Tag: 100-200

In 2019,Journal of Molecular Structure included an article by Eserci, Hande; Senkuytu, Elif; Okutan, Elif. COA of Formula: C6H15NO. The article was titled 《New cyclotriphosphazene based nanotweezers bearing perylene and glycol units and their non-covalent interactions with single walled carbon nanotubes》. The information in the text is summarized as follows:

We report on the design, synthesis and characterization of three new amphiphilic four fragment cyclotriphosphazene nanotweezers based on thermally stable carrier/router cyclotriphosphazene, extended polycyclic aromatic perylene bisimides with hydrophobic aliphatic tail and solvophilic glycol units, suitable for the exfoliation of single-walled carbon nanotubes (SWCNTs). The ultrasonication of SWCNT and new cyclotriphosphazene derivatives provided disentangled and undamaged SWCNTs, which interact with the perylene units through π-π interactions. The newly synthesized perylene-cyclotriphosphazenes were characterized by elemental anal., mass, 31P, 1H and 13C NMR techniques. The photophyisical behavior of cyclotriphosphazene derivatives and their nanocomposites were investigated via UV- Vis absorption and fluorescence emission spectroscopy. It was found that non-geminal- cis-tris- perylenebisimide substituted compound exhibit an addnl. fluorescence peak compared with the parent compounds which is consistent with an intramol. excimer formation. Prepared nanocomposites were also characterized via Raman spectroscopy and the morphol. features were analyzed by HR- TEM. The quality of the nanocomposite dispersions in water were evaluated by zeta potential anal.6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.COA of Formula: C6H15NO

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In 2019,Journal of Organic Chemistry included an article by Barman, Milan K.; Das, Kuhali; Maji, Biplab. Category: alcohols-buliding-blocks. The article was titled 《Selective Hydroboration of Carboxylic Acids with a Homogeneous Manganese Catalyst》. The information in the text is summarized as follows:

Catalytic reduction of carboxylic acid to the corresponding alc. is a challenging task of great importance for the production of a variety of value-added chems. Herein, a Mn-catalyzed chemoselective hydroboration of carboxylic acids was developed with a high turnover number (>99,000) and turnover frequency (>2000 h-1) at 25°. This method displayed tolerance of electronically and sterically differentiated substrates with high chemoselectivity. Importantly, aliphatic long-chain fatty acids, including biomass-derived compounds, can efficiently be reduced. Mechanistic studies revealed that the reaction occurs through the formation of active Mn-hydride species via an insertion and bond metathesis type mechanism.(4-Bromophenyl)methanol(cas: 873-75-6Category: alcohols-buliding-blocks) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Category: alcohols-buliding-blocks It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2017 ,《Sulfated cyclodextrins as water-soluble chiral NMR solvating agents for cationic compounds》 was published in Tetrahedron: Asymmetry. The article was written by Dalvano, Brielle E.; Wenzel, Thomas J.. The article contains the following contents:

The utility of sulfated cyclodextrins as water-soluble chiral NMR solvating agents for cationic substrates is described. Sulfated α-, β- and γ-cyclodextrin with degrees of substitution of 12, 13 and 14, resp., a sulfated β-cyclodextrin with a degree of substitution of 9 and a sulfobutyl ether β-cyclodextrin with a degree of substitution of 6.3 were examined Results with 33 water-soluble cationic organic salts are reported. Chiral differentiation with the sulfated cyclodextrins is compared to prior results obtained with anionic carboxymethylated and phosphated cyclodextrins. The highly sulfated cyclodextrins are often more effective at causing enantiomeric differentiation in 1H NMR spectra than the sulfobutyl ether, carboxymethylated and phosphated cyclodextrins, and are recommended as the 1st choice of a chiral solvating agent for the anal. of chiral cationic organic salts in aqueous solution After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Computed Properties of C7H7BrOIn 2020 ,《Iron Catalyzed Synthesis of Pyrimidines Under Air》 appeared in Advanced Synthesis & Catalysis. The author of the article were Mondal, Rakesh; Sinha, Suman; Das, Siuli; Chakraborty, Gargi; Paul, Nanda D.. The article conveys some information:

A well-defined Fe(II)-complex featuring redox non-innocent 2-phenylazo-(1,10-phenanthroline) ligand, as a catalyst, a wide array of 2,4,6-trisubstituted pyrimidines I (R = NH2, Me, Ph, 4-chlorophenyl, cyclopropy; R1 = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R2 = Ph, cyclopropyl, 4-(trifluoromethyl)phenyl, etc.) was prepared via multicomponent dehydrogenative coupling of primary R2CH2OH and secondary alcs. R1CH(CH3)OH with amidines NH2N(R)=NH under air at 100°C. A few control experiments were carried out to understand and unveil the plausible reaction mechanism. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6Computed Properties of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Computed Properties of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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In 2022,Lagu, Bharat; Wu, Xinyuan; Kulkarni, Santosh; Paul, Rakesh; Becherer, J. David; Olson, Lyndsay; Ravani, Stella; Chatzianastasiou, Athanasia; Papapetropoulos, Andreas; Andrzejewski, Sylvia published an article in Journal of Medicinal Chemistry. The title of the article was 《Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart》.Related Products of 27489-62-9 The author mentioned the following in the article:

CD38 is one of the major NAD (NAD+)- and NADP (NADP+)-consuming enzymes in mammals. NAD+, NADP+, and their reduced counterparts are essential coenzymes for numerous enzymic reactions, including the maintenance of cellular and mitochondrial redox balance. CD38 expression is upregulated in age-associated inflammation as well as numerous metabolic diseases, resulting in cellular and mitochondrial dysfunction. Recent literature studies demonstrate that CD38 is activated upon ischemia/reperfusion (I/R), leading to a depletion of NADP+, which results in endothelial damage and myocardial infarction in the heart. Despite increasing evidence of CD38 involvement in various disease states, relatively few CD38 enzymic inhibitors have been reported to date. Herein, we describe a CD38 enzymic inhibitor (MK-0159, IC50 = 3 nM against murine CD38) that inhibits CD38 in in vitro assay. Mice treated with MK-0159 (I) show strong protection from myocardial damage upon cardiac I/R injury compared to those treated with NAD+ precursors (nicotinamide riboside) or the known CD38 inhibitor, 78c. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 27489-62-9

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In 2022,Panczyk-Straszak, Katarzyna; Rapacz, Anna; Marona, Henryk; Zelaszczyk, Dorota; Karczewska, Elzbieta; Zajac, Martyna; Skiba-Kurek, Iwona; Siwek, Agata; Waszkielewicz, Anna published an article in ChemistrySelect. The title of the article was 《Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols》.Electric Literature of C6H13NO The author mentioned the following in the article:

Forty new aminoalkanol derivatives with potential anticonvulsant activity were designed and synthesized. In vivo studies (mice, i.p. administration) showed anticonvulsant activity (maximal electroshock seizure test, MES test) of nineteen compounds, (ED50 values and protective indexes PI ranging 22.62-78.30 mg/kg b.w. and 1.78-4.25, resp.). Compounds 30 (R,S-1-((2-(2-(2-chloro-5-methylphenoxy)ethoxy)ethyl)amino)propan-2-ol), 31 (R,S-2-((2-(2-(2-chloro-5-methylphenoxy)ethoxy)ethyl)amino)propan-1-ol) and 33 (S enantiomer of 31) showed relatively low ED50 values (26.45-34.26 mg/kg b.w.) accompanied by PI indexes above 3. Compounds 30 and 31 were investigated in terms of mechanism of action (5-HT1A receptors binding assay and in silico database screening) and safety against gastrointestinal flora (both compounds proved safe). An integral part of the study was also a comprehensive structure-activity relationship, including current and previously obtained results for aminoalkanol derivatives In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C6H13NO

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In 2022,Liang, Xuewu; Xie, Yongle; Liu, Xuyi; Xu, Hui; Ren, Hairu; Tang, Shuai; Liu, Qi; Huang, Min; Shao, Xueqing; Li, Chunpu; Zhou, Yu; Geng, Meiyu; Xie, Zuoquan; Liu, Hong published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis》.Recommanded Product: 27489-62-9 The author mentioned the following in the article:

As a complex pathogenesis driven by immune inflammatory factors and intestinal microbiota, the treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of these important pathogenic factors to reach a favorable therapeutic effect. In the current study, we discovered a series of imidazo[4,5-c]quinoline derivatives that potently and simultaneously inhibited two primary proinflammatory signaling pathways JAK/STAT and NF-κB. Especially, lead compound 8l showed potent inhibitory activities against interferon-stimulated genes (IC50: 3.3 nM) and NF-κB pathways (IC50: 150.7 nM) and decreased the release of various proinflammatory factors at the nanomolar level, including IL-6, IL-8, IL-1β, TNF-α, IL-12, and IFN-γ. In vivo, 8l produced a strong anti-inflammatory activity in both dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute enteritis models and restored the structural composition of gut microbiota. Collectively, this study provided valuable lead compounds for the treatment of IBD and revealed the great anti-inflammatory potential of the simultaneous suppression of JAK/STAT and NF-κB signals.trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: 27489-62-9

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In 2022,Zhu, Huilong; Zhou, Qianqian; Liu, Na; Xing, Junhao; Yao, Weijun; Dou, Xiaowei published an article in Advanced Synthesis & Catalysis. The title of the article was 《Relay Rhodium(I)/Acid Catalysis for Rapid Access to Benzo-2H-Pyrans and Benzofurans》.Formula: C6H7BO3 The author mentioned the following in the article:

Relay rhodium(I)/Broensted acid catalysis for tandem arylation-cyclization reaction was developed. Chemodivergent syntheses of benzo-2H-pyrans I [R = H, 6-Cl, 6-Me; R1 = n-Pr, cyclopropyl, i-BuCH2, PhCH2, PhCH2OCH2; R2 = Ph, R3 = Me, n-Pr, Ph, 4-MeOC6H4, etc.; R2 = H, R3 = H, Et, Ph; R2R3 = (CH2)4, o-C6H4-o-C6H4; etc.] and benzofurans II (R = H, 4-F, 5-Me, 6-F; R1 = Ph, 4-MeOC6H4, 2-thienyl, etc.; R2 = H, Me, n-pentyl, Ph; R3 = H) from propargyl alcs. R1CCCR2R3OH and R-substituted ortho-hydroxylated arylboronic acids were achieved under this relay catalysis system. An ortho-hydroxy effect on changing the chemoselectivity and reactivity was observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

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Chang, Chia-Wei; Shen, Ming-Hui; Lin, Wan-Yi; Wu, Chia-Ti; Tseng, Yu-Hsuan; Liao, Chih-Wei; Chang, Chun-Ting; Cheng, Ming-Hsiang; Chen, Jiun-Tai published an article in 2022. The article was titled 《Effects of Anion and Cross-Linker on the Surface Hydrophilicity and Selective Solvent-Induced Swelling of Poly(ionic liquid) Elastomers》, and you may find the article in ACS Applied Polymer Materials.SDS of cas: 627-18-9 The information in the text is summarized as follows:

Poly(ionic liquid)s (PILs) have attracted great attention because they preserve conventional characteristics of polymers while having special features of ionic liquids, such as good ionic conductivity and excellent electrochem. and thermal stability. The solvent absorption behaviors and solvent-induced responsiveness of PIL elastomers, however, have been less investigated. In this work, we prepare two PILs, poly[C3mim-MA][Br] and poly[C3mim-MA][TFSI], and examine their surface hydrophilicities and solvent-induced responsiveness. Ionic liquid monomers are synthesized and then polymerized with initiators and crosslinkers via free radical polymerization, forming PIL elastomers. The anions in the monomers can be replaced using an ion exchange process to prepare PIL elastomers with different anions. The surface properties, swelling behaviors, and solvent responsiveness of the PIL elastomer films with different anions and crosslinker ratios are investigated. The surface hydrophilicities of the PIL films are characterized by water contact angle measurements; the poly[C3mim-MA][Br] elastomer films are more hydrophilic than the poly[C3mim-MA][TFSI] elastomer films. Due to the different hydrophilicities, the poly[C3mim-MA][Br] and poly[C3mim-MA][TFSI] elastomer films can be swollen selectively in water and acetone, resp. For both elastomers, the swelling degrees are higher at lower crosslinking densities, and the volume expansions can be up to 655%. Furthermore, we investigate the solvent-vapor-induced responsiveness of bilayer films of PIL elastomers and polyimide (PI) tapes. The bilayer films can be bent selectively by exposing them to water or acetone vapors, depending on the anions. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.SDS of cas: 627-18-9

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Simonova, Maria; Ilgach, Dmitry; Kaskevich, Ksenia; Nepomnyashaya, Maria; Litvinova, Larisa; Filippov, Alexander; Yakimansky, Alexander published an article in 2021. The article was titled 《Novel Amphiphilic Polyfluorene-Graft-(Polymethacrylic Acid) Brushes: Synthesis, Conformation, and Self-Assembly》, and you may find the article in Polymers (Basel, Switzerland).SDS of cas: 627-18-9 The information in the text is summarized as follows:

Novel polyfluorene polymer brushes with polymethacrylic acid side chains were obtained by atom transfer radical polymerization (ATRP) and activator generated by electron transfer (AGET) ATRP of tert-Bu methacrylate on polyfluorene multifunctional macro-initiator, followed by protonolysis of the tert-Bu groups of the side chains. Kinetics of polymerization and mol. weights were fully characterized. These polymer brushes luminesce in the blue region of the spectrum with high quantum yields (0.64-0.77). It was shown that the luminescence intensity of polymer brushes is higher than the luminescence intensity of the macro-initiator (0.61). Moreover, due to their amphiphilic nature, they can form unimol. micelles when an alc. solution of the polymer brush is injected into water. These properties can potentially be used in drug delivery and bioimaging. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

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