Tag: 100-200

In 2019,ACS Catalysis included an article by Bains, Amreen K.; Kundu, Abhishek; Yadav, Sudha; Adhikari, Debashis. Computed Properties of C7H9NO2. The article was titled 《Borrowing Hydrogen-Mediated N-Alkylation Reactions by a Well-Defined Homogeneous Nickel Catalyst》. The information in the text is summarized as follows:

We report herein a well-defined and bench-stable azo-phenolate ligand-coordinated nickel catalyst which can efficiently execute N-alkylation of a variety of anilines by alc. We demonstrate that the redox-active azo ligand can store hydrogen generated during alc. oxidation and redelivers the same to an in-situ-generated imine bond to result in N-alkylation of amines. The reaction has wide scope, and a large array of alcs. can directly couple to a variety of anilines. Mechanistic studies including deuterium labeling to the substrate establishes the borrowing hydrogen method from alcs. and pinpoints the crucial role of the redox-active azo moiety present on the ligand backbone. Isolation of the ketyl intermediate in its trapped form with a radical quencher and higher kH/kD for the alc. oxidation step suggest altogether a hydrogen-atom transfer (HAT) to the reduced azo backbone to pave alc. oxidation as opposed to the conventional metal-ligand bifunctional mechanism. This example clearly demonstrates that an inexpensive base metal catalyst can accomplish an important coupling reaction with the help of a redox-active ligand backbone. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C7H9NO2

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In 2019,Nature Communications included an article by Wang, Dan; Wang, Pan; Wang, Shengchun; Chen, Yi-Hung; Zhang, Heng; Lei, Aiwen. Product Details of 873-75-6. The article was titled 《Direct electrochemical oxidation of alcohols with hydrogen evolution in continuous-flow reactor》. The information in the text is summarized as follows:

Herein, an electrochem. oxidation of various alcs. in a continuous-flow reactor without external oxidants, base or mediators to afford aldehydes or ketones was reported. The robust electrochem. oxidation was performed for a variety of alcs. with good functional group tolerance, high efficiency and atom economy, whereas mechanistic studies support the benzylic radical intermediate formation and hydrogen evolution. The electrochem. oxidation proved viable on diols with excellent levels of selectivity for the benzylic position. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Product Details of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Product Details of 873-75-6 It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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In 2018,Dey, Subal; Ahmed, Estak Md; Dey, Abhishek published 《Activation of Co(I) State in a Cobalt-Dithiolato Catalyst for Selective and Efficient CO2 Reduction to CO》.Inorganic Chemistry published the findings.Name: 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Reduction of CO2 holds the key to solving 2 major challenges taunting the society-clean energy and clean environment. There is an urgent need for the development of efficient nonnoble metal-based catalysts that can reduce CO2 selectively and efficiently. Unfortunately, activation and reduction of CO2 can only be achieved by highly reduced metal centers jeopardizing the energy efficiency of the process. A CO dehydrogenase inspired Co complex bearing a dithiolato ligand can reduce CO2, in wet MeCN, to CO with ∼95% selectivity over a wide potential range and 1559 s-1 rate with a remarkably low overpotential of 70 mV. Unlike most of the transition metal-based systems that require reduction of the metal to its formal zerovalent state for CO2 reduction, this catalyst can reduce CO2 in its formal +1 state making it substantially more energy efficient than any system known to show similar reactivity. While covalent donation from 1 thiolate increases electron d. at the Co(I) center enabling it to activate CO2, protonation of the bound thiolate, in the presence of H2O as a proton source, plays a crucial role in lowering overpotential (thermodn.) and ensuring facile proton transfer to the bound CO2 ensuring facile (kinetics) reactivity. A very covalent Co(III)-C bond in a Co(III)-COOH intermediate is at the heart of selective protonation of the O atoms to result in CO as the exclusive product of the reduction In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 2,6-Pyridinedimethanol

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In 2018,Cai, Wangshui; Wang, Shuang; Jalani, Hitesh B.; Wu, Junxian; Lu, Hongjian; Li, Guigen published 《Oxidative Cascade Reaction of N-Aryl-3-alkylideneazetidines and Carboxylic Acids: Access to Fused Pyridines》.Organic Letters published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

A versatile silver-promoted oxidative cascade reaction of N-aryl-3-alkylideneazetidines with carboxylic acids is reported, providing a very efficient pathway to functionalized fused pyridines. This method allows introduction of fused pyridine ring systems to heterocycles, drugs, and natural products. A mechanistic study revealed that silver salt is essential for the chemo- and regioselective ring expansion, sequential oxidative nucleophilic additions, and oxidative aromatization. This approach represents the first example of the strained N-heterocycles undergoing a cascade reaction with a π bond and a nucleophile together.Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 2012,Ishida, Naoki; Yuhki, Tatsuya; Murakami, Masahiro published 《Synthesis of Enantiopure Dehydropiperidinones from α-Amino Acids and Alkynes via Azetidin-3-ones》.Organic Letters published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

Chiral dehydropiperidinones were synthesized in enantiopure form from α-amino acids and alkynes via nickel-catalyzed insertion into azetidin-3-one intermediates. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Xu, Xianjun; Feng, Huangdi; Zhang, Xiaoyong; Song, Liangliang; Van Meervelt, Luc; Van der Eycken, Johan; Harvey, Jeremy N.; Van der Eycken, Erik V. published an article on February 11 ,2022. The article was titled 《Pd-Catalyzed Ring Restructuring of Oxazolidines with Alkenes Leading to Fused Polycyclic Indolizines》, and you may find the article in Organic Letters.Product Details of 157142-48-8 The information in the text is summarized as follows:

A palladium-catalyzed reaction of N-propargyl oxazolidines with alkenes for the synthesis of indolizidines has been developed. Through a sequential 6-exo-dig cyclization/proton transfer/[3+2] cycloaddition/cycloreversion/aromatization process, a series of fused polycyclic indolizines are obtained in moderate to good yields with high functional group tolerance. Exptl. and theor. studies suggest that the [3+2] cycloaddition/cycloreversion of the oxazolidine ring probably involves C-C and C-O bond cleavage, providing a new ring restructuring approach for the synthesis of heterocycles. The experimental process involved the reaction of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Product Details of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 157142-48-8

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The author of 《Nickel-catalyzed C-N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling》 were Yue, Huifeng; Zhu, Chen; Shen, Li; Geng, Qiuyang; Hock, Katharina J.; Yuan, Tingting; Cavallo, Luigi; Rueping, Magnus. And the article was published in Chemical Science in 2019. Application In Synthesis of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:

Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, exptl. mechanistic investigations and d. functional theory (DFT) calculations in combination with wavefunction anal. have been performed to understand the catalytic cycle in more detail. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application In Synthesis of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 4,4-Diethoxybutan-1-amine

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Liu, Jingping; Yu, Dan; Yang, Yong; You, Huichao; Sun, Minzhi; Wang, Yaxin; Shen, Xu; Liu, Zhong-Quan published an article in Organic Letters. The title of the article was 《Free-Radical-Promoted Dehydrogenative Coupling of Polyfluorinated Alcohol with Quinone, Chromone, and Coumarin》.Safety of 3,3,3-Trifluoropropan-1-ol The author mentioned the following in the article:

A free-radical-mediated dehydrogenative cross-coupling reaction of polyfluorinated alc. with quinone, coumarin, and chromone was developed. It provides a sustainable and practical strategy for installation of fluorine atom into organic mols. by using polyfluorinated alcs. In the experimental materials used by the author, we found 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

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《Star polymerization of norbornene derivatives using a tri-functionalized Blechert’s olefin metathesis catalystã€?was written by Zhou, Chulu; Hou, Cuiping; Cheng, Jianhua. Recommanded Product: 89466-08-0 And the article was included in Polymer Chemistry in 2020. The article conveys some information:

Blechert’s catalyst (III), one of the powerful olefin metathesis catalysts in ring closing metathesis (RCM), was demonstrated to show living ROMP characteristics towards conventional norbornene derivatives The obtained homopolymers and block copolymers have very narrow D and controlled mol. weights The tri-functionalized ROMP initiator (IV) based on Blechert’s catalyst was isolated in good yield, and showed highly efficient activity in the star polymerization of norbornene derivatives, including bulky fourth generation dendrons, to afford tri-arm star polymers with a precise mol. weight and narrow D. The difference in the solution properties between tri-arm star polymers and linear polymers with similar mol. weights was studied by tandem GPC/light scattering. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

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《Fluoresceinated Aminohexanol Tethered Inositol Hexakisphosphate: Studies on Arabidopsis thaliana and Drosophila melanogaster and Docking with 2P1M Receptorã€?was written by Thakur, Sujeet Kumar; Goswami, Krishnendu; Rao, Pallavi; Kaushik, Shivam; Singh, Bhanu Pratap; Kain, Pinky; Asthana, Shailendra; Bhattacharjee, Saikat; Guchhait, Prasenjit; Eswaran, Sambasivan V.. Recommanded Product: 6-Aminohexan-1-ol And the article was included in ACS Omega in 2020. The article conveys some information:

Inositol hexakisphosphate (InsP6; phytic acid) is considered as the second messenger and plays a very important role in plants, animals, and human beings. It is the principal storage form of phosphorus in many plant tissues, especially in dry fruits, bran, and seeds. The resulting anion is a colorless species that plays a critical role in nutrition and is believed to cure many diseases. A fluoresceinated aminohexanol tethered inositol hexakisphosphate (III) had been synthesized earlier involving many complicated steps. We describe here a simple two-step synthesis of (III) and its characterization using different techniques such as matrix-assisted laser desorption ionization mass spectrometry, tandem mass spectrometry, and Fourier transform IR, UV-visible, UV-fluorescence, 1H NMR (NMR), and two-dimensional NMR spectroscopies. The effect of (III) has been investigated in the model systems, Arabidopsis thaliana and Drosophila melanogaster. Using Schrodinger software, computational studies on the binding of (III) with the protein 2P1M (Auxin-receptor TIR1-adaptor ASK1 complex) has revealed strong binding propensity with this compound These studies on the fluoresceinated tethered phytic acid could have far reaching implications on its efficacy for human health and treatment of diseases (cancer/tumor and glioblastoma) and for understanding phosphorous recycling in the environment, especially for plant systems. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Recommanded Product: 6-Aminohexan-1-ol

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