Tag: 100-200

In 2013,Wang, Jie; Zhu, Xiao-hua; Chen, Guo-hua published 《Process improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride》.Hecheng Huaxue published the findings.Formula: C3H8ClNO The information in the text is summarized as follows:

A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, SN2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by 1H NMR, IR and MS. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Formula: C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Pennelliiside D, a New Acyl Glucose from Solanum pennellii and Chemical Synthesis of Pennelliisides》 was published in Molecules in 2022. These research results belong to Masimbula, Rishni; Kobayashi, Hiroto; Nakashima, Tenki; Nambu, Yurika; Kitaoka, Naoki; Matsuura, Hideyuki. SDS of cas: 54-17-1 The article mentions the following:

Acyl glucoses are a group of specialized metabolites produced by Solanaceae. Solanum pennellii, a wild-type tomato plant, produces acyl glucoses in its hair-like epidermal structures known as trichomes. These compounds have been found to be herbicides, microbial growth inhibitors, or allelopathic compounds However, there are a few reports regarding isolation and investigation of biol. activities of acyl glucoses in its pure form due to the difficulty of isolation. Here, we report a new acyl glucose, pennelliiside D, isolated and identified from S. pennellii. Its structure was determined by 1D NMR and 2D NMR, together with FD-MS anal. To clarify the absolute configuration of the acyl moiety of 2-methylbutyryl in the natural compound, two possible isomers were synthesized starting from β-D-glucose pentaacetate. By comparing the spectroscopic data of natural and synthesized compounds of isomers, the structure of pennelliiside D was confirmed to be 3,4-O-diisobutyryl-2-O-((S)-2-methylbutyryl)-D-glucose. Pennelliiside D and its constituent fatty acid moiety, (S)-2-methylbutanoic acid, did not show root growth-inhibitory activity. Addnl., chem. synthesis pathways toward pennelliisides A and B were adapted to give 1,6-O-dibenzylpennelliisides A and B. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.SDS of cas: 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C3H8ClNOIn 2019 ,《tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity》 was published in RSC Advances. The article was written by Kotb, Ahmed; Abutaleb, Nader S.; Hagras, Mohamed; Bayoumi, Ashraf; Moustafa, Mahmoud M.; Ghiaty, Adel; Seleem, Mohamed N.; Mayhoub, Abdelrahman S.. The article contains the following contents:

The structure-activity and structure-kinetic relationships of a new tert-butylphenylthiazole series with oxadiazole linkers were conducted with the objective of obtaining a new orally available antibacterial compounds Twenty-two new compounds were prepared, purified and identified. Their activity against methicillin-resistant Staphylococcus aureus were examined Compound 20 with 3-hydroxyazetidine as a nitrogenous side chain showed promising activity against twenty-four clin. isolates, including vancomycin-resistant staphylococcal and enterococcal species with MIC values ranging from 4-8 μg mL-1. Addnl. advantages of this compound include an ability to eradicate staphylococcal biofilm mass in a dose-dependent manner as well as high metabolic stability after an oral dose of 25 mg kg-1 with a biol. half-life that exceeds 5 h and a plasma concentration (Cmax) that exceeds the MIC values. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ksila, Mohamed; Vejux, Anne; Prost-Camus, Emmanuelle; Durand, Philippe; Ghzaiel, Imen; Nury, Thomas; Duprey, Dorian; Meziane, Smail; Masmoudi-Kouki, Olfa; Latruffe, Norbert; Ghrairi, Taoufik; Prost, Michel; Lizard, Gerard; Vervandier-Fasseur, Dominique published an article in Molecules. The title of the article was 《Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells》.Related Products of 26153-38-8 The author mentioned the following in the article:

