Tag: 100-200

The author of 《Fe3O4@FSM-16-SO3H as a novel magnetically recoverable nanostructured catalyst: preparation, characterization and catalytic application》 were Hashemi-Uderji, Somayeh; Abdollahi-Alibeik, Mohammad; Ranjbar-Karimi, Reza. And the article was published in Journal of Porous Materials in 2019. Name: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Fe3O4@FSM-16-SO3H was prepared as new magnetically recoverable catalyst and characterized by SEM, BET, XRD, EDS, VSM and FT-IR techniques. The catalytic activity was investigated in the reaction of various aldehydes, Et cyanoacetate, dimedone and ammonium acetate for the preparation of Polyhydroquinolines in one pot. This protocol suggests benefits in terms of higher yields and short reaction time. In addition, the catalyst could be separated using an external magnet and is reusable many times without significant loss of activity. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Matrix matters: Hyperbranched flame retardants in aliphatic and aromatic epoxy resins》 were Battig, Alexander; Markwart, Jens C.; Wurm, Frederik R.; Schartel, Bernhard. And the article was published in Polymer Degradation and Stability in 2019. Name: 5-Hexen-1-ol The author mentioned the following in the article:

Library of phosphorus-based flame retardants: phosphates and phosphoramides of low and high molar mass synthesis and their behavior investigation in two epoxy resins: one aliphatic and one aromatic The pyrolytic and burning behavior of the two resins (via TGA, TG-FTIR, Hot stage FTIR, Py-GC/MS, PCFC, DSC, LOI, UL-94, Cone calorimeter) are analyzed and compared to the results of flame retardant (FR)-containing composites. A decomposition pathway incorporating the identified modes of action and known chem. mechanisms is proposed. The overlap of decomposition temperature (Tdec) ranges of matrix and FR determines the efficacy of the system. Low molar mass FRs strongly impact material properties like Tg but are very reactive, and high molar mass variants are more thermally stable. Varying P-O and P-N content of the FR affects decomposition, but the chem. structure of the matrix also guides FR behavior. Thus, phosphates afford lower fire load and heat release in aliphatic epoxy resins, and phosphoramides can act as additives in an aromatic matrix or a reactive FRs in aliphatic ones. The chem. structure and the structure-property relationship of both FR and matrix are central to FR performance and must be viewed not as two sep. but as one codependent system. In the part of experimental materials, we found many familiar compounds, such as 5-Hexen-1-ol(cas: 821-41-0Name: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Name: 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Engelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B.. Recommanded Product: 89466-08-0. The article was titled 《Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors》. The information in the text is summarized as follows:

The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase inhibitors (TKIs) are accompanied by marked tumor shrinkage, the response is usually not durable. Most patients relapse within two years of therapy often due to acquisition of an addnl. mutation in EGFR kinase domain that confers resistance to TKIs. Crucially, oncogenic EGFR harboring both resistance mutations, T790M and C797S, can no longer be inhibited by currently approved EGFR TKIs. Here, we describe the discovery of BI-4020, which is a noncovalent, wild-type EGFR sparing, macrocyclic TKI. BI-4020 potently inhibits the above-described EGFR variants and induces tumor regressions in a cross-resistant EGFRdel19 T790M C797S xenograft model. Key was the identification of a highly selective but moderately potent benzimidazole followed by complete rigidification of the mol. through macrocyclization. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of the Iranian Chemical Society included an article by Maleki, Ali; Eskandarpour, Vahid. Recommanded Product: 3-Hydroxybenzaldehyde. The article was titled 《Design and development of a new functionalized cellulose-based magnetic nanocomposite: preparation, characterization, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives》. The information in the text is summarized as follows:

In this work, a facile protocol for the preparation of a new cellulose-based functionalized magnetic nanocomposite catalyst is described. The structure and morphol. of the prepared nanomaterial was characterized by SEM, energy-dispersive X-ray anal., X-ray diffraction patterns, and Fourier transform IR spectroscopy analyses. Then, its catalytic activity was investigated in the synthesis of 2,4-dihydropyrano[2,3-c]pyrazole I (R1 = CN, COOEt; R2 = H, 3-OH, 3-NO2, etc.; R3 = H, Me) and spiro[indoline-3,4′-pyrano[2,3-c] pyrazole derivatives II (R1 = CN, COOEt; R4 = 6-NO2, H, 5-Cl; R5 = H, Bn, Et, etc.) through a one-pot four-component reaction between isatin or aldehydes or acetophenones, ethylacetoacetate, hydrazine hydrate, and malononitrile or ethylcyanoacetate in short reaction times, high yields, and mild conditions. The nanocomposite was simply separated by an external magnet and reused several times without remarkable loss of activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Recommanded Product: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,European Journal of Medicinal Chemistry included an article by Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng. Electric Literature of C6H13NO. The article was titled 《Synthesis and evaluation of pyrimidoindole analogs in umbilical cord blood ex-vivo expansion》. The information in the text is summarized as follows:

The synthesis of pyrimidoindole analogs I [R = dimethylamino, 3-chloro-4-fluoroanilino, 3,4-dimethoxyphenthylamino, etc.] and II [R1 = anilino, morpholino, indole-3-ethylamino, etc.] and identified 6 compounds to be potent in promoting HSC ex vivo expansion. In particular, analog I [R = 2-(6,7-dimethoxy-1,2,3,4-trtrahydroisoquinolino)ethylamino (III)] was found to be the most effective in stimulating ex-vivo expansion of UCB CD34+ cells and CD34+CD38- cells. Initial data indicated that compound III promoted the absolute number of long term HSCs and inhibited their differentiation. UCB HSCs expanded with III retained adequate multi-lineage differentiation capacity. In addition, compound III was not cytotoxic at its test concentrations, suggested that it merits further investigation for potential clin. applications. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of the Indian Chemical Society included an article by Kavitha, G.; Vedhi, C.. HPLC of Formula: 1195-59-1. The article was titled 《Synthesis and characterization of benzoin α-oxime and 2,6-pyridine dimethanol and its application of anti-corrosion behaviour》. The information in the text is summarized as follows:

Synthesis of benzoin α-oxime and 2,6-pyridine dimethanol through eco-friendly method. These synthesized compounds are characterized by UV-Visible, FTIR and NMR spectral techniques. Anti-corrosion behavior of benzoin α-oxime and 2,6-pyridine dimethanol both the compounds studied with 2 N sulfuric acid on mild steel. The anti-corrosion behavior of the synthesized compounds was studied by subjecting to weight loss measurements, polarization studies and electrochem. impedance spectra (EIS) for the assessment of its performance. The studies were made with 2 N sulfuric acid as the corroding medium, but with the inhibitors concentration in the range of 50-350 ppm. The results revealed that the inhibitor studied perform better in the medium and function by the mechanism of adsorption on the metal surface. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Sandfort, Frederik; Strieth-Kalthoff, Felix; Klauck, Felix J. R.; James, Michael J.; Glorius, Frank published 《Deaminative Borylation of Aliphatic Amines Enabled by Visible Light Excitation of an Electron Donor-Acceptor Complex》.Chemistry – A European Journal published the findings.Safety of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl radicals derived from the single-electron reduction of redox-active pyridinium salts, which can be isolated or generated in situ, were borylated in a visible light-mediated reaction with bis(catecholato)diboron. No catalyst or further additives were required. The key electron donor-acceptor complex was characterized in detail by both exptl. and computational investigations. The synthetic potential of this mild protocol was demonstrated through the late-stage functionalization of natural products and drug mols. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Safety of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Balaji, B. S.; Dalal, Neha published 《An expedient, chemoselective N-chloroacetylation of amino alcohols under metal-free bio-compatible conditions》.Green Chemistry Letters and Reviews published the findings.Related Products of 27489-62-9 The information in the text is summarized as follows:

For the first time, the authors report an efficient, highly chemoselective N-chloroacetylation of amino compounds (amino alcs., amino acids) by chloroacetyl chloride, without compromising its high reactivity, to give chloroacetamides in phosphate buffer within 20 min. A systematic study of the effects of buffers, metal salts and HCl scavengers to optimize the reaction conditions is described. Intermol. competitive reactions were carried out and showed that anilines and aliphatic amines could be selectively N-chloroacylated in the presence of alcs. and phenols. The acylated products were obtained in high yields and could be easily isolated without chromatog. separation This reaction represents the first example of a metal-free bio-compatible synthesis under neutral conditions. This method is eco-friendly, easily scalable and robust. Intramol. competitive reactions of aminoalcs. were further studied and gave various N-chloroacetamides in very good yields. Finally, this protocol was conveniently extended to the synthesis of ceramides. In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Yang, Guo-Hui; Li, Yao; Li, Xin published 《Chirality Sensing of Molecules with Diverse Functional Groups by Using N-tert-Butyl Sulfinyl Squaramide》.Asian Journal of Organic Chemistry published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

The readily available bifunctional 3,5-[di(trifluoromethyl)]phenyl-substituted N-tert-Bu sulfinyl squaramide was used as a unique chiral solvating agent. The strong hydrogen-bonding donor ability of this chiral compound led to its effective use in the chiral recognition of multiple guest mols. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2014,Gentles, Robert G.; Ding, Min; Bender, John A.; Bergstrom, Carl P.; Grant-Young, Katharine; Hewawasam, Piyasena; Hudyma, Thomas; Martin, Scott; Nickel, Andrew; Regueiro-Ren, Alicia; Tu, Yong; Yang, Zhong; Yeung, Kap-Sun; Zheng, Xiaofan; Beno, Brett R.; Camac, Daniel M.; Chang, Chong-Hwan; Gao, Mian; Morin, Paul E.; Sheriff, Steven; Tredup, Jeff; Wan, John; Witmer, Mark R.; Xie, Dianlin; Hanumegowda, Umesh; Knipe, Jay; Mosure, Kathy; Santone, Kenneth S.; Parker, Dawn D.; Zhuo, Xiaoliang; Lemm, Julie; Liu, Mengping; Pelosi, Lenore; Rigat, Karen; Voss, Stacey; Wang, Yi; Wang, Ying-Kai; Colonno, Richard C.; Gao, Min; Roberts, Susan B.; Gao, Qi; Ng, Alicia; Meanwell, Nicholas A.; Kadow, John F. published 《Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase》.Journal of Medicinal Chemistry published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

Described herein are structure-activity relationship studies that resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors. Subsequent iterations of analog design and syntheses successfully addressed off-target activities, most notably human pregnane X receptor (hPXR) transactivation, and led to significant improvements in the physicochem. properties of lead compounds Those analogs exhibiting improved solubility and membrane permeability were shown to have notably enhanced pharmacokinetic profiles. Addnl., a series of alkyl bridged piperazine carboxamides was identified as being of particular interest, and from which the compound BMS-791325 (I) was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clin. evaluation. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts