Tag: 100-200

The author of 《Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites》 were Lartia, Remy; Vallee, Coelio; Defrancq, Eric. And the article was published in Organic & Biomolecular Chemistry in 2020. HPLC of Formula: 6346-09-4 The author mentioned the following in the article:

The com. available and cheap nucleotide phosphoramidites are routinely used for the oligonucleotide (ODN) assembly. T, isobutyryl-dG (iBudG), benzoyl-dA (BzdA), acetyl-dC (AcdC) and benzoyl-dC (BzdC) derivatives are sufficient to produce orthogonally protected ODNs. Clean and efficient (ca. 30%-70% yield) post-synthetic amination of an ODN assembled with such phosphoramidites was selectively achieved at the N4 position of a singly introduced BzdC. Such a method represents a novel and cheap strategy for the user-friendly post-modification of oligonucleotides at the internal position. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4HPLC of Formula: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 6346-09-4

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The author of 《Molecular and physiological characterization of the monosaccharide transporters gene family in Medicago truncatula》 were Komaitis, Fotios; Kalliampakou, Katerina; Botou, Maria; Nikolaidis, Marios; Kalloniati, Chrysanthi; Skliros, Dimitrios; Du, Baoguo; Rennenberg, Heinz; Amoutzias, Grigoris D.; Frillingos, Stathis; Flemetakis, Emmanouil. And the article was published in Journal of Experimental Botany in 2020. Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The author mentioned the following in the article:

Monosaccharide transporters (MSTs) represent key components of the carbon transport and partitioning mechanisms in plants, mediating the cell-to-cell and long-distance distribution of a wide variety of monosaccharides. In this study, we performed a thorough structural, mol., and physiol. characterization of the monosaccharide transporter gene family in the model legume Medicago truncatula. The complete set of MST family members was identified with a novel bioinformatic approach. Prolonged darkness was used as a test condition to identify the relevant transcriptomic and metabolic responses combining MST transcript profiling and metabolomic anal. Our results suggest that MSTs play a pivotal role in the efficient partitioning and utilization of sugars, and possibly in the mechanisms of carbon remobilization in nodules upon photosynthate-limiting conditions, as nodules are forced to acquire a new role as a source of both C and N.rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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COA of Formula: C6H13NOIn 2019 ,《An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Lei, Hongrui; Jia, Fang; Cao, Meng; Wang, Jie; Guo, Ming; Zhu, Minglin; Zuo, Daiying; Zhai, Xin. The article conveys some information:

The pyrimidine-2,4-diamine analogs exerted excellent activities in down-regulation of ALK phosphorylation. However, the prevalent drug-resistant site-mutation has gradually prevented the agents from being widely used. Herein, we conducted an exploration of high affinity moiety that bound to the solvent-front region (G1202R located) within the ATP binding site of ALK leading to the synthesis of thirty-five pyrimidine-2,4-diamine derivatives Among these compounds, urea group was extensively derivatized which finally resulted in the identification of the ‘semi-free urea’ compound 39. All compounds were assayed cytotoxicity and enzymic activities and 39 turned out to be the most potent one with IC50 values of 2.1, 0.91, 4.3 and 0.73 nM towards ALKwt, ALKL1196M, ALKG1202R and ROS1, resp. The performances of 39 on ALK- & ROS1-dependent cell lines were in good accordance with enzymic activities with IC50 values below 0.06μM. Besides, 39 induced cell apoptosis in a dose-dependent manner in H2228 cells. Finally, the binding models of 39 with ALKwt, ROS1, ALKL1196M and ALKG1202R were ideally established which further clearly elucidated their mode of action within the active site. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9COA of Formula: C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C6H13NO

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Name: 2,6-PyridinedimethanolIn 2021 ,《Synthetic platform for mono-functionalised tridentate macrocycles as key precursors of mechanically-linked macromolecular systems》 appeared in Organic Chemistry Frontiers. The author of the article were Sharma, Atul Kumar; Malineni, Jagadeesh; Box, Simon; Ghiassinejad, Sina; van Ruymbeke, Evelyne; Fustin, Charles-Andre. The article conveys some information:

We report here a synthetic platform toward mono-functionalized tridentate macrocycles based on a pyridine-2,6-bis-carboxamide motif. These macrocycles bear a variety of functional groups at the fourth position of the pyridine, giving access to a wide range of synthetic methods for further derivatization or preparation of more complex structures such as mech. interlocked mols. or polymer materials. To illustrate the potential of this family of macrocycles a series of square planar palladium complex-based pseudorotaxanes, containing different axles and functional groups on the ring, are synthesized, and then used to prepare a macro-pseudorotaxane, i.e. a polymer containing a rotaxane junction, and mech.-linked gels by a one-pot and a polyrotaxane approach. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Name: 2,6-Pyridinedimethanol

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In 2022,Awalt, Jon Kyle; Nguyen, Anh T. N.; Fyfe, Tim J.; Thai, Bui San; White, Paul J.; Christopoulos, Arthur; Jorg, Manuela; May, Lauren T.; Scammells, Peter J. published an article in Journal of Medicinal Chemistry. The title of the article was 《Examining the Role of the Linker in Bitopic N6-Substituted Adenosine Derivatives Acting as Biased Adenosine A1 Receptor Agonists》.Synthetic Route of C6H15NO The author mentioned the following in the article:

The adenosine A1 receptor is a therapeutic target based on its ability to provide cardioprotection during episodes of myocardial ischemia and reperfusion injury. However, the clin. translation of A1R agonists has been hindered by dose-limiting adverse effects (bradycardia and hypotension). Previously, we demonstrated that the bitopic agonist VCP746 (1), consisting of an adenosine pharmacophore linked to an allosteric moiety, can stimulate cardioprotective A1R signaling effects in the absence of unwanted bradycardia. This study maps the structure-activity relationships of 1 through modifications to the linker moiety. Derivatives differing in the flexibility, length, and nature of the linker were assessed, which revealed that the linker is tolerant of several modifications including added rigidity. Ligands featuring 1,4-disubstituted 1,2,3-triazoles were the most biased of the novel analogs but also displayed sub-nanomolar potency in a cAMP accumulation assay at the A2BR. To our knowledge, 10 is the most potent A2BR agonist published to date. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Synthetic Route of C6H15NO

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In 2022,Rapp, Mario R.; Leis, Wolfgang; Zinna, Francesco; Di Bari, Lorenzo; Arnold, Tamara; Speiser, Bernd; Seitz, Michael; Bettinger, Holger F. published an article in Chemistry – A European Journal. The title of the article was 《Bright Luminescence by Combining Chiral [2.2]Paracyclophane with a Boron-Nitrogen-Doped Polyaromatic Hydrocarbon Building Block》.Name: 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Novel BN-doped compounds based on chiral, tetrasubstituted [2.2]paracyclophane and NBN-benzo[f,g]tetracene were synthesized by Sonogashira-Hagihara coupling. Conjugated ethynyl linkers allow electronic communication between the π-electron systems through-bond, whereas through-space interactions are provided by strong π-π overlap between the pairs of NBN-building blocks. Excellent optical and chiroptical properties in racemic and enantiopure conditions were measured, with molar absorptivities up to ε=2.04 × 105 M-1 cm-1, fluorescence quantum yields up to ΦPL = 0.70, and intense, mirror-image electronic CD and circularly polarized luminescence signals of the magnitude of 10-3 for the absorption and luminescence dissymmetry factors. Computed glum,calculated values match the exptl. ones. Electroanal. data show both oxidation and reduction of the ethynyl-linked tetra-NBN-substituted paracyclophane, with an overlap of 2 redox processes for oxidation leading to a diradical dication. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Name: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Name: 2-Hydroxyphenylboronic acid

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《A new fluorescent probe for sensing of biothiols and screening of acetylcholinesterase inhibitors》 was written by Wu, Shengjun; Li, Yuge; Deng, Tao; Wang, Xiaojuan; Hu, Shiyou; Peng, Guiyuan; Huang, Xin-an; Ling, Yanwu; Liu, Fang. SDS of cas: 89466-08-0 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

A new N2O-type BODIPY probe (LF-Bop)(I) has been proposed for the selective and sensitive detection of biol. relevant small mol. thiols. This detection is based on the Michael addition reaction between the thiol and nitrostyrene groups in the probe, which decreases the quenching effect from the nitro group, thus resulting in the recovery of the deep-red fluorescence from the BODIPY structure. LF-Bop is able to detect all tested free thiols through a fluorescence turn-on assay. The lowest limit of detection (LOD) for glutathione is down to nanomolar levels (220 nM). Based on this probe, the authors have developed a new fluorescence assay for the screening of acetylcholinesterase inhibitors. In total, 11 natural and synthetic alkaloids have been evaluated. Both exptl. measurements and theor. mol. docking results reveal that both natural berberine and its synthetic derivative dihydroberberine are potential inhibitors of acetylcholinesterase. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
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《Rhodium-Catalysed Asymmetric Synthesis of 4-Alkyl-4H-Chromenes》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Chang, Zhiqian; Yao, Jian; Dou, Xiaowei. Reference of 2-Hydroxyphenylboronic acid The article mentions the following:

A general method for the catalytic asym. synthesis of 4-alkyl-4H-chromenes I [R1 = Me, Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4; R2 = n-Pr, cyclopropyl, Ph, etc.; R3 = H, 6-Me, 6-Cl, 6-F, 7-F] was developed. With readily available β-alkyl-substituted enones and 2-hydroxylated arylboronic acids, a rhodium-catalyzed asym. conjugate addition/intramol. hemi-acetalization/acid-promoted dehydration sequence led to the formation of 4-alkyl-4H-chromenes in up to 99% yield and with up to >99% ee. The current study remedied the methodol. deficiency in asym. synthesis of 4-alkyl-4H-chromenes I. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid

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Alcohol – Wikipedia,
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The author of 《Synthesis of Phosphoryl Thioamides via Three-Component Reaction of Phosphinic Chlorides with Amines and Sulfur》 were Kozlov, Mikhail; Kozlov, Andrey; Komkov, Alexander; Lyssenko, Konstantin; Zavarzin, Igor; Volkova, Yulia. And the article was published in Advanced Synthesis & Catalysis in 2019. COA of Formula: C6H15NO The author mentioned the following in the article:

A straightforward, practical, and atom-economical three-component synthesis of phosphoryl thioamides from phosphinic chlorides, elemental sulfur, and aliphatic amines has been developed. The scope and limitations of this transformation have been investigated. This protocol is distinguished by metal- and organic solvent-free conditions, and high tolerance to various functional groups; it can be adapted for scaled-up synthesis.6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.COA of Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
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SDS of cas: 6346-09-4On October 15, 2021 ,《Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach》 was published in Journal of Organic Chemistry. The article was written by Skrotzki, Eric A.; Vandavasi, Jaya Kishore; Newman, Stephen G.. The article contains the following contents:

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic mols., including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.4,4-Diethoxybutan-1-amine(cas: 6346-09-4SDS of cas: 6346-09-4) was used in this study.

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.SDS of cas: 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts