Tag: 100-200

In 2018,Boca, Roman; Rajnak, Cyril; Moncol, Jan; Titis, Jan; Valigura, Dusan published 《Breaking the Magic Border of One Second for Slow Magnetic Relaxation of Cobalt-Based Single Ion Magnetsã€?Inorganic Chemistry published the findings.Safety of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Instead of assembling complex clusters and/or expensive lanthanide-based systems as single ion magnets, we are focusing on mononuclear cobalt(II) systems among which the complex under study, [Co(pydca)(dmpy)]2·H2O (1), shows a field supported slow magnetic relaxation on the order of seconds at low temperature (pydca = pyridine-2,6-dicarboxylato, dmpy = 2,6-dimethanolpyridine). The low-frequency relaxation time is as slow as τ(LF) = 1.35(6) s at T = 1.9 K and BDC = 0.4 T. The properties of 1 are compared to the previously reported nickel and copper analogs which were the first examples of single ion magnets in the family of Ni(II) and Cu(II) complexes. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol

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In 2018,Sasano, Yusuke; Kogure, Naoki; Nagasawa, Shota; Kasabata, Koki; Iwabuchi, Yoshiharu published �-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities�Organic Letters published the findings.Recommanded Product: 27489-62-9 The information in the text is summarized as follows:

The chemoselective oxidation of alcs. containing electron-rich sulfur functionalities (e.g., 1,3-dithianes and sulfides) into their corresponding carbonyl compounds with the sulfur groups can sometimes be a demanding task in modern organic chem. A reliable method for this transformation, which features azaadamantane-type nitroxyl radical/copper catalysis using ambient air as the terminal oxidant is reported. The superiority of the developed method was demonstrated by comparing it with various conventional alc. oxidation methods. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHRâ€? to form imines (R2C=NRâ€?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 27489-62-9

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In 2016,Barday, Manuel; Ho, Kelvin Y. T.; Halsall, Christopher T.; Aissa, Christophe published 《Regioselective Synthesis of 3-Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogatesã€?Organic Letters published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

The poor regioselectivity of the [4 + 2] cycloaddition of 3-azetidinones with internal alkynes bearing two alkyl substituents via nickel-catalyzed carbon-carbon activation is addressed using 1,3-enynes as substrates. The judicious choice of substitution on the enyne enables complementary access to each regioisomer of 3-hydroxy-4,5-alkyl-substituted pyridines, which are important building blocks in medicinal chem. endeavors. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 2002,Hayashi, Kazuhiko; Hiki, Shinsuke; Kumagai, Toshio; Nagao, Yoshimitsu published 《Synthesis of azetidine derivatives using 1-azabicyclo[1.1.0]butaneã€?Heterocycles published the findings.Quality Control of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

A THF solution of 1-azabicyclo[1.1.0]butane (2), obtained from 2,3-dibromopropylamine hydrobromide, was treated with HCl-EtOH, 48% HBr, ClCO2Et, Ts2O, HCO2H-2.7N HCl-MeOH, or Ac2O-3N HCl to give the corresponding 3-monosubstituted and 1,3-disubstituted azetidine derivatives (e.g. 77% 1-Carboethoxy-3-chloroazetidine). Similar treatment of 2 with AcSH afforded 1-acetyl-3-acetylthioazetidine, which was converted to 1-(1,3-thiazolidin-2-yl)azetidine-3-thiol hydrochloride. 2 And various bromides were heated to furnish 3-bromoazetidine derivatives (e.g. 45% 3-bromo-1-cyanomethylazetidine) and/or N,N-disubstituted 2,3-dibromopropylamines (e.g. 42% 2,3-dibromo-1-(N,N-dibenzylamino)propane). The reaction of 2 with benzoyl peroxide or N-bromosuccinimide gave each corresponding 1,3-disubstituted azetidine derivative (11% 1-benzoyl-3-benzoylperoxyazetidine or 3% 3-Bromo-1-(tetrahydrofuran-2-yl)azetidine). In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Quality Control of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Quality Control of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 1992,Nagao, Yoshimitsu; Abe, Takao; Shimizu, Hisashi; Kumagai, Toshio; Inoue, Yoshinori published 《Asymmetric synthesis of new non-natural 1β-methylcarbapenems bearing methylthio group at the C6 positionã€?Heterocycles published the findings.Recommanded Product: 18621-18-6 The information in the text is summarized as follows:

The asym. total synthesis of 1β-methylcarbapenems I (n = 1, 2) has been accomplished starting from optically active 4-substituted azetidin-2-one II and using the thiols III. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
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Zhang, Hongpeng; Zhao, Dongbing published their research in ACS Catalysis in 2021. The article was titled 《Synthesis of Silicon-Stereogenic Silanols Involving Iridium-Catalyzed Enantioselective C-H Silylation Leading to a New Ligand Scaffold》.Related Products of 126456-43-7 The article contains the following contents:

Despite a growing focus on the construction of highly enantioenriched silicon-stereogenic organosilicon compounds, the enantioselective synthesis of silicon-stereogenic silanols through asym. catalysis remains a considerable challenge. Herein, we realized enantioselective construction of silicon-stereogenic diarylsilanols via an Ir-catalyzed C-H silylation of diarylsilanols along with stereospecific substitution or Tamao-Fleming oxidation This strategy gives rise to a class of chiral diol catalyst cores (PSiOLs). Transformation of PSiOLs led to the ligand possessing both Si and P-stereocenters, which is capable of inducing excellent enantioselectivity in the rhodium(I)-catalyzed conjugate 1,4-addition of aryl boronic acids to cyclohexenone. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 126456-43-7

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Sampson, Jessica; Bruening, Meaghan; Akhtar, Muhammed Naseem; Jaseer, E. A.; Theravalappil, Rajesh; Garcia, Nestor; Agapie, Theodor published their research in Organometallics in 2021. The article was titled 《Copolymerization of Ethylene and Long-Chain Functional α-Olefins by Dinuclear Zirconium Catalysts》.HPLC of Formula: 821-41-0 The article contains the following contents:

Bimetallic catalysts have shown promise for improving polar comonomer incorporation by late transition metals, but such effects are underexplored using early transition metal catalysts. Herein, the copolymerization of ethylene and α-olefins bearing alc. groups was performed using mono- and dizirconium bisamine bisphenolate catalysts in the presence of MAO and AliBu3. Under these conditions, catalyst activity was retained with comonomer incorporation trends mirroring those observed with unfunctionalized α-olefins, i.e., lower incorporation by bimetallic catalysts. Although incorporation levels are low, these data provide mechanistic insight for polar comonomer incorporation. These results are consistent with our earlier proposal that larger comonomers sterically clash with the distal metal center of the bimetallic catalysts, leading to lower incorporation. Addnl., a bimetallic mechanism for polar comonomer coordination and incorporation is not supported by the current data.5-Hexen-1-ol(cas: 821-41-0HPLC of Formula: 821-41-0) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.HPLC of Formula: 821-41-0

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Maji, Milan; Borthakur, Ishani; Guria, Saikat; Singha, Suman; Kundu, Sabuj published their research in Journal of Catalysis in 2021. The article was titled 《Direct access to 2-(N-alkylamino)pyrimidines via ruthenium catalyzed tandem multicomponent annulation/N-alkylation》.Recommanded Product: 100-55-0 The article contains the following contents:

A new cooperative ruthenium complex catalyzed tandem multicomponent synthesis of 2-(N-alkylamino)pyrimidines I [R = Ph, 4-MeOC6H4; R1 = 4-MeC6H4, 4-BrC6H4, 2-thienyl, etc.; R2 = H, Me; R3 = Ph, 4-FC6H4, cyclohexyl, etc.; R2R3 = (CH2)5] directly from guanidine salt and alcs. was developed. The reactions proceeded through the dehydrogenation of alcs., followed by C-C coupling and sequential C-N coupling with guanidine and primary alc., with the elimination of three equivalent of hydrogen gas. In this work, application of both the acceptorless dehydrogenative coupling (ADC) and borrowing hydrogen (BH) strategies were accomplished in a single reaction. This catalytic method tolerated a wide range of substrates. The viability of the current method was demonstrated by preparative scale synthesis of a few products. A plausible catalytic cycle was proposed based on various control experiments, mechanistic studies and DFT calculations Remarkably, 42 new 2-(N-alkylamino)pyrimidines were synthesized following this catalytic protocol. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 100-55-0

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《225Ac-H4py4pa for Targeted Alpha Therapy》 was written by Li, Lily; Rousseau, Julie; Jaraquemada-Pelaez, Maria de Guadalupe; Wang, Xiaozhu; Robertson, Andrew; Radchenko, Valery; Schaffer, Paul; Lin, Kuo-Shyan; Benard, Francois; Orvig, Chris. Product Details of 1195-59-1 And the article was included in Bioconjugate Chemistry in 2021. The article conveys some information:

Herein, we present the syntheses and characterization of a new undecadendate chelator, H4py4pa, and its bifunctional analog H4py4pa-phenyl-NCS, conjugated to the monoclonal antibody, Trastuzumab, which targets the HER2+ cancer. H4py4pa possesses excellent affinity for 225Ac (α, t1/2 = 9.92 d) for targeted alpha therapy (TAT), where quant. radiolabeling yield was achieved at ambient temperature, pH = 7, in 30 min at 10-6 M chelator concentration, leading to a complex highly stable in mouse serum for at least 9 d. To investigate the chelation of H4py4pa with large metal ions, lanthanum (La3+), which is the largest nonradioactive metal of the lanthanide series, was adopted as a surrogate for 225Ac to enable a series of nonradioactive chem. studies. In line with the 1H NMR spectrum, the DFT (d. functional theory)-calculated structure of the [La(py4pa)]- anion possessed a high degree of symmetry, and the La3+ ion was secured by two distinct pairs of picolinate arms. Furthermore, the [La(py4pa)]- complex also demonstrated a superb thermodn. stability (log K[La(py4pa)]- ~20.33, pLa = 21.0) compared to those of DOTA (log K[La(DOTA)]- ~24.25, pLa = 19.2) or H2macropa (log K[La(macropa)]- = 14.99, pLa ~8.5). Moreover, the functional versatility offered by the bifunctional py4pa precursor permits facile incorporation of various linkers for bioconjugation through direct nucleophilic substitution. In this work, a short phenyl-NCS linker was incorporated to tether H4py4pa to Trastuzumab. Radiolabeling studies, in vitro serum stability, and animal studies were performed in parallel with the DOTA-benzyl-Trastuzumab. Both displayed excellent in vivo stability and tumor specificity. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 1195-59-1

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Formula: C6H12O6On September 15, 2021 ,《Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii》 was published in Carbohydrate Polymers. The article was written by Sun, Yuqing; Huo, Jinxi; Zhong, Shi; Zhu, Jianxun; Li, Yougui; Li, Xiaojun. The article contains the following contents:

Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. SHPS-1 consisted of arabinose, mannose, glucose, and galactose at a molar ratio of 2.2:15.7:49.3:32.8. SHPS-1 had a backbone containing 1,3-linked β-D-Glcp and 1,6-linked α-D-Galp residues, and Araf, Manp and Galp units were attached as oligosaccharidic side chains to the backbone at C-6 of some glucopyranoses. SHPS-1 decreased phosphorylation level of STAT-1 and expression levels of STAT-1 targeted genes such as iNOS and TNF-α in lipopolysaccharide-stimulated macrophage RAW 264.7 cells. Furthermore, SHPS-1 promoted the expression of IL-10 and macrophage mannose receptor CD 206, markers of tissue repairing macrophages. SHPS-1 alleviated ulcerative colitis in mice by decreasing pro-inflammatory genes and increasing anti-inflammatory and tissue repairing genes. Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Formula: C6H12O6

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