Tag: 100-200

On September 30, 2022, Mori, Nagisa; Murphy, Neil; Sawada, Norie; Achaintre, David; Yamaji, Taiki; Scalbert, Augustin; Iwasaki, Motoki; Inoue, Manami; Gunter, Marc J.; Tsugane, Shoichiro published an article.Category: alcohols-buliding-blocks The title of the article was Prediagnostic plasma polyphenol concentrations and colon cancer risk: The JPHC nested case-control study. And the article contained the following:

Epidemiol. studies that assessed the associations between dietary polyphenol intakes and colon cancer risk have reported largely null results, possibly due to measurement error associated with dietary assessment. We adopted an objective approach by measuring prediagnostic plasma concentrations of 35 polyphenols and assessing associations with colon cancer risk.We conducted a nested-case control study within the Japan Public Health Center-based prospective study (JPHC Study) utilizing plasma samples collected at the time of a five-year follow-up survey between 1995 and 1999. We identified colon cancer cases who developed cancer during the follow-up from the time of blood collection. Controls were matched by age, sex, area code, population size of the area, season of blood collection, year of blood collection, and duration of fasting time before the blood collection. Prediagnostic concentrations of 35 polyphenols from 375 incident colon cancer cases (followed until 2012) and 710 matched controls were measured by tandem mass spectrometry coupled with ultra-high-pressure liquid chromatog. We used multivariable conditional logistic regression models adjusted for established colon cancer risk factors to estimate odds ratios (ORs) and 95% confidence intervals (CIs).In sexes combined log2-transformed multivariable models, circulating levels of 3,4-dihydroxyphenylpropionic acid (P = 0.02), ferulic acid (P = 0.02), and caffeic acid (P = 0.03) were inversely, and 3-hydroxybenzoic acid (P = 0.03) was pos., associated with colon cancer risk. For men only, circulating levels of 3,4-dihydroxyphenylpropionic acid was inversely, and 3,5-dihydroxyphenylpropionic acid, gallic acid, (+)-epigallocatechin, 3-hydroxybenzoic acid, and epicatechin were pos., associated with colon cancer risk. In women, plasma caffeic acid and ferulic acid concentration were inversely associated with colon cancer risk. However, all these associations were nonsignificant after adjustment for multiple comparisons. The remaining polyphenols were not associated with colon cancer risk. Coffee-derived 3,4-dihydroxyphenylpropionic acid, ferulic acid, and caffeic acid concentrations were inversely associated with colon cancer risk although the association were nonsignificant after adjustment for multiple comparisons. These results support a possible role of coffee polyphenols in preventing colorectal cancer. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to colon cancer risk prediagnosis blood plasma polyphenol japan, colon cancer, japanese, phytochemicals, plasma, polyphenols, Animal Nutrition: Other and other aspects.Category: alcohols-buliding-blocks

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On December 31, 2022, Xie, Fei; Jiang, Xue; Yi, Yang; Liu, Zi-Jia; Ma, Chen; He, Jin; Xun, Zhi-ming; Wang, Meng; Liu, Meng-yu; Yao, Mawulikplimi Adzavon; Zhao, Peng-xiang; Ma, Xue-mei published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status. And the article contained the following:

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochem. parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, resp. Pathway enrichment anal. showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage anal. and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biol. effects of mol. hydrogen. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to lactobacillus ruminococcus clostridium hydrogen rich water intake gas inhalation, Animal Nutrition: Other and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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Fu, Yousi; Wang, Yali; Wang, Xingguo; Sun, Yidan; Ren, Jianlin; Fang, Baishan published an article in 2022, the title of the article was Responses of human gut microbiota abundance and amino acid metabolism in vitro to berberine.Computed Properties of 473-81-4 And the article contains the following content:

The intestine is a potential location for berberine (BBR) to exert its therapeutic effects, but the understanding of the influences of BBR on the gut microbiota is limited. Through in vitro fermentation of human intestinal microbiota, author investigated the effects of BBR on microbiota composition and metabolism The result indicated that BBR reduced the production of acetic acid and propionic acid and had no effect on the content of butyric acid. Anal. of the 16S rRNA gene-based community revealed that BBR increased the abundance of Faecalibacterium and decreased the abundance of Bifidobacterium, Streptococcus and Enterococcus. Through metabolomics anal., BBR treatment regulated various amino acid metabolism pathways of intestinal microbiota, especially tyrosine, serine and L-glutamate. Author study presented direct impacts of BBR on the intestinal microbiota, which provided the probable targets of the therapies by BBR and supported further exploration of the underlying mechanisms. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to berberine amino acid metabolism gut microbiota, Animal Nutrition: Other and other aspects.Computed Properties of 473-81-4

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On May 31, 2021, Vlckova, Hana Kocova; Catapano, Maria Carmen; Mitasik, Lucia; Kotland, Ondrej; Nejmanova, Iveta; Pourova, Jana; Mladenka, Premysl; Novakova, Lucie published an article.HPLC of Formula: 621-37-4 The title of the article was Featuring ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma. And the article contained the following:

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to plasma isoflavonoid phenolics lc ms pharmacokinetics, high-resolution mass spectrometry, low-molecular weight analytes, metabolites, phenolics, quadrupole-time-of-flight, Pharmacology: Methods and other aspects.HPLC of Formula: 621-37-4

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On March 31, 2013, Schrauwen, Patrick; Timmers, Silvie; Hesselink, Matthijs K. C. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Blocking the entrance to open the gate. And the article contained the following:

A review. The research of Keung et al. (2013) entitled ‘Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice’ is reviewed with commentary and references The article by these authors revisits the Randle hypothesis of a reciprocal relationship between fat and glucose oxidation Inhibition of mitochondrial entry of fatty acids by oxfenicine resulted in improved glucose tolerance and insulin sensitivity in high-fat diet-fed mice, while body mass was maintained. The authors confirmed that oxfenicine was indeed able to reduce fat oxidation with a concomitant increase in glucose oxidation facilitated by increased pyruvate dehydrogenase activity. GLUT4 translocation was improved. The results of Keung et al. may provide insight into new targets for diabetes treatment. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to review etomoxir cpt1 inhibitor antidiabetic agent type 2 diabetes, Pharmacology: Reviews and other aspects.Quality Control of H-Phg(4-OH)-OH

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On September 30, 1997, Bazylak, Grzegorz; Aboul-Enein, Hassan Y. published an article.Product Details of 2160-93-2 The title of the article was Chemometric account for retention of lysosomotropic alkanolamines in planar chromatography systems. And the article contained the following:

Planar chromatog. retention data (in form of thermodynamically meaningful RM coefficients) for twelve model alkanolamines, indicating lysosomotropic activity, were determined in eighty chromatog. systems using eight different silica gel layers with varied chem. bonded stationary phases. In performed TLC experiments, aqueous binary mobile phases containing methanol or acetonitrile as organic modifier, in five different proportions, were applied. Addnl., nine quantum chem. descriptors were calculated for test solutes by a semi-empirical mol. modeling procedure (AM1) to describe their structural properties. Chemometric technique by the multivariate method of principal components anal. (PCA) was applied to the all completed chromatog. retention and computational chem. data for identification of the most selective and useful planar chromatog. systems as well as mol. interactions of solutes which affect their retention phenomena in the particular separation mode. The statistically significant relationship was revealed between quant. measure of antimicrobial activity of alkanolamines and values of calculated scores of principal components. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to alkanol amine lysosomotropic chemometry planar chromatog, Pharmacology: Methods and other aspects.Product Details of 2160-93-2

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On January 10, 2013, Liu, Xingjin; Zhang, Xuke published a patent.Safety of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives for treating bacteria and protozoan infection. And the patent contained the following:

The title C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives I [wherein wherein R1 = H, OH, or OMe; R2 = OH; R3 = organic substituent with optional heteroatom(s); R4 = H, Cbz, Bz, or Ac] or pharmaceutically acceptable salts thereof were prepared for treating bacteria and protozoan infections. For example, II was prepared in a multi-step synthesis. Some title compounds showed antibacterial activity with MIC of 0.125 pg/mL, which is 32 times better than Azithromycin and Clarithromycin. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Safety of (2-Fluorophenyl)methanethiol

The Article related to preparation erythromycin a antibacterial agent human, Carbohydrates: Amines and other aspects.Safety of (2-Fluorophenyl)methanethiol

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Ono, Kenjiro; Tsuji, Mayumi; Yamasaki, Tritia R.; Pasinetti, Giulio M. published an article in 2020, the title of the article was Anti-aggregation effects of phenolic compounds on 伪-synuclein.SDS of cas: 621-37-4 And the article contains the following content:

A review. The aggregation and deposition of 伪-synuclein (伪S) are major pathol. features of Parkinson’s disease, dementia with Lewy bodies, and other 伪-synucleinopathies. The propagation of 伪S pathol. in the brain plays a key role in the onset and progression of clin. phenotypes. Thus, there is increasing interest in developing strategies that attenuate 伪S aggregation and propagation. Based on cumulative evidence that 伪S oligomers are neurotoxic and critical species in the pathogenesis of 伪-synucleinopathies, we and other groups reported that phenolic compounds inhibit 伪S aggregation including oligomerization, thereby ameliorating 伪S oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit 伪S oligomerization and mediate aggregated 伪S-induced neurotoxicity. Addnl., 3-HPPA, 3,4-diHBA, 3-HBA, and 4-hydroxybenzoic acid significantly attenuated intracellular 伪S seeding aggregation in a cell-based system. This review focuses on recent research developments regarding neuroprotective properties, especially anti-伪S aggregation effects, of phenolic compounds and their metabolites by the gut microbiome, including our findings in the pathogenesis of 伪-synucleinopathies. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to review phenolics anti aggregation alpha synuclein neurotoxicity, parkinson鈥檚 disease, gut microbiome, phenolic compounds, 伪-synuclein, Toxicology: Reviews and other aspects.SDS of cas: 621-37-4

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Sugiyama, Fuya; Iwamoto, Shinji published an article in 2020, the title of the article was Morphology and pore structure of zirconia particles preparedby the thermal treatment of zirconium tetra-n-propoxide in glycols.Category: alcohols-buliding-blocks And the article contains the following content:

Zirconia particles were prepared by thermal treatment of zirconium(IV) tetra-n-propoxide (ZNP) in C2-C6 glycols (Glycothermal method) at 300掳C and morphol. and pore structures of the products were examined Xray diffraction results revealed that nanocrystals of tetragonal zirconia phase were mainly obtained in all cases. However, the morphol. and pore structures of the products were quite different depending on the glycols used. The products prepared in 1,4-butanediol (1,4-BG) were spherical particles with ca. 5渭 m size while aggregations of fine particles were observed for other glycols. The samples obtained in 1,4-BG had large surface areas and showed narrow pore-size distributions in the mesopore region. To investigate the formation process of the products having such a unique morphol. and pore system, the mixtures of ZNP and glycols were heated at lower temperatures It was found that the thermal reaction of ZNP in 1,4-BG at 200掳C afforded intermediates with layered structures, which subsequently changed into nanocrystalline ZrO2 at elevated temperatures These stepwise crystallization processes attribute to the unique morphol. and pore system of the products obtained by the thermal treatment of ZNP in 1,4-BG. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Category: alcohols-buliding-blocks

The Article related to zirconia tetra n propoxide glycol thermal treatment pore structure, Ceramics: Ceramics and other aspects.Category: alcohols-buliding-blocks

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On February 1, 2021, Zhong, Shifa; Zhang, Kai; Wang, Dong; Zhang, Huichun published an article.Computed Properties of 111-29-5 The title of the article was Shedding light on “Black Box” machine learning models for predicting the reactivity of HO路 radicals toward organic compounds. And the article contained the following:

Developing quant. structure-activity relationships (QSARs) is an important approach to predicting the reactivity of HO radicals toward newly emerged organic compounds However, it is yet unknown whether this method makes predictions by choosing meaningful structural features rather than spurious ones, which is vital for trusting the models. In this study, we developed QSAR models for the logkHO路 values of 1089 organic compounds in the aqueous phase by two ML algorithms-deep neural networks (DNN) and eXtreme Gradient Boosting (XGBoost), and interpreted the built models by the SHapley Additive exPlanations (SHAP) method. The results showed that for the contribution of a given structural feature to logkHO. for different compounds, DNN and XGBoost treated it as a fixed and variable value, resp. We then developed an ensemble model combining the DNN with XGBoost, which achieved satisfactory predictive performance for all three datasets: Training dataset: R-square (R2) 0.89-0.91, root-mean-squared-error (RMSE) 0.21-0.23, and mean absolute error (MAE) 0.15-0.17; Validation dataset: R2 0.63-0.78, RMSE 0.29-0.32, and MAE 0.21-0.25; and Test dataset: R2 0.60-0.71, RMSE 0.30-0.35, and MAE 0.23-0.25. This study offered some much-needed mechanistic insights into a ML-assisted environmental task, which are important for evaluating the trustworthiness of the ML-based models, further improving the models for specific applications, and leveraging the implicit knowledge the models carry. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to black box machine learning model radical organic compound, Water: Analysis and other aspects.Computed Properties of 111-29-5

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