Tag: 100-200

In 2019,Asian Journal of Chemistry included an article by Tripathi, Vishwa Deepak; Shukla, Akhilesh Kumar; Mohammed, Hasan Shamran. Application of 100-83-4. The article was titled 《Regioselective three component domino synthesis of polyhydrospiro[indoline-3,3′-pyrrolizine]-2-one via [3+2] cycloaddition reaction》. The information in the text is summarized as follows:

The synthesis and characterization of novel hexahydrospiro[indoline-3,3′-pyrrolizine]-2-one derivatives in good to excellent yields via [3+2] cycloaddtion reaction in regioselective manner was reported. These compounds were synthesized via multicomponent reaction of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline at room temperature All the synthesized hexahydrospiro mols. were characterized by 1H and 13C NMR, IR spectra, mass spectra and elemental anal. Regioselectivity in synthesized mols. were also explained on the basis of secondary orbital interactions. A simple and facile methodol. was developed which has great importance in synthetic chem. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Physics: Conference Series included an article by Cantillo, R.; Percino, J.; Murillo, E. A.. Quality Control of (4-Bromophenyl)methanol. The article was titled 《Synthesis and characterization of a derivative of carbazole obtained from bromobenzyl alcohol》. The information in the text is summarized as follows:

4-(9H-Carbazol-9-yl)benzenemethanol has been prepared by the reaction of carbazole and 4-bromobenzyl alc. The compound has been characterized by X-ray diffraction, IR and UV-visible spectroscopies, and 1H NMR. Its thermal stability has been evaluated. 4-(9H-Carbazol-9-yl)benzenemethanol exhibits yellow fluorescence. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Quality Control of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Quality Control of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Asian Journal of Organic Chemistry included an article by Xia, Qiangqiang; Shi, Zuodong; Yuan, Jiangpei; Bian, Qilong; Xu, Yuanqing; Liu, Baoying; Huang, Yongwei; Yang, Xiaobo; Xu, Hao. Formula: C7H7BrO. The article was titled 《Visible-light-enabled selective oxidation of primary alcohols through hydrogen-atom transfer and its application in the synthesis of quinazolinones》. The information in the text is summarized as follows:

A visible-light-enabled selective oxidation of alcs. to aldehydes RCHO [R = (CH2)4CH3, Ph, 2-thienyl, etc.] was developed under transition-metal-free conditions. Utilizing eosin Y as the direct hydrogen-atom transfer (HAT) photocatalyst and mol. oxygen as the terminal oxidant, both aromatic and aliphatic aldehydes could be obtained in moderate to good yields. Using this approach, various quinazolinones I [R1 = Me, Ph, 4-BrC6H4, etc.; R2 = H, Cl, Br, MeO, NO2; R3 = H, n-Pr, n-hexyl, etc.], including two real drug mols., were easily synthesized from the corresponding o-aminobenzamides and alcs. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
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In 2018,Journal of Medicinal Chemistry included an article by Sellmer, Andreas; Stangl, Hubert; Beyer, Mandy; Gruenstein, Elisabeth; Leonhardt, Michel; Pongratz, Herwig; Eichhorn, Emerich; Elz, Sigurd; Striegl, Birgit; Jenei-Lanzl, Zsuzsa; Dove, Stefan; Straub, Rainer H.; Kraemer, Oliver H.; Mahboobi, Siavosh. Recommanded Product: 126456-43-7. The article was titled 《Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors》. The information in the text is summarized as follows:

Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising new drugs for the therapy of these diseases. Whereas pan-HDACi inhibit all 11 Zn2+-dependent histone deacetylases (HDACs) and cause a broad spectrum of side effects, specific inhibitors of histone deacetylase 6 (HDAC6i) are supposed to have less side effects. The authors present the synthesis and biol. evaluation of Marbostats, novel HDAC6i that contain the hydroxamic acid moiety linked to tetrahydro-β-carboline derivatives The lead compound Marbostat-100 is a more potent and more selective HDAC6i than previously established well-characterized compounds in vitro as well as in cells. Moreover, Marbostat-100 is well tolerated by mice and effective against collagen type II induced arthritis. Thus, Marbostat-100 represents a most selective known HDAC6i and the possibility for clin. evaluation of a HDAC isoform-specific drug.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Povedailo, V. A.; Stupak, A. P.; Tsybulsky, D. A.; Shmanai, V. V.; Yakovlev, D. L. published 《Fluorescence Quenching of Carboxyfluoresceins Conjugated Convalently to Oligonucleotides》.Journal of Applied Spectroscopy published the findings.Reference of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Dynamic and static quenching of 6-(2′,7′-dimethoxy-4′,5′-dichloro)carboxyfluorescein (JOE) by nucleosides (deoxyadenosine, deoxycytidine, deoxyguanosine, thymidine, and deoxyuridine) in Tris-acetate buffer solution was analyzed using the Stern-Volmer equation. Only one of the five nucleosides, deoxyguanosine, exhibited predominantly static quenching. The fluorescence quantum yields in buffer solution of 5- and 6-carboxyfluorescein (FAM) and 5-and 6-JOE bound covalently to the oligonucleotide by a rigid linker (4-trans-aminocyclohexanol) were greater than those of their analogs with a flexible linker (6-aminohexanol). It was shown that fluorescence quenching in systems with a flexible linker occurred mainly through van-der-Waals contact of the fluorophore with guanine. An increase in the number of consecutively located guanines in the oligonucleotides and their duplexes bound to the dye by a linker decreased the fluorescence quantum yield. Quantum-chem. calculations using the Gaussian 09 program provided an interpretation for the low-frequency shifts of 5-FAM and 5-JOE absorption and fluorescence spectra relative to those of the 6-isomers. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Su, Bo; Zhou, Tai-Gang; Li, Xian-Wei; Shao, Xiao-Ru; Xu, Pei-Lin; Wu, Wen-Lian; Hartwig, John F.; Shi, Zhang-Jie published 《A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds》.Angewandte Chemie, International Edition published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Iridium catalysts containing dative nitrogen ligands are highly active for the borylation and silylation of C-H bonds, but chiral analogs of these catalysts for enantioselective silylation reactions have not been developed. We report a new chiral pyridinyloxazoline ligand for enantioselective, intramol. silylation of sym. diarylmethoxy diethylsilanes. Regioselective and enantioselective silylation of unsym. substrates was also achieved in the presence of this newly developed system. Preliminary mechanistic studies imply that C-H bond cleavage is irreversible, but not the rate-determining step. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2016,Johansson, Anders; Loefberg, Christian; Antonsson, Madeleine; von Unge, Sverker; Hayes, Martin A.; Judkins, Robert; Ploj, Karolina; Benthem, Lambertus; Linden, Daniel; Brodin, Peter; Wennerberg, Marie; Fredenwall, Marlene; Li, Lanna; Persson, Joachim; Bergman, Rolf; Pettersen, Anna; Gennemark, Peter; Hogner, Anders published 《Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties》.Journal of Medicinal Chemistry published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

A novel series of melanin concentrating hormone receptor 1 (MCHr1) antagonists were the starting point for a drug discovery program that culminated in the discovery of 103 (AZD1979). The lead optimization program was conducted with a focus on reducing lipophilicity and understanding the physicochem. properties governing CNS exposure and undesired off-target pharmacol. such as hERG interactions. An integrated approach was taken where the key assay was ex vivo receptor occupancy in mice. The candidate compound 103 displayed appropriate lipophilicity for a CNS indication and showed excellent permeability with no efflux. Preclin. GLP toxicol. and safety pharmacol. studies were without major findings and 103 was taken into clin. trials. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Tian, Jun; Yu, Shanshan; Guo, Hongyu; Zhu, Maoshuai; Lu, Kai; Jiang, Yixuan; Yang, Jiaqiao; Yu, Xiaoqi; Pu, Lin published an article in European Journal of Organic Chemistry. The title of the article was 《Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Govindaraju, Santhosh; Daniel, Nobi Kunnathu; Tabassum, Sumaiya published an article in Materials Today: Proceedings. The title of the article was 《Sulfamic acid catalyzed grinding: A facile one-pot approach for the synthesis of polysubstituted pyrazoles under green conditions》.Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

A competent, rapid and simple grinding procedure for the synthesis of pharmacol. relevant polysubstituted pyrazoles catalyzed by sulfamic acid was reported via multicomponent reaction of substituted benzaldehydes, 4-nitrophenylacetonitrile, hydrazine hydrate, Et acetoacetate under solvent-free reaction conditions. In this reported protocol, four different reactants featuring diverse functional groups were assembled in one pot, enabling the synthesis of more diverse mol. structures in a facile manner. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choe, Hye Rin; Han, Sung Su; Kim, Yong-Il; Hong, Changhyun; Cho, Eun Jin; Nam, Ki Min published an article in 2021. The article was titled 《Understanding and Improving Photocatalytic Activity of Pd-Loaded BiVO4 Microspheres: Application to Visible Light-Induced Suzuki-Miyaura Coupling Reaction》, and you may find the article in ACS Applied Materials & Interfaces.SDS of cas: 89466-08-0 The information in the text is summarized as follows:

The effective utilization of visible light is required for exploiting photocatalytic reactions in indoor and outdoor environments. In this study, Pd-supported BiVO4 microspheres (Pd-BiVO4) were prepared for visible light-induced photocatalytic reactions. Under irradiation with a white light-emitting diode, the obtained Pd-BiVO4 composite exhibited considerably improved catalytic activity for the decomposition of an organic dye compared with other BiVO4 catalysts. The Pd-BiVO4 composite was also effective for catalytic organic transformation via the visible light-induced Suzuki-Miyaura coupling reaction. The photogenerated electrons in the conduction band of BiVO4 flowed to the Pd nanoparticles and amplified cross-coupling reaction. The influence of the crystal structure and grain size of BiVO4 and the role of the deposited Pd nanoparticles were fully investigated to elucidate the visible light activity of the catalyst. This system highlights the possibility of an indoor light source with low energy d. for sustainable organic transformations. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
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