Alcohols-buliding-blocks

Isolation, characterization and prediction of biological activity of two new fatty esters and a phenol from the heartwood of Pterocarpus Marsupium Roxb was written by Katiyar, Deepti;Singh, Vijender;Ali, Mohammed. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2017.Application of 69393-72-2 This article mentions the following:

Objective: The current investigation involves the isolation, characterization and prediction of biol. activity spectra of the phytoconstituents from the ethanolic extract of the heartwood of Pterocarpus marsupium roxb. (Fabaceae). Methods: The heartwood (3 kg) was extracted in alc. by cold maceration for 21 d and the compounds were isolated by column chromatog. The compounds thus isolated were characterised and their structures were elucidated by using assorted spectral data anal., i.e., IR radiation spectroscopy (IR), proton NMR (¹HNMR), carbon thirteen NMR (¹C³ NMR) and direct anal. in real time mass spectrometry (DART-MS). PASS (prediction of activity spectra for substances) computer program was used to predict the biol. activity spectra of the isolated compounds Results: Phytochem. investigation of ethanolic extract of the heartwood of Pterocarpus marsupium led to isolate two fatty esters and a phenolic compound characterised as n-octanyl n-octadeca-9,12-dienoate (n-octanyl linoleiate, 1), n-dodecanyl n-octadeca-9,12-dienoate (n-dodecanyl linoleiate, 2) and 2, 3-dioxymethylene phenol (3). These phytoconstituents are reported for first time in the heartwood of Pterocarpus marsupium Roxb. The in silico profiling of these phytoconstituents exhibited their broad spectra of biol. activity. Compounds (1) and (2) showed their maximum activity as All-trans-retinyl-palmitate hydrolase inhibitor, anti eczematic, lipid metabolism regulator, etc. and compound (3) was found to be active as membrane integrity agonist, aspulvinone dimethylallyl transferases inhibitor, carminative, neurotransmitter uptake inhibitor, etc. Conclusion: These isolated phytoconstituents can be used as the marker compounds to establish the identity, quality and purity of the drug. The results of PASS prediction shall be very useful for establishing these phytoconstituents as active pharmacol. moieties. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application of 69393-72-2).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 69393-72-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists was written by Okano, Masahiko;Mito, Jun;Maruyama, Yasufumi;Masuda, Hirofumi;Niwa, Tomoko;Nakagawa, Shin-ichiro;Nakamura, Yoshitaka;Matsuura, Akira. And the article was included in Bioorganic & Medicinal Chemistry in 2009.SDS of cas: 155975-19-2 This article mentions the following:

Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1 R,2 S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Mol. modeling clarified the structural factors contributing to the high affinity and selectivity of (1 R,2 S)-17. In the experiment, the researchers used many compounds, for example, tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2SDS of cas: 155975-19-2).

tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 155975-19-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts was written by Yin, Shenxiang;Zheng, Qingshu;Chen, Jie;Tu, Tao. And the article was included in Journal of Catalysis in 2022.Product Details of 873-76-7 This article mentions the following:

The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcs. to corresponding carboxylic acids was accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 x 10⁴ turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Product Details of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, physical properties and application of a series of new polyoxometalate-based ionic liquids was written by Martinetto, Yohan;Basset, Salome;Pegot, Bruce;Roch-Marchal, Catherine;Camerel, Franck;Jeftic, Jelena;Cottyn-Boitte, Betty;Magnier, Emmanuel;Floquet, Sebastien. And the article was included in Molecules in 2021.Product Details of 1122-71-0 This article mentions the following:

This paper deals with the preparation and the characterization of four new ionic liquids resulting from the pairing of various polyoxotungstates or polyoxomolybdates with the cation trihexyltetradecylphosphonium. The phys. properties measured by different techniques evidence that the viscosity and the rheol. behaviors of such POM-based ionic liquids, POM-ILs, strongly depend on the nature of the POM, especially its charge. Playing on the nature of the POM, we can indeed obtain Newtonian liquids or some much more viscous materials exhibiting characteristics of resins or pseudo-plastics. In a second part of this study, the potentialities of using such materials both as solvent and catalyst for the oxidation of a series of alcs. are presented as proof of concept. This part highlights great differences in strength and selectivity as a function of the POM-IL used. Furthermore, a very simple way to recycle the catalyst is also presented. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology was written by Mills, Carolyn E.;Waltmann, Curt;Archer, Andre G.;Kennedy, Nolan W.;Abrahamson, Charlotte H.;Jackson, Alexander D.;Roth, Eric W.;Shirman, Sasha;Jewett, Michael C.;Mangan, Niall M.;Olvera de la Cruz, Monica;Tullman-Ercek, Danielle. And the article was included in Nature Communications in 2022.Safety of 1,2-Propanediol This article mentions the following:

Abstract: Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study compartment morphol. as a factor in mediating encapsulated pathway performance. Using the 1,2-propanediol utilization microcompartment (Pdu MCP) system from Salmonella enterica serovar Typhimurium LT2, we find that we can shift the morphol. of this protein nanoreactor from polyhedral to tubular by removing vertex protein PduN. Anal. of the metabolic function between these Pdu microtubes (MTs) shows that they provide a diffusional barrier capable of shielding the cytosol from a toxic pathway intermediate, similar to native MCPs. However, kinetic modeling suggests that the different surface area to volume ratios of MCP and MT structures alters encapsulated pathway performance. Finally, we report a microscopy-based assay that permits rapid assessment of Pdu MT formation to enable future engineering efforts on these structures. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on the conversion of acrylic C=C double bonds during dark reaction after UV curing using infrared spectroscopy was written by Ma, Guo-zhang;Wu, Jian-bing;Xu, Bing-she. And the article was included in Guangpuxue Yu Guangpu Fenxi in 2010.Safety of Diethyleneglycoldiacrylate This article mentions the following:

IR spectroscopy was used to determine 1 648-1 589 cm^-1 characteristic absorption peak area so as to study the conversation of acrylic C=C double bonds after UV curing. The effects of photoinitiators, active diluents and UV curing resins on the conversion of C=C double bonds were also studied. 40%-85% Of C=C double bonds were conversed during dark reaction after 45 s UV curing. Dark reaction will be changed gently after 1.75 h, but 95% conversion of C=C double bonds needed more than 24 h. The rates of polymerization and conversation were affected by photoinitiators, the concentration of photoinitiator, oxygen inhibition, and C=C functional groups of active diluents. The rate of polymerization was affected by the C=C functional groups and types of UV curing resins, but conversation was not. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic Hydroboration and Reductive Amination of Carbonyl Compounds by HBpin using a Zinc Promoter was written by Kumar, Ravi;Rawal, Parveen;Banerjee, Indrani;Pada Nayek, Hari;Gupta, Puneet;Panda, Tarun K.. And the article was included in Chemistry – An Asian Journal in 2022.Safety of (4-Chlorophenyl)methanol This article mentions the following:

The chemoselective hydroboration of aldehydes and ketones, catalyzed by Zinc(II) complexes [κ²-(PyCH:NR)ZnX₂] (1, R = CPh₃, X = Cl; 2, R = 2,6-ⁱPr₂C₆H₃, X = I), by pinacolborane (HBpin) at ambient temperature and under solvent-free conditions, which produced the corresponding borate esters in high yield, is reported. Zinc metal complexes 1 and 2 were derived in 80-90% yield from the reaction of iminopyridine [PyCH:NR] with anhydrous zinc dichloride in dichloromethane at room temperature The solid-state structures of both zinc complexes were confirmed using X-ray crystallog. Zinc complex 1 was also used as a competent pre-catalyst in the reductive amination of carbonyl compounds with HBpin under mild and solvent-free conditions to afford a high yield (up to 97%) of the corresponding secondary amines. The wider substrate scope of both reactions was explored. Catalytic protocols using zinc as a pre-catalyst demonstrated an atom-economic and green method with diverse substrates bearing excellent functional group tolerance. Computational studies established a plausible mechanism for catalytic hydroboration. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Safety of (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Assay of terpin hydrate and codeine elixir by gas chromatography was written by Wasselman, Harold J.. And the article was included in Journal of Pharmaceutical Sciences in 1968.Reference of 2451-01-6 This article mentions the following:

Terpin hydrate and codeine after extraction from the elixir are separated and determined with the aid of two internal standards and the use of temperature-programmed gas chromatog. Using the same method, elixir of terpin hydrate can also be determined A precision and accuracy study for both elixirs is included. 25 references. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Reference of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids was written by Bolduc, Trevor G.;Lee, Cayo;Chappell, William P.;Sammis, Glenn M.. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 873-76-7 This article mentions the following:

Thionyl fluoride (SOF₂) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH₄ (13 examples, 33-80% yields). In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7HPLC of Formula: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volumetric and Ultrasonic Studies on Interactions of Hexylene and Propylene Glycols in Aqueous Solutions of Glutaraldehyde at Different Temperatures was written by Kaur, Parminder;Chakraborty, Nabaparna;Kumar, Harsh;Singla, Meenu;Juglan, Kailash Chandra. And the article was included in Journal of Solution Chemistry in 2022.HPLC of Formula: 57-55-6 This article mentions the following:

To determine the various interactions between glutaraldehyde and glycols (hexylene and propylene), various thermodn. and acoustic properties have been analyzed by using the d. (ρ) and ultrasonic velocity (c) of liquid mixtures of (hexylene or propylene + aqueous glutaraldehyde solutions), resp., in the concentration ranges from (0.01 to 0.04) mol·kg^-1 at the temperatures of 293.15, 298.15, 303.15, 308.15 K. Thermodn. parameters including the apparent molar volume (V_Φ) and partial molar volume (V⁰Φ) have been calculated from the d. values. These parameters show that the (solute-solvent) interaction for propylene glycol is weaker as compared to hexylene glycol. Acoustic parameters including the apparent molar isentropic compressibility (K_Φ,s) and partial molar isentropic compression (K⁰Φ,s) have been determined by using ultrasonic velocity values. Pair and triplet interaction coefficients have also been determined by using partial molar volume of transfer and partial molar isentropic compression of transfer. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6HPLC of Formula: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts