyl)- [55218-90-1], and 4-(m-aminophenyl)-2-formylpyridine thiosemicarbazone (I) [52583-84-3] were prepared from 4-phenylpyridine [939-23-1] by methylation with MeLi, nitration, separation of isomers as HCl or HNO3 salts, N-oxidation, rearrangement with Ac2O, hydrolysis, and oxidation of the resulting carbinol of the nitro group and reaction with thiosemicarbazide. Of the title compounds, only I was active, increasing the life span of mice bearing Sarcoma 180 ascites cells by ∼20 days. 2-Formyl-4-phenylpyridine thiosemicarbazone [55218-79-6] was only marginally active in the mouse sarcoma test. Structure-activity relations are discussed. In addition to this study using (4-Phenylpyridin-2-yl)methanol, there are many other studies that have used (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application In Synthesis of (4-Phenylpyridin-2-yl)methanol) was used in this study.

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol

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The author of 《Extraction and characterization of starch from the tubers of antigonon leptopus species》 were Hemke, A. T.; Sangle, N. D.; Chandak, K. K.; Pounikar, A. R.; Umekar, M. J.. And the article was published in World Journal of Pharmaceutical Research in 2020. Formula: C6H12O6 The author mentioned the following in the article:

Starch is a natural polymer and is a group of polysaccharides composed of glucopyranose units joined together by glycosidic linkages. Starch is an important polysaccharide extensively used in many industries like food, cosmetic, paper, textile, pharmaceutical etc. It is found to be present in appreciable quantity in stem, roots, leaves, seeds, fruits and tubers. Hence this study was conducted to isolate and characterize starch from tuber of Antigonon leptopus species. In this work starch from Antigonon leptopus tubure was extracted and % starch yield was calculated as well as evaluated for its macroscopic characters, Preliminary phytochem. screening of aqueous extract for the presence of carbohydrate, tannins , saponins and flavonoids. The result showed that there was a sufficient amount of starch yield. The compound microscope it showed the presence of round and oval shaped small and large starch particles, single as well as in groups. The diamond and prism shaped calcium oxalate crystals were also seen. Thus starch of tuber Antigonon leptopus species shows good properties and could serve as alternatives for the production of industrial products that may require starch. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Formula: C6H12O6

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Naito, Youichiro; Sugiura, Masanori; Yamaura, Yasunari; Fukaya, Chikara; Yokoyama, Kazumasa; Nakagawa, Yoshiaki; Ikeda, Tokuji; Senda, Mitsugi; Fujita, Toshio published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:

Various catechol derivatives (β-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. Their structure-activity relationships were examined quant. with substituent and structural parameters and regression anal. The variations of the inhibitory activity were explained in bilinear hydrophobic parameter (log P) terms, and steric (mol. thickness) and electronic (1H-NMR chem. shift of the proton adjacent to the catechol group) parameter terms. The hydrophobicity of the inhibitor mol. was important, and the optimum value of log P was ∼4.3-4.6, beyond which inhibition did not increase further. A lower electron d. of the aromatic ring containing the catechol group and the greater thickness of the lipophilic side chains were unfavorable to the activity. The results added a physicochem. basis for the selection of candidate compounds for developmental studies. In the experimental materials used by the author, we found 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Safety of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

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Frankowski, Kevin J.; Patnaik, Samarjit; Wang, Chen; Southall, Noel; Dutta, Dipannita; De, Soumitta; Li, Dandan; Dextras, Christopher; Lin, Yi-Han; Bryant-Connah, Marthe; Davis, Danielle; Wang, Feijun; Wachsmuth, Leah M.; Shah, Pranav; Williams, Jordan; Kabir, Md; Zhu, Edward; Baljinnyam, Bolormaa; Wang, Amy; Xu, Xin; Norton, John; Ferrer, Marc; Titus, Steve; Simeonov, Anton; Zheng, Wei; Mathews Griner, Lesley A.; Jadhav, Ajit; Aube, Jeffrey; Henderson, Mark J.; Rudloff, Udo; Schoenen, Frank J.; Huang, Sui; Marugan, Juan J. published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis》.Reference of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial. The experimental part of the paper was very detailed, including the reaction process of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Reference of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Reference of 4,4-Diethoxybutan-1-amine

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Safety of 3,3,3-Trifluoropropan-1-olOn November 15, 2021 ,《Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yu, Jia-Hui; Xu, Xiao-Fang; Hou, Wen; Meng, Ying; Huang, Mei-Yan; Lin, Jing; Chen, Wei-Min. The article conveys some information:

The Staphylococcus aureus can switch to a transient genotype-invariant dormancy, known as a persister, to survive treatment with high doses of antibiotics. This transient persister is an important reason underlying its resistance. There is an urgent need to find new antibacterial agents capable of eradicating methicillin-resistant S. aureus (MRSA) persisters. In this study, 37 new derivatives of cajaninstilbene acid (CSA) were designed and synthesized, and their biol. activity against MRSA persisters was evaluated. Most of the newly synthesized derivatives exhibit more potent antimicrobial properties against S. aureus and MRSA than CSA itself, and 23 of the 37 derivatives show a tendency to eradicate MRSA persisters. A representative compound, I, was demonstrated to target bacterial cell membranes. It eradicated the adherent biofilm of MRSA in a concentration dependent manner, and showed a synergistic antibacterial effect with piperacilin. In a model mouse abscess caused by MRSA persisters, I effectively reduced the bacterial load in vivo. These results indicate that I is a potential candidate for treatment of MRSA persister infections. In the experiment, the researchers used many compounds, for example, 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

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《New complexes of liquid crystal discotic triphenylenes: induction of the double gyroid phase》 was written by Otmakhova, O. A.; Piryazev, A. A.; Bondarenko, G. N.; Shandryuk, G. A.; Maryasevskaya, A. V.; Merekalov, A. S.; Ivanov, D. A.; Talroze, R. V.. Electric Literature of C3H7BrOThis research focused ontriphenylene discotic liquid crystal preparation phase transition self assembly. The article conveys some information:

Electron donor-acceptor liquid crystals have been attracting considerable attention due to possible applications in optoelectronics and photonics. The creation of such charge transfer complexes is a powerful and flexible instrument for modifying the structures and properties compared to those of the initial components. In the present work, such an approach is exemplified on new complexes formed via non-covalent interactions of triphenylene discotics, namely, 2,3,6,7,10,11-hexakis(pentyloxy) triphenylene (H5T) and 2-(acryloyloxypropyloxy)-3,6,7,10,11-pentapentylox-triphenylene (TPh-3A), with an electron acceptor, β-(2,4,7-trinitro-9-fluorenylideneaminooxy) propionic acid (TNF-carb). The structure of thin supported films of H5T, TPh-3A and their blends with TNF-carb was investigated by grazing-incidence wide-angle X-ray scattering using a synchrotron source. At room temperature, the pristine discotics crystallize in orthorhombic unit cells whereas the self-assembly of H5T and TPh-3A with TNF-carb results in a double gyroid and hexagonal phases, resp. Formation of the double gyroid phase with the lattice parameter of 36.5 Å is driven by phase separation between the aromatic and alkyl regions of the system. It is supposed that the TNF-carb mols. of the complex are positioned in the nodes of the structure while the H5T mols. are located in the struts adjoining the nodes via triple junctions. For the hexagonal crystal of the TPh-3A/TNF-carb complex, the acceptor mols. are likely located in the interstices between the neighboring supramol. columns of TPh-3A. The mol. structures of the blends were also explored by means of FTIR spectroscopy. A detailed FTIR spectra anal. illustrates fine changes in inter-mol. bonds. For example, the initially dimerized acceptor mols. totally disappear in the complex structures whereas in TPh-3A/TNF-carb addnl. H-bonds between the carboxylate group in TNF-carb and the ester group of TPh-3A form. The exptl. data allows putting forward possible mol. models of the complex structures. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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《Hydrotrifluoromethylthiolation of Unactivated Alkenes and Alkynes with Trifluoromethanesulfonic Anhydride through Deoxygenative Reduction and Photoredox Radical Processes》 was written by Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling. Related Products of 821-41-0This research focused onunactivated alkene alkyne trifluoromethanesulfonic anhydride hydrotrifluoromethylthiolation deoxygenative reduction photoredox; deoxygenation; hydrotrifluoromethylthiolation; photoredox catalysis; radical reactions; trifluoromethanesulfonic anhydrides. The article conveys some information:

An ongoing challenge in trifluoromethylthiolation reactions is the use of less expensive and easily available trifluoromethylthio sources. Herein, we disclose an unprecedented usage of trifluoromethanesulfonic anhydride (Tf2O) as a radical trifluoromethylthiolating reagent. Hydrotrifluoromethylthiolation of unactivated alkenes and alkynes with Tf2O in the presence of PMePh2 and H2O under visible-light photoredox catalysis gave the addition products. The trifluoromethylthio radical (.SCF3) was first formed from Tf2O through a photoredox radical processes and deoxygenative reduction of PMePh2, and H2O serves as the H-atom donor for the hydrotrifluoromethylthiolation reaction. This reaction provides a new strategy for radical trifluoromethylthiolation. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Related Products of 821-41-0

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