Alcohols-buliding-blocks

Using COSMO-RS to Predict Hansen Solubility Parameters was written by Wojeicchowski, Jose Pedro;Ferreira, Ana M.;Okura, Tifany;Pinheiro Rolemberg, Marlus;Mafra, Marcos R.;Coutinho, Joao A. P.. And the article was included in Industrial & Engineering Chemistry Research in 2022.COA of Formula: C3H8O2 This article mentions the following:

Hansen solubility parameters (HSP) provide essential information on the nature of solvents, being a useful tool in their selection for product and process design. In this work, linear models were developed to estimate HSP based on the use of COSMO-RS (conductor-like screening model for realistic solvents) descriptors. Hansen solubility parameters for 195 compounds were obtained from the literature and classified into two categories: training set (133 compounds) and testing set (62 compounds). Then a factorial regression was carried out to predict dispersion, hydrogen-bonding interaction, and polar contribution of HSP (δ_D, δ_H, and δ_P, resp.) based on σ-moments and energy COSMO-RS descriptors. The description of the dispersion contribution was the least successful due to the low variability of the exptl. data, despite the database containing compounds of a widely different chem. nature. The models obtained proved to be more than simple math. equations since a phys. meaning is achieved when COSMO-RS descriptors are used. The models developed were then applied to the test database. An excellent performance was observed, with δ_H showing the highest R² (0.90), and the MAE obtained were 0.98, 1.74, and 1.44 MPa^1/2 for δ_D, δ_H, and δ_P, resp., which are lower than those found in previous works. Finally, HSP data for caffeine, nicotine, paracetamol, and D-camphor were estimated The results were close to the literature data and those predictive by the HSPiP software. Moreover, it was shown that δ_P and δ_H drive the mols.’ polarity, impacting their log K_ow (a quant. measure of polarity). This work shows that COSMO-RS descriptors are a tool to predict HSP through linear models, opening new doors in the screening, design, and selection of solvents to be used in chem. processes. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6COA of Formula: C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of Aryl-Substituted 3,3a,4,5-Tetrahydropyrrolo[1,2-a] quinolin-1(2H)-ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrido[1,2-a]quinolin-1-ones was written by Watts, Field M.;Bunce, Richard A.. And the article was included in Synthesis in 2019.Name: (3-Methyl-2-nitrophenyl)methanol This article mentions the following:

A new route to the title benzo-fused angular tricyclic amides 3,3a,4,5-tetrahydropyrrolo- and 2,3,4,4a,5,6-hexahydro-1 H-pyrido[1,2- a]quinolin-1-ones is reported from 1-( tert-butyl) 6-Et 3-oxohexanedioate and 1-( tert-butyl) 7-Et 3-oxoheptanedioate. Alkylation of these β-keto diesters with a series of 2-nitrobenzyl bromides followed by acid hydrolysis and decarboxylation gives Et 6-(2-nitrophenyl)-4-oxohexanoates and Et 7-(2-nitrophenyl)-5-oxoheptanoates, resp. Reductive amination under hydrogenation conditions followed by ester hydrolysis and condensative ring closure affords the final lactam products. The reactions proceed cleanly and only two chromatog. purifications are required. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Name: (3-Methyl-2-nitrophenyl)methanol).

(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (3-Methyl-2-nitrophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comprehensive chocolate aroma characterization in beverages containing jackfruit seed flours and cocoa powder was written by Spada, Fernanda Papa;de Alencar, Severino Matias;Purgatto, Eduardo. And the article was included in Future Foods in 2022.Computed Properties of C10H20O This article mentions the following:

Jackfruit (Artocarpus heterophyllus Lam) occurs abundantly in Brazil, but its seeds are often underutilized in food nutrition. Previously, we showed that roasted jackfruit seeds are an innovative source of chocolate aroma. In this study, we characterized the volatile content of exptl. beverages containing jackfruit seed flours as compared to non-alk. cocoa powder. The three key results of this study were that (i) the fermented jackfruit seed flour beverage (FJSBev) was similar to the non-alk. cocoa powder beverage (CTRLBev); (ii) similar volatile groups (acids, alcs., aldehydes, ester, furans, and pyrazines) were identified in the samples (FJSBev and CTRLBev); (iii) the beverages contained volatile compounds with a low threshold of cocoa attributes (butter, cocoa, coffee, floral, fruit, green, honey, mushroom, nut, and roasted). To conclude, the beverage formulation containing fermented jackfruit seeds had more volatile compounds and odor-active constituents than that with non-alk. cocoa powder. Collectively, our data demonstrate that fermentation is critical to producing a chocolate aroma. Fermented jackfruit seed flours could be used as a partial or total additive to improve chocolate aroma in food formulations. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Computed Properties of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halomonas montanilