Tag: 100-200

Name: (4-Bromophenyl)methanolIn 2019 ,《Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy》 was published in Journal of Organic Chemistry. The article was written by Genc, Sertac; Arslan, Burcu; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya. The article contains the following contents:

Iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyzed the β-alkylation of secondary alcs. with primary alcs. and acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones through a borrowing hydrogen pathway. The β-alkylated alcs., including cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minute amount of the catalyst with a catalytic amount of NaOH or KOH under the air atm., liberating water (and H2 in the case of quinoline synthesis) as the sole byproduct. Notably, this system demonstrated turnover numbers of 940,000 (for β-alkylation of secondary alcs. with primary alcs. by using down to 0.0001 mol % = 1 ppm of the catalyst) and 9200 (acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones). After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Name: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Name: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Safety of (4-Bromophenyl)methanolIn 2020 ,《Ruthenium(II) Complexes of Heteroditopic N-Heterocyclic Carbene Ligands: Efficient Catalysts for C-N Bond Formation via a Hydrogen-Borrowing Strategy under Solvent-Free Conditions》 was published in Inorganic Chemistry. The article was written by Donthireddy, S. N. R.; Mathoor Illam, Praseetha; Rit, Arnab. The article contains the following contents:

Both imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) have evolved to be elite groups of N-heterocyclic carbene (NHC) ligands for homogeneous catalysis. To develop efficient Ru(II)-based catalysts incorporating these ligands for C-N bond-forming reactions via H-borrowing methodol., the authors used chelating ligands integrated with ImNHC and mesoionic tzNHC donors connected via a CH2 spacer with a diverse triazole backbone. The synthesized Ru(II) complexes 3 are highly efficient for C-N bond formation across a wide range of primary amine and alc. substrates under solvent-free conditions, and among all of the complexes studied here, catalyst 3a with a mesityl substituent displayed maximum activity. Catalyst 3a is also effective for the selective mono-N-methylation of various anilines using MeOH as a coupling partner, known to be relatively more difficult than other alcs. Also, complex 3a also delivers various substituted quinolines successfully via the reaction of 2-aminobenzyl alc. with several secondary alcs. Importantly, catalyst 3a exhibited the highest activity among the reported Ru(II) complexes for both the N-benzylation of aniline [achieving a turnover number (TON) of 50000] and the realization of quinoline 8a by reacting 2-aminobenzyl alc. with 2-phenylethanol (attaining a TON of 30000). The significance of electronic tuning in the Ru(II) complexes of chelating ligands featuring a combination of ImNHC and tzNHC donors with various triazole backbones is demonstrated by applying them in diverse C-N bond-forming reactions via a H-borrowing strategy. Notably, the Ru(II) complex 3a having an N-mesityl substituent displayed the highest activity among known Ru(II) complexes for both the N-benzylation of aniline [a turnover number (TON) of 50000] and the synthesis of quinoline via the reaction of 2-aminobenzyl alc. with 2-phenylethanol (a TON of 30000). In the experimental materials used by the author, we found (4-Bromophenyl)methanol(cas: 873-75-6Safety of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Safety of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Related Products of 27489-62-9In 2018 ,《α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes》 was published in Inorganic Chemistry. The article was written by Biancalana, Lorenzo; Batchelor, Lucinda K.; Funaioli, Tiziana; Zacchini, Stefano; Bortoluzzi, Marco; Pampaloni, Guido; Dyson, Paul J.; Marchetti, Fabio. The article contains the following contents:

Ruthenium half-sandwich η6-p-cymene cationic diimine complexes [(η6-cymene)RuCl(RN:CHCHNR)][NO3] (R = Cy, 4-HOC6H10, 4-HOC6H4, 2-MeCO2C6H4OCOC6H4, 4-C7H15OCOC6H4) were prepared and examined for cytotoxicity and antitumor activity. α-Diimines are among the most robust and versatile ligands available in synthetic coordination chem., possessing finely tunable steric and electronic properties. A series of novel cationic ruthenium(II) p-cymene complexes bearing simple α-diimine ligands, [(η6-p-cymene)RuCl{κ2N-(HCNR)2}]NO3 (1-3; R = Cy, 4-C6H10OH, 4-C6H4OH), were prepared in near-quant. yields as their nitrate salts. [2]NO3 displays high water solubility The potential of the α-diimine ligand in [3]NO3 as a carrier of bioactive mols. was investigated via esterification reactions with the hydroxyl groups. Thus, the double-functionalized derivatives [(η6-p-cymene)RuCl{κ2N-(HCN(4-C6H4OCO-R))2}]NO3 (4, 5, 6; R = Me, 2-MeCO2C6H4, 4-C7H15) were obtained in good-to-high yields. UV-vis and multinuclear NMR spectroscopy and cyclic voltammetric studies in aqueous solution revealed only minor ruthenium chloride hydrolytic cleavage, biol. accessible reduction potentials, and pH-dependent behavior of [3]NO3. D. functional theory anal. was performed in order to compare the Ru-Cl bond strength in [1]+ with the analogous ethylenediamine complex, showing that the higher stability observed in the former is related to the electron-withdrawing properties of the α-diimine ligand. In vitro cytotoxicity studies were performed against tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK-293) cell lines, with the complexes bearing simple α-diimine ligands ranging from inactive to IC50 values in the low micromolar range. The complexes functionalized with bioactive components, i.e., [5]NO3 and [6]NO3, exhibited a marked increase in the cytotoxicity with respect to the precursor [3]NO3.trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Related Products of 27489-62-9

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Application of 89466-08-0In 2021 ,《Ni, Pd, and Pt complexes of a tetradentate dianionic thiosemicarbazone-based ONNS ligand》 appeared in Dalton Transactions. The author of the article were Haseloer, Alexander; Denkler, Luca Mareen; Jordan, Rose; Reimer, Max; Olthof, Selina; Schmidt, Ines; Meerholz, Klaus; Hoerner, Gerald; Klein, Axel. The article conveys some information:

New tetradentate phenolate ONNS thiosemicarbazone (TSC) ligands and their Ni(II), Pd(II) and Pt(II) complexes were studied. The diamagnetic and square planar configured orange or red complexes show reversible reductive electrochem. and in part reversible oxidative electrochem. at very moderate potentials. DFT calculations show essentially pyridyl-imine centered lowest unoccupied MOs (LUMO) while the highest occupied MOs (HOMO) receive contributions from the phenolate moiety, the metal d orbitals and the TSC thiolate atom in keeping with UV-visible spectroelectrochem. DFT calculations in conjunction with IR spectra showed details of the mol. structures, the UV-visible absorptions were modelled through TD-DFT calculation with very high accuracy. UPS is fully consistent with UV-visible absorption and TD-DFT calculated data and shows decreasing HOMO-LUMO gaps along the series Pd > Pt > Ni. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application of 89466-08-0

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Synthetic Route of C6H15NOIn 2021 ,《Semi-Interpenetrating Polymer Network Electrolytes Based on a Spiro-Twisted Benzoxazine for All-Solid-State Lithium-Ion Batteries》 appeared in ACS Applied Energy Materials. The author of the article were Lee, Jen-Yu; Yu, Tsung-Yu; Chung, Pei-Hsuan; Lee, Wen-Ya; Yeh, Shih-Chieh; Wu, Nae-Lih; Jeng, Ru-Jong. The article conveys some information:

A spiro-twisted benzoxazine, namely, 6,6′-(6,6,6′,6′-tetramethyl-6,6′,7,7′-tetrahydro-2H,2′H-8,8′-spirobi[indeno[5,6-e][1,3]oxazin]-3,3′(4H,4′H)-diyl)bis(hexan-1-ol) (TSBZ6D), was successfully developed as a semi-interpenetrating polymer network (s-IPN) matrix for solid polymer electrolytes (SPEs). The designed spiro-twisted mol. structure of TSBZ6D constitutes an SPE matrix with a high fractional free volume that facilitates the transport of lithium ions. In the meantime, its crosslinking network structure enables a remarkable enhancement in the mech. properties of SPEs. When combined with poly(ethylene oxide) (PEO) electrolytes, the TSBZ6D s-IPN imparts an enhancement of >300 and 1100% in tensile stress and in tensile strain, resp., to the PEO-TSBZ6D (PT) composite SPEs over the PEO/lithium salt sample. Electrochem. testing of sym. Li/PT/Li cells indicates the effectiveness of PT SPEs in mitigating the short-circuiting problem caused by Li dendrite formation. We demonstrated that a specific capacity of 166 mAh g-1 (0.1 C) at 80 °C and a promising cycle stability have been achieved by an all-solid-state LiFePO4/PT/Li. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO

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In 2022,Li, Xiaohua; He, Qiuqin; Fan, Renhua published an article in Organic Chemistry Frontiers. The title of the article was 《Divergent synthesis of 4-amino indoles with free amine groups via tandem reaction of 2-alkynylanilines》.Reference of trans-4-Aminocyclohexanol The author mentioned the following in the article:

A process for the divergent synthesis of a variety of 4-amino indoles I [R = Ph, 3-MeC6H4, 4-ClC6H4, etc.; R2 = Me, Et, Ph, etc.; R3 = H, i-Pr, CH2CH2OH, etc.; R4 = H, n-hexyl, cyclopentyl, etc.] having N1 or C4 free amine groups via via tandem reaction of 2-alkynylanilines with amines was reported. This process involved an oxidative dearomatization, an imine exchange, a cascade 1,4-addition/cyclization/aromatization, and a selective deprotection. The formed 4-amino indoles could be converted to 4,7-difunctionalized indoles II [R5 = i-Pr, CH(Me)(Et), CHPh, etc.; R6 = H, C(O)OMe, C(O)OEt; R7 = CH2(2,4-di-MeOC6H3), CH(C(O)Ph)(CH2C(O)Ph), CH(Ph)(OH)(CF3), etc.] via selective Friedel-Crafts alkylation. After reading the article, we found that the author used trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Reference of trans-4-Aminocyclohexanol

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In 2022,Luo, Xu-Feng; Ni, Hua-Xiu; Ma, Hui-Li; Qu, Zhong-Ze; Wang, Jie; Zheng, You-Xuan; Zuo, Jing-Lin published an article in Advanced Optical Materials. The title of the article was 《Fused π-Extended Multiple-Resonance Induced Thermally Activated Delayed Fluorescence Materials for High-Efficiency and Narrowband OLEDs with Low Efficiency Roll-Off》.Computed Properties of C6H7BO3 The author mentioned the following in the article:

The simultaneous achievement of multiple-resonance thermally activated delayed fluorescence (MR-TADF) materials with strong narrowband emission and efficient reverse intersystem crossing (RISC) process can further promote the advancement of organic light-emitting diodes (OLEDs). Herein, a new strategy is proposed to achieve two π-extended MR-TADF emitters (NBO and NBNP) peaking at 487 and 500 nm via fusing conjugated high-triplet-energy units (carbazole, dibenzofuran) into boron-nitrogen (B/N) framework, aiming to increase charge transfer delocalization of the B/N skeleton and minimize singlet-triplet energy gap (ΔEST). This strategy endows the two emitters with full width at half maximum of 27 and 29 nm, and high photoluminescence efficiencies above 90% in doped films, resp. Addnl., considerable rate constants of RISC are obtained due to the small ΔEST (0.12 and 0.09 eV) and large spin-orbital coupling values. Consequently, the OLEDs based on NBO and NBNP show the maximum external electroluminescence quantum efficiency of up to 26.1% and 28.0%, resp., accompanied by low-efficiency roll-off. These results provide a feasible design strategy to construct efficient MR-TADF materials for OLEDs with suppressed efficiency roll-off. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

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Shen, Wenbo; Du, Bin; Liu, Jiaoshi; Zhuo, Haitao; Yang, Chuluo; Chen, Shaojun published an article in 2021. The article was titled 《A facile approach for the preparation of liquid crystalline polyurethane for light-responsive actuator films with self-healing performance》, and you may find the article in Materials Chemistry Frontiers.HPLC of Formula: 627-18-9 The information in the text is summarized as follows:

In this study, liquid crystalline polyurethane was prepared by quaternization between ordinary polyurethane and mesogenic monomers. Meanwhile, a fast light-responsive actuator film with self-healing performance based on liquid crystalline polyurethane was successfully fabricated. In the film, the mesogenic units of the nematic compound were grafted on the polyurethane main chain, leading to liquid crystal phase of the polymer. The photoresponsive units of the liquid crystalline azobenzene were utilized as photosensitive components, and polyurethane was employed as the polymer matrix to endow the material with good film-forming and mech. properties. The as-obtained actuator film not only showed a quick response and large shape deformation upon UV-irradiation but also exhibited temperature-induced self-healing performance. Moreover, the as-prepared light-responsive actuator film exhibited excellent properties coupled with easy fabrication, low cost, and good film-forming and relevant mech. properties, showing promise for future practical applications in photo-driven and optomech. devices.3-Bromopropan-1-ol(cas: 627-18-9HPLC of Formula: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.HPLC of Formula: 627-18-9

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The author of 《Grafting of Polymer Brushes from Xanthate-Functionalized Silica Particles》 were Ohno, Kohji; Yahata, Yoshikazu; Sakaue, Motokazu; Ladmiral, Vincent. And the article was published in Chemistry – A European Journal in 2019. COA of Formula: C6H12O The author mentioned the following in the article:

Monodisperse silica particles (SiPs) were surface-modified with a newly designed silane coupling agent comprising a triethoxysilane and an alkyl halide, namely, 6-(triethoxysilyl)hexyl 2-bromopropionate, which was further treated with potassium O-Et dithiocarbonate (PEX) to immobilize xanthate mols. on the particle surfaces. Surface-initiated macromol. design via interchange of xanthates (MADIX) polymerization of vinyl acetate (VAc) was conducted with the xanthate-functionalized SiPs. The polymerization was well controlled and produced SiPs coated with poly(vinyl acetate) (PVAc) with a well-defined target molar mass and a graft d. of about 0.2 chains nm-2. Dynamic light scattering and TEM measurements revealed that the hybrid particles were highly dispersible in good solvents without any aggregation. The PVAc brushes were hydrolyzed with hydrochloric acid to produce poly(vinyl alc.) brushes on the SiP surfaces. In addition, the number of xanthate mols. introduced on the SiP surfaces could be successfully controlled by adjusting the concentration of PEX. Thus, the SiPs have two functionalities: xanthates able to act as a MADIX chain-transfer agent and alkyl bromide initiation sites for atom transfer radical polymerization (ATRP). By using these unique bifunctional particles, mixed polymer brushes were constructed on the SiPs by MADIX of VAc followed by ATRP of styrene or Me methacrylate. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0COA of Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.COA of Formula: C6H12O

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The author of 《Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle》 were Prakash, Thazha P.; Mullick, Adam E.; Lee, Richard G.; Yu, Jinghua; Yeh, Steve T.; Low, Audrey; Chappell, Alfred E.; Oestergaard, Michael E.; Murray, Sue; Gaus, Hans J.; Swayze, Eric E.; Seth, Punit P.. And the article was published in Nucleic Acids Research in 2019. Formula: C6H15NO The author mentioned the following in the article:

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium of the muscle tissues to enhance ASO functional uptake. We synthesized structurally diverse saturated and unsaturated fatty acid conjugated ASOs with a range of hydrophobicity. The binding affinity of ASO fatty acid conjugates to plasma proteins improved with fatty acid chain length and highest binding affinity was observed with ASO conjugates containing fatty acid chain length from 16 to 22 carbons. The degree of unsaturation or conformation of double bond appears to have no influence on protein binding or activity of ASO fatty acid conjugates. Activity of fatty acid ASO conjugates correlated with the affinity to albumin and the tightest albumin binder exhibited the highest activity improvement in muscle. Palmitic acid conjugation increases ASO plasma Cmax and improved delivery of ASO to interstitial space of mouse muscle. Conjugation of palmitic acid improved potency of DMPK, Cav3, CD36 and Malat-1 ASOs (3- to 7-fold) in mouse muscle. Our approach provides a foundation for developing more effective therapeutic ASOs for muscle disorders. After reading the article, we found that the author used 6-Aminohexan-1-ol(cas: 4048-33-3Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Formula: C6H15NO

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