Tag: 100-200

Related Products of 27489-62-9In 2019 ,《Discovery of [1,2,4]Triazolo[4,3-a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction》 appeared in Journal of Medicinal Chemistry. The author of the article were Qin, Mingze; Cao, Qi; Zheng, Shuaishuai; Tian, Ye; Zhang, Haotian; Xie, Jun; Xie, Hongbo; Liu, Yajing; Zhao, Yanfang; Gong, Ping. The article conveys some information:

Inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction using small-mol. inhibitors is an emerging immunotherapeutic approach. A novel series of [1,2,4]triazolo[4,3-a]pyridines were designed and found to be potent inhibitors of the PD-1/PD-L1 interaction. Among them, compound I exhibited the most potent activity, as assessed by homogeneous time-resolved fluorescence assay, with an IC50 of 92.3 nM. Furthermore, I dose-dependent elevated interferon-γ production in a coculture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. The authors concluded that I is a promising lead compound for the development of inhibitors of the PD-1/PD-L1 interaction. In addition, the authors explored the structure-activity relationships of the newly synthesized [1,2,4]triazolo[4,3-a]pyridines and demonstrated that a ring fusion strategy can be employed for designing analogs of the Bristol-Myers Squibb chem. series. These studies pave the way for future drug design. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 27489-62-9

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In 2022,Sharavyeva, Yu. O.; Siutkina, A. I.; Chashchina, S. V.; Novikova, V. V.; Makhmudov, R. R.; Shipilovskikh, S. A. published an article in Russian Chemical Bulletin. The title of the article was 《Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates》.Recommanded Product: (4-Bromophenyl)methanol The author mentioned the following in the article:

New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2H)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with alcs. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.(4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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Wang, Xin; Guo, Zhi; Da, Xiang; Xie, Xingyi published an article in 2022. The article was titled 《Antimicrobial polyurethane foams blown by CO2 adducts from polyethylenimines grafted with alkyl quaternary ammonium groups》, and you may find the article in Journal of Applied Polymer Science.Quality Control of 3-Bromopropan-1-ol The information in the text is summarized as follows:

Based on previous endeavors on antimicrobial polyurethane (PU) foams and CO2-releasing environment-friendly blowing agents, we explored a series of modified polyethylenimine (PEI)-CO2 adducts, serving as both blowing and antimicrobial agents for PUs. For this purpose, a quaternary ammonium chain with a C12 alkyl (C12+), either alone or together with neutral (C8 and C12) alkyls, was grafted onto branched PEI (Mn = 25,000 Da) backbones prior to saturation with CO2. The resultant four CO2 adducts, 5C12+5C8-, 5C12+5C12-, 10C12+- and 15C12+-PEI-CO2 (where the number indicates grafting rate in percentage of each side chain), all can well disperse into PU foaming mixtures, generating flexible PU foams with antimicrobial activity. 15C12+-PEI-CO2 displays the best dispersibility and highest foaming efficiency, while 10C12+-PEI-CO2 is the most antimicrobial toward both Gram pos. and neg. bacteria. The relatively high grafting rate in 15C12+-PEI-CO2 drives the formation of micelle-like particles in the foaming system; the outermost hydrophobic chains can somewhat prevent the internal quaternary ammoniums from accessing to the neg. charged cell membrane of bacteria, causing a reduction in antimicrobial efficacy compared with that of 10C12+-PEI-CO2. The developed PEI-CO2 adducts might replace the traditional ozone depletion and/or global warming blowing agents, and would show prolonged antimicrobial activity over rapidly leachable small mol. antimicrobial agents. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

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In 2019,Current Organocatalysis included an article by Mosallanezhad, Asiyeh; Kiyani, Hamzeh. SDS of cas: 100-83-4. The article was titled 《Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid》. The information in the text is summarized as follows:

The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields.3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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In 2017,Yu, Jianfei; Duan, Meng; Wu, Weilong; Qi, Xiaotian; Xue, Peng; Lan, Yu; Dong, Xiu-Qin; Zhang, Xumu published 《Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones》.Chemistry – A European Journal published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

We have successfully developed a series of novel and modular ferrocene-based amino-phosphine-alc. (f-Amphol) ligands and applied them to iridium-catalyzed asym. hydrogenation of various simple ketones to afford the corresponding chiral alcs. with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200,000). Control experiments and d. functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asym. hydrogenation. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Sun, Zhong; Duan, XiXin; Gnanasekarc, Pitchaimari; Yan, Ning; Shi, Junyou published an article in Biomass Conversion and Biorefinery. The title of the article was 《Review: cascade reactions for conversion of carbohydrates using heteropolyacids as the solid catalysts》.Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The author mentioned the following in the article:

A review. Abstract: Conversion of biomass into renewable chems. and fuels has received significant attention as an approach to enhance global sustainability. Biomass conversion, especially carbohydrate conversion, commonly involves cascade reactions. During these cascade reactions, various activity sites on carbohydrates may have different reactivities that enable us to control the final products through adjusting these activity sites. Heteropolyacids (HPAs), one of the major solid acid catalysts, are extensively used in biomass conversion owing to their numerous excellent physicochem. properties, such as strong Bronsted acidity, oxidizability, structural versatility, and easy design. Accordingly, this review aims to outline recent breakthroughs in obtaining platform chems. from carbohydrates by cascade reactions involving heteropolyacid catalysts. Moreover, the relationship between the final products and the structure of heteropolyacid catalysts is discussed and insights will help us to design more efficient solid acid catalysts for conversion of biomass to more sustainable chem. products. The experimental part of the paper was very detailed, including the reaction process of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Liu, Xiaocui; Zhang, Zhicai; Xu, Ling; Shi, Wenjing; Sun, Quanshan; Ding, Chongyang; Zheng, Huihua; Wang, Feng published an article in LWT–Food Science and Technology. The title of the article was 《Dioscorea saponin transforms the structure of truffle exo-polysaccharide and enhances its antioxidant activity》.COA of Formula: C6H12O6 The author mentioned the following in the article:

Dioscorea saponin (DS) can increase the exo-polysaccharide production of Tuber melanosporum. In the present study, we assessed the effect of DS on the structure and antioxidant activity of exo-polysaccharide. In the absence of DS, only one exo-polysaccharide (TP1) composed of mannose, rhamnose and glucose was isolated. However, two exo-polysaccharides (STP1 and STP2) were isolated in the presence of DS. STP1 was composed of glucose, galactose and arabinose, and STP2 consisted of rhamnose, glucose, galactose and arabinose. The skeletal structure of TP1, STP1 and STP2 was composed of α-D-glucopyranose. The antioxidant activity of exo-polysaccharide exhibited a concentration-dependent manner. The DPPH radical-scavenging rate (61.37%) and total antioxidant activity (50.02%) of STP were higher compared with TP1. The STP increased the DPPH radical-scavenging rate depending on the increase of the maximum rate of the reaction at saturating substrate concentrations (kcat), while STP increased the reducing power depending on the kcat and affinity of substrate to STP. The inhibitory action of STP on hydroxyl radical generation depended on the blockage of Fe2+ by STP, making it unable to react with H2O2 to form ·OH, and STP could bind to the Fe2+- H2O2 complex and prevent the Fe2+ from turning H2O2 into product. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1COA of Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.COA of Formula: C6H12O6

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In 2011,Organic & Biomolecular Chemistry included an article by Nie, Yao; Xiao, Rong; Xu, Yan; Montelione, Gaetano T.. Related Products of 133082-13-0. The article was titled 《Novel anti-Prelog stereospecific carbonyl reductases from Candida parapsilosis for asymmetric reduction of prochiral ketones》. The information in the text is summarized as follows:

The application of biocatalysis to the synthesis of chiral mols. is one of the greenest technologies for the replacement of chem. routes due to its environmentally benign reaction conditions and unparalleled chemo-, regio- and stereoselectivities. We have been interested in searching for carbonyl reductase enzymes and assessing their substrate specificity and stereoselectivity. We now report a gene cluster identified in Candida parapsilosis that consists of four open reading frames including three putative stereospecific carbonyl reductases (scr1, scr2, and scr3) and an alc. dehydrogenase (cpadh). These newly identified three stereospecific carbonyl reductases (SCRs) showed high catalytic activities for producing (S)-1-phenyl-1,2-ethanediol from 2-hydroxyacetophenone with NADPH as the coenzyme. Together with CPADH, all four enzymes from this cluster are carbonyl reductases with novel anti-Prelog stereoselectivity. SCR1 and SCR3 exhibited distinct specificities to acetophenone derivatives and chloro-substituted 2-hydroxyacetophenones, and especially very high activities towards Et 4-chloro-3-oxobutyrate, a β-ketoester with important pharmaceutical potential. Our study also showed that genomic mining is a powerful tool for the discovery of new enzymes. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Related Products of 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Related Products of 133082-13-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Application of 54-17-1On October 31, 2020 ,《New caryophyllene-type sesquiterpene and flavonol tetraglycoside with sixteen known compounds from sword bean (Canavalia gladiata)》 was published in Food Science and Biotechnology. The article was written by An, Hyun Jeong; Kim, Eun Hee; Lee, Hyoung Jae; Cho, Jeong-Yong; Moon, Jae-Hak. The article contains the following contents:

Eighteen compounds including new caryophyllene-type sesquiterpene and flavonol tetraglycoside were purified and isolated from sword beans (Canavalia gladiata). Two new compounds, (Z,1R,7S,9S)-7-hydroxy-11,11-dimethyl-8-methylenebicyclo[7.2.0]undec-4-ene-4-carboxylic acid (2) and kaempferol-7-O-α-L-dirhamnopyranosyl(1 → 2;1 → 6)-O-β-D-glucopyranosyl(1 → 2)-O-α-L-rhamnopyranoside (9), were identified. Other known compounds including Me gallate (1), (2S,3S,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol 1-O-β-D-glucopyranoside (3), (2S,3S,4E,8Z)-2-aminooctadeca-4,8-diene-1,3-diol 1-O-β-D-glucopyranoside (4), lupeol (5), trilinolein (6), 1,6-di-O-galloyl β-D-glucopyranoside (7), N-(2-methoxybenzoyl)homoserine (8), dihydrophaseic acid (10), dillenetin (11), kaempferol-7-O-[2-O-β-D-glucopyranosyl-6-O-α-L-rhamnopyranosyl]-α-L-rhamnopyranoside (12), canavalioside (13), kaempferol-3-O-[2-O-β-D-glucopyranosyl-6-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (14), kaempferol-3-O-(2,6-O-α-L-dirhamnopyranosyl)-β-D-glucopyranoside (15), kaempferol-3-O-rutinoside (16), gladiatoside A1 (17), and gladiatoside B1 (18) were identified. The chem. structures of these compounds were determined by ESI-MS and NMR analyses. In the experiment, the researchers used many compounds, for example, rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Application of 54-17-1

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《Palladium-Catalyzed Para-Selective Difluoromethylation of Arene Esters》 was written by Tu, Guangliang; Wang, Dongjie; Yuan, Chunchen; Zhang, Jingyu; Zhao, Yingsheng. Product Details of 2240-88-2 And the article was included in Journal of Organic Chemistry on August 21 ,2020. The article conveys some information:

Highly efficient, palladium-catalyzed, para-selective difluoromethylation of arene esters has been developed using [1,1′-biphenyl-2-yl]dicyclohexylphosphine as the effective ligand. A wide variety of arene esters bearing various functional groups were all compatible with the reaction conditions, leading to para-difluoromethylated products in moderate to good yields. Moreover, benzamide and benzenesulfonamide were also well-tolerated, suggesting that this novel catalyst system has broad applications to a variety of substrates. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Product Details of 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Product Details of 2240-88-2

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