Tag: 100-200

Formula: C6H7NOIn 2020 ,《Synthesis and characterization of N,N-chelate manganese complexes and applications in C-N coupling reactions》 appeared in Inorganica Chimica Acta. The author of the article were Das, Kuhali; Kumar, Amol; Jana, Akash; Maji, Biplab. The article conveys some information:

Bidentate NN-ligands were derived from the reaction between aldehydes and 2-(aminomethyl)pyridine. The treatment of these ligands with Mn(CO)5Br gave complexes that are highly bench stable. The complexes were characterized by various anal. and spectral methods. Single-crystal XRD of complex Mn-2 was performed, which indicates an octahedral geometry around the metal center. The complexes efficiently catalyze the N-alkylation of anilines with alcs. under optimized reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C6H7NO

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Related Products of 627-18-9In 2020 ,《Multi pH-sensitive polymer-drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis》 appeared in Biomaterials Science. The author of the article were Zhou, Yuanhang; Zhou, Chuhang; Zou, Yang; Jin, Yao; Han, Shidi; Liu, Qi; Hu, Xinping; Wang, Leqi; Ma, Yining; Liu, Yan. The article conveys some information:

Combination therapy has been proved to be an effective strategy to inhibit metastasis, however, its efficacy is always compromised by the poor delivery efficiency of drugs. In this study, multi pH-sensitive polymer-drug conjugate mixed micelles were fabricated by the self-assembly of PEOz-PLA-ace-Cur, a conjugate of curcumin (Cur) with poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) through the linkage of the pH-cleavable acetal bond, and PEOz-PLA-imi-DOX, a conjugate of doxorubicin (DOX) with PEOz-PLA through the linkage of the pH-cleavable benzoic imine bond. The mixed conjugate micelles (PP-Cur/PP-DOX-Mix-PMs) with accurately and conveniently controlled mass ratio of the two drugs were demonstrated to have a small particle size (40-128 nm), high drug loading capacity and pH-dependent drug release behavior. Notably, PP-Cur5/PP-DOX1-Mix-PMs exhibited slower DOX release under physiol. conditions compared with PEOz-PLA-imi-DOX micelles, resulting in deeply reduced side effects in vivo. Furthermore, the mixed conjugate micelles showed synergistically enhanced inhibition of MDA-MB-231 cell growth and metastasis evidenced by the results of in vitro anti-invasion, wound healing and anti-migration assessment, and in vivo bioluminescence imaging in nude mice, and significant reduction of the side effects of DOX compared with dual drug phys. loaded polymeric micelles. Mechanistic studies demonstrated that the possible inhibitory mechanism of PP-Cur5/PP-DOX1-Mix-PMs on tumor metastasis could be assigned to their inhibition of the invasion, migration, intravasation and extravasation of tumor cells. In conclusion, the multi pH-sensitive polymer-drug conjugate mixed micelles with synergistically enhanced anti-tumor and anti-metastasis activity are potential candidates for safe and effective cancer combination therapy.3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Related Products of 627-18-9

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In 2022,Dong, Min; Zheng, Guili; Gao, Feng; Li, Min; Zhong, Chen published an article in Frontiers in Pharmacology. The title of the article was 《Three-carbon linked dihydroartemisinin-isatin hybrids: design, synthesis and their antiproliferative anticancer activity》.Recommanded Product: 3-Bromopropan-1-ol The author mentioned the following in the article:

Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were designed, synthesized. The antiproliferative activity against lung cancer cell lines including drug-sensitive A549, doxorubicin-resistant A549 (A549/DOX) and cisplatin-resistant A549 (A549/DDP) lung cancer cell lines was tested. The cytotocivity towards normal lung epithelial BEAS-2B cell line was also investigated. From the structure-activity relationship (SAR), it was found that hydrogen bond donors (especially hydroxime and thiosemicarbazide) at C-3 position and electron-withdrawing groups (fluoro and chloro) at C-5 position of isatin moiety were beneficial for the activity. A significant part of them (half maximal inhibitory concentration/IC50: 5.72-55.52 μM) demonstrated considerable antiproliferative activity, and the activity was superior to that of dihydroartemisinin (IC50: 69.42-88.03 μM) and artemisinin (IC50: >100 μM). In particular, two hybrids 6a, e (IC50: 5.72-9.84 μM) were not inferior to doxorubicin (IC50: 4.06 μM) and cisplatin (IC50: 9.38 μM) against drug-sensitive A549 cells and were more potent than doxorubicin (IC50: 54.32 and 15.10 μM) and cisplatin (IC50: 19.74 and 66.89 μM) against multidrug-resistant A549/DOX and A549/DDP lung cancer cell lines. In addition, hybrids 6a, e (IC50: >100 μM) showed no toxicity towards BEAS-2B cells, proving their excellent selectivity profile. Furthermore, hybrid 6a also possessed good stability in mouse and human microsomes, as well as excellent pharmacokinetic properties. Accordingly, hybrid 6a could serve as a promising anti-lung cancer chemotherapeutic candidate for further preclin. evaluations. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

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In 2022,Kim, Dongwon; Seo, Kyeong-Deok; Shim, Yoon-Bo; Lee, Kyungsuh; Lee, Sang Hak; Lee, Young-A.; Jung, Ok-Sang published an article in Dalton Transactions. The title of the article was 《Pair of chiral 2D silver(I) enantiomers: chiral recognition of L- and D-histidine via differential pulse voltammetry》.Related Products of 126456-43-7 The author mentioned the following in the article:

Self-assembly of AgPF6 with a pair of chiral tridentate ligands (1S,1’S,1”S,2R,2’R,2”R) and (1R,1’R,1”R,2S,2’S,2”S)-(benzenetricarbonyltris(azanediyl))tris(2,3-dihydro-1H-indene-2,1-diyl)triisonicotinate (s,r-L) and (r,s-L) in a mixture of methanol and dioxane yields 2D sheets consisting of [Ag(s,r-L)](PF6)·3C4H8O2·0.5H2O and [Ag(r,s-L)](PF6)·3C4H8O2·0.5H2O, resp. The differential pulse voltammetric (DPV) technique using the pair of chiral 2D-sheet enantiomers was employed for chiral discrimination of amino acid enantiomers, and was an effective tool for enantio-recognition of L- and D-histidines. Both the size and the binding site of amino acids were strongly dependent on electrochem. enantio-recognition via the chiral 2D sheets. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 126456-43-7

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Wang, Xiao-Xu; Xu, Yuan-Tai; Zhang, Zhi-Lin; Lu, Xi; Fu, Yao published an article in 2022. The article was titled 《NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes and the ligand effects on regioselectivity》, and you may find the article in Nature Communications.Quality Control of 5-Hexen-1-ol The information in the text is summarized as follows:

Herein, a NiH-catalyzed proximal-selective hydroalkylation of unactivated alkenes e.g., N-(quinoline-8-yl)pent-4-enamide to access β- or γ-branched alkyl carboxylic acids and β-, γ- or δ-branched alkyl amines e.g., 4-methyl-N-(quinolin-8-yl)octanamide was reported. A broad range of alkyl iodides and bromides e.g., 1-iodobutane with different functional groups can be installed with excellent regiocontrol and availability for site-selective late-stage functionalization of biorelevant mols. Under modified reaction conditions with NiCl2(PPh3)2 as the catalyst, migratory hydroalkylation takes place to provide β- (rather than γ-) branched products. The keys to success are the use of aminoquinoline and picolinamide as suitable directing groups and combined exptl. and computational studies of ligand effects on the regioselectivity and detailed reaction mechanisms. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Quality Control of 5-Hexen-1-ol

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Casnati, Alessandra; Lichosyt, Dawid; Lainer, Bruno; Veth, Lukas; Dydio, Pawel published their research in Organic Letters in 2021. The article was titled 《Multicatalytic Approach to One-Pot Stereoselective Synthesis of Secondary Benzylic Alcohols》.Reference of 5-Hexen-1-ol The article contains the following contents:

Here, one-pot, multicatalytic protocols that convert alkenes, unsaturated aliphatic alcs., and aryl boronic acids into secondary benzylic alcs. with high stereoselectivities (typically >95:5 er) under sequential catalysis that integrates alkene cross-metathesis, isomerization, and nucleophilic addn was reported. Prochiral allylic alcs. was converted to any stereoisomer of the product with high stereoselectivity (>98:2 er, >20:1 dr). The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Reference of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
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Cheedarala, Ravi Kumar; Chidambaram, Ramasamy R.; Siva, Ayyanar; Song, Jung Il published their research in RSC Advances in 2021. The article was titled 《An aerobic oxidation of alcohols into carbonyl synthons using bipyridyl-cinchona based palladium catalyst》.Formula: C6H7NO The article contains the following contents:

An aerobic oxidation of primary and secondary alcs. RCH2OH (R = 2-methylphenyl, cyclohexyl, naphthalen-1-yl, pyridin-4-yl, etc.) to resp. aldehydes RCHO and ketones RCO using a bipyridyl-cinchona alkaloid based palladium catalytic system (PdAc-5) I·2Br using oxygen at moderate pressure was reported. The PdAc-5 catalyst was analyzed using SEM, EDAX, and XPS anal. The above catalytic system is used in experiments for different oxidation systems which include different solvents, additives, and bases which are cheap, robust, non-toxic, and com. available on the industrial bench. The obtained products are quite appreciable in both yield and selectivity (70-85%). In addition, numerous important studies, such as comparisons with various com. catalysts, solvent systems, mixture of solvents, and catalyst mole%, were conducted using PdAc-5. The synthetic strategy of oxidation of alc. into carbonyl compounds was well established and all the products were analyzed. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7NO

