Tag: 100-200

《A New Chirally Organized Trifluoromethylanthrylmethanol Derivative and Its Application as Chiral Solvating Agent》 was written by Monteagudo, Eva; de March, Pedro; Alvarez-Larena, Angel; Virgili, Albert. Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused ontrifluoromethylanthrylmethanol chiral solvating agent. The article conveys some information:

The synthesis and structure of 1,1′-(((10,10′-(1,1′-binaphthalene)-2,2′-diylbis(oxy))bis(methylene))bis(anthracene-10,9-diyl))bis(2,2,2-trifluoroethanol), 4, is reported. This compound owns both axial and central chirality allowing its use as a chiral solvating agent (CSA) for the enantiomeric composition determination of several mixtures of chiral aromatic alcs. and amines using NMR. The study of the resulting diastereoisomeric complexes was carried out by determining its stoichiometry and association binding constants In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 5-Hexen-1-olIn 2020 ,《Rhodium(III)-Catalyzed C-H Olefination of Aromatic/Vinyl Acids with Unactivated Olefins at Room Temperature》 was published in Organic Letters. The article was written by Jambu, Subramanian; Jeganmohan, Masilamani. The article contains the following contents:

A Rh(III)-catalyzed COOH-assisted C-H alkenylation of aromatic acids with unactivated alkenes at room temperature is described. Further, the highly challenging β-C-H olefination of acrylic acids with unactivated olefins was also demonstrated. In these reactions, ortho-alkenylated aromatic/vinylic acids were prepared in good to excellent yields. A possible reaction mechanism involving ortho C-H activation and a five-membered rhodacycle formation was proposed and supported by the deuterium-labeling studies and isolation of a key rhodacycle intermediate. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application In Synthesis of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 2,6-PyridinedimethanolIn 2020 ,《Manganese Complex of a Rigidified 15-Membered Macrocycle: A Comprehensive Study》 appeared in Inorganic Chemistry. The author of the article were Pota, Kristof; Molnar, Eniko; Kalman, Ferenc Krisztian; Freire, David M.; Tircso, Gyula; Green, Kayla N.. The article conveys some information:

Owing to the increasing importance of manganese(II) complexes in the field of magnetic resonance imaging (MRI), large efforts were devoted to find an appropriate ligand for Mn(II) ion encapsulation by providing balance between the seemingly contradictory requirements (i.e., thermodn. stability and kinetic inertness vs. low ligand denticity enabling water mol.(s) to be coordinated in its metal center). Among these ligands, a large number of pyridine or pyridol based open-chain and macrocyclic chelators were studied so far. As a next step in the development of these chelators, 15-pyN3O2Ph and its transition metal complexes were synthesized and characterized using established methods. The 15-pyN3O2Ph ligand incorporates both pyridine and ortho-phenylene units to decrease ligand flexibility. The thermodn. properties, protonation and stability constants, were determined using pH-potentiometry; the solid-state structures of two protonation states of the free ligand and its manganese complex were obtained by single crystal x-ray diffractometry. The results show a seven-coordinate metal center with two water mols. in the first coordination sphere. The longitudinal relaxivity of [Mn(15-pyN3O2Ph)]2+ is 5.16 mM-1s-1 at 0.49 T (298 K). Furthermore, the r2p value of 11.72 mM-1s-1 (0.49 T), which is doubled at 1.41 T field, suggests that design of this Mn(II) complex does achieve some characteristics required for contrast imaging. In addition, 17O NMR measurements were performed to access the microscopic parameters governing this key feature (e.g., water exchange rate). Finally, manganese complexes of ligands with analogous polyaza macrocyclic scaffold were studied as low mol. weight Mn(CAT) mimics. Here, the authors report the H2O2 disproportionation study of [Mn(15-pyN3O2Ph)]2+ to demonstrate the versatility of this ligand scaffold as well. The highly rigidified 15-pyN3O2Ph ligand and its Mn(II) complex was synthesized and characterized using pH potentiometry, 1H relaxometry, and x-ray diffractometry. As a result of the aromatic structural moieties, the longitudinal and transverse relaxivities turned out to be outstanding (5.16 and 11.72 mM-1s-1) compared to other lower mol. weight MRI contrast agents. Also, this seven-coordinate complex can act as an effective H2O2 disproportionation catalyst, similar to MnCAT mimics. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2,6-Pyridinedimethanol

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Mills, L. Reginald; Gygi, David; Ludwig, Jacob R.; Simmons, Eric M.; Wisniewski, Steven R.; Kim, Junho; Chirik, Paul J. published an article in 2022. The article was titled 《Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands》, and you may find the article in ACS Catalysis.Recommanded Product: 89466-08-0 The information in the text is summarized as follows:

Cobalt(II) halides in combination with phenoxyimine (FI) ligands generated efficient precatalysts in situ for the C(sp2)-C(sp3) Suzuki-Miyaura cross-coupling between alkyl bromides and neopentylglycol (hetero)arylboronic esters. The protocol enabled efficient C-C bond formation with a host of nucleophiles and electrophiles (36 examples, 34-95%) with precatalyst loadings of 5 mol %. Studies with alkyl halide electrophiles that function as radical clocks support the intermediacy of alkyl radicals during the course of the catalytic reaction. The improved performance of the FI-cobalt catalyst was correlated with decreased lifetimes of cage-escaped radicals as compared to those of diamine-type ligands. Studies of the phenoxy(imine)-cobalt coordination chem. validate the L,X interaction leading to the discovery of an optimal, well-defined, air-stable mono-FI-cobalt(II) precatalyst structure. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiangchao; Yang, Chenchen; Li, Shun; Meng, Chong; Yu, Junjie; Yang, Jiazhi; Li, Feng published an article in 2021. The article was titled 《From selective transfer hydrogenation to selective hydrogen auto-transfer process: An efficient method for the synthesis of alkenyl ketones via iridium-catalyzed α-alkylation of ketones with alkenyl alcohols》, and you may find the article in Journal of Catalysis.Safety of 5-Hexen-1-ol The information in the text is summarized as follows:

A strategy for the synthesis of alkenyl ketones via the α-alkylation of ketones with alkenyl ketones was proposed and accomplished. In the presence of a metal-ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)], a series of desirable products were obtained in high yields. Mechanistic investigation revealed that functional groups in the ligand are crucial for the activity of catalyst and selective transfer hydrogenation is the determining step of the formation of alkenyl ketones as products. Notably, the present research exhibited also the unique potential of metal-ligand bifunctional catalysts for the activation of unsaturated alcs. as electrophiles for hydrogen auto-transfer process. In the part of experimental materials, we found many familiar compounds, such as 5-Hexen-1-ol(cas: 821-41-0Safety of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Safety of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casalta, Clement; Gourlaouen, Christophe; Bouzbouz, Samir published an article in 2021. The article was titled 《Iridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water》, and you may find the article in Organic Letters.Computed Properties of C6H7BO3 The information in the text is summarized as follows:

Allylic arylation of α-fluoro but-1-enoic acid amides with arylboronic acids was carried out in water by comparing the catalytic activity of iridium(III) and rhodium(III). Ir(III) has shown a strong superiority over Rh(III) to give allyl-aryl coupling products with excellent stereoselectivity in favor of the Z-isomer. The origin of high stereoselectivity is perhaps because of the a coordination of iridium Ir-N or Ir-O.2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Le Barbu-Debus, Katia; Zehnacker, Anne published their research in Chirality in 2021. The article was titled 《Competition between inter and intramolecular hydrogen bond evidenced by vibrational circular dichroism spectroscopy: The case of (1S,2R)-(-)-cis-1-amino-2-indanol》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The article contains the following contents:

The IR (IR) absorption and vibrational CD (VCD) spectra of an intramolecularly hydrogen-bonded chiral amino-alc., (1S,2R)-(-)-cis-1-amino-2-indanol, are studied in DMSO-d6. The spectra are simulated at the d. functional theory (DFT) level within the frame of the cluster-in-the-liquid model. Both IR and VCD spectra show a clear signature of the formation of intermol. hydrogen bonds at the detriment of the intramol. OH …N interaction present in the isolated mol. Two solvent mols. are necessary to reproduce the exptl. spectra. Whereas the first DMSO mol. captures the main spectral modifications due to hydrogen bond formation between the solute and the solvent, the second DMSO mol. is necessary for a good description of the Boltzmann contribution of the different complexes, based on their Gibbs free energy.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products》 was written by Chen, Kuang-Yao; Chen, Yi-Ju; Cheng, Chien-Ju; Jhan, Kai-Yuan; Chiu, Cheng-Hsun; Wang, Lian-Chen. Electric Literature of C7H6O2 And the article was included in Biomedical Journal in 2021. The article conveys some information:

