Tag: 100-200

Category: alcohols-buliding-blocksIn 2021 ,《Design and synthesis of novel terpyridine-based ligands with one and two terminal aurophilic moieties and their Rh(III) and Ru(II) complexes for the adsorption on metal surfacesã€?was published in Polyhedron. The article was written by Salimova, Irina O.; Berezina, Anna V.; Shikholina, Ilona A.; Zyk, Nikolai V.; Beloglazkina, Elena K.. The article contains the following contents:

Novel terpyridine ligands with one and two terminal aurophilic sulfur containing fragments, (S)-11-(4-([2,2′:6′,2”-terpyridin]-4′-yl)phenoxy)undecyl 5-(1,2-dithiolan-3-yl)pentanoate (7), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11a), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,2-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11b), (S)-((5-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11c) were synthesized and employed to synthesis of mononuclear ruthenium(II) and rhodium(III) complexes. Electrochem. studies of the obtained ligands and coordination compounds and their ability to chemisorb on gold electrodes surfaces have been carried out. Among the obtained metal complexes, compounds with the min. time of chemisorption with the formation of Au-S bonds were revealed, which are complexes of 3,4- and 3,5-substituted phenylterpyridines. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks

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《Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditionsã€?was published in Nature Chemistry in 2020. These research results belong to Becker, Marc R.; Wearing, Emily R.; Schindler, Corinna S.. Electric Literature of C6H12O The article mentions the following:

Intermol. [2+2] photocycloadditions represent a powerful method for the synthesis of highly strained, four-membered rings. Although this approach is commonly employed for the synthesis of oxetanes and cyclobutanes, the synthesis of azetidines via intermol. aza Paterno-́Buchi reactions remains highly underdeveloped. Here the authors report a visible-light-mediated intermol. aza Paterno-́Buchi reaction that uses the unique triplet state reactivity of oximes, specifically 2-isoxazoline-3-carboxylates. The reactivity of this class of oximes can be harnessed via the triplet energy transfer from a com. available iridium photocatalyst and allows for [2+2] cycloaddition with a wide range of alkenes. This approach was characterized by its operational simplicity, mild conditions and broad scope, and allows for the synthesis of highly functionalized azetidines from readily available precursors. Importantly, the accessible azetidine products can be readily converted into free, unprotected azetidines, which represents a new approach to access these highly desirable synthetic targets. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Electric Literature of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Electric Literature of C6H12O

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《anti-Hydroarylation of Activated Internal Alkynes: Merging Pd and Energy Transfer Catalysisã€?was published in Organic Letters in 2020. These research results belong to Corpas, Javier; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C.. Name: 2-Hydroxyphenylboronic acid The article mentions the following:

A general catalytic anti-hydroarylation of electron-deficient internal alkynes compatible with both electron-poor and electron-rich aryl reagents is reported. This selectivity is achieved through a sequential syn-carbopalladation of the alkyne by an Ar-Pd species, followed by a tandem, Ir-photocatalyzed, counter-thermodn. E �Z isomerization. The use of ortho-substituted boronic acids enables direct access to pharmaceutically relevant heterocyclic cores via a cascade process. Mechanistic insight into the involvement of Ar-Pd vs. Pd-H as an active species is provided. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Name: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Name: 2-Hydroxyphenylboronic acid

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《Handy and highly efficient oxidation of benzylic alcohols to the benzaldehyde derivatives using heterogeneous Pd/AlO(OH) nanoparticles in solvent-free conditionsã€?was published in Scientific Reports in 2020. These research results belong to Goksu, Haydar; Sen, Fatih. Electric Literature of C7H7BrO The article mentions the following:

The selective oxidation of benzylic alcs. was performed by using com. available aluminum oxy-hydroxide-supported palladium (Pd/AlO(OH)) nanoparticles (0.5 weight% Pd, about 3 nm size) under mild conditions. The oxidation method comprises the oxidation of benzyl alcs. catalyzed by aluminum oxy-hydroxide-supported palladium under ultrasonic and solvent-free conditions and a continuous stream of O2. The characterization of aluminum oxy-hydroxide-supported palladium nanocatalyst was conducted by several advanced anal. techniques including scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and elemental anal. by ICP-OES. The oxidation of a variety of benzyl alc. compounds were tested by the aluminum oxy-hydroxide-supported palladium nanoparticles, and all expected oxidation products were obtained by the high conversion yields within 3 h. The reaction progress was monitored by TLC (Thin-layer chromatog.), and the yields of the products were determined by 1H-NMR and 13C NMR anal. The experimental process involved the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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The author of 《Heteroarene Phosphinylalkylation via a Catalytic, Polarity-Reversing Radical Cascadeã€?were Buquoi, J. Quentin; Lear, Jeremy M.; Gu, Xin; Nagib, David A.. And the article was published in ACS Catalysis in 2019. COA of Formula: C6H12O The author mentioned the following in the article:

A polarity-reversing radical cascade strategy for alkene difunctionalization by vicinal C-C and C-P bond formation has been developed. This approach to concurrently adding phosphorus and a heteroarene across an olefin is enabled by photocatalytic generation of electrophilic P-centered radicals. Upon chemoselective addition to an olefin, the resulting nucleophilic C-centered radical selectively combines with electrophilic heteroarenes, such as pyridines. This multicomponent coupling scheme for phosphinylalkylation complements classic two-component methods for hydrophosphinylation of alkenes and C-H phosphinylation of arenes. Included competition and photoquenching experiments provide insight into the selectivity and mechanism of this polarity-reversal pathway. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0COA of Formula: C6H12O) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.COA of Formula: C6H12O

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The author of 《A Highly Active PN3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditionsã€?were Homberg, Leonard; Roller, Alexander; Hultzsch, Kai C.. And the article was published in Organic Letters in 2019. Product Details of 873-75-6 The author mentioned the following in the article:

A highly active Mn(I) catalyst based on a nonsym. PN3-ligand scaffold for the N-alkylation of amines with alcs. using the borrowing hydrogen methodol. is reported. A broad range of anilines and the more challenging aliphatic amines were alkylated with primary and secondary alcs. Moreover, the combination of low catalyst loadings and mild reaction conditions provides high efficiency for this atom-economic transformation. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Product Details of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Product Details of 873-75-6 It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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The author of �-BocNH-ABNO-catalyzed aerobic oxidation of alcohol at room temperature and atmospheric pressure�were Zhao, Yajing; Li, Yutong; Shen, Zhenlu; Hu, Xinquan; Hu, Baoxiang; Jin, Liqun; Sun, Nan; Li, Meichao. And the article was published in Tetrahedron Letters in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

A transition-metal-free catalytic system has been developed for selective transformation of alc., e.g., 1,2,3,4-tetrahydronaphthalen-1-ol to aldehydes or ketones, e.g., 1,2,3,4-tetrahydronaphthalen-1-one. The reactions were performed with 3-(tert-butoxycarbonylamino)-9-azabicyclo[3.3.1]nonane N-oxyl (3-BocNH-ABNO) as the catalyst, NaNO2 as the co-catalyst, mol. oxygen as the terminal oxidant, and AcOH as the solvent under room temperature This catalytic system exhibited broad functional group tolerance. A series of alc. substrates, including primary and secondary benzylic alcs., heteroaromatic analogs, primary and secondary aliphatic alcs., could be converted into their corresponding aldehydes and ketones in good conversions and selectivities. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Category: alcohols-buliding-blocks)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cmâˆ?1 (ν19b mode) does not overlap with any of the other bands.Category: alcohols-buliding-blocks

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The author of 《Development of Imidazo[1,2-a]pyridine Derivatives with an Intramolecular Hydrogen-Bonded Seven-Membered Ring Exhibiting Bright ESIPT Luminescence in the Solid Stateã€?were Mutai, Toshiki; Muramatsu, Tatsuya; Yoshikawa, Isao; Houjou, Hirohiko; Ogura, Masaru. And the article was published in Organic Letters in 2019. Formula: C6H7BO3 The author mentioned the following in the article:

Imidazo[1,2-a]pyridine derivatives with different hydroxyaryl units (1-3), which could potentially form an intramol. hydrogen-bonded seven-membered ring in either a planar or a twisted conformation, were newly developed, and the effect of conformation and steric repulsion on the excited-state intramol. proton transfer (ESIPT) luminescence was evaluated. Among them, 1 and 2 formed an intramol. hydrogen-bonded seven-membered ring in the crystalline state and exhibited efficient ESIPT luminescence in the solid state (quantum yield up to 0.45).2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

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In 2019,Catalysis Letters included an article by Khalifeh, Reza; Shahimoridi, Roghayeh; Rajabzadeh, Maryam. Name: 3-Hydroxybenzaldehyde. The article was titled 《Design and Synthesis of Novel Cage like CuFe2O4 Hollow Nanostructure as an Efficient Catalyst for Synthesis of 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)sã€? The information in the text is summarized as follows:

Cage like CuFe2O4 hollow nanostructure has been synthesized successfully using hard template method under the hydrothermal condition. Cu(NO3)2·6H2O, Fe(NO3)2·9H2O and glucose were dissolved in water, and the mixture was heated to 180 °C in an autoclave. The removal of carbon was achieved by calcination at 800 °C and finally, the cage like CuFe2O4 hollow structure was obtained. This cage like CuFe2O4 hollow structure was characterized by FE-SEM, EDS, TEM and XRD. The catalytic performance of this hollow nanostructure was evaluated for the synthesis of bis pyrazol-5-ols. To this end, the one pot condensation reactions of phenylhydrazine, Et acetoacetate and different aromatic aldehyde at 80 °C under the solvent free condition were performed. The optimum amount of applied catalyst for this transformation was obtained to be 0.04 mol %. Noteworthy, catalyst was easily recoverable and was reused for 7 times with the remaining of its initial structure as well as its catalytic activity. Cage like CuFe2O4 hollow nanostructure are stably and efficiently attainable for conversion of precursors to 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

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In 2018,MedChemComm included an article by Panczyk, Katarzyna; Zelaszczyk, Dorota; Koczurkiewicz, Paulina; Sloczynska, Karolina; Pekala, Elzbieta; Zeslawska, Ewa; Nitek, Wojciech; Zmudzki, Pawel; Marona, Henryk; Waszkielewicz, Anna. Formula: C6H13NO. The article was titled 《Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acidsã€? The information in the text is summarized as follows:

A series of new phenoxyacetamides were prepared via multistep chem. synthesis as a continuation of the research carried out on di- and tri-substituted phenoxyalkyl and phenoxyacetyl derivatives of amines. The obtained compounds varied in an amide component, for example aminoalkanol or (un)modified amino acid moieties were introduced. The structures of selected products were confirmed by means of crystallog. methods. All compounds were the subject of preliminary screening for potential anticonvulsant activity (MES, 6 Hz and/or scMET tests) and neurotoxicity (rotarod) in mice after i.p. administration, while several active compounds were subsequently examined in addnl. models (e.g. MES and rotarod – rats, p.o. or i.p., hippocampal kindling – rats, i.p.). Finally, safety studies (cytotoxicity and cell proliferation assays on astrocytes, metabolic stability assessment, mutagenicity evaluation) were performed for several active compounds, including the most promising one (R-(-)-2-(2,6-dimethylphenoxy)-N-(1-hydroxypropan-2-yl)acetamide, MES ED50 = 12.00 mg per kg b.w., rats, p.o.). The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Formula: C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C6H13NO

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