Tag: 100-200

Kutlu, Turkan; Yildirim, Isil; Karabiyik, Hande; Kilincli, Ayten; Tekedereli, Ibrahim; Gok, Yetkin; Dikmen, Miris; Aktas, Aydin published their research in Journal of Molecular Structure in 2021. The article was titled 《Cytotoxic activity and apoptosis induction by a series Ag(I)-NHC complexes on human breast cancer cells and non-tumorigenic epithelial cell line》.HPLC of Formula: 627-18-9 The article contains the following contents:

The main problems encountered in treatment with anticancer drugs, undesired side effects, and toxicity. One of the most important parameters in cell transport is the lipophilic and solubility property of the drug. Enough with the potential effects, side effects with minimal demand for new anticancer compounds, mechanisms of action of the compound can meet because of increased efforts to be clarified. In this case, scientists were encouraged to do new research. In particular, the organometallic compounds are one of the topics focused lately. Ag(I)-NHC complexes are one of the most important classes of organometallic compounds Although the anticancer activity of Ag(I)-NHC complexes have been known recently times, the anticancer effects of 2-morpholino Et substituted benzimidazolium derivative, lipophilic, and solubility properties. Ag(I)-NHC complexes have not unknown yet. Therefore, we aimed to investigate of cytotoxic effect and apoptosis mechanism on breast cancer cell lines (MCF7), breast adenocarcinoma cell lines (MDA-MB-231), and non-tumorigenic epithelium cell lines (MCF 10A) of new Ag(I)-NHC complexes that derivative from morpholine-linked benzimidazole, were synthesized and antimicrobial activity was determined in our previous study. The cytotoxicity was determined by the MTS method, and the apoptosis mechanisms were determined the cell cycle, Annexin V, and caspase-3 anal. A new benzimidazolium salt bearing morpholino Et substituent (2) was synthesized. This benzimidazolium salt was characterized by NMR and FT-IR spectroscopic method and elemental anal. technique. Also, the structure of the new benzimidazolium salt was confirmed by single-crystal X-ray diffraction. Ag(I)-NHC complexes inhibited the growth of MCF7 and MDA-MB-231 cells depending on the dosage and time. The complexes 3a and 3b exhibited a significant difference p < 0.05; p < 0.001; and p < 0.001 level depend on depending on the increase in concentration on cancer cells. All compound induced by apoptosis was associated with stopping the cell cycle in phase G1 and the caspase-3 activity exhibited. The complex 3c was the lowest number of caspase-activating cells (2.1%) compared with both the control and other complexes in MDA-MB-231 cells. But the complex 3a was the highest number of caspase-activating cells (% 9.6). These findings have shown that these new Ag(I)-NHC complexes can be important new anticancer agents for breast cancer treatments. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9HPLC of Formula: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.HPLC of Formula: 627-18-9

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Midya, Siba P.; Subaramanian, Murugan; Babu, Reshma; Yadav, Vinita; Balaraman, Ekambaram published their research in Journal of Organic Chemistry in 2021. The article was titled 《Tandem Acceptorless Dehydrogenative Coupling-Decyanation under Nickel Catalysis》.SDS of cas: 1195-59-1 The article contains the following contents:

Nickel-catalyzed acceptorless dehydrogenative coupling of alcs. with nitriles followed by decyanation of nitriles to access diversely substituted olefins was reported. This unprecedented C=C bond-forming methodol. takes place in a tandem manner with the formation of formamide as a sole byproduct. The significant advantages of this strategy were the low-cost nickel catalyst, good functional group compatibility (ether, thioether, halo, cyano, ester, amino, N/O/S heterocycles; 43 examples), synthetic convenience, and high reaction selectivity and efficiency. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1SDS of cas: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 1195-59-1

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《Synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles, and in vivo pharmacokinetics depending on the structural characteristics》 was written by Matsuno, Jun; Kanamaru, Takuma; Arai, Koichi; Tanaka, Rena; Lee, Ji Ha; Takahashi, Rintaro; Sakurai, Kazuo; Fujii, Shota. Safety of 3,5-Dihydroxybenzaldehyde And the article was included in Journal of Controlled Release in 2020. The article conveys some information:

For designing nanoparticles as drug carriers, a covalently crosslinked structure is necessary for the structural stability in vivo. In this study, we prepared core crosslinked nanoparticles through the formation of nanoemulsions stabilized by poly(ethylene glycol) (PEG)-bearing surfactants. The structural characteristics of these particles were carefully evaluated using small-angle scattering techniques including dynamic, static, x-ray, and neutron scattering. The particles demonstrated high stability even in vivo, with the suppression of premature drug release owing to the crosslinked structure. Interestingly, the ability to retain encapsulated mols. was dependent on the mol. weight of PEG in vivo, presumably due to the difference in the crowding d. of PEG chains at the outermost surface. This suggests that conferring structural stability via a core crosslinked structure is surely important, but we also need to consider controlling the crowding d. of the hydrophilic polymer chains in the particle shell when designing drug carriers. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

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《Scalable Route to Electroactive and Light Active Perylene Diimide Dye Polymer Binder for Lithium-Ion Batteries》 was written by Ranque, Pierre; George, Chandramohan; Dubey, Rajeev K.; van der Jagt, Remco; Flahaut, Delphine; Dedryvere, Remi; Fehse, Marcus; Kassanos, Panagiotis; Jager, Wolter F.; Sudhoelter, Ernst J. R.; Kelder, Erik M.. Reference of 6-Aminohexan-1-ol And the article was included in ACS Applied Energy Materials in 2020. The article conveys some information:

Developing multifunctional polymeric binders is key to the design of energy storage technologies with value-added features. We report that a multigram-scale synthesis of perylene diimide polymer (PPDI), from a single batch via polymer analogous reaction route, yields high mol. weight polymers with suitable thermal stability and minimized solubility in electrolytes, potentially leading to improved binding affinity toward electrode particles. Further, it develops strategies for designing copolymers with virtually any desired composition via a subsequent grafting, leading to purpose-built binders. PPDI dye as both binder and electroactive additive in lithium half-cells using lithium iron phosphate exhibits good electrochem. performance. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Reference of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Reference of 6-Aminohexan-1-ol

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《Surface-Deactivated Core-Shell Metal-Organic Framework by Simple Ligand Exchange for Enhanced Size Discrimination in Aerobic Oxidation of Alcohols》 was written by Kim, Seongwoo; Lee, Jooyeon; Jeoung, Sungeun; Moon, Hoi Ri; Kim, Min. HPLC of Formula: 873-75-6 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Herein, through a simple post-synthetic ligand exchange (PSE) method, surface-deactivated (only core-active) core-shell-type MOF catalysts was synthesized, which contain TEMPO groups on the ligand as active sites for aerobic oxidation of alcs. to afford aldehydes or ketones. The porous but catalytically inactive shell ensured the size-selective permeability by sieving effects and induced all reactions to took place in the pores of the catalytically active core. Because PSE is a facile and universal approach, this could be rapidly applied to a variety of MOF-based catalysts for enhancing reaction selectivity. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6HPLC of Formula: 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.HPLC of Formula: 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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《Enzymatic synthesis of biobased polyesters utilizing aromatic diols as the rigid component》 was written by Pellis, Alessandro; Weinberger, Simone; Gigli, Matteo; Guebitz, Georg M.; Farmer, Thomas J.. Formula: C7H9NO2 And the article was included in European Polymer Journal in 2020. The article conveys some information:

In the present work, the biocatalyzed synthesis of a series of aromatic-aliphatic polyesters based on the aliphatic diesters di-Me succinate, di-Me adipate and di-Me sebacate and the aromatic diols 2,5-bis(hydroxymethyl)furan, 3,4-bis(hydroxymethyl)furan and 2,6-pyridinedimethanol were investigated. A similar series of polyesters based on the petroleum-based 1,3-benzenedimethanol, 1,4-benzenedimethanol and 1,4-benzenediethanol were also synthesized for comparison. Data show that the enzymic syntheses were successful starting from all diols, with the obtained polymers having isolated yields between 67 and over 90%, number average mol. weights between 3000 Da and 5000 Da and d.p. (DP) of 6-18 (based on the used aliphatic diesters and aromatic diols) when polymerized in di-Ph ether as solvent. Only using 3,4-bis(hydroxymethyl)furan as the diol led to shorter oligomers with isolated yields around 50% and DPs of 3-5. DSC and TGA thermal analyses show clear correlation between polymer crystallinity and aliphatic carbon chain length of the diester. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C7H9NO2

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《Copper Bis(oxazoline)-Catalyzed Enantioselective Alkynylation of Benzopyrylium Ions》 was published in Chemistry – A European Journal in 2020. These research results belong to Guan, Yong; Attard, Jonathan W.; Mattson, Anita E.. Related Products of 126456-43-7 The article mentions the following:

The stereocontrolled construction of biol. relevant chromanones and tetrahydroxanthones were achieved through the addition of alkynes to benzopyrylium trilfates under the influence of copper bis(oxazoline) catalysis. Excellent levels of enantiocontrol (63-98% ee) were achieved in the addition of a variety of alkynes to an array of chromenones with a hydrogen in the 2-position. Promising levels of enantiocontrol (54-67% ee) were achieved in the alkynylation of chromenones with esters in the 2-position, generating tertiary ether stereocenters resembling those frequently found in naturally occurring metabolites.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Related Products of 126456-43-7

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《Hydrosilylation of Aldehydes and Ketones Catalysed by Bis(phosphinite) Pincer Platinum Hydride Complexes》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Chang, Jiarui; Fang, Fei; Zhang, Jie; Chen, Xuenian. SDS of cas: 873-75-6 The article mentions the following:

Bis(phosphinite) pincer platinum hydride complexes, [2,6-(R2PO)2C6H3]PtH (R = tBu, iPr), were synthesized, characterized and applied to the hydrosilylation of aldehydes and ketones. NMR study and single crystal X-ray diffraction anal. indicated that the hydrides in these two platinum complexes are comparatively less hydridic: down-field 1H NMR resonances (0.71 and 0.98 ppm) and weak Pt-H interactions were observed Both the platinum complexes were found to be good catalysts for the hydrosilylation of aldehydes and ketones with phenylsilane. The corresponding alcs. were isolated in good to excellent yields following basic hydrolysis of the resultant hydrosilylation products and turnover frequencies (TOFs) up to 3200 h-1 were achieved at 60° in toluene, which are much higher than those of the hydrosilylation catalyzed by the corresponding nickel pincer hydride complexes. A possible mechanism for the present hydrosilylation process was discussed. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6SDS of cas: 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.SDS of cas: 873-75-6 It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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《Direct oxidation of alcohols catalysed by heterometallic complex [CuNi(bz)3(bpy)2]ClO4 to aldehydes and ketones mediated by hydrogen peroxide as a terminal oxidant》 was published in Inorganica Chimica Acta in 2020. These research results belong to Asthana, Mrityunjaya; Syiemlieh, Ibanphylla; Kumar, Arvind; Lal, Ram A.. Reference of 3-Pyridinemethanol The article mentions the following:

A ligand and additive-free [CuNi(bz)3(bpy)2]ClO4 catalyst system that efficiently and selectively catalyzed the oxidation of a range of primary and secondary benzylic alcs., 1-heteroaryl alcs., cinnamyl alc. and aliphatic alcs. mediated by hydrogen peroxide to the corresponding aldehydes and ketones, resp. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Reference of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 3-Pyridinemethanol

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The author of 《Pyridine-bridged bifunctional organocatalysts for the synthesis of cyclic carbonates from carbon dioxide》 were Liu, Quan-Yao; Shi, Lei; Liu, Ning. And the article was published in Journal of Chemical Research in 2019. Quality Control of 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Hydroxyl- and carboxyl-functionalized imidazolium halides were used as efficient bifunctional organocatalysts for the synthesis of cyclic carbonates from CO2 and epoxides under mild reaction conditions. Control experiments suggested that the cycloaddition reaction was realized by the combination of the nucleophilic halide anions with hydroxyl and carboxyl groups as hydrogen bond donors. Moreover, the bifunctional organocatalysts was easily recycled five times by simple filtration; however, a loss of activity was observed In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Quality Control of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Quality Control of 2-Hydroxyphenylboronic acid

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