Tag: 100-200

Piyanuch, Pornthip; Patawanich, Pramsak; Sirirak, Jitnapa; Suwatpipat, Kullatat; Kamkaew, Anyanee; Burgess, Kevin; Wanichacheva, Nantanit published their research in Journal of Hazardous Materials in 2021. The article was titled 《Rapid and visual detection of Cd2+ based on aza-BODIPY near infrared dye and its application in real and biological samples for environmental contamination screening》.Application of 1195-59-1 The article contains the following contents:

Cadmium highly toxic and hazardous, and it can adversely affect human health leading to serious disorders. Herein, a water-soluble near-IR sensor based on aza-BODIPY (1) was developed for dual determination of Cd2+ in environmental and biol. media. This sensor exhibited color change from colorless to green along with a fluorescence enhancement in the near-IR (NIR) region via photoinduced electron transfer (PET) after complexation with Cd2+. Sensor 1 can be employed in aqueous media at physiol. pH for quant. monitoring. It shows rapid response with high sensitivity (detection limit of 2.8 ppb; linear correlation over [Cd2+] 1.33 – 6.67 μM) and selectivity over potentially interfering ions. NIR sensor 1 can be used to determine [Cd2+] in living cells and environmental samples. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 1195-59-1

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Mishra, Sanket J.; Liu, Weiya; Beebe, Kristin; Banerjee, Monimoy; Kent, Caitlin N.; Munthali, Vitumbiko; Koren, John III; Taylor, John A. III; Neckers, Leonard M.; Holzbeierlein, Jeffrey; Blagg, Brian S. J. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition》.Related Products of 27489-62-9 The article contains the following contents:

The 90 kD heat shock proteins (Hsp90) are mol. chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-mol. inhibitors of Hsp90 have entered clin. trials for the treatment of cancer, all of which bind the Hsp90 N-terminus and exhibit pan-inhibitory activity against all four Hsp90 isoforms, which may lead to adverse effects. The development of Hsp90 isoform-selective inhibitors represents an alternative approach toward the treatment of cancer and may limit some of these detriments. Described herein, is a structure-based approach to develop isoform-selective inhibitors of Hsp90β, which induces the degradation of select Hsp90 clients without concomitant induction of Hsp90 levels. Together, these initial studies support the development of Hsp90β-selective inhibitors as a method for overcoming the detriments associated with pan-inhibition. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 27489-62-9

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Kiesow, Andreas; Teuscher, Nico; Morawietz, Maria; Eick, Sigrun published their research in Oral health & preventive dentistry in 2021. The article was titled 《In Vitro Surface Investigation of Calcium Fluoride-like Precipitation on Human Enamel after Topical Treatment with the Organic Fluoride Nicomethanol Hydrofluoride.》.Computed Properties of C6H7NO The article contains the following contents:

PURPOSE: The topical fluoride treatment of teeth can lead to a formation of CaF2-like material, which is considered to play a significant role in caries prevention. Different types of fluoride sources are applied. The aim of this study was to analyse the in vitro fluoridation effect of the lesser known organic fluoride compound nicomethanol hydrofluoride (NH) regarding fluoride accumulation and morphological changes on dental enamel surfaces. Materials and Methods: The fluoridation effect was investigated by scanning electron microscopy (SEM) and energy dispersive x-ray analysis (EDX) after treatment with fluoride solutions at a concentration of 1350 ppm F - and a pH value of 5.5. NH was tested against inorganic sodium fluoride (NaF) as reference. Fluoridation was done on pellicle-free and pellicle-covered enamel. Results: Formation of globular CaF2-like material was observed for both fluoride types. However, NH led to considerably higher calcium fluoride accumulation on the enamel surface as shown by both EDX and SEM. The globule diameters varied between 0.2 and 0.8 µm. Cross-sectional analysis revealed that the globular precipitates lay directly on the enamel surface; only the very surface-near volume was affected. No statistically significant difference of the fluoridation effect was measured with vs without saliva pre-treatment. Conclusion: The experiments showed a 6 times greater F - surface uptake on dental enamel with NH compared to sodium fluoride, thus suggesting an important role of NH during remineralization phases, fostering equilibrium between de- and remineralization. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C6H7NO

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Kobayashi, Masaki; Yamaguchi, Hiroki; Suzuki, Takeyuki; Obora, Yasushi published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Cross β-alkylation of primary alcohols catalysed by DMF-stabilized iridium nanoparticles》.Recommanded Product: 3-Pyridinemethanol The article contains the following contents:

A simple method for the cross β-alkylation of linear alcs. R(CH2)2OH (R = octyl, cyclohexylmethyl, Ph, 3-benzyl-4-hydroxybutyl, etc.) with benzyl alcs. R1CH2OH (R1 = Ph, cyclopropyl, thiophen-2-yl, etc.) in the presence of DMF-stabilized iridium nanoparticles was developed. The nanoparticles were prepared in one-step and thoroughly characterized. Furthermore, the optimum reaction conditions have a wide substrate scope and excellent product selectivity. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 3-Pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Light-Activated Adhesion and Debonding of Underwater Pressure-Sensitive Adhesives》 was written by Tseng, Yen-Ming; Narayanan, Amal; Mishra, Kaushik; Liu, Xinhao; Joy, Abraham. Safety of 3-Bromopropan-1-ol And the article was included in ACS Applied Materials & Interfaces in 2021. The article conveys some information:

Pressure-sensitive adhesives (PSAs) such as sticky notes and labels are a ubiquitous part of modern society. PSAs with a wide range of peel adhesion strength are designed by tailoring the bulk and surface properties of the adhesive. However, designing an adhesive with strong initial adhesion but showing an on-demand decrease in adhesion has been an enduring challenge in the design of PSAs. To address this challenge, we designed alkoxyphenacyl-based polyurethane (APPU) PSAs that show a photoactivated increase and decrease in peel strength. With increasing time of light exposure, the failure mode of our PSAs shifted from cohesive to adhesive failure, providing residue-free removal with up to 83% decrease in peel strength. The APPU-PSAs also adhere to substrates submerged underwater and show a similar photoinduced decrease in adhesion strength. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Safety of 3-Bromopropan-1-ol

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Alcohol – Wikipedia,
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《Creation of discrete active site domains via mesoporous silica poly(styrene) composite materials for incompatible acid-base cascade reactions》 was written by Cleveland, Jacob W.; Kumar, Dharam Raj; Cho, Jinwon; Jang, Seung Soon; Jones, Christopher W.. Reference of 5-Hexen-1-ol And the article was included in Catalysis Science & Technology in 2021. The article conveys some information:

This work highlights the design and synthesis of bifunctional mesoporous silicate – polymer composite dual acid-base supported cascade catalysts. Compartmentalization of the two incompatible active sites is sought by segregating acid sites on the silica surface, and base sites within polymer chains and/or polymer domains. The ability to isolate and segregate active sites via control of the mesoporous silica pore size and polymer mol. weight is probed with silica samples functionalized by a grafting-to process. Supplemental activator and reducing agent (SARA) atom transfer radical polymerization is used to synthesize random copolymers containing protected primary amines. Thiol-ene ‘click’ chem. facilitates silica functionalization via a convergent approach, with the ene-functionalized polymer end group and silica-grafted thiols forming SBA/MCM-SH-poly(styrene-co-2-(4-vinylbenzyl)isoindoline-1,3-dione). Polymer deprotection and thiol oxidation produces primary amine/sulfonic acid containing composite catalysts. With the polymer supported Lewis base and silica grafted Bronsted acid, the two-step deacetalization – Knoevenagel condensation cascade is explored to assess the ability of these polymer/silica hybrids to segregate active sites, allowing both acid and base site accessibility. Six composite catalysts are synthesized and tested in individual and cascade reactions with kinetic results demonstrating that lower mol. weight SBA-15-P1 and MCM-41-P1 catalysts outperform (higher turnover frequencies and initial rates) their higher mol. weight analogs, as well as a polymer-free system containing mol. active sites dispersed on the silica surface. Higher mol. weight composite catalysts perform more poorly due to limited chain solubility, mass transfer limitations, and poor catalyst accessibility. In many cases, the polymer chains effectively thread into the mesopores, with higher mol. weight polymers leading to pore blockage and inhibited mass transfer. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Reference of 5-Hexen-1-ol

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《First Stereoselective Total Synthesis of Modiolin》 was written by Rao, G. Padma; Mohan, B. Sathish; Siddaiah, V.. Product Details of 821-41-0 And the article was included in Russian Journal of Organic Chemistry in 2020. The article conveys some information:

The first stereoselective total synthesis of the linear pentaketide Modiolin has been performed via Jacobsen’ hydrolytic kinetic resolution and 2C-Wittig homologation as key steps. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Product Details of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Product Details of 821-41-0

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Alcohol – Wikipedia,
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《Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models》 was written by Amaradhi, Radhika; Banik, Avijit; Mohammed, Shabber; Patro, Vidyavathi; Rojas, Asheebo; Wang, Wenyi; Motati, Damoder Reddy; Dingledine, Ray; Ganesh, Thota. Recommanded Product: 2-Hydroxyphenylboronic acid And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathol. in central nervous system diseases such as epilepsy, Alzheimer’s disease, and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will be useful to attenuate the inflammatory consequences of EP2 activation and to reduce the severity of these chronic diseases. We recently developed a brain-permeable EP2 antagonist 1 (TG6-10-1), which displayed anti-inflammatory and neuroprotective actions in rodent models of status epilepticus. However, this compound exhibited moderate selectivity to EP2, a short plasma half-life in rodents (1.7 h) and low aqueous solubility (27μM), limiting its use in animal models of chronic disease. With lead-optimization studies, we have developed several novel EP2 antagonists with improved water solubility, brain penetration, high EP2 potency, and selectivity. These novel inhibitors suppress inflammatory gene expression induced by EP2 receptor activation in a microglial cell line, reinforcing the use of EP2 antagonists as anti-inflammatory agents. After reading the article, we found that the author used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

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《Efficient FRET Approaches toward Copper(II) and Cyanide Detections via Host-Guest Interactions of Photo-Switchable [2]Pseudo-Rotaxane Polymers Containing Naphthalimide and Merocyanine Moieties》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Ho, Feng-Cheng; Huang, Yi-Jing; Weng, Chang-Ching; Wu, Chia-Hua; Li, Yaw-Kuen; Wu, Judy I.; Lin, Hong-Cheu. Application of 1195-59-1 The article mentions the following:

A supramol. [2]pseudo-rotaxane containing a naphthalimide-based pillararene host and a spiropyran-based imidazole guest was synthesized and investigated in a semiaq. solution with 90% water fraction. Upon UV exposure, the close-form structure of nonemissive spiropyran guest could be transformed into the open-form structure of red-emissive merocyanine guest reversibly, which was utilized as a monofluorophoric sensor to detect copper(II) and cyanide ions. Moreover, the naphthalimide host as an energy donor with green photoluminescence (PL) emission at 505 nm was complexed with the merocyanine guest as an energy acceptor with red PL emission at 650 nm in 1:1 molar ratio to generate a [2]pseudo-rotaxane polymer, which was further verified by the diffusion coefficients of DOSY NMR (NMR) measurements. Due to the Förster resonance energy transfer (FRET) processes, the bifluorophoric [2]pseudo-rotaxane produced more efficient ratiometric PL behavior to induce a stronger red PL emission than that of the monofluorophoric guest; therefore, the PL sensor responses of the supramol. [2]pseudo-rotaxane toward copper(II) and cyanide ions could be further amplified via the FRET-OFF processes to turn off red PL emission of the reacted merocyanine acceptor and to recover green PL emission of the naphthalimide donor. Accordingly, the best and prominent values of the limit of detection (LOD) for the host-guest detections toward Cu2+ and CN- were 0.53 and 1.34μM, resp. The highest red MC emission with the optimum FRET processes of [2]pseudo-rotaxane was maintained around room temperature (20-40°C) in wide pH conditions (pH = 3-13), which can be utilized in the cell viability tests to prove the nontoxic and remarkable biomarker of [2]pseudo-rotaxane to detect Cu2+ and CN- in living cells. The developed FRET-OFF processes with ratiometric PL behavior of the bifluorophoric supramol. [2]pseudo-rotaxane polymer will open a new avenue to the future applications of chemo- and biosensors. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1195-59-1

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Alcohol – Wikipedia,
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Sitte, Nikolai A.; Ghiringhelli, Francesca; Shevchenko, Grigory A.; Rominger, Frank; Hashmi, A. Stephen K.; Schaub, Thomas published an article in Advanced Synthesis & Catalysis. The title of the article was 《Copper-Catalysed Synthesis of Propargyl Alcohol and Derivatives from Acetylene and other Terminal Alkynes》.Computed Properties of C8H7NO The author mentioned the following in the article:

A copper(I)/phosphine system that homogeneously catalyzed the alkynylation of formaldehyde with acetylene or terminal alkynes to afford propargyl alc. and derivatives RCCCH2OH [R = Ph, 4-MeOC6H4, 3-HOC6H4, etc.] was reported. Using acetylene at atm. pressure, the catalyst consisting of <1 mol% copper(I) phenylacetylide and a trialkyl bisphosphine ligand showed a high selectivity toward the formation of propargyl alcs. rather than 1,4-butynediol, which was not reported for common heterogeneous copper acetylide catalysts. The biphasic water/toluene reaction mixture allowed the separation of targeted products with the aqueous layer and catalyst recycling via the organic layer. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Computed Properties of C8H7NO) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C8H7NO

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Alcohol – Wikipedia,
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