Trans-resveratrol is a natural polyphenol showing numerous biol. properties, especially anti-tumoral and antioxidant activity. Among numerous resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting biol. activities. In the present study, we synthesized a series of imine analogs of trans-resveratrol (seven aza-stilbenes) following an easy and low-cost procedure of green chem. The toxicity of synthesized aza-stilbenes, which is currently unknown, was evaluated on murine neuronal N2a cells, comparatively to trans-resveratrol, by considering: cell d. evaluated by staining with sulforhodamine 101; esterase activity, which is a criteria of cell viability, by staining with fluorescein diacetate; and transmembrane mitochondrial potential, which is known to decrease during cell death, by staining with DiOC6(3) using flow cytometry. In addition, the antioxidant activity was quantified with the KRL (Kit Radicaux Libres) assay, the DPPH (2,2- diphenyl-1-picrylhydrazyl radical) assay and the FRAP (ferric reducing antioxidant power) assay. The PAOT (Pouvoir Antioxidant Total) score was also used. The aza-stilbenes provide different cytotoxic and antioxidant activities, which are either higher or lower than those of trans-resveratrol. Based on their cytotoxic and antioxidant characteristics, all synthesized aza-stilbenes are distinguished from trans-resveratrol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Kangkang; Li, Jin-Feng; Yin, Bing; Zeng, Fanlong published an article in ChemCatChem. The title of the article was 《Investigation of NNN Pincer Ruthenium(II) Complexes with a Pendant Hydroxyl Group for N-Monomethylation of amines and Nitroarenes by Methanol》.HPLC of Formula: 89466-08-0 The author mentioned the following in the article:

A family of air- and moisture-stable NNN pincer ruthenium(II) complexes with a pendant OH were developed, which exhibit unprecedented high reactivity and selectivity in N-monomethylation of amines and nitroarenes using methanol. The study reveals adopting the combination of 1H-pyrazole-1-yl and 3,5-dimethyl-4-hydroxyethyl-1H-pyrazol-1-yl as the two assistant arms of the pyridyl-backbone is a suitable choice. The mechanism study discloses that, during the catalytic cycle, dehydrogenation of methanol to form formaldehyde is a fast and reversible step. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhang, Zhou; Han, Faming; Fang, Jie; Zhao, Chaowei; Li, Shuai; Wu, Yonggang; Zhang, Yuefeng; You, Shengyong; Wu, Binghui; Li, Weiwei published an article in CCS Chemistry. The title of the article was 《An organic-inorganic hybrid material based on benzo[ghi]perylenetri-imide and cyclic titanium-oxo cluster for efficient perovskite and organic solar cells》.Synthetic Route of C6H15NO The author mentioned the following in the article:

Perovskite and organic solar cells usually require electron-transport interlayers to efficiently transport electrons from the photoactive layer to the metal electrode. In general, pure organic or inorganic materials are applied into the interlayers, but organic-inorganic hybrid materials have been rarely reported for this application. In this work, we report using the first titanium-oxo cluster-based organic-inorganic hybrid as the interlayer material by introducing large π-conjugated benzo[ghi]perylenetriimides as an organic part via a simple ligand-exchange reaction. This new hybrid material showed excellent solubility, well-aligned energy levels, and excellent electron mobilities, enabling its great potential application as an interlayer in solar cells such as perovskite and organic solar cells, providing high power conversion efficiencies of >20% and 16%, resp. Therefore, we claim that our present work introduces a new class of cluster-based organic-inorganic hybrid interlayer materials that exhibit promising application in organic electronics. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Synthetic Route of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marchesi, Elena; Bovolenta, Matteo; Preti, Lorenzo; Capobianco, Massimo L.; Mamchaoui, Kamel; Bertoldo, Monica; Perrone, Daniela published an article in 2021. The article was titled 《Synthesis and Exon-Skipping Properties of a 3′-Ursodeoxycholic Acid-Conjugated Oligonucleotide Targeting DMD Pre-mRNA: Pre-Synthetic versus Post-Synthetic Approach》, and you may find the article in Molecules.Computed Properties of C6H15NO The information in the text is summarized as follows:

Steric blocking antisense oligonucleotides (ASO) are promising tools for splice modulation such as exon-skipping, although their therapeutic effect may be compromised by insufficient delivery. To address this issue, we investigated the synthesis of a 20-mer 2′-OMe PS oligonucleotide conjugated at 3′-end with ursodeoxycholic acid (UDCA) involved in the targeting of human DMD exon 51, by exploiting both a pre-synthetic and a solution phase approach. The two approaches have been compared. Both strategies successfully provided the desired ASO 51 3′-UDC in good yield and purity. It should be pointed out that the pre-synthetic approach insured better yields and proved to be more cost-effective. The exon skipping efficiency of the conjugated oligonucleotide was evaluated in myogenic cell lines and compared to that of unconjugated one: a better performance was determined for ASO 51 3′-UDC with an average 9.5-fold increase with respect to ASO 51. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Computed Properties of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zi; Ren, Xiangzhu; Sun, Peng; Ding, Hao; Li, Shumu; Zhao, Yilin; Zhang, Ke published an article in 2021. The article was titled 《Protecting-Group-Free Iterative Exponential Growth Method for Synthesizing Sequence-Defined Polymers》, and you may find the article in ACS Macro Letters.Electric Literature of C7H6O3 The information in the text is summarized as follows:

As a main synthetic strategy for monodisperse sequence-defined polymers, the known iterative exponential growth (IEG) methods were all developed on protecting-group chem., where the addnl. deprotection reactions increased their synthetic steps and decreased their atom economy. In this study, we developed a protecting-group-free IEG method for the formation of sequence-defined polymers by combining three orthogonal click reactions of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), sulfur-fluoride exchange reaction (SuFEx), and Ugi four-component reaction (Ugi-4CR). In this approach, oligomer synthesis began with three parallel CuAAC, SuFEx, and Ugi-4CR couplings among three monomers each with two orthogonal clickable end groups. By iteratively applying parallel CuAAC, SuFEx, and Ugi-4CR to couple three resultant oligomers, each having two orthogonal clickable terminals, this approach could exponentially grow three different sequence-defined polymers simultaneously with high efficiency, requiring no protecting-group chem. Addnl., each Ugi-4CR coupling reaction could introduce two external side groups to provide the mol. variation and side-chain functionalization for the resultant sequence-defined polymers. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wagner, Stefan; de Moura Gatti, Fernando; Silva, Daniel G.; Ortiz Zacarias, Natalia V.; Zweemer, Annelien J. M.; Hermann, Sven; De Maria, Monica; Koch, Michael; Weiss, Christina; Schepmann, Dirk; Heitman, Laura H.; Tschammer, Nuska; Kopka, Klaus; Junker, Anna published an article in 2021. The article was titled 《Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors》, and you may find the article in ChemMedChem.Quality Control of 3-Bromopropan-1-ol The information in the text is summarized as follows:

Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as 18F-labeled PET tracers. The derivatives were evaluated extensively for their off-target profile at 48 different targets. The most potent and selective candidate was applied in vivo in a biodistribution study, demonstrating a promising profile for further preclin. development. This compound represents the first potential nonpeptidic PET tracer for the imaging of CCR2 receptors. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ai, Liankun; Ajibola, Ibrahim Yusuf; Li, Baolin published their research in RSC Advances in 2021. The article was titled 《Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction》.Application In Synthesis of 2-Hydroxyphenylboronic acid The article contains the following contents:

An efficient method to synthesize benzothieno[3,2-b]benzofurans such as I [R = H, 3-Cl, 3-t-Bu; R1 = H, 7,8-di-F, 8-Me, etc.] via intramol. dehydrogenative C-H/O-H coupling had been developed. Good to excellent yields (64-91%) could be obtained no matter if the substituted group was electron-donating or electron-withdrawing. Notably, three-to-six fused ring thienofuran compounds I could be constructed using this method. A reaction mechanism study showed that 1,1-diphenylethylene could be completely inhibited the reaction. Therefore, it was a radical pathway initiated by single electron transfer between the hydroxyl of the substrate and the copper catalyst. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application In Synthesis of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts