Alcohols-buliding-blocks

Halobenzyl alcohols as structurally simple organogelators was written by Prathap, Annamalai;Ravi, Arthi;Pathan, Javed R.;Sureshan, Kana M.. And the article was included in CrystEngComm in 2019.Recommanded Product: 1777-82-8 This article mentions the following:

We report 11 simple halobenzyl alcs., each comprising of only 16 atoms, as organogelators for aliphatic hydrocarbon solvents. Comparison of PXRD profiles of wet gels and xerogels with the simulated profiles from the single crystal XRD data confirmed that the mol. packing in gels and crystals are identical. Therefore single crystal X-ray structures were analyzed to understand the mol. level interactions involved in the self-assembly in gel state. Each of these compounds undergoes a faster linear assembly along the crystallog. direction associated with the OH···O hydrogen bond and a supplementary non-covalent interaction (NCI). In directions perpendicular to the direction of OH···O Hydrogen bonding, mols. associate through various relatively weaker NCIs. Notably, halogen bonds, X···X, C-H···X interactions play major role in the lateral growth. In the case of gels, the linear growth is faster than lateral growth leading to the formation of long fibers, which entangles to a 3D fibrous network. This study reveals that halogen atoms in halobenzyl alcs. impart mol. features that contribute to their self-assembly in solution and hence in gelation. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia (L.) in porcine coronary artery was written by Alamgeer;Asif, Hira;Chohan, Tahir Ali;Irfan, Hafiz Muhammad;Asim, Mulazim Hussain;Bukhari, Syed Nasir Abbas;Younis, Waqas;Althobaiti, Yusuf S.;Ullah, Aman;Khan, Abdul Qayyum;Hakami, Alqassem Y.. And the article was included in Biomedicine & Pharmacotherapy in 2022.Quality Control of 5-Isopropyl-2-methylphenol This article mentions the following:

Mentha (M.) longifolia (L.) is traditionally used for various ailments. The current study was intended to explore the underlying vasorelaxation mechanisms of M. longifolia. Aqueous-methanol extract from the aerial parts of M. longifolia was prepared and subjected to activity-guided fractionation. The vasorelaxant activity was performed using porcine coronary arteries with intact and denuded endothelium. In-vitro PDE inhibitory activity of the active fraction was carried out using the radio-enzymic assay. The active fraction was also subjected to GCMS. Docking and mol. dynamic simulation studies were also performedWe had observed that aqueous-methanolic extract induced relaxation in the coronary artery in a dose-dependent manner when the endothelium was intact and denuded. n-butanol fraction (MLB) has produced a maximum effect, and it was selected for mechanistic studies. MLB has significantly enhanced the relaxation produced by cAMP and cGMP, elevating atrial natriuretic peptide, sodium nitroprusside, isoproterenol, and forskolin. The pre-treatment with MLB inhibited the contractile response produced by KCl, U46619, and CaCl2 in without endothelium rings. MLB has non-selectively inhibited the PDE isoforms. GCMS anal. of MLB has revealed the presence of menthol, thymol, and carvacrol in the active fraction. Docking and mol. dynamic simulation studies have indicated that thymol can be a competitive inhibitor for PDE1. It is postulated that an n-butanol fraction of Mentha longifolia produced endothelium-independent relaxation due to increased levels of cAMP and cGMP caused by the inhibition of various PDEs. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Quality Control of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of a thermoresponsive crosslinked MEO₂MA polymer coating on microclusters of iron oxide nanoparticles was written by Lapresta-Fernandez, Alejandro;Salinas-Castillo, Alfonso;Capitan-Vallvey, Luis Fermin. And the article was included in Scientific Reports in 2021.Application of 109-17-1 This article mentions the following:

Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe₃O₄) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO₂MA) is successfully developed. Magnetic aggregates of large size, around 150-200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70°C. These polymerizable groups provide a covalent attachment of the P(MEO₂MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49°C. The hybrid Fe₃O₄@P(MEO₂MA) microgel exhibits a lower critical solution temperature of 21.9°C below the corresponding value for P(MEO₂MA) (bulk, 26°C). The MEO₂MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric anal. while magnetic properties by vibrating sample magnetometry. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of ospemifene on moderate or severe symptoms of vulvar and vaginal atrophy was written by Bruyniks, N.;Nappi, R. E.;Castelo-Branco, C.;de Villiers, T. J.;Simon, J.. And the article was included in Climacteric in 2016.Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

To determine whether assessment of all moderate-to-severe symptoms at baseline gives a more accurate evaluation of the treatment effect of ospemifene in vulvovaginal atrophy (VVA) than the most bothersome symptom (MBS) approach. Data were pooled from two pivotal phase-III clin. trials evaluating the efficacy and safety of oral ospemifene 60 mg/day for the treatment of symptoms of VVA (n = 1463 subjects). Symptoms of vaginal dryness, dyspareunia, and vaginal and/or vulvar irritation/itching reported as moderate or severe at baseline were evaluated. Clin. relevant differences between ospemifene and placebo were analyzed using a four-point severity scoring system and presented as improvement, substantial improvement, or relief. Subjects in these studies reported statistically significant improvement, substantial improvement, and relief for vaginal dryness (p < 0.00001), dyspareunia (p < 0.001) and statistically significant improvement and relief for vaginal and/or vulvar irritation/itching (p < 0.01) from baseline to week 12 with ospemifene compared with placebo. A similar trend was observed for women who reported substantial improvement of vaginal and/or vulvar irritation/itching. For drug registration purposes, the use of the MBS model is appealing because of its simplicity and ease of scientific validation. However, the MBS model may underestimate the total magnitude of the clin. benefit of ospemifene treatment for symptomatic women suffering from VVA. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Second-Generation Palladium Catalyst System for Transannular C-H Functionalization of Azabicycloalkanes was written by Cabrera, Pablo J.;Lee, Melissa;Sanford, Melanie S.. And the article was included in Journal of the American Chemical Society in 2018.Product Details of 230615-52-8 This article mentions the following:

This article describes the development of a second-generation catalyst system for the transannular C-H functionalization of alicyclic amines. Pyridine- and quinoline-carboxylate ligands are shown to be highly effective for increasing the reaction rate, yield, and scope of Pd-catalyzed transannular C-H arylation reactions of azabicyclo[3.1.0]hexane, azabicyclo[3.1.1]heptane, azabicyclo[3.2.1]octane, and piperidine derivatives Mechanistic studies reveal that the pyridine/quinoline-carboxylates play a role in impeding both reversible and irreversible catalyst decomposition pathways. These ligands enable the first reported examples of the transannular C-H arylation of the ubiquitous tropane, 7-azanorbornane, and homotropane cores. Finally, the pyridine/quinoline-carboxylates are shown to promote both transannular C-H arylation and transannular C-H dehydrogenation on a homotropane substrate. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Product Details of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stepwise Access of Emissive Ir(III) Complexes Bearing a Multi-Dentate Heteroaromatic Chelate: Fundamentals and Applications was written by Zheng, Zhong;Zhu, Ze-Lin;Ho, Cheuk-Lam;Yiu, Shek-Man;Lee, Chun-Sing;Suramitr, Songwut;Hannongbua, Supa;Chi, Yun. And the article was included in Inorganic Chemistry in 2022.Computed Properties of C9H10BrNO2 This article mentions the following:

Three multi-dentate coordinated chelates LnH₂ (n = 1, 2, and 3), comprising a linked 1-(pyridin-2-yl)ethylbenzene and one pyrazolyl pyridine unit and showing either tridentate or tetradentate coordination modes, are successfully designed and synthesized. Dinuclear Ir(III) complexes [Ir(κ⁴-Ln)(μ-Cl)]₂ bearing tetradentate coordinated κ⁴-Ln chelate (2a, n = 1; 2b, n = 2; 2c, n = 3) were next obtained en route from the resp. intermediate [Ir(κ³-LnH)Cl(μ-Cl)]₂ bearing the tridentate coordinated κ³-LnH chelate (1a, n = 1; 1b, n = 2; 1c, n = 3). Next, mononuclear Ir(III) complexes Ir(κ⁴-Ln)(thd) (3a, n = 1; 3b, n = 2; 3c, n = 3) with the tetradentate chelate were obtained upon treatment of 2 with 2,2,6,6-tetramethyl-3,5-heptanedione (thd)H in the presence of K₂CO₃. Concurrently, methylation of 2c in the presence of ⁿBu₄NCl afforded tridentate Ir(κ³-L3HMe)Cl₃ (4) and, next, can be converted to tetradentate Ir(κ⁴-L3Me)Cl₂ (5) by further cyclometalation and HCl elimination in refluxing diethylene glycol monoethyl ether solution The Ir(III) complexes 3a, 4, and 5 were unambiguously identified using spectroscopic methods, together with single-crystal x-ray structural analyses on Ir(III) derivatives 3a, 4, and 5. Their photophys. and electrochem. properties were also investigated and compared with results from theor. studies. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Computed Properties of C9H10BrNO2).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C9H10BrNO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution was written by Song, Danzi;Cui, Jiwei;Sun, Huanli;Nguyen, Tri-Hung;Alcantara, Sheilajen;De Rose, Robert;Kent, Stephen J.;Porter, Christopher J. H.;Caruso, Frank. And the article was included in ACS Applied Materials & Interfaces in 2017.Safety of Diethyleneglycoldiacrylate This article mentions the following:

Surface modification is frequently used to tailor the interactions of nanoparticles with biol. systems. In most cases, the chem. nature of the treatments employed to modify the biol. interface (for example attachments of hydrophilic polymers or targeting groups) is the focus of attention. However, isolation of the fundamental effects of the materials employed to modify the interface are often confounded by secondary effects imparted by the underlying substrate. Herein, we demonstrate that polymer replica particles templated from degradable mesoporous silica provide a facile means to evaluate the impact of surface modification on the biol. interactions of nanomaterials, independent of the substrate. Poly(ethylene glycol) (PEG), poly(N-(2 hydroxypropyl)methacrylamide) (PHPMA), and poly(methacrylic acid) (PMA) were templated onto mesoporous silica, crosslinked and the residual particles removed. The resulting nanoparticles, comprising interfacial polymer alone, were then investigated using a range of in vitro and in vivo tests. As expected, the PEG particles showed the best stealth properties and these trends were consistent in both in vitro and in vivo studies. PMA particles showed the highest cell association in cell lines in vitro and were rapidly taken up by monocytes in ex vivo whole blood, properties consistent with the very high in vivo clearance subsequently seen in rats. In contrast, PHPMA particles showed rapid association with both granulocytes and monocytes in ex vivo whole blood, even though in vivo clearance was less rapid than the PMA particles. Rat studies confirmed better systemic exposure for PEG and PHPMA particles when compared to PMA particles. This study provides a new avenue for investigating material-dependent biol. behaviors of polymer particles, irresp. of the properties of the underlying core, and provides insights for the selection of polymer particles for future biol. applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells was written by Abedi, Fatemeh;Davaran, Soodabeh;Hekmati, Malak;Akbarzadeh, Abolfazl;Baradaran, Behzad;Moghaddam, Sevil Vaghefi. And the article was included in Journal of Nanobiotechnology in 2021.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Abstract: The combination therapy which has been proposed as the strategy for the cancer treatment could achieve a synergistic effect for cancer therapies and reduce the dosage of the applied drugs. On account of the the unique properties as the high absorbed water content, biocompatibility, and flexibility, the targeting nanogels have been considred as a suitable platform. Herein, a non-toxic pH/thermo-responsive hydrogel P(NIPAAm-co-DMAEMA) was synthesized and characterized through the free-radical polymerization and expanded upon an easy process for the preparation of the smart responsive nanogels; i.e., the nanogels were used for the efficient and controlled delivery of the anti-cancer drug doxorubicin (DOX) and chemosensitizer curcumin (CUR) simultaneously like a promising strategy for the cancer treatment. The size of the nanogels, which were made, was about 70 nm which is relatively optimal for the enhanced permeability and retention (EPR) effects. The DOX and CUR co-loaded nanocarriers were prepared by the high encapsulation efficiency (EE). It is important to mention that the controlled drug release behavior of the nanocarriers was also investigated. An enhanced ability of DOX and CUR-loaded nanoformulation to induce the cell apoptosis in the HT-29 colon cancer cells which represented the greater antitumor efficacy than the single-drug formulations or free drugs was resulted through the In vitro cytotoxicity. Overall, according to the data, the simultaneous delivery of the dual drugs through the fabricated nanogels could synergistically potentiate the antitumor effects on the colon cancer (CC). [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploiting the enzymatic machinery of Arthrobacter atrocyaneus for oxidative kinetic resolution of secondary alcohols was written by Silva, Camila R.;Souza, Juliana C.;Araujo, Lidiane S.;Kagohara, Edna;Garcia, Thais P.;Pelizzari, Vivian H.;Andrade, Leandro H.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2012.Recommanded Product: 171032-87-4 This article mentions the following:

We evaluated Arthrobacter atrocyaneus (R1AF57) as producer of oxidoreductases for oxidative kinetic resolution of racemic secondary alcs. via oxidation reaction. This bacterium was isolated from Amazon soil samples using medium enriched with (RS)-1-(4-methylphenyl)ethanol as a carbon source. The kinetic resolution of several secondary alcs. through enantioselective oxidation mediated by resting cells and growing cells of A. atrocyaneus was efficiently achieved for the most alcs. In general, it was possible to obtain only the (S)-enantiomer from (RS)-1-arylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ultraviolet Light Detectable Circularly Polarized Room Temperature Phosphorescence in Chiral Naphthalimide Self-Assemblies was written by An, Shuguo;Gao, Liang;Hao, Aiyou;Xing, Pengyao. And the article was included in ACS Nano in 2021.Category: alcohols-buliding-blocks This article mentions the following:

The combination of circularly polarized luminescence (CPL) and pure-organic room temperature phosphorescence (RTP) potentially facilitates the construction of organic chiroptical optoelectronics and display materials, which however are challenging to use in realizing smart control of luminescent colors and switchable chiroptical properties. Here, we show a host-guest strategy to fabricate color-tunable RTP-based circularly polarized phosphorescence. Naphthalimides were conjugated directly to chiral segments, of which supramol. chirality and CPL activities in solid-states could be triggered by substituting bromine atoms on amines. Introducing tetracyanobenzene as an achiral host matrix via simple grinding would allow for the intersystem crossing to trigger red RTP and corresponding CPL by excitation lower than 320 nm, with a large Stokes shift more than 300 nm. The critical excitation wavelength of the RTP switch is determined by the absorbance of tetracyanobenzene. When the excitation wavelength was larger than 320 nm, blue fluorescence dominated with turned off RTP and CPL. The excitation wavelength-dependent RTP and CPL switch allows for detecting UV light, showing distinguishable red-blue luminescent color transition, accompanied by on/off RTP. Changing the host matrix from tetracyanobenzene to tricyanobenzene or dicyanobenzene could adjust the critical detecting wavelength limit from 320 to 300 nm. This work establishes a strategy to realize color-tunable, UV light detectable RTP and CPL under smart control. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts