Tag: 100-200

Application In Synthesis of 3-HydroxybenzaldehydeIn 2019 ,《Fe3O4@nano-cellulose/Cu(II): a bio-based and magnetically recoverable nano-catalyst for the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivativesã€?appeared in RSC Advances. The author of the article were Safajoo, Nasrin; Mirjalili, Bi Bi Fatemah; Bamoniri, Abdolhamid. The article conveys some information:

Fe3O4@nano-cellulose/Cu(II) as a green bio-based magnetic catalyst was prepared through in situ co-precipitation of Fe2+ and Fe3+ ions in an aqueous suspension of nano-cellulose. The mentioned magnetically heterogeneous catalyst was characterized by FT-IR, XRD, VSM, FESEM, TEM, XRF, EDS and TGA. In this research, the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives I (R = 4-Cl, 2-NO2, 3,4-(OH)2, etc.) was developed via a three component reaction of aromatic aldehydes RC6H4CHO, 2-aminobenzothiazole and Et acetoacetate using Fe3O4@nano-cellulose/Cu(II) under solvent-free condition at 80 °C. Some advantages of this protocol are good yields, environmentally benign, easy work-up and moderate reusability of the catalyst. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 100-83-4In 2021 ,《Synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism in the presence of a novel quinoline-based dendrimer-like ionic liquidã€?appeared in RSC Advances. The author of the article were Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali; Rouhani, Shamila; Azizi, Shohreh; Olomola, Temitope O.; Maaza, Malik; Msagati, Titus A. M.. The article conveys some information:

In the present study, the synthesis of a novel quinoline-based dendrimer-like ionic liquid I was reported. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform IR spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric anal. (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety II (R = Ph, 2-chlorophenyl, thiophen-2-yl, etc.) and III via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target mols. II ad III were achieved in short reaction times and high yields. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Mansawat, Woraluk; Yukhet, Phanomsak; Bhanthumnavin, Worawan; Reiser, Oliver; Vilaivan, Tirayut published an article in Synlett. The title of the article was 《Kinetic Resolution of dl-Hydrobenzoins Catalyzed by Copper(II) Complexes of C2-Symmetric Thiophene-Derived Ligandsã€?SDS of cas: 126456-43-7 The author mentioned the following in the article:

C2-Sym. chiral amino alc. ligands with a central thiophene moiety were shown to be effective in combination with CuCl2 for the asym. acylation of dl-hydrobenzoins. In contrast to previously developed chiral ligands, readily available acetyl chloride and acetic anhydride can be used as reagents, in addition to benzoyl chloride, giving rise to the corresponding monoacylated products in up to 99% ee ( S= 532). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.SDS of cas: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Taheri, Maryam; Aslani, Samira; Ghafouri, Hossein; Mohammadi, Asadollah; Akbary Moghaddam, Vaha; Moradi, Nastarn; Naeimi, Hananeh published an article in BMC Chemistry. The title of the article was 《Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors on PC12 cellsã€?Formula: C7H6O2 The author mentioned the following in the article:

The loss of cholinergic neurotransmission in Alzheimer′s disease (AD) patientsâ€?brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation of ACh is a promising approach for AD treatment. In the present study, a series of 2-chloro-3-hydrazinopyrazine derivatives (CHP1-5) were designed, synthesized, and biol. evaluated as potential multifunctional anti-AD agents. In addition, the chem. structures and purity of the synthesized compounds were elucidated through using IR, 1H and 13C NMR, and elemental analyses. Further, the intended compounds were assessed in vitro for their AChE inhibitory and neuroprotective effects. Furthermore, DPPH, FRAP and ABTS assays were utilized to determine their antioxidant activity. The statistical anal. was performed using one-way ANOVA. Based on the results, CHP4 and CHP5 exhibited strong AChE inhibitory effects with the IC50 values of 3.76 and 4.2 μM compared to the donepezil (0.53 μM), resp. The study examined the effect and mol. mechanism of CHP4 on the Ab1-42-induced cytotoxicity in differentiated PC12 cells. At concentrations of 0-100 μM, CHP4 was non-toxic in PC12. Addnl., Ab1-42 significantly stimulated tau hyperphosphorylation and induced differentiated PC12 cell death. Further, CHP4 resulted in diminishing the Ab1-42-induced toxicity in PC12 cell significantly. CHP4 at 30 μM concentration significantly increased the Ab1-42-induced HSP70 expression and decreased tau hyperphosphorylation. According to the results of our studies CHP4 can be considered as safe and efficient AChEI and employed as a potential multifunctional anti-AD agent. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Chen, Kuang-Yao; Chen, Yi-Ju; Cheng, Chien-Ju; Jhan, Kai-Yuan; Wang, Lian-Chen published an article in Biomolecules. The title of the article was 《Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stressã€?Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Excretory-secretory products (ESPs) are the main research targets for investigating the hosts and helminths interaction. Parasitic worms can migrate to parasitic sites and avoid the host immune response by secreting this product. Angiostrongylus cantonensis is an important food-borne zoonotic parasite that causes severe neuropathol. damage and symptoms, including eosinophilic meningitis or meningoencephalitis in humans. Benzaldehydes are organic compounds composed of a benzene ring and formyl substituents. This compound has anti-inflammatory and antioxidation properties. Previous studies showed that 3-hydroxybenzaldehyde (3-HBA) and 4-hydroxybenzaldehyde (4-HBA) can reduce apoptosis in A. cantonensis ESP-treated astrocytes. These results on the protective effect underlying benzaldehyde have primarily focused on cell survival. The study was designed to investigate the mol. mechanisms of endoplasmic reticulum stress (ER stress) and oxidative stress in astrocytes in A. cantonensis ESP-treated astrocytes and to evaluate the therapeutic consequent of 3-HBA and 4-HBA. First, we initially established the RNA-seq dataset in each group, including normal, ESPs, ESPs + 3-HBA, and ESPs + 4-HBA. We also found that benzaldehyde (3-HBA and 4-HBA) can stimulate astrocytes to express ER stress-related mols. after ESP treatment. The level of oxidative stress could also be decreased in astrocytes by elevating antioxidant activity and reducing ROS generation. These results suggested that benzaldehyde may be a potential therapeutic compound for human angiostrongyliasis to support brain cell survival by inducing the expression levels of ER stress- and oxidative stress-related pathways. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Spitzer, Lea; Lecommandoux, Sebastien; Cramail, Henri; Jerome, Francois published an article in 2021. The article was titled 《Sequential acid-catalyzed alkyl glycosylation and oligomerization of unprotected carbohydratesã€? and you may find the article in Green Chemistry.Name: 3-Bromopropan-1-ol The information in the text is summarized as follows:

An efficient method has been developed to synthesize end-functionalized oligosaccharides from unprotected monosaccharides in a one-pot/two-step approach. In the first step, mannose (and glucose) was functionalized with an alkyne group at the anomeric position through the Fisher-glycosylation reaction with propargyl alc. as a glycosyl acceptor. N the second step, the functionalized monosaccharides were oligomerized and the exptl. conditions were optimized by varying the temperature, time and the molar ratio between alc. and sugar to reach an oligosaccharide up to 8 units. The obtained oligosaccharides showed complete propargylation at their reducing chain-end and were successfully coupled to oleic acid via the Huisgen reaction, affording bio-based surfactants. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Name: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yonghe; Zhao, Ruibo; Liu, Jia; Kong, Hao; Zhang, Kebiao; Zhang, Yuan-Ning; Kong, Xiangdong; Zhang, Quan; Zhao, Yanli published their research in Biomaterials in 2021. The article was titled 《Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapyã€?SDS of cas: 26153-38-8 The article contains the following contents:

The development of activatable photosensitizers (PSs) is of particular interest for achieving tumor photodynamic therapy (PDT) with minimal side effects. However, the in vivo applications of PSs are limited by complex physiol. and biol. delivery barriers. Herein, boron dipyrromethene (BDP)-based nanoparticles are developed through the self-assembly of a multifunctional “”one-for-all”” building block for enhanced tumor penetration and activatable PDT. The nanoparticles show excellent colloidal stability and long circulation lifetime in blood. Once they reach the tumor site, the first-stage size reduction occurs due to the hydrolysis of the Schiff base bond between polyethylene glycol and the cyclic Arg-Gly-Asp peptide in the acidic tumor microenvironment (pHâˆ?.5), facilitating tumor penetration and specific recognition by cancer cells overexpressing integrin ανβ3 receptors. Upon the endocytosis by cancer cells, the second-stage size reduction is triggered by more acidic pH in lysosomes (pHâˆ?.5). Importantly, the protonated diethylamino groups can block photoinduced electron transfer from the amine donor to the excited PSs and accelerate complete disassembly of the nanoparticles into single PS mol., with the recovery of the fluorescence and photoactivity for efficient PDT. This study presents a smart PS delivery strategy involving acidity-triggered hierarchical disassembly from the nano to mol. scale for precise tumor PDT. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8SDS of cas: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.SDS of cas: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Joerg, Manuela; Khajehali, Elham; van der Westhuizen, Emma T.; C. Choy, K. H.; Shackleford, David M.; Tobin, Andrew B.; Sexton, Patrick M.; Valant, Celine; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J. published their research in ChemMedChem in 2021. The article was titled 《Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptorã€?Application In Synthesis of 2-Hydroxyphenylboronic acid The article contains the following contents:

This study investigated the structure-activity relationships of 4-phenylpyridin-2-one and 6-phenylpyrimidin-4-one M1 muscarinic acetylcholine receptor (M1 mAChRs) pos. allosteric modulators (PAMs). The presented series focuses on modifications to the core and top motif of the reported leads, MIPS1650 and MIPS1780. Profiling of our novel analogs showed that these modifications result in more nuanced effects on the allosteric properties compared to our previous compounds with alterations to the biaryl pendant. Further pharmacol. characterization of the selected compounds in radioligand binding, IP1 accumulation and β-arrestin 2 recruitment assays demonstrated that, despite primarily acting as affinity modulators, the PAMs displayed different pharmacol. properties across the two cellular assays. The novel PAM I is a potential lead candidate for further development of peripherally restricted M1 PAMs, due to its lower blood-brain-barrier (BBB) permeability and improved exposure in the periphery compared to lead MIPS1780.. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application In Synthesis of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Organic Letters included an article by Huang, Rong; Li, Zhihong; Yu, Jianghui; Chen, Hongli; Jiang, Biao. Synthetic Route of C6H13NO. The article was titled 《H2O-Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reactionsã€? The information in the text is summarized as follows:

A H2O-regulated chemoselective addition in oxa- and aza-Michael reactions for aminoalcs. and mixtures of structurally similar alcs. and amines was reported. The oxa-Michael reactions might be kinetically controlled, and the reactions to produce O-selective products were slowed by the addition of water. The electrophilicity of Michael acceptors and the steric hindrance of Michael donors also affect the ratios of O/N products. This method offers novel ideas over conventional metal-catalyzed or ligand-induced strategies. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Synthetic Route of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Nature Catalysis included an article by Maity, Soham; Potter, Tyler J.; Ellman, Jonathan A.. Related Products of 821-41-0. The article was titled 《Î?Branched amines by catalytic 1,1-addition of C-H bonds and aminating agents to terminal alkenesã€? The information in the text is summarized as follows:

The convergent synthesis of α-branched amines e.g., I was achieved from three readily accessible starting materials: aromatic C-H bond substrates, terminal alkenes and aminating agents. This reaction proceeded by an intermol. formation of C-C and C-N bonds at the sp3 carbon branch site through an uncommon 1,1-alkene addition pathway. Ethylene and propylene feedstock chems. were effective alkene inputs, with ethylene in particular provided one-step synthesis of α-Me branched amines, a motif prevalent in drug structures. The reaction was scalable and 1% loading of an air-stable dimeric rhodium precatalyst was effective for several different types of products. The use of chiral catalysts also enabled the asym. synthesis of α-branched amines. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Related Products of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts