Tag: 100-200

《Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases》 was written by Dang, Xiawei; Zhang, Lihong; Franco, Antonietta; Li, Jiajia; Rocha, Agostinho G.; Devanathan, Sriram; Dolle, Roland E.; Bernstein, Peter R.; Dorn, Gerald W.. Related Products of 27489-62-9 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Mutations in the mitochondrial fusion protein mitofusin (MFN) 2 cause the chronic neurodegenerative condition Charcot-Marie-Tooth disease type 2A (CMT2A), for which there is currently no treatment. Small-mol. activators of MFN1 and MFN2 enhance mitochondrial fusion and offer promise as therapy for this condition, but prototype compounds have poor pharmacokinetic properties. Herein, we describe a rational design of a series of 6-phenylhexanamide derivatives whose pharmacokinetic optimization yielded a 4-hydroxycyclohexyl analog, 13, with the potency, selectivity, and oral bioavailability of a preclin. candidate. Studies of 13cis- and trans-4-hydroxycyclohexyl isostereomers unexpectedly revealed functionality and protein engagement exclusively for the trans form, 13B(I). Preclin. absorption, distribution, metabolism, and excretion (ADME) and in vivo target engagement studies of 13B support further development of 6-phenylhexanamide derivatives as therapeutic agents for human CMT2A. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron-Catalyzed Direct Julia-Type Olefination of Alcohols》 was written by Landge, Vinod G.; Babu, Reshma; Yadav, Vinita; Subaramanian, Murugan; Gupta, Virendrakumar; Balaraman, Ekambaram. Synthetic Route of C6H7NO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Herein, we report an iron-catalyzed, convenient, and expedient strategy for the synthesis of styrene and naphthalene derivatives with the liberation of dihydrogen. The use of a catalyst derived from an earth-abundant metal provides a sustainable strategy to olefins. This method exhibits wide substrate scope (primary and secondary alcs.) functional group tolerance (amino, nitro, halo, alkoxy, thiomethoxy, and S- and N-heterocyclic compounds) that can be scaled up. The unprecedented synthesis of 1-Me naphthalenes proceeds via tandem methenylation/double dehydrogenation. Mechanistic study shows that the cleavage of the C-H bond of alc. is the rate-determining step. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Synthetic Route of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Synthetic Route of C6H7NO

Referemce:
Alcohol – Wikipedia,
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《Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells》 was written by de Souza, Vanessa P.; Santos, Fabiano S.; Rodembusch, Fabiano S.; Braga, Carolyne B.; Ornelas, Catia; Pilli, Ronaldo A.; Russowsky, Dennis. Product Details of 100-83-4 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields. The photophys. studies revealed dual fluorescence emission, attributed to excited enol forms (E*) and tautomeric (K*) species, resp., due to the ESIPT mechanism. The cytotoxic activity of all compounds was evaluated against MCF-7, Caco-2 and PC3 cancer cell lines and PNT2 normal prostate cells. The fluorescent Monastrol derivative 8f was the most active with cytotoxic activity very similar to cisplatin, whereas derivative 8c was the most selective towards the PC3 prostate cancer cells. The confocal laser scanning microscopy images of PC3 and MCF-7 cancer cell lines were acquired after incubation of the fluorescent Biginelli hybrids 8c and 8f, resp., demonstrating efficient cellular uptake of both compounds and strong fluorescence within the intracellular medium. These results show that the new hybrid 3,4-dihydropyrimidin-2-(thi)ones are dual-function bioactive compounds that act both as fluorescent probes and antineoplastic agents. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Product Details of 100-83-4

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《One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids》 was written by Ikawa, Takashi; Sun, Jing Kai; Takagi, Akira; Akai, Shuji. Related Products of 89466-08-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids 2-OH-3-R-4-R1-5-R2-C6HB(OH)2 (R = H, Me, F; R1 = H, F; R2 = H, F, CN, OCF3, etc.) was developed. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60°C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles e.g., 1,3-diphenylisobenzofuran to produce multisubstituted fused benzenes e.g., 9,10-diphenyl-9,10-dihydro-9,10-epoxyanthracene. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

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Alcohol – Wikipedia,
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《Cyclometalated Ruthenium Pincer Complexes as Catalysts for the α-Alkylation of Ketones with Alcohols》 was published in Chemistry – A European Journal in 2020. These research results belong to Piehl, Patrick; Amuso, Roberta; Alberico, Elisabetta; Junge, Henrik; Gabriele, Bartolo; Neumann, Helfried; Beller, Matthias. Related Products of 100-55-0 The article mentions the following:

Ruthenium PNP pincer complexes bearing supplementary cyclometalated C,N-bound ligands have been prepared and fully characterized for the first time. By replacing CO and H- as ancillary ligands in such complexes, addnl. electronic and steric modifications of this topical class of catalysts are possible. The advantages of the new catalysts are demonstrated in the general α-alkylation of ketones with alcs. following a hydrogen autotransfer protocol. Herein, various aliphatic and benzylic alcs. were applied as green alkylating agents for ketones bearing aromatic, heteroaromatic or aliphatic substituents as well as cyclic ones. Mechanistic investigations revealed that during catalysis, Ru carboxylate complexes are predominantly formed whereas neither the PNP nor the CN ligand are released from the catalyst in significant amounts In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Influence of catalyst nuclearity on copper-catalyzed aerobic alcohol oxidation》 was published in Dalton Transactions in 2020. These research results belong to Krittametaporn, Nuttaporn; Chantarojsiri, Teera; Virachotikul, Arnut; Phomphrai, Khamphee; Kuwamura, Naoto; Kojima, Tatsuhiro; Konno, Takumi; Sangtrirutnugul, Preeyanuch. Electric Literature of C7H7BrO The article mentions the following:

Reactions of CuX with the bis(triazolyl) ligand Hbtm [bis(1-benzyl-1H-1,2,3-triazol-4-yl)phenylmethanol] in CH2Cl2 afforded trinuclear copper(II) complexes with a core structure (μ-X)Cu3(μ-κ3-N,O,N-btm)3(L)2+ [X = Cl, L = CH3OH (1); X = Br, L = H2O (2)], while a similar reaction of [Cu(CH3CN)4](PF6) with the mono(triazolyl) ligand HPhtm [(1-benzyl-1H-1,2,3-triazol-4-yl)diphenylmethanol] resulted in the mononuclear complex [Cu(κ2-N,O-Phtm)(κ2-N,O-HPhtm)(κ1-N-HPhtm)][PF6] (3). The structural characterization of these complexes was made by single-crystal x-ray crystallog. in combination with elemental and ESI mass analyses. Catalytic studies toward aerobic oxidation of benzyl alc. to benzaldehyde revealed that the trinuclear 1 and 2 exhibited higher activities than the mononuclear 3 in both CH3CN and EtOH/H2O solvent systems. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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Alcohol – Wikipedia,
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The author of 《Design and synthesis a mitochondria-targeted dihydronicotinamide as radioprotector》 were Zhang, Yu-Rui; Wang, Jun-Ying; Li, Yuan-Yuan; Meng, Yuan-Yuan; Zhang, Yuan; Yang, Fu-Jun; Xu, Wen-Qing. And the article was published in Free Radical Biology & Medicine in 2019. Reference of 3-Bromopropan-1-ol The author mentioned the following in the article:

Radiation-induced damage to the mitochondrial macromols. and electron transfer chain (ETC), causing the generation of primary and secondary reactive oxygen (ROS) species. The continuous ROS production after radiation will trigger cell oxidative stress and ROS-mediated nucleus apoptosis and autophagy signaling pathways. Scavenging radiation-induced ROS effectively can help mitochondria to maintain their physiol. function and relief cells from oxidative stress. Nicotinamide is a critical endogenous antioxidant helping to neutralize ROS in vivo. In this study, we designed and synthesized a novel mitochondrial-targeted dihydronicotinamide (Mito-N) with the help of mitochondrial membrane potential to enter the mitochondria and scavenge ROS. According to experiment results, Mito-N significantly increased cell viability by 30.75% by neutralizing the accumulated ROS and resisting DNA strands breaks after irradiation Furthermore, the mice survival rate also improved with the treatment of Mito-N, by effectively ameliorating the hematopoietic system infliction under LD irradiation In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Reference of 3-Bromopropan-1-ol

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Alcohol – Wikipedia,
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The author of 《Manganese-Catalyzed Acceptorless Dehydrogenative Coupling of Alcohols With Sulfones: A Tool To Access Highly Substituted Vinyl Sulfones》 were Waiba, Satyadeep; Barman, Milan K.; Maji, Biplab. And the article was published in Journal of Organic Chemistry in 2019. Recommanded Product: (4-Bromophenyl)methanol The author mentioned the following in the article:

The development of first-row-transition-metal catalysts that can match with the reactivities of the noble metals is considered to be challenging yet very much a desirable goal in homogeneous catalysis. It has become even more fascinating to develop processes where these metals show a unique reactivity and selectivity than their higher congeners. Herein, we report on the catalytic activity of a pincer complex of the abundant earth metal manganese for an unprecedented acceptorless dehydrogenative coupling of alkyl sulfones with alcs. Thus, highly functionalized vinyl sulfones were obtained in moderate to good yields. Both benzylic and aliphatic alcs. could be utilized, and several functional groups including bromides and iodides are tolerated under the reaction conditions. The reaction is environmentally benign, producing dihydrogen and water as byproducts. Preliminary mechanistic experiments involving kinetic, deuterium-labeling, and NMR experiments were performed.(4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Direct growth of Au nanoparticles on g-C3N4 for photocatalytic selective alcohol oxidations》 were Liang, Hao; Wang, Jinguo; Jin, Bei; Li, Dianfeng; Men, Yong. And the article was published in Inorganic Chemistry Communications in 2019. COA of Formula: C7H7BrO The author mentioned the following in the article:

Direct growth of Au nanoparticles on g-C3N4 has been successfully achieved by a facile in-situ redox reaction between oxidative Au precursor and reductive gases produced via urea decomposition for the first time, which exhibits the highly enhanced activity for selective alc. oxidations in aqueous medium under visible-light irradiation due to the synergetic effects of the increased surface area, the enhanced light-harvesting ability and the improved separation efficiency of photocharges. Meanwhile, this photocatalyst also demonstrates strong stability, showing good potential in practical applications. This work can deliver some new insights to develop highly active photocatalysts for organic transformation reactions. In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6COA of Formula: C7H7BrO) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.COA of Formula: C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Ultrasonics Sonochemistry included an article by Taheri-Ledari, Reza; Rahimi, Jamal; Maleki, Ali. COA of Formula: C7H6O2. The article was titled 《Synergistic catalytic effect between ultrasound waves and pyrimidine-2,4-diamine-functionalized magnetic nanoparticles: Applied for synthesis of 1,4-dihydropyridine pharmaceutical derivatives》. The information in the text is summarized as follows:

A convenient strategy for synthesis of the various derivatives of 1,4-dihydropyridine (1,4-DHP), as one of the most important pharmaceutical compounds I (R = Ph, 3NO2C6H4, 4ClC6H4, etc.; R1 = Me, Et), II, is presented in this study. For this purpose, firstly, magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated and suitably coated by silica network (SiO2) and trimethoxy vinylsilane (TMVS). Then, their surfaces were well functionalized with pyrimidine-2,4-diamine (PDA) as the main active sites for catalyzing the synthesis reactions. In this regard, the performance of three different methods including reflux, microwave (MW) and ultrasound wave (USW) irradiations have been comparatively monitored via studying various analyses on the fabricated nanocatalyst (Fe3O4/SiO2-PDA). Concisely, high efficiency of the USW irradiation (in an ultrasound cleaning bath with a frequency of 50 kHz and power of 250 W/L) has been well proven through the investigation of the main factors such as excellent surface-functionalization, core/shell structure conservation, particle uniformity, close size distribution of the particles, and great inhibition of the particle aggregation. Then, the effectiveness of the USW irradiation as a promising co-catalyst agent has been clearly demonstrated in the 1,4-dihydropyridines I, II synthesis reactions. It has been concluded that the USW could provide more appropriate conditions for activation of the catalytic sites of Fe3O4/SiO2-PDA NPs. However, high reaction yields (89%) have been obtained in the short reaction times (10 min) due to the substantial synergistic effect between the presented nanocatalyst and USW. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4COA of Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.COA of Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts