Tag: 100-200

《Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis》 was written by Tear, Westley F.; Bag, Seema; Diaz-Gonzalez, Rosario; Ceballos-Perez, Gloria; Rojas-Barros, Domingo I.; Cordon-Obras, Carlos; Perez-Moreno, Guiomar; Garcia-Hernandez, Raquel; Martinez-Martinez, Maria Santos; Ruiz-Perez, Luis Miguel; Gamarro, Francisco; Gonzalez Pacanowska, Dolores; Caffrey, Conor R.; Ferrins, Lori; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P.. HPLC of Formula: 27489-62-9 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against human kinases GSK-3β, CDK-2, and CDK-4 were leveraged to try to improve the selectivity of the series, resulting in 23a which showed selectivity for T. b. brucei over these three human enzymes. In parallel, properties known to influence the absorption, distribution, metabolism, and excretion (ADME) profile of the series were optimized resulting in 20g being progressed into an efficacy study in mice. Though 20g showed toxicity in mice, it also demonstrated CNS penetration in a PK study and significant reduction of parasitemia in four out of the six mice. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9HPLC of Formula: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 27489-62-9

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《Helical supramolecular polymers with rationally designed binding sites for chiral guest recognition》 was written by Salikolimi, Krishnachary; Praveen, Vakayil K.; Sudhakar, Achalkumar Ammathnadu; Yamada, Kuniyo; Horimoto, Noriko Nishizawa; Ishida, Yasuhiro. Computed Properties of C9H11NO And the article was included in Nature Communications in 2020. The article conveys some information:

Since various helical supramol. polymers became available, their application to mol. chirality recognition have been anticipated but not extensively studied. So far, only a few examples of chiral reactions have been reported, but none for chiral separation Here, we report the application of a helical supramol. polymer to the enantio-separation of chiral guest mols. The monomer of this supramol. polymer is the salt-pair of a dendritic carboxylic acid with an enantiopure amino alc. In an apolar solvent, this salt-pair stacks via hydrogen bonds to form a helical polymer. In conjunction with this carboxylic acid, various amino alcs. afford supramol. polymers, whose helical handedness is determined by the stereochem. of the amino alcs. When two salts with the same chirality are mixed, they undergo copolymerization, while those with opposite chirality do not. Owing to this stereoselective copolymerizability, the helical supramol. polymer could bias the enantiomeric composition of chiral amino alcs. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Computed Properties of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C9H11NO

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《Copper-immobilized ionic liquid as an alternative to organic solvents in the one-pot synthesis of bioactive dihydropyrano[2,3-c]pyrazole derivatives》 was published in Applied Organometallic Chemistry in 2020. These research results belong to Ghafuri, Hossein; Kazemnezhad Leili, Maede; Esmaili Zand, Hamid Reza. Category: alcohols-buliding-blocks The article mentions the following:

In this study, a novel Cu-immobilized ionic liquid (IL) I · 3Cu(OAc)3- 3(H2O)was designed, characterized, and employed as both promoter and solvent in the synthesis of some dihydropyrano[2,3-c]pyrazoles II (R = C6H5, 2,4-(Cl)2C6H3, (CH2)2CH3, etc.; R1 = H, 4-O2NC6H4). The synthesized ionic liquid I · 3Cu(OAc)3- 3(H2O) was characterized by 1H NMR, 13C NMR, FTIR, ICP and EDX anal. and showed high catalytic activity to proceed the synthesis of bioactive dihydropyrano[2,3-c]pyrazole derivatives II. This method has the advantage of using the IL as a green medium for the synthesis of the products in high to excellent yields within short reaction times.3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Category: alcohols-buliding-blocks

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《Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Djuidje, Ernestine Nicaise; Sciabica, Sabrina; Buzzi, Raissa; Dissette, Valeria; Balzarini, Jan; Liekens, Sandra; Serra, Elena; Andreotti, Elisa; Manfredini, Stefano; Vertuani, Silvia; Baldisserotto, Anna. Recommanded Product: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Oxidative stress is the product or etiol. of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. A series of benzothiazole derivatives I (R = H, COOH, SO2NH2; R1 = Ph, 2-hydroxyphenyl, 3,4-dihydroxyphenyl, etc.) was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenol and different benzaldehydes R1CHO. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of I (R = H, R1 = 2,5-dihydroxyphenyl (A); R = H, R1 = 2,4,5-trihydroxyphenyl) as very interesting potential compounds for the design of multifunctional drugs. In particular, compound (A) is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32% inhibition with IC50 = 4.79μM. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 3,5-Dihydroxybenzaldehyde

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《Ultrasonic accelerated efficient synthesis of aminobenzochromenes using Ag2Cr2O7 nanoparticles as a reusable heterogeneous catalyst》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Ebrahimi, Mitra; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza. Recommanded Product: 3-Hydroxybenzaldehyde The article mentions the following:

Ag2Cr2O7 nanoparticles were found to be an exceedingly effective catalyst for the mild and green synthesis of aminobenzochromenes I (R = H, 4-Br, 3-Cl, 4-CN, 3-OH, 3-NO2) and II. The reaction was performed under ultrasonic irradiation as an innocuous tool and in water as a green solvent at room temperature This method encompasses several sustainable and economic benefits. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Recommanded Product: 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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《N-Heterocyclic Carbene-Catalyzed Activation of Ynals for the Construction of Functional Pyridines》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Li, Jia-Hui; Duan, Xiao-Yong; Tian, Zhao-Hui; Zheng, Yi-Fan; Qi, Jing. Electric Literature of C9H11NO The article mentions the following:

N-heterocyclic carbene-catalyzed activation of ynals for rapid synthesis of pyridine derivatives with important utilities was reported. This successful strategy using NHC-bound alkynyl acyl azolium as the key intermediate further improved the application of N-Ts 2-aminoacrylate as a nucleophile. Importantly, this work introduced an ester substituent to pyridines that was easily transformed to other functional groups.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Electric Literature of C9H11NO

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The author of 《N-Doped Yellow TiO2 Hollow Sphere-Mediated Visible-Light-Driven Efficient Esterification of Alcohol and N-Hydroxyimides to Active Esters》 were Singha, Krishnadipti; Ghosh, Subhash Ch.; Panda, Asit Baran. And the article was published in Chemistry – An Asian Journal in 2019. Safety of 3-Pyridinemethanol The author mentioned the following in the article:

A simple synthetic protocol for N-doped yellow TiO2 (N-TiO2) hollow spheres as an efficient visible-light-active photocatalyst using aqueous titanium peroxocarbonate complex (TPCC) solution as precursor and NH4OH was developed. In the developed strategy, the ammonium ion of TPCC and NH4OH acts as nitrogen source and structure-directing agent. The synthesized N-TiO2 hollow spheres were capable of promoting the synthesis of active esters ArCO2R [Ar = Et, 4-ClC6H4, 2-furyl, etc.; R = 2,5-dioxopyrrolidin-1-yl, 1,3-dioxoisoindolin-2-yl] of N-hydroxyimide and alc. through simultaneous selective oxidation of alc. to aldehyde followed by cross-dehydrogenative coupling (CDC) under ambient conditions upon irradiation of visible light. It was possible to develop a novel and cost-effective one-pot strategy for the synthesis of important esters and amides on gram scale using the developed strategy. The catalytic activity of N-TiO2 hollow spheres was much superior to that of other reported N-TiO2 samples as well as TiO2 with varying morphol. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Safety of 3-Pyridinemethanol

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The author of 《Reaction condition controlled nickel(II)-catalyzed C-C cross-coupling of alcohols》 were Zhang, Meng-Juan; Li, Hong-Xi; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping. And the article was published in Organic & Biomolecular Chemistry in 2019. SDS of cas: 873-75-6 The author mentioned the following in the article:

A controlled approach to a diverse range of β-alkylated secondary alcs., α-alkylated ketones and α,β-unsaturated ketones using the acceptorless dehydrogenation coupling methodol. employing a Ni(II) 4,6-dimethylpyrimidine-2-thiolate cluster catalyst under different reaction conditions was reported. This catalyst could tolerate a wide range of substrates and exhibited a high activity for the annulation reaction of secondary alcs. with 2-aminobenzyl alcs. to yield quinolines. This work is an example of precise chemoselectivity control by careful choice of reaction conditions. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6SDS of cas: 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.SDS of cas: 873-75-6 It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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The author of 《Selective trimethylsilylation of alcohols and phenols with hexamethyldisilazane catalyzed by LaCoO3 perovskite》 were Mehdipour, Ebrahim; Baharlouei, Ehsan; Zarnegar, Zohre. And the article was published in Iranian Chemical Communication in 2019. Name: 3-Pyridinemethanol The author mentioned the following in the article:

Trimethylsilylation of alcs. and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of primary and secondary alcs. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 3-Pyridinemethanol

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The author of 《Mediator and Additive Free Trifluoromethyl-Fluorination of Terminal Alkenes by Persistent Perfluoroalkyl Radical》 were Sato, Azusa; Ponomarenko, Maksym V.; Ono, Taizo; Roeschenthaler, Gerd-Volker; Soloshonok, Vadim A.. And the article was published in European Journal of Organic Chemistry in 2019. Related Products of 821-41-0 The author mentioned the following in the article:

It was found that the persistent perfluoro-3-ethyl-2,4-dimethyl-3-pentyl radical (PPFR) could serve as a source of both trifluoromethyl-radical and fluorine atom in the reactions with terminal olefins. The dual reactivity of the persistent PPFR allowed for both trifluoromethylation and fluorination of terminal olefins. This new approach towards di-functionalized 1-CF3-2-F-alkanes RCHFCH2CF3 [R = CH2HC(CO2Et)2, Bn, 3-ClC6H4CH2, etc.] demonstrated the widespread synthetic potential. Preliminary data strongly suggested potentially high synthetic value of this methodol. new transformation. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Related Products of 821-41-0

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Alcohol – Wikipedia,
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