Human cerebral angiostrongyliasis, induced by Angiostrongylus cantonensis, is an emerging disease in many parts of the world. A. cantonensis is also an important causative agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans. 3-Hydroxybenzaldehyde (3-HBA) and 4-Hydroxybenzaldehyde (4-HBA) have been shown to increase intracellular antioxidant activity, vasculoprotective potency, wound healing, and cell migration. However, the function of 3-HBA and 4-HBA in mouse astrocytes in response to A. cantonensis young adults excretory-secretory products (ESPs) treatment remains unclear. Here, we examined the effect of 3-HBA and 4-HBA by real-time qPCR, western blotting, and cell viability assay in astrocytes after A. cantonensis young adults ESPs treatment. The real-time qPCR, western blotting were employed to detect the expression of apoptosis- and Shh pathway-related mol. The percentage of cell viability was monitored by CCK-8 assay. We demonstrated that expression of apoptosis-related mols. was increased in response to A. cantonensis young adults ESPs treatment. However, the cell viability of astrocytes was elevated by treatment with 3-HBA and 4-HBA. Further investigation found that 3-HBA and 4-HBA activate the Shh signaling pathway and inhibit apoptosis-related mol. expression. These findings were confirmed using A. cantonensis young adults ESPs to activate apoptosis-related pathways in astrocytes. Moreover, 3-HBA and 4-HBA induced a protective phenotype through regulation of apoptosis in response to A. cantonensis young adults ESPs treatment. Hence, 3-HBA and 4-HBA represent potential therapeutic drugs for the treatment of human angiostrongyliasis. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Electric Literature of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Electric Literature of C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline-Biphenyl Hybrids》 was written by Coa, Juan Carlos; Yepes, Andres; Carda, Miguel; Conesa-Milian, Laura; Upegui, Yulieth; Robledo, Sara M.; Cardona-G, Wilson. Name: 2-Hydroxyphenylboronic acid And the article was included in ChemistrySelect in 2020. The article conveys some information:

The synthesis, in-silico studies, antiprotozoal and cytotoxic activities of eleven quinoline-biphenyl hybrids I [R = H, 4-HO, 3,4-di-MeO] were described. The structure of the synthesized products was elucidated by a combination of spectrometric anal. The synthesized compounds I were evaluated against Plasmodium falciparum and amastigotes forms both Leishmania (V)panamensis and Trypanosoma cruzi. Cytotoxicity was evaluated against human U-937 macrophages. Compound I [R = H] showed similar activity than meglumine antimoniate and compound I [R = 4-HO] exhibited an activity similar to that of benznidazole. Compound I [R = 3,4-di-MeO] showed the best activity against P. falciparum. Although these compounds were toxic for mammalian U-937 cells, however they may still have potential to be considered as candidates for drug development because of their antiparasite activity. Mol. docking was used to determine the in-silico inhibition of some of the designed compounds against PfLDH and cruzipain, two important pharmacol. targets involved in antiparasitic diseases. All hybrids I were docked to the three-dimensional structures of PfLDH and T. cruzi cruzipain as enzymes using AutoDock Vina. Notably, the docking results showed that the most active compoundsI [R = 4-HO] (CE50: 11.33μg/mL for T. cruzi) and I [R = 3,4-di-MeO] (CE50: 8.84μg/mL for P. falciparum) exhibited the highest scoring pose (-7.5 and -7.7 kcal/mol, resp.). This result showed a good correlation between the predicted scores with the exptl. data profile, suggesting that these ligands could act as competitive inhibitors of PfLDH or T. cruzi cruzipain enzymes resp. Finally, in-silico ADME studies of the quinoline hybrids showed that these novel compounds have suitable drug-like properties, making them potentially promising agents for antiprotozoal therapy. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Name: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Name: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Electrochemical alcohols oxidation mediated by N-hydroxyphthalimide on nickel foam surface》 was written by Behrouzi, Leila; Bagheri, Robabeh; Mohammadi, Mohammad Reza; Song, Zhenlun; Chernev, Petko; Dau, Holger; Najafpour, Mohammad Mahdi; Kaboudin, Babak. HPLC of Formula: 100-55-0 And the article was included in Scientific Reports in 2020. The article conveys some information:

Alc. to aldehyde conversion is a critical reaction in the industry. Herein, a new electrochem. method is introduced that converts 1 mmol of alcs. to aldehydes and ketones in the presence of N-hydroxyphthalimide (NHPI, 20 mol%) as a mediator; this conversion is achieved after 8.5 h at room temperature using a piece of Ni foam (1.0 cm2) and without adding an extra-base or a need for high temperature Using this method, 10 mmol (1.08 g) of benzyl alc. was also successfully oxidized to benzaldehyde (91%) without any byproducts. This method was also used to oxidize other alcs. with high yield and selectivity. In the absence of a mediator, the surface of the nickel foam provided oxidation products at the lower yield. After the reaction was complete, nickel foam (anode) was characterized by a combination of SEM (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS), XPS, and spectroelectrochem., which pointed to the formation of nickel oxide on the surface of the electrode. On the other hand, using other electrodes such as Pt, Cu, Fe, and graphite resulted in a low yield for the alc. to aldehyde conversion. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts