Tag: 100-200

The author of 《A Design Strategy for Single-Stranded Helicates using Pyridine-Hydrazone Ligands and PbII》 were Lobo, Maureen J.; Moratti, Stephen C.; Hanton, Lyall R.. And the article was published in Chemistry – An Asian Journal in 2019. COA of Formula: C7H9NO2 The author mentioned the following in the article:

The reactions of α,α-Pyridine-hydrazone (py-hz) ligands (L1-L5) with Pb(CF3SO3)2·H2O resulted in rare examples of discrete single-stranded helical PbII complexes. L1 and L2 formed nonhelical mononuclear complexes [PbL1(CF3SO3)2]·CHCl3 and [PbL2(CF3SO3)2][PbL2CF3SO3]CF3SO3·CH3CN, which reflected the high coordination number and effective saturation of PbII by the ligands. The reaction of L3 with PbII resulted in a dinuclear meso-helicate [Pb2L3(CF3SO3)2Br]CF3SO3·CH3CN with a Pb stereochem.-active lone pair. L4 directed single-stranded helicates with PbII, including [Pb2L4(CF3SO3)3]CF3SO3·CH3CN and [Pb2L4CF3SO3(MeOH)2](CF3SO3)3·2MeOH·2H2O. The acryloyl-modified py-hz ligand L5 formed helical and nonhelical complexes with PbII, including a trinuclear PbII complex [Pb3L5(CF3SO3)5]CF3SO3·3MeCN·Et2O. The high denticity of the long-stranded py-hz ligands L4 and L5 was essential to the formation of single-stranded helicates with PbII. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1COA of Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H9NO2

Referemce:
Alcohol – Wikipedia,
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In 2019,Reactive & Functional Polymers included an article by Bialek, Marzena; Fryga, Julia. Category: alcohols-buliding-blocks. The article was titled 《Effective copolymerization of ethylene with α,ω-alkenols and homopolymerization of α,ω-alkenols catalyzed by aminophenolate zirconium complex》. The information in the text is summarized as follows:

A zirconium complex of diamine-bis(phenolate) ligand, [(tBu2O2NN’)ZrCl]2(μ-O) where (tBu2O2NN’) = Me2N(CH2)2N(CH2-2-O–3,5-tBu2-C6H2)2, activated with (iBu)3Al/Ph3CB(C6F5)4, was for the first time used in copolymerization of ethylene with unsaturated alcs. (CH2 = CH(CH2)nCH2OH, where n = 7, 8, 3). The hydroxyl groups of comonomers were protected with R3-xAlClx (where x = 0 or 1, R = iBu, Et). In contrast to the formerly reported catalysts, the activity of this catalyst is much higher in ethylene/alkenols copolymerization than in ethylene homopolymerization and its lifetime is long. Moreover, the copolymers with high polar comonomer contents (up to 16.4 mol%, 52.3 wt%) were produced. The effects of copolymerization conditions such as comonomer/protecting agent molar ratio, comonomer concentration, ethylene pressure and reaction time on the catalyst activity and comonomer incorporation were studied. In addition, polyalkenols were synthesized by the coordination polymerization of α,ω-alkenols with the use of [(tBu2O2NN’)ZrCl]2(μ-O) and rac-Et(Ind)2ZrCl2 for reference DSC, TG, GPC, SEM, 1H and 13C NMR, and FTIR methods were used to characterize the (co)polymerization products. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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In 2019,Journal of Molecular Liquids included an article by Kanth, Priyanka; Singh, Hemant Kumar; Kumar, Vijay; Singh, Sachin Kumar; Rao, D. S. Shankar; Prasad, S. Krishna; Singh, Bachcha. Recommanded Product: 26153-38-8. The article was titled 《Effect of regioisomerism on the self-assembly, photophysical and gelation behavior of aroylhydrazone based polycatenars: Synthesis and characterization》. The information in the text is summarized as follows:

The five series of aroylhydrazone based polycatenars differing from each other in number and position of alkoxy chains on one end of the core; keeping other end the same was reported. A systematic variation in the structures was carried out to understand the effect of position and chain length on the mesophase behavior. In the case of single alkoxy chain at 4-position, there was a transition from Smectic C to Smectic A mesophase during cooling and Smectic A to Smectic C transition in heating cycle in all the homologues except n = 6 & n = 8. In the case of two alkoxy chains at 3-, 5-positions, the compounds were non-mesogenic in nature. On changing the position of alkoxy chains from 3-, 5-positions to 3-, 4-positions, intermol. forces weaken and these compounds become liquid crystalline and show columnar rectangular mesophase resulting from the effect of regioisomerism. Moving on to the series with three alkoxy chains, it was observed that 2-, 3-, 4-trialkoxy substituted compounds exhibited columnar rectangular mesophase except lower chain length (n = 6 & 8) while 3-, 4-, 5-trialkoxy substituted aroylhydrazones showed columnar rectangular mesophase; except n = 10 which showed columnar oblique mesophase. Thus it was established that on increasing d. of alkoxy chains around one terminal, mesophase changes from smectic to columnar mesophase. Temperature dependent Raman studies confirmed the presence of intermol. hydrogen bonding. Further, effect of substitution pattern did not show much influence on the photophys. properties of the mesogenic series in solid and solution state. However, the non-mesogenic series showed a different absorption and emission transition from the mesogenic series in solid and solution state. Solid state fluorescence studies showed almost similar emission maxima in all the series. However, it was also noticed that non-mesogenic series showed maximum red shift emission maxima in solid state as compared to that of solution All the series showed good gelation properties with less than 1% CGC (wt%) suggesting the strong ability of mols. to form gel. These H-bonded liquid-crystalline gels have immense potential for applications in emissive displays. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 26153-38-8

Referemce:
Alcohol – Wikipedia,
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Safety of 2-Hydroxyphenylboronic acidIn 2019 ,《Ruthenium(III)-bis(phenolato)bipyridine/TiO2 hybrids: unprecedented photocatalytic hydrogen evolution》 was published in Dalton Transactions. The article was written by Mongal, Binitendra Naath; Tiwari, Amritanjali; Malapaka, Chandrasekharam; Pal, Ujjwal. The article contains the following contents:

In this work, two new bis-(hydroxyphenyl)bipyridine based ruthenium complexes with 4-picoline (coded as MCS-B4M) and isonicotinic acid (coded as MCS-B5M), which act as ancillary ligands, have been synthesized and employed for the first time as photosensitizers in photocatalytic hydrogen evolution studies. The photocatalyst MCS-B5M/TiO2-Pt showed an impressive hydrogen generation rate of up to 4.2 mmol h-1 and turnover number (TON) of 84 959 after 5 h. The better performance of B5TP over B4TP was due to the higher excited state lifetime of MCS-B5M (∼2.6 ns) than that of MCS-B4M (∼1.4 ns). This leads to a higher probability of electron transfer to the TiO2/Pt composite in the case of the former and a stronger coupling of MCS-B5M excited states with the conduction band of the TiO2/Pt composite by the -COOH linkers of the isonicotinic acid moiety, resulting in better photosensitization as observed in the UV-Vis (DRS mode) absorbance study. The comparative study of the two dyes clearly shows the manifestations of their resp. ancillary ligands having contrasting electronic properties. This work gives a new class of ruthenium photosensitizers as efficient light harvesting photocatalysts.2-Hydroxyphenylboronic acid(cas: 89466-08-0Safety of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Safety of 2-Hydroxyphenylboronic acid

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Alcohol – Wikipedia,
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HPLC of Formula: 1195-59-1In 2021 ,《Pincer Ligand Enhanced Rhodium-Catalyzed Carbonylation of Formaldehyde: Direct Ethylene Glycol Production》 was published in Asian Journal of Organic Chemistry. The article was written by Meyer, Tim; Konrath, Robert; Kamer, Paul C. J.; Wu, Xiao-Feng. The article contains the following contents:

Formaldehyde is one of the most important bulk chems. and is produced on a million tone scale (52 million tons in 2017).[1] Since the middle of the last century, the challenge has remained to produce the valuable ethylene glycol (EG) directly from the C1 building block formaldehyde in a single step. In the systems reported so far, the reaction conditions were very harsh, often with pressures above 400 bar. However, under milder conditions, the selectivity was on the side of glycol aldehyde (GA) and the hydrogenation product methanol. Only traces of EG could be generated in the presence of a Rh catalyst. Herein, the authors describe a new Rh catalyst system with pincer ligand, which allows the direct one pot synthesis of EG from easy to handle paraformaldehyde (PFA) at remarkable mild conditions (70 bar, 100°C) and overcomes the aforementioned limitations with yield up to 40%. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1195-59-1

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Alcohol – Wikipedia,
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Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《A novel resveratrol derivative induces oxidative stress, G1 cell cycle arrest and premature senescence in A549 cells》 appeared in Latin American Journal of Pharmacy. The author of the article were Yang, Jie; Li, Jing; Qu, Xiao-Yu; Liu, Guo-Yun; Liu, Ren-Min. The article conveys some information:

Resveratrol has been reported to be a potential chemopreventive and anticancer agent. However, its poor bioavailability is being considered as a major obstacle in translating its effects in humans. Here, we report the synthesis and the anti-proliferative activities of fluorinated groups (CF3 and OCF3) substituted resveratrol derivatives A novel OCF3 substituted active derivative (A-3) owning the excellent stability and cell uptake ability in A549 cells, could improve the anti-proliferative activity (about 5 fold). In addition, A-3 could cause a clear block of cells in G1 phase (81.5%) and induce obvious premature senescence, via an apoptosis-independent mechanism; while resveratrol could cause an accumulation of cells in S phase (57.8%). Besides, A-3 treatment could cause an oxidized cellular environment in A549 cells. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

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Alcohol – Wikipedia,
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Name: 3-PyridinemethanolIn 2022 ,《Reductive Alkylation of Azides and Nitroarenes with Alcohols: A Selective Route to Mono- and Dialkylated Amines》 appeared in Journal of Organic Chemistry. The author of the article were Borthakur, Ishani; Maji, Milan; Joshi, Abhisek; Kundu, Sabuj. The article conveys some information:

Herein, we demonstrated an efficient protocol for reductive alkylation of azides/nitro compounds via a borrowing hydrogen (BH) method. By following this protocol, selective mono- and dialkylated amines were obtained under mild and solvent-free conditions. A series of control experiments and deuterium-labeling experiments were performed to understand this catalytic process. Mechanistic studies suggested that the Ir(III)-H was the active intermediate in this reaction. KIE study revealed that the breaking of the C-H bond of alc. might be the rate-limiting step. Notably, this solvent-free strategy disclosed a high TON of around 5600. Based on kinetic studies and control experiments, a metal-ligand cooperative mechanism was proposed. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C7H6O2In 2020 ,《An Organocatalytic Newer Synthetic Strategy Toward the Access of Polyfunctionalized 4H-Pyrans via Multicomponent Reactions》 appeared in Polycyclic Aromatic Compounds. The author of the article were Ramesh, Rathinam; Jayamathi, Jayaraj; Karthika, Chinnagoundar; Malecki, Jan Grzegorz; Lalitha, Appaswami. The article conveys some information:

An energy efficient, facile, and environmentally benign synthetic method to obtain pharmaceutically fortunate, diverse 4H-pyrans from frequently accessible aryl aldehydes, malononitrile, and dissimilar 1,3-diketoesters is described. The reactions took place smoothly at ambient temperature using 2-aminopyridine as a low-cost organocatalyst. The present domino strategy furnishes, the desired products in high yields with shorter reaction times. The structures of the o-nitro substituted skeletons were unambiguously confirmed by mono-crystal XRD. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
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Computed Properties of C6H13NOIn 2021 ,《Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005》 appeared in Journal of Medicinal Chemistry. The author of the article were Papa, Patrick; Whitefield, Brandon; Mortensen, Deborah S.; Cashion, Dan; Huang, Dehua; Torres, Eduardo; Parnes, Jason; Sapienza, John; Hansen, Joshua; Correa, Matthew; Delgado, Mercedes; Harris, Roy; Hegde, Sayee; Norris, Stephen; Bahmanyar, Sogole; Plantevin-Krenitsky, Veronique; Liu, Zheng; Leftheris, Katerina; Kulkarni, Ashutosh; Bennett, Brydon; Hur, Eun Mi; Ringheim, Garth; Khambatta, Godrej; Chan, Henry; Muir, Jeffrey; Blease, Kate; Burnett, Kelven; LeBrun, Laurie; Morrison, Lisa; Celeridad, Maria; Khattri, Roli; Cathers, Brian E.. The article conveys some information:

The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines such as interleukin-2 (IL-2). Herein, we report the synthesis and structure-activity relationship (SAR) of a novel series of PKC-θ inhibitors. Through a combination of structure-guided design and exploratory SAR, suitable replacements for the basic C4 amine of the original lead (3) were identified. Property-guided design enabled the identification of appropriately substituted C2 groups to afford potent analogs with metabolic stability and permeability to support in vivo testing. With exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression, a favorable safety profile, and demonstrated in vivo efficacy in models of acute and chronic T cell activation with oral dosing, CC-90005 (57) was selected for clin. development. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Computed Properties of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H13NO

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HPLC of Formula: 27489-62-9In 2022 ,《Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells》 appeared in Journal of Medicinal Chemistry. The author of the article were Zhang, Shiyan; Yan, Ziqin; Li, Yafang; Gong, Yang; Lyu, Xilin; Lou, Jianfeng; Zhang, Daizhou; Meng, Xiangjing; Zhao, Yujun. The article conveys some information:

Despite recent clin. progress in peptide-based dual inhibitors of MDM2/4, small-mol. ones with robust antitumor activities remain challenging. To tackle this issue, 31 (YL93) was structure-based designed and synthesized, which had MDM2/4 binding Ki values of 1.1 and 642 nM, resp. In three MDM4-overexpressing cancer cell lines harboring wild-type p53, 31 shows improved cell growth inhibition activities compared to RG7388, an MDM2-selective inhibitor in late-stage clin. trials. Mechanistic studies show that 31 increased cellular protein levels of p53 and p21 and upregulated the expression of p53-targeted genes in RKO cells with MDM4 amplification. In addition, 31 induced cell-cycle arrest and apoptosis in western blot and flow cytometry assays. Taken together, dual inhibition of MDM2/4 by 31 elicited stronger antitumor activities in vitro compared to selective MDM2 inhibitors in wild-type p53 and MDM4-overexpressing cancer cells. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9HPLC of Formula: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 27489-62-9

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Alcohol – Wikipedia,
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