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《Magneto-structural studies of an unusual [MnIIIMnIIGdIII(OR)4]4- partial cubane from 2,2′-bis-p-tBu-calix[4]arene》 was written by Coletta, Marco; Sanz, Sergio; Cutler, Daniel J.; Teat, Simon J.; Gagnon, Kevin J.; Singh, Mukesh K.; Brechin, Euan K.; Dalgarno, Scott J.. Recommanded Product: 1195-59-1 And the article was included in Dalton Transactions in 2020. The article conveys some information:

Reaction of 2,2′-bis-p-tBu-calix[4]arene (H8L) with MnCl2·4H2O, GdCl3·6H2O and 2,6-pyridinedimethanol (H2pdm) affords [MnIIIMnIIGdIII(H3L)(pdmH)(pdm)(MeOH)2(dmf)]·3MeCN·dmf (3·3MeCN·dmf) upon vapor diffusion of MeCN into the basic dmf/MeOH mother liquor. 3 Crystallizes in the tetragonal space group P41212 with the asym. unit comprising the entire cluster. The highly unusual core contains a triangular arrangement of MnIIIMnIIGdIII ions housed within a [MnIIIMnIIGdIII(OR)4]4- partial cubane. Magnetic susceptibility and magnetization data reveal best fit parameters JMn(II)-Mn(III) = +0.415 cm-1, JMn(III)-Gd(III) = +0.221 cm-1, JMn(II)-Gd(III) = -0.258 cm-1 and DMn(III) = -4.139 cm-1. Theor. derived magnetic exchange interactions, anisotropy parameters, and magneto-structural correlations for 3 are in excellent agreement with the exptl. data. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 1195-59-1

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《Design and synthesis of a versatile cooperative catalytic aerobic oxidation system with co-immobilization of palladium nanoparticles and laccase into the cavities of MCF》 was written by Moradi, Sirvan; Shokri, Zahra; Ghorashi, Nadya; Navaee, Aso; Rostami, Amin. Recommanded Product: 100-55-0 And the article was included in Journal of Catalysis in 2020. The article conveys some information:

We have designed a versatile reusable cooperative catalyst oxidation system, consisting of palladium nanoparticles and laccase with unprecedented reactivity. This biohybrid catalyst was synthesized by the stepwise immobilization of laccase as an enzyme and Pd as a nanometallic component into the same cavity of siliceous mesocellular foams (MCF). MCF and nanobiohybrid catalyst were characterized by BET, SAXS, SEM, EDX elemental mapping, ICP-OES, TEM, TGA, FT-IR, and XPS techniques and the stepwise immobilization of laccase enzyme and Pd onto MCF was evaluated through several compelling electrochem. studies. The present catalytic system exhibits high activity toward (i) aerobic oxidation of alcs. to the corresponding carbonyl compounds, (ii) aerobic oxidation of cyclohexanol and cyclohexanone to phenol and (iii) aerobic dehydrogenation of important N-heteocyclic compounds (tetrahydro quinazolines, quinazolonones, pyrazolines and 1,4-diydropyridines) in the presence of catalytic amount of hydroquinone (HQ) as mediator in phosphate buffer (0.1 M, pH 4.5, 4 mL)/THF (4%, 1 mL) as solvent under mild conditions. The immobilization of both oxygen-activating catalyst (laccase) and oxidizing catalyst (Pd) onto the same support makes the present catalyst system superior to other currently available heterogeneous palladium based catalytic aerobic oxidation systems. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 100-55-0

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《Synthesis of indole-based acetohydrazide analogs: their in vitro and in silico thymidine phosphorylase studies》 was written by Taha, Muhammad; Aldhamin, Ebaa Ahmed Jassim; Almandil, Noor Barak; Anouar, El Hassane; Uddin, Nizam; Alomari, Munther; Rahim, Fazal; Adalat, Bushra; Ibrahim, Mohamad; Nawaz, Fasial; Iqbal, Naveed; Alghanem, Bandar; Altolayyan, Abdulelah; Khan, Khalid Mohammed. Category: alcohols-buliding-blocks And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this study, a series of indole-based acetohydrazides I [R = 4-HOC6H4, 2-MeOC6H4 2,3-(HO)2C6H3, 2,4-(MeO)2C6H3, etc.] were synthesized and characterized. The products I were tested for their thymidine phosphorylase inhibitory potential. These derivatives inhibited thymidine phosphorylase at different concentration ranging from 1.10 ± 0.10 to 41.10 ± 1.10μM when compared with the standard 7-deazaxanthine (IC50 value 38.68 ± 1.12μM). The compound I [R = 2,4,6-(HO)3C6H2] was found to be the most potent among the series with IC50 1.10 ± 0.10μM. The structure activity relationships have been established for all compounds keeping in the view the role of substitution and the effect of functional group which significantly affect thymidine phosphorylase activity. The nature of binding interactions of the most potent compounds and active sites of the enzymes was confirmed through mol. docking study. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Category: alcohols-buliding-blocks

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