Tag: 100-200

On October 31, 2021, Yang, Jing; Hao, Yuxin; Li, Nana; Wang, Chunyu; Liu, Yongping published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Metabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation. And the article contained the following:

Raspberry leaves, byproducts in raspberry production, are also a rich source of bioactive phytochems. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS anal. and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has pos. effects on gut microbiota and potential value of maintaining intestinal health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to raspberry leaf extract phenolic compound gastric digestion colonic fermentation, Placeholder for records without volume info and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

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On June 4, 2021, Wang, Sheng; Yu, Jiahao; Ye, Haiqiao; Chi, Mingbo; Yang, Heng; Wang, Haihui; Cao, Fan; Li, Wenqiang; Kong, Lingmei; Wang, Lin; Chen, Rui; Yang, Xuyong published an article.Reference of 1-Decanethiol The title of the article was Low-Threshold Amplified Spontaneous Emission in Blue Quantum Dots Enabled by Effectively Suppressing Auger Recombination. And the article contained the following:

The amplified spontaneous emissions in blue quantum dots (QDs) are still constrained by their high thresholds due to the challenge in engineering alloyed core-shell interface in the QDs with a wide bandgap to suppress Auger recombination. Compared with their red and green counterparts, the larger reactivity difference between the alloyed shell precursors makes it hard to regulate the composition and structure of the shell, and the smaller potential barrier between the core and the alloyed shell in blue QDs renders charge carriers tunneling into surface defects easier. Here, we employ a Lewis soft base ligand, 1-decanethiol, to balance the mismatched reactivity between Zn and Cd precursors for crafting a thick gradient alloyed shell with gradually increased potential barrier, which can not only restrict the charge carriers tunneling but also smooth the confinement potential. As a result, the resulting blue QDs show a long Auger lifetime of 1.3 ns, and a low threshold of 6.9 μJ cm-2 excited by a femtosecond laser, which is the record value among all reported blue-emitting nanocrystals and comparable to those of state-of-the-art red and green QDs. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Reference of 1-Decanethiol

The Article related to blue quantum dot amplified spontaneous emission suppressing auger recombination, Placeholder for records without volume info and other aspects.Reference of 1-Decanethiol

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On April 30, 2022, Yu, Yi; Jiang, Yimin; Wu, Shaofen; Shi, Zhaojiang; Wu, Jinnan; Yuan, Yaofeng; Ye, Keyin published an article.Application In Synthesis of 1-Decanethiol The title of the article was Electrochemistry enabled selective vicinal fluorosulfenylation and fluorosulfoxidation of alkenes. And the article contained the following:

Both sulfur and fluorine play important roles in organic synthesis, the life science, and materials science. The direct incorporation of these elements into organic scaffolds with precise control of the oxidation states of sulfur moieties is of great significance. Herein, we report the highly selective electrochem. vicinal fluorosulfenylation and fluorosulfoxidn. reactions of alkenes, which were enabled by the unique ability of electrochem. to dial in the potentials on demand. Preliminary mechanistic investigations revealed that the fluorosulfenylation reaction proceeded through a radical-polar crossover mechanism involving a key episulfonium ion intermediate. Subsequent electrochem. oxidation of fluorosulfides to fluorosulfoxides were readily achieved under a higher applied potential with the adventitious H2O in the reaction mixture The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

The Article related to alkene thiol selective vicinal fluorosulfenylation fluorosulfoxidn electrochem, Placeholder for records without volume info and other aspects.Application In Synthesis of 1-Decanethiol

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Mohammadifarani, Ahmad; Mousavi, Hosna Sadat Zamani; Hosseini, Amin; Aliabadi, Alireza published an article in 2020, the title of the article was Synthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects.Related Products of 621-37-4 And the article contains the following content:

Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ± 0.6 μM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to mercapto triazole phenylacetamide derivative cytotoxicity apoptosis anticancer, Placeholder for records without volume info and other aspects.Related Products of 621-37-4

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On July 31, 2017, Perinu, Cristina; Bernhardsen, Ida M.; Svendsen, Hallvard F.; Jens, Klaus-J. published an article.Product Details of 2160-93-2 The title of the article was CO2 Capture by Aqueous 3-(Methylamino)propylamine in Blend with Tertiary Amines: An NMR Analysis. And the article contained the following:

Aqueous 3-(Methylamino)propylamine (MAPA) in blend with 2-(Diethylamino)ethanol (DEEA) and other tertiary amines, which mainly differ from DEEA in the number of hydroxyl functions (-OH) and/or in the length and structure of their alkyl chain, are investigated. After absorption of carbon dioxide (CO2) at 40°C, quant. 13C NMR experiments are performed to calculate the concentration of the species in each blend at equilibrium, together with qual. NMR experiments for signal assignment. Speciation and absorption capacity data are discussed in terms of chem. structure and basicity of the tertiary amines. In general, it is observed that, at increasing pKa of the tertiary amines (decreasing number of -OH on the structure), there is a decrease of MAPA and primary and secondary MAPA carbamates, and an increase of MAPA dicarbamate, (bi)carbonate and of the absorption capacity. Within the mols. with the same number of -OH but differently branched, some exceptions are found. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to methylaminopropylamine tertiary amine solvent blend nmr carbon dioxide capture, Air Pollution and Industrial Hygiene: Other and other aspects.Product Details of 2160-93-2

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On November 30, 2018, Li, Yong-Xin; Yang, Jia-Ying; Alcantara, Miguel; Abelian, Grigor; Kulkarni, Ashutosh; Staubli, Ursula; Foster, Aalan C. published an article.HPLC of Formula: 32462-30-9 The title of the article was Inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 are effective in in vivo models of schizophrenia and visual dysfunction. And the article contained the following:

The N-methyl-D-aspartate receptor coagonist D-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We tested inhibitors of ASCT1 and ASCT2 for their effects in rodent models of schizophrenia and visual dysfunction, which had previously been shown to be responsive to D-serine. L-4-fluorophenylglycine (L-4FPG), L-4-hydroxyPG (L-4OHPG), and L-4-chloroPG (L-4ClPG) all showed high plasma bioavailability when administered systemically to rats and mice. L-4FPG showed good brain penetration with brain/plasma ratios of 0.7-1.4; however, values for L-4OHPG and L-4ClPG were lower. Systemically administered L-4FPG potently reduced amphetamine-induced hyperlocomotion in mice, whereas L-4OHPG was 100-fold less effective and L-4ClPG inactive at the doses tested. L-4FPG and L-4OHPG did not impair visual acuity in naive rats, and acute systemic administration of L-4FPG significantly improved the deficit in contrast sensitivity in blue light-treated rats caused by retinal degeneration. The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to neutral amino acid transporter asct1 asct2 schizophrenia visual dysfunction, Placeholder for records without volume info and other aspects.HPLC of Formula: 32462-30-9

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Moon, Jihyeon; Ok, Kang Min published an article in 2022, the title of the article was (R)- and (S)-[C8H10NO3]2[NbOF5]: noncentrosymmetric niobium oxyfluorides with large optical anisotropy.Formula: C8H9NO3 And the article contains the following content:

Huge crystals of noncentrosym. (NCS) organic-inorganic hybrid niobium oxyfluorides, (R)-[C8H10NO3]2[NbOF5] [(R)-Nb] and (S)-[C8H10NO3]2[NbOF5] [(S)-Nb], have been easily grown via a slow evaporation method in high yields through the systematic driving of chiral structure-directing agents, 4-hydroxy-D-(-)-2-phenylglycine [(R)-HPG] and 4-hydroxy-L-(+)-2-phenylglycine [(S)-HPG], resp. Both (R)-Nb and (S)-Nb crystallizing in the NCS nonpolar space group, P21212, exhibit pseudo-three-dimensional structures assembled via multiple hydrogen bonding interactions between distorted [Nb(O/F)2F4]2- octahedra and the resp. protonated HPG cations. Interestingly, crystals of (R)-Nb and (S)-Nb exhibit large birefringence (ηnexp) of [email protected] nm attributable to the strong p-p interactions arising from the stacked benzene rings in HPG cations. The reported materials exhibit strong stability in most solvents in a wide range of polarities. Detailed characterization studies, including thermal properties, various spectroscopic analyses, second-harmonic generation measurements, and electronic structure calculations on the reported materials, are also described. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to carboxybenzyloxy ammonium niobium pentoxide noncentrosym optical anisotropy, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

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On March 31, 2022, Luo, Ming; Li, Aixin; Wang, Feiqi; Jiang, Junfeng; Wang, Zhengbiao; You, Jiangfeng published an article.COA of Formula: C8H8O3 The title of the article was Integrative analysis of multiple metabolomes and transcriptome revealed color expression mechanism in red skin root syndrome of Panax ginseng. And the article contained the following:

Red skin root syndrome causes reduction of both production and quality of Panax ginseng (ginseng). However, its development process and key metabolites are still unknown. Multiple metabolomes including non-targeted metabolome, and anthocyanins-targeted and carotenoids-targeted metabolomes were performed on field grown red skin and healthy ginseng. The detected metabolites were analyzed in combination with previous transcriptome results. The total metabolite profiles revealed that primary metabolites especially citrate was decreased, but secondary metabolites mainly involved in phenylpropanoid pathway were increased in red skin ginseng compared to those in healthy ginseng. Targeted metabolome found that each gram of fresh red skin ginseng sample contained 8 μg β-carotene, 0.56 μg α-carotene, 0.017 μg rutin, 0.248 μg chalcone, and some anthocyanins including 0.023 μg cyanidin and 0.037 μg quercetin 3-O-glucoside, albeit in low concentrations but higher than those in healthy ginseng. Furthermore, integrative metabolome and transcriptome anal. revealed that changes of metabolites related to anthocyanins synthesis were correlated with the related gene expression patterns. Addnl., jasmonate (JA) and its precursor 12-oxophytodienoic acid increased their concentrations dramatically in red skin ginseng, suggesting the possible role of JA or JA signaling pathway in regulating red skin syndrome. Consistently, the expressions of 17 MYB transcription factors were differentially regulated in red skin ginseng. JA related cis-elements are widely distributed at their promoters. Taken together, our study revealed reduction of primary metabolism but increase of secondary metabolism in red skin ginseng. MYB transcription factors of JA signal pathway were supposed to mediate accumulation of anthocyanins and carotenoids that contributed to the development of red skin ginseng. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).COA of Formula: C8H8O3

The Article related to panax red skin root syndrome metabolome transcriptome color expression, Placeholder for records without volume info and other aspects.COA of Formula: C8H8O3

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Dankani, Abduljabbar I.; Aminu, Suleiman; Saidu, Umar; Ladan, Mukhtar J. published an article in 2022, the title of the article was Analogues of dipicolinic acid, phenanthroline, and N-ethylmaleimide as potential inhibitors of Plasmodium falciparum falcilysin.Application of 473-81-4 And the article contains the following content:

In a bid to meet its amino acid requirements, Plasmodium falciparum utilizes falcilysin (in addition to other proteases) to aid in cleaving the host Hb at the polar residues. The dependence of the parasite on the host Hb could lead to increased disease severity in the host. In this study, mol. docking analyses were used to evaluate the binding interactions of dipicolinic acid, phenanthroline, and N-ethylmaleimide analogs to P. falciparum falcilysin. The protein databank and the CheBI database were used to find P. falciparum falcilysin and the compounds, resp. The protein and the collected compounds were imported into PyRx virtual screening software and the docking was initiated. Following that, Discovery Studio was utilized to virtualize the 2D and 3D interactions. The binding energies of 4,7-diphenyl-1,10- phenanthroline 4′,4″-disulfonate and 4,7-diphenyl-1,10-phenanthroline 4′,4″-disulfonic acid were both more than -10.0 kcal/mol among the phenanthroline analogs while only oleanolic acid and N-ethylsuccinimide-mycothiol conjugate from the dipicolinic acid and Nethylmaleimide analogs had binding energies of -9.7 and -9.4 kcal/mol resp. The higher binding energies were attributable to hydrogen bond interactions as well as other interactions between the chems. and the amino acid residues of the falcilysin. The analogs were shown to be moderately safe in pharmacokinetic investigations and scaled Lipinski′s rule of five (RO5). The findings of the study revealed that analogs of dipicolinic acid, phenanthroline, and N-ethylmaleimide could serve as potential inhibitors of P. falciparum falcilysin. Thus, the compounds can be used as leads or structural scaffolds in the hunt for new therapeutic candidates against the enzyme. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application of 473-81-4

The Article related to plasmodium falcilysin dipicolinic acid phenanthroline n ethylmaleimide, Placeholder for records without volume info and other aspects.Application of 473-81-4

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Yang, Xiuxiu; Li, Haiyu; Zhao, Xiaofang; Liao, Wei; Zhang, Claire Xi; Yang, Zhongqiang published an article in 2020, the title of the article was A novel, label-free liquid crystal biosensor for Parkinson′s disease related alpha-synuclein.Application of 143-10-2 And the article contains the following content:

A liquid crystal biosensor based on DNA aptamer for sensitive detection of Parkinson′s Disease (PD) related alpha-synuclein was developed. This LC biosensor is constructed using a simple and label free method, and it not only enables early PD diagnosis, but also provides a general platform for detection based on DNA aptamer. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application of 143-10-2

The Article related to sequence liquid crystal biosensor parkinson’s disease alpha synuclein, Placeholder for records without volume info and other aspects.Application of 143-10-2

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