Tag: 100-200

The author of 《Inclusion of the phytoalexin trans-resveratrol in native cyclodextrins: a thermal, spectroscopic, and X-Ray structural study》 were Catenacci, Laura; Sorrenti, Milena; Bonferoni, Maria Cristina; Hunt, Lee; Caira, Mino R.. And the article was published in Molecules in 2020. Recommanded Product: 54-17-1 The author mentioned the following in the article:

The aim of the study was to determine the feasibility of complexation between the antioxidant trans-resveratrol (RSV) and underivatized cyclodextrins (CDs) using a variety of preparative methods, including phys. mixing, kneading, microwave irradiation, co-evaporation, and co-precipitation techniques. Products were characterized using differential scanning calorimetry (DSC), simultaneous thermogravimetric/DSC anal. (TGA/DSC), Fourier transform IR (FT-IR) spectroscopy, and powder X-ray diffraction (PXRD). With a-CD and RSV, sample amorphization was revealed by PXRD and FT-IR, but no definitive inclusion complexation was evident. Similar results were obtained in attempts to complex RSV with CD. However, complex formation between -CD and RSV was evident from observation of an endo-/exothermic effect appearing in the DSC trace of the product from kneading and was further corroborated by FT-IR and PXRD methods. The latter technique indicated complexation unequivocally as the diffraction peak profile for the product matched that for known isostructural CD complexes. Single crystal X-ray anal. followed, confirming the predicted complex between CD and RSV. A combination of 1H NMR and TGA data yielded the complex formula (CD)3·(RSV)4·(H2O)62. However, severe disorder of the RSV mols. prevented their modeling. In contrast, our previous studies of the inclusion of RSV in methylated CDs yielded crystals with only minor guest disorder. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Recommanded Product: 54-17-1) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Recommanded Product: 54-17-1

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《Prebiotic Agrocybe cylindracea crude polysaccharides combined with Lactobacillus rhamnosus GG postpone aging-related oxidative stress in mice》 was published in Food & Function in 2022. These research results belong to Wu, Linxiu; Liu, Xiaoyan; Hu, Rongkang; Chen, Yixuan; Xiao, Meifang; Liu, Bin; Zeng, Feng. Category: alcohols-buliding-blocks The article mentions the following:

This study aimed to investigate the potential anti-aging mechanisms of Agrocybe cylindracea crude polysaccharides (APS), when used synergistically with Lactobacillus rhamnosus GG (APS + LGG) in a D-galactose-induced aging mouse model. In the Morris water maze test, APS + LGG showed a significantly higher memory and learning capacity compared to untreated, APS only treated and LGG treated mice. This was thought to be mediated by increased levels of brain-derived neurotrophic factor, which decreased escape latency. In addition to this, in the aging mouse model, APS + LGG co-treatment markedly alleviated liver oxidation and metabolism by enhancing the antioxidant activity of enzymes; this decreased the lipid metabolism and peroxidation levels. Furthermore, high throughput sequencing anal. revealed that an APS + LGG supplemented feed increased the relative abundance of pos. bacteria in the gut microbiota such as Alloprevotella and Parvibacter. Importantly, Alloprevotella and Parvibacter showed a neg. relationship with low d. lipoprotein-cholesterol in the Spearman correlation anal. These results illustrate that APS, in combination with LGG, postponed aging related oxidative stress when used as a prebiotic. The proposed mechanism for this is the reduction in liver oxidation and lipid metabolism, as well as the regulation of gut microbiota. The experimental process involved the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Category: alcohols-buliding-blocks)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Category: alcohols-buliding-blocks

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《Biophysical, Biochemical, and Molecular Docking Investigations of Anti-Glycating, Antioxidant, and Protein Structural Stability Potential of Garlic》 was published in Molecules in 2022. These research results belong to Khan, Mohd W. A.; Otaibi, Ahmed A.; Alsukaibi, Abdulmohsen K. D.; Alshammari, Eida M.; Al-Zahrani, Salma A.; Sherwani, Subuhi; Khan, Wahid A.; Saha, Ritika; Verma, Smita R.; Ahmed, Nessar. Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The article mentions the following:

Garlic has been reported to inhibit protein glycation, a process that underlies several disease processes, including chronic complications of diabetes mellitus. Biophys., biochem., and mol. docking investigations were conducted to assess anti-glycating, antioxidant, and protein structural protection activities of garlic. Results from spectral (UV and fluorescence) and CD (CD) anal. helped ascertain protein conformation and secondary structure protection against glycation to a significant extent. Further, garlic showed heat-induced protein denaturation inhibition activity (52.17%). It also inhibited glycation, advanced glycation end products (AGEs) formation as well as lent human serum albumin (HSA) protein structural stability, as revealed by reduction in browning intensity (65.23%), decrease in protein aggregation index (67.77%), and overall reduction in cross amyloid structure formation (33.26%) compared with pos. controls (100%). The significant antioxidant nature of garlic was revealed by FRAP assay (58.23%) and DPPH assay (66.18%). Using mol. docking anal., some of the important garlic metabolites were investigated for their interactions with the HSA mol. Mol. docking anal. showed quercetin, a phenolic compound present in garlic, appears to be the most promising inhibitor of glucose interaction with the HSA mol. Our findings show that garlic can prevent oxidative stress and glycation-induced biomol. damage and that it can potentially be used in the treatment of several health conditions, including diabetes and other inflammatory diseases. After reading the article, we found that the author used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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《A Zirconium Indazole Carboxylate Coordination Polymer as an Efficient Catalyst for Dehydrogenation-Cyclization and Oxidative Coupling Reactions》 was written by Sang, Xinxin; Hu, Xinyu; Tao, Rong; Zhang, Yilin; Zhu, Haiyan; Wang, Dawei. Category: alcohols-buliding-blocksThis research focused onzirconium indazole carboxylate coordination polymer catalyst preparation; disubstituted benzimidazole preparation; phenylenediamine benzyl alc dehydrogenative cyclization zirconium catalyst; alkyl ester preparation; benzyl cyanide alkyl hydroperoxide oxidative coupling zirconium catalyst. The article conveys some information:

A novel porous zirconium coordination polymer (Zr-IDA) from 1-(carboxymethyl)-1H-indazole-5-carboxylic acid was developed and characterized. The Zr-IDA catalyst contains porous and highly crystalline particles with a quasi-spherical morphol. around 100 nm in size and Zr was coordinated with both O and N as shown by FT-IR and XPS measurements. The catalyst showed good catalytic activity in the synthesis of 1,2-disubstituted-benzimidazoles I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = H, Me] via dehydrogenative cyclization reaction of benzyl alcs. with phenylenediamines. Similarly, alkyl-esters R2C(O)OC(CH3)2R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, Et, Ph] were synthesized via oxidative coupling of benzyl cyanides with alkyl-hydroperoxides. Mechanistic investigations were carried out to study these reactions and the developed catalytic system in more detail.(4-Bromophenyl)methanol(cas: 873-75-6Category: alcohols-buliding-blocks) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Category: alcohols-buliding-blocks It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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Reference of 5-Hexen-1-olIn 2021 ,《Spreading Dynamics of a Precursor Film of Ionic Liquid or Water on a Micropatterned Polyelectrolyte Brush Surface》 was published in Langmuir. The article was written by Shiomoto, Shohei; Higuchi, Hayato; Yamaguchi, Kazuo; Takaba, Hiromitsu; Kobayashi, Motoyasu. The article contains the following contents:

Time evolution of the microscopic wetting velocity of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI-TFSI) or water on a micrometer-scale line-patterned surface with a poly(3-sulfopropyl methacrylate) brush and a hydrophobic perfluoroalkyl monolayer was precisely measured by direct observation using optical microscopy and a selective dyeing method over a long period (178 days). When a liquid droplet was placed on the dyed line-patterned brush surface, the liquid penetrated and spread into the polymer brush layer, forming a precursor thin film that extended beyond the macroscopic contact line. The elongation proceeded in two stages by an adiabatic process followed by a diffusive process. The elongation distance X increased with time in proportion to t2.6 for water and t0.81 for EMI-TFSI during the adiabatic process. In a diffusive process, the advancing velocity of the precursor film was markedly reduced to be expressed as X t0.66 for water and Xn t0.21 for EMI-TFSI, indicating that the diffusive process was affected by the energy dissipation of the wetting system. The high viscosity and the strong mol. interaction of EMI-TFSI with the polymer brush gave a large entropy change during the wetting process to result in a slower spreading velocity. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Reference of 5-Hexen-1-ol

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Recommanded Product: 627-18-9In 2022 ,《Design and Self-Assembly of Sugar-Based Amphiphiles: Spherical to Cylindrical Micelles》 was published in Langmuir. The article was written by Argudo, Pablo G.; Spitzer, Lea; Jerome, Francois; Cramail, Henri; Camacho, Luis; Lecommandoux, Sebastien. The article contains the following contents:

Sugar-based amphiphiles are a relevant natural alternative to synthetic ones due to their biodegradable properties. An understanding of their structure-assembly relationship is needed to allow the concrete synthesis of suitable derivatives Here, four different mannose-derivative surfactants are characterized by pendant drop, dynamic light scattering, small-angle X-ray scattering, cryotransmission electron microscopy, and mol. dynamics techniques in aqueous media. Measurements denote how the polysaccharide average d.p. () and the addition of a hydroxyl group to the hydrophobic tail, and thus the presence of a second hydrophilic moiety, affect their self-assembly. A variation in the of the amphiphile has no effect in the critical micelle concentration in contrast to a change in the hydrophobic mol. region. Moreover, high- amphiphiles self-assemble into spherical micelles irresp. of the hydroxyl group presence. Low- amphiphiles with only one hydrophilic moiety form cylindrical micelles, while the addition of a hydroxyl group to the tail leads to a spherical shape. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 627-18-9

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Related Products of 1195-59-1In 2021 ,《A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(I)》 was published in RSC Advances. The article was written by Liu, Yiqing; Kang, Ting; He, Qian; Hu, Yuefu; Zuo, Zeping; Cao, Zhihua; Ke, Bowen; Zhang, Weiyi; Qi, Qingrong. The article contains the following contents:

The disruption of copper homeostasis (Cu+/Cu2+) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu+ in physiol. and pathol. processes prompted the development of improved methods of Cu+ anal. Herein, a new near-IR (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu+ was developed based on a Cu+-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu+, and was successfully applied for bioimaging of Cu+ in living cells. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1195-59-1

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SDS of cas: 627-18-9In 2021 ,《Ultrahigh-Throughput Detection of Enzymatic Alcohol Dehydrogenase Activity in Microfluidic Droplets with a Direct Fluorogenic Assay》 appeared in ChemBioChem. The author of the article were Klaus, Miriam; Zurek, Paul Jannis; Kaminski, Tomasz S.; Pushpanath, Ahir; Neufeld, Katharina; Hollfelder, Florian. The article conveys some information:

The exploration of large DNA libraries of metagenomic or synthetic origin is greatly facilitated by ultrahigh-throughput assays that use monodisperse water-in-oil emulsion droplets as sequestered reaction compartments. Millions of samples can be generated and analyzed in microfluidic devices at kHz speeds, requiring only micrograms of reagents. The scope of this powerful platform for the discovery of new sequence space is, however, hampered by the limited availability of assay substrates, restricting the functions and reaction types that can be investigated. Here, we broaden the scope of detectable biochem. transformations in droplet microfluidics by introducing the first fluorogenic assay for alc. dehydrogenases (ADHs) in this format. We have synthesized substrates that release a pyranine fluorophore (8-hydroxy-1,3,6-pyrenetrisulfonic acid, HPTS) when enzymic turnover occurs. Pyranine is well retained in droplets for >6 wk (i. e. 14-times longer than fluorescein), avoiding product leakage and ensuring excellent assay sensitivity. Product concentrations as low as 100 nM were successfully detected, corresponding to less than one turnover per enzyme mol. on average The potential of our substrate design was demonstrated by efficient recovery of a bona fide ADH with an >800-fold enrichment. The repertoire of droplet screening is enlarged by this sensitive and direct fluorogenic assay to identify dehydrogenases for biocatalytic applications. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

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Alcohol – Wikipedia,
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《Highly efficient N-heterocyclic carbene/ruthenium catalytic systems for the acceptorless dehydrogenation of alcohols to carboxylic acids: effects of ancillary and additional ligands》 was written by Wang, Wan-Qiang; Cheng, Hua; Yuan, Ye; He, Yu-Qing; Wang, Hua-Jing; Wang, Zhi-Qin; Sang, Wei; Chen, Cheng; Verpoort, Francis. SDS of cas: 4048-33-3 And the article was included in Catalysts in 2020. The article conveys some information:

The transition-metal-catalyzed alc. dehydrogenation to carboxylic acids has been identified as an atom-economical and attractive process. Among various catalytic systems, Ru-based systems have been the most accessed and investigated ones. With our growing interest in the discovery of new Ru catalysts comprising N-heterocyclic carbene (NHC) ligands for the dehydrogenative reactions of alcs., we designed and prepared five NHC/Ru complexes ([Ru]-1-[Ru]-5) bearing different ancillary NHC ligands. Moreover, the effects of ancillary and addnl. ligands on the alc. dehydrogenation with KOH were thoroughly explored, followed by the screening of other parameters. Accordingly, a highly active catalytic system, which is composed of [Ru]-5 combined with an addnl. NHC precursor L5, was discovered, affording a variety of acid products in a highly efficient manner. Gratifyingly, an extremely low Ru loading (125 ppm) and the maximum TOF value until now (4800) were obtained. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.SDS of cas: 4048-33-3

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《Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli》 was published in ChemMedChem in 2020. These research results belong to Elamri, Isam; Radloff, Melanie; Hohmann, Katharina F.; Nimbarte, Vijaykumar D.; Nasiri, Hamid R.; Bolte, Michael; Safarian, Schara; Michel, Hartmut; Schwalbe, Harald. Electric Literature of C7H6O3 The article mentions the following:

The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of mol. oxygen to water and contribute to the proton motive force. The cytochrome bo3 oxidase (cyt bo3) acts as the primary terminal oxidase under atm. oxygen levels, whereas the bd-type oxidase is most abundant under microaerobic conditions. In E. coli, both types of respiratory terminal oxidase (HCO and bd-type) use ubiquinol-8 as electron donor. Here, we assess the inhibitory potential of newly designed and synthesized 3-alkylated Lawson derivatives through L-proline-catalyzed three-component reductive alkylation (TCRA). The inhibitory effects of these Lawson derivatives on the terminal oxidases of E. coli (cyt bo3 and cyt bd-I) were tested potentiometrically. Four compounds were able to reduce the oxidoreductase activity of cyt bo3 by more than 50 % without affecting the cyt bd-I activity. Moreover, two inhibitors for both cyt bo3 and cyt bd-I oxidase could be identified. Based on mol.-docking simulations, we propose binding modes of the new Lawson inhibitors. The mol. fragment benzyl enhances the inhibitory potential and selectivity for cyt bo3, whereas heterocycles reduce this effect. This work extends the library of 3-alkylated Lawson derivatives as selective inhibitors for respiratory oxidases and provides mol. probes for detailed investigations of the mechanisms of respiratory-chain enzymes of E. coli. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

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