Tag: 100-200

Category: alcohols-buliding-blocksIn 2022 ,《Advances in Stereoselective Iron(II)-Catalyzed Synthesis of Sulfilimines with N-Mesyloxycarbamates》 was published in Helvetica Chimica Acta. The article was written by Lai, Calvine; Lebel, Helene. The article contains the following contents:

A stereoselective amination of thioethers R1SR2 to access sulfilimines (R)-R1R2SNC(O)OR3 [R1 = Ph, naphthalen-2-yl, thiophen-2-yl, etc., R2 = Me, Et, R3 = (4-methylphenyl)methyl, diphenylmethyl, 2,2,2-trichloroethyl, etc.] using N-mesyloxycarbamates MsOHNC(O)OR3 in a catalytic system composed of iron(II) chloride and a pyridine oxazoline (PyOX) ligand, e.g., (S)-5,5-dimethyl-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole, has been developed. The reaction proceeds with modest to good yields and selectivities (up to 86:14 d.r. and 72:28 e.r.). Selectivity was controlled by both the structure of the chiral ligand and the amination reagent. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 26153-38-8In 2020 ,《In vitro study and structure-activity relationship analysis of stilbenoid derivatives as powerful vasorelaxants: Discovery of new lead compound》 was published in Bioorganic Chemistry. The article was written by Chan, Sock Ying; Loh, Yean Chun; Oo, Chuan Wei; Yam, Mun Fei. The article contains the following contents:

The development of vasorelaxant as the antihypertensive drug is important as it produces a rapid and direct relaxation effect on the blood vessel muscles. Resveratrol (RV), as the most widely studied stilbenoid and the lead compound, inducing the excellent vasorelaxation effect through the multiple signalling pathways. In this study, the in vitro vascular response of the synthesized trans-stilbenoid derivatives were primarily evaluated by employing the phenylephrine (PE)-precontracted endothelium-intact isolated aortic rings. Herein we report trans-3,4,4′-trihydroxystilbene (SB 8b) exhibited surprisingly more than 2-fold improvement to the maximal relaxation (Rmax) of RV. This article also highlights the characterization of the aromatic protons in terms of their unique splitting patterns in 1H NMR. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8SDS of cas: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.SDS of cas: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 100-83-4In 2019 ,《Core-shell structured magnetic silica supported propylamine/molybdate complexes: an efficient and magnetically recoverable nanocatalyst》 was published in New Journal of Chemistry. The article was written by Neysi, Maryam; Zarnegaryan, Ali; Elhamifar, Dawood. The article contains the following contents:

In the present study, a novel core-shell structured magnetic silica supported propylamine/molybdate complex (Fe3O4@SiO2/Pr-N♂Mo[Mo5O18]) is prepared, characterized and applied as an effective and easily recoverable nanocatalyst. The chem. composition, crystalline structure, thermal stability, morphol. and particle size of this nanomaterial were studied using Fourier transform IR (FT-IR) spectroscopy, energy dispersive X-ray (EDX), transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), SEM (SEM), thermal gravimetric (TG) and vibration sample magnetometer (VSM) analyses. This nanomaterial was used as an efficient and magnetically reusable catalyst for the synthesis of pyrano-pyrazole derivatives under moderate conditions and gave the corresponding products in high yield and selectivity. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Product Details of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 100-83-4In 2019 ,《SBA-15@Glycine-M (M= Ni and Cu): Two green, novel and efficient catalysts for the one-pot synthesis of 5-substituted tetrazole and polyhydroquinoline derivatives》 appeared in Solid State Sciences. The author of the article were Tamoradi, Taiebeh; Ghorbani-Choghamarani, Arash; Ghadermazi, Mohammad; Veisi, Hojat. The article conveys some information:

Two catalysts were prepared by the immobilization of Ni and Cu on ordered mesoporous silica (SBA-15) coated with glycine. The proposed catalysts were characterized by FT-IR, XRD, BET, TGA, EDX, and ICP-OES studies and were successfully applied in the synthesis of 5-substituted tetrazoles and polyhydroquinoline derivatives This designed protocol offered several advantages including the use of com. available and inexpensive materials, simple procedure, short reaction times, high yield, and easily separable and reusable catalyst. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 873-75-6In 2019 ,《Copper-catalyzed tandem oxidative synthesis of quinazolinones from 2-aminobenzonitriles and benzyl alcohols》 appeared in Organic Chemistry Frontiers. The author of the article were Hu, Yongke; Li, Shaozhong; Li, Huaju; Li, Yanxing; Li, Jin; Duanmu, Chuansong; Li, Bindong. The article conveys some information:

An efficient and practical copper-catalyzed process for the synthesis of substituted quinazolinones I (R1 = C6H5, 4-MeOC6H4, 4-FC6H4, etc.; R2 = 6-Me, 6-OMe, 5-F, etc.) from simple and readily available 2-aminobenzonitriles and benzyl alcs. is described. This method features high functional-group tolerance and could afford a variety of desirable products in good to excellent yields with air as the sole oxidant. Moreover, a possible reaction mechanism is proposed according to the control experiments and reported literature. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Application of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application of 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C6H7NOIn 2019 ,《Polypyridyl iridium(III) based catalysts for highly chemoselective hydrogenation of aldehydes》 appeared in Journal of Catalysis. The author of the article were Pandrala, Mallesh; Resendez, Angel; Malhotra, Sanjay V.. The article conveys some information:

Iridium-catalyzed transfer hydrogenation (TH) of carbonyl compounds using HCOOR (R = H, Na, NH4) as a hydrogen source is a pivotal process as it provides the clean process and is easy to execute. However, the existing highly efficient iridium catalysts work at a narrow pH; thus, does not apply to a wide variety of substrates. Therefore, the development of a new catalyst which works at a broad pH range is essential as it can gain a broader scope of utilization. Here we report highly efficient polypyridyl iridium(III) catalysts, [Ir(tpy)(L)Cl](PF6)2 {where tpy = 2,2′:6′,2”-Terpyridine, L = phen (1,10-Phenanthroline), Me2phen (4,7-Dimethyl-1,10-phenanthroline), Me4phen (3,4,7,8-Tetramethyl-1,10-phenanthroline), Me2bpy (4,4′-Dimethyl-2-2′-dipyridyl)} for the chemoselective reduction of aldehydes to alcs. in aqueous ethanol and sodium formate as the hydride source. The reaction can be carried out efficiently in broad pH ranges, from pH 6 to 11. These catalysts are air stable, easy to prepare using com. available starting materials, and are highly applicable for a wide range of substrates, such as electron-rich or deficient (hetero)arenes, halogens, phenols, alkoxy, ketones, esters, carboxylic acids, cyano, and nitro groups. Particularly, acid and hydroxy groups containing aldehydes were reduced successfully in basic and acidic reaction conditions, demonstrating the efficiency of the catalyst in a broad pH range with high conversion rates under microwave irradiation In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Computed Properties of C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C3H7BrOIn 2019 ,《Synthesis of mechanically strong waterborne poly(urethane-urea)s capable of self-healing at elevated temperatures》 appeared in European Polymer Journal. The author of the article were Nevejans, Sil; Ballard, Nicholas; Rivilla, Ivan; Fernandez, Mercedes; Santamaria, Antxon; Reck, Bernd; Asua, Jose M.. The article conveys some information:

Although various chemistries were introduced into polyurethanes to obtain self-healing abilities, implementing these materials in applications requiring high strength is challenging as strong materials imply a limited mol. motion, but without movement of polymer chains self-healing is not possible. Here, waterborne poly(urethane-urea)s (PU(U)s) based on aromatic disulfide compounds are developed which balance these contradictory requirements by presenting good mech. properties at room temperature, while showing the mobility necessary for healing when moderately heated. The influence of hard monomers on the stability and mobility of the materials is studied by scratch closure, cut healing and rheol. measurements, so that the limits of the readily available aromatic disulfide compounds, bis(4-aminophenyl)- and bis(4-hydroxyphenyl)disulfide, can be determined Subsequently, a modified aromatic disulfide compound, bis[4-(3′-hydroxypropoxy)phenyl]disulfide, with increased reactivity, solubility and flexibility is synthesized and incorporated into the PU backbone, so that materials with more attractive mech. properties, reaching ultimate tensile strengths up to 23 MPa, and self-healing abilities at elevated temperatures could be obtained. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Synthetic Route of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Synthetic Route of C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Du, Xin; Zhao, Huan; Li, Xinling; Zhang, Lizhi; Dong, Yunhui; Wang, Ping; Zhang, Daopeng; Liu, Qing; Liu, Hui published an article in 2021. The article was titled 《Ligand-Regulated Palladium-Catalyzed Regiodivergent Hydroarylation of the Distal Double Bond of Allenamides with Aryl Boronic Acid》, and you may find the article in Journal of Organic Chemistry.Related Products of 89466-08-0 The information in the text is summarized as follows:

The ligand-regulated regiodivergent hydroarylation of the distal double bond of allenamides with aryl boronic acid was achieved in the presence of Pd(II) catalysts, delivering a variety of functionalized enamide with excellent E selectivity and Markovnikov/anti-Markovnikov selectivity. Two possible coordination intermediates probably are responsible for the regiodivergent hydroarylation: (1) The coordination Intermediate I, which probably is formed through the coordination of MeCN, distal double bond, Ph to Pd, led to the aryl group away from the Intermediate I, inducing excellent E selectivity and anti-Markovnikov selectivity. (2) A switch of regioselectivity to 1,2-Markovnikov hydroarylation was obtained using bidentate phosphine ligand (dppf or Xantphos). The formed coordination Intermediate II led to the N-tether away from the Intermediate II and at the trans position of aryl, resulting in excellent E selectivity and Markovnikov selectivity. Meanwhile, tentative study on the mechanism proved that the hydron source of this hydroarylation is more likely to be boronic acid. The transmetalation between aryl boronic acid and Pd catalyst was the initial step of this transformation. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jianfeng; Liu, Dan; Yang, Qianqian; Ge, Yan; Tang, Jinkui; Qi, Zhenhui published their research in New Journal of Chemistry in 2021. The article was titled 《Magnetic investigation in di- and tetranuclear lanthanide complexes》.Computed Properties of C7H9NO2 The article contains the following contents:

By using a crab-like hydrazone ligand, dinuclear and tetranuclear dysprosium-based complexes Dy2 and Dy4 have been isolated. Magnetic investigation reveals that complex Dy2 shows typical single-mol. magnet behavior under a zero field, benefiting from the ferromagnetic coupling between the DyIII ions, while Dy4 possesses a diamagnetic ground state with the anisotropy axes of DyIII ions in centripetal arrangement. The magnetic anisotropies and couplings were confirmed by ab initio calculations In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ritmaleni; Hastutitama, A. N. A.; Persitamaia, I.; Restiwardani, T.; Eksakta, A.; Munandar, R. F.; Abdullah, M. S.; Purwanto, A. E.; Astuti, P.; Sardjiman published their research in Rasayan Journal of Chemistry in 2021. The article was titled 《Synthesis and antibacterial activity of dibenzylidene-cyclohexanone》.Safety of 3-Hydroxybenzaldehyde The article contains the following contents:

Dibenzylidene-cyclohexanones I (R = 3-O2NC6H4, 2-CH3OC6H4, 4-OH-3-CH3OC6H3, etc.) were synthesized by reacting aromatic aldehydes RCHO with cyclohexanone in the acidic condition through the carbonyl condensation reaction. The antibacterial activity was tested by using microdilution method against K. pneumonia, E. coli, S. aureus, B. subtilis and E. faecalis. The isolated products were obtained as pure curcumin analogs with moderate to high yield. The antibacterial assay showed that I (R = 3-OHC6H4) gave MIC and MBC at 50μg/mL in E. coli, S. aureus, and E. faecalis. Moreover, it showed that the percentage inhibition of B. subtilis was around 54% at a concentration of 25μg/mL. Among all the tested compounds, I (R = 3-OHC6H4) showed better activity against all those bacteria while none showed activity against K. pneumonia. A I (R = 2,5-CH3OC6H3) was obtained as the compound with the highest yield and I (R = 3-OHC6H4) was the most potent compound While I (R = 2-OH-3-C2H5OC6H3) was the most potent compound according to the docking study. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts