Tag: 100-200

An investigation by thermal analysis of glycosidic natural sweeteners was written by Santana, Naienne da S.;Mothe, Cheila G.;de Souza, Marcio Nele;Mothe, Michelle G.. And the article was included in Journal of Thermal Analysis and Calorimetry.Formula: C4H10O4 This article mentions the following:

The demand for non-nutritive sweeteners of natural origin has increased in recent years, mainly driven by health concerns and the quest for a healthier lifestyle. This work aimed to investigate the content of steviol glycosides from Stevia rebaudiana Bertoni and cucurbitane glycosides from monk fruit in com. samples of sweeteners using thermal anal. techniques (TG/DTG, DTA, and DSC), FTIR, EDS. Four com. samples were analyzed based on steviol glycosides (E, E2, E3, E4) and one sample based on cucurbitane glycosides (M1). The thermogravimetry (TG) results showed that the thermal stability order of the samples till 200 掳C was equal to E4 > M1 鈮?E2 > E > E3. Despite being marketed based on different natural glycosides, thermal anal. techniques showed similar thermal profiles between E2 and M1 samples. The DSC curves of these samples showed clear erythritol melting events, and the FTIR spectra confirmed the presence of this polyol in E2 and M1 samples. On the other hand, the DSC curve and the FTIR spectrum confirmed the presence of xylitol in the composition of the E4 sample. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Formula: C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C4H10O4

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Alcohol – Wikipedia,
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Chemoenzymatic Deracemization of Secondary Alcohols by using a TEMPO-Iodine-Alcohol Dehydrogenase System was written by Mendez-Sanchez, Daniel;Mangas-Sanchez, Juan;Lavandera, Ivan;Gotor, Vicente;Gotor-Fernandez, Vicente. And the article was included in ChemCatChem in 2015.Computed Properties of C8H9ClO This article mentions the following:

A deracemization system for secondary alcs. was established after the anal. of individual steps and their compatibility in one pot. The chem. oxidation and bioreduction occurred in a sequential manner to yield 1-arylethanols and lineal aliphatic alcs. with excellent conversions and enantiomeric excess values. The oxidation step was performed by using 2,2,6,6-tetramethylpiperidin-1-oxyl and iodine. This chem. process was extremely favored by sonication, which allowed quant. formation of the corresponding ketone intermediates after just 1 h. Simple destruction of iodine in the same pot allowed sequential bioreduction of the ketones by using either Prelog or antiPrelog enzymes, which led to the preparation of the enantiopure alcs. in excellent yields. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Computed Properties of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C8H9ClO

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Alcohol – Wikipedia,
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Controlled self-assembly into diverse stimuli-responsive microstructures: from microspheres to branched cylindrical micelles and vesicles was written by Zhou, Xiaoteng;Li, Lingxiao;Qin, He;Ning, Bo;Li, Junpei;Kan, Chengyou. And the article was included in RSC Advances in 2018.Application of 60463-12-9 This article mentions the following:

A series of amphiphilic PDMAEMA-SS-PCL chains with variable ratios of hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to hydrophobic poly(蔚-caprolactone) (PCL) were prepared via ring-opening polymerization, in which the two different moieties were linked via a disulfide bond with reduction responsiveness. After crosslinking by the photodegradable o-nitrobenzyl linkage, the amphiphilic chains could self-assemble into microspheres, branched cylindrical micelles and vesicles, which were responsive to the reduction agent DL-dithiothreitol and UV light irradiation through different mechanisms. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 60463-12-9

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Alcohol – Wikipedia,
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Selectfluor-Enabled C(sp³)-H Alkoxylation of 3-Methylfuranocoumarins was written by Qin, Zengxin;Zhao, Mengfei;Zhang, Kaixin;Goto, Masuo;Lee, Kuo-Hsiung;Li, Jizhen. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C7H6Cl2O This article mentions the following:

A facile and metal-free method for the direct C(sp³)-H bond alkoxylation of 3-methylfuranocoumarins I (R = H, Me, NO₂; R¹ = H; R² = H; R¹R² = -CH=CH-CH=CH-; R³ = H, Me) and 4,17-dimethyl-11,15-dioxacyclopenta[a]phenanthren-12-one with alcs. R⁴OH (R⁴ = iso-Pr, cyclopentyl, 3-(2-bromophenyl)propyl, etc.) has been disclosed. Selectfluor enabled the (hetero)benzylic C-H etherification by tuning the reaction temperature and solvent. Various alcs. were compatible in this transformation with suitable yields. The mechanistic studies revealed that the reaction might undergo the double addition process of alcs., as well as the departure of a fluoride anion and the formation of an oxonium ion. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C7H6Cl2O

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Alcohol – Wikipedia,
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Microbial transformation of nitrogen-containing heterocyclic compounds. I. Hydroxylation of isomeric mono- and dimethylpyridines by microscopic fungi was written by Modyanova, L. V.;Vorob’eva, L. I.;Shibilkina, O. K.;Dovgilevich, E. V.;Terent’ev, P. B.;Kost, A. N.. And the article was included in Biotekhnologiya in 1990.HPLC of Formula: 102074-19-1 This article mentions the following:

By screening a number of museum microorganism cultures a group of microscopic fungi active in transforming mono- and dimethylpyridines was detected. It is only the Me substituent that undergoes oxidation, not the pyridine ring itself. Peculiarities of oxidative transformation of isomeric mono- and dimethylpyridines to the corresponding hydroxymethylpyridines were elucidated. For methylpyridines the pyridylcarbinol yield was independent of the Me substituent position. For dimethylpyridines only 1 Me group is subjected to hydroxylation, the ratio of the pyridylcarbinols obtained mainly depending on the substituent arrangement in the pyridine ring. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1HPLC of Formula: 102074-19-1).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 102074-19-1

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fine tuning of the orifice size of an open-cage fullerene by placing selenium in the rim: insertion/release of molecular hydrogen was written by Chuang, Shih-Ching;Murata, Yasujiro;Murata, Michihisa;Mori, Sadayuki;Maeda, Shuhei;Tanabe, Fumiyuki;Komatsu, Koichi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Name: Sodium 2-methyl-2-propanethiolate This article mentions the following:

A newly synthesized open-cage fullerene containing Se in the rim of the 13-membered-ring orifice allows milder conditions for H insertion, and the rate for H release is ca. three times faster than its S analog. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Name: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

伪-Oxygenation of Benzylic Ethers to Esters Using MnO_x-N@C Catalyst was written by Liu, Jing;Wan, Cong;Zheng, Aili;Wang, Lianyue;Yin, Kaiyue;Liu, Dandan;Wang, Shengde;Ren, Lanhui;Gao, Shuang. And the article was included in Youji Huaxue in 2019.Name: (2,4-Dichlorophenyl)methanol This article mentions the following:

A catalytic system for the oxidation of benzylic ethers 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆CH₂OR⁵ (R = H, OH, Cl, OMe, etc.; R¹ = H, Me, OMe, CF₃; RR¹ = -CH=CH-CH=CH-; R² = H, i-Pr, Cl, Ph, etc.; R¹R² = -OCH₂O-; R³ = H; R⁴ = H, Cl; R³R⁴ = -CH=CH-CH=CH-; R⁵ = Me, Et, Bn; R⁴R⁵ = -(CH₂)₂-, -CH₂-) to esters 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆C(O)OR⁵ has been developed utilizing reusable MnO_x-N@C as catalyst and tert-Bu hydroperoxide (TBHP) as benign oxidant under neat condition. The catalytic oxidation system has good functional groups tolerance and excellent chemoselectivity, and this catalytic procedure can also be scaled up. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Name: (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1 was written by Zhang, Xiaoyan;Urbanski, Maud;Patel, Mona;Zeck, Roxanne E.;Cox, Geoffrey G.;Bian, Haiyan;Conway, Bruce R.;Beavers, Mary Pat;Rybczynski, Philip J.;Demarest, Keith T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Application of 1634-34-0 This article mentions the following:

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Indole-O-glucoside and benzimidazole-O-glucoside exhibited potent in vitro SGLT2 inhibitory activity. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Application of 1634-34-0).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 1634-34-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine was written by Yang, Gao-feng;Li, Guang-xun;Huang, Jin;Fu, Ding-qiang;Nie, Xiao-kang;Cui, Xin;Zhao, Jin-zhong;Tang, Zhuo. And the article was included in Journal of Organic Chemistry in 2021.Computed Properties of C9H9F3O This article mentions the following:

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chem. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with sym. and unsym. o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1). In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Computed Properties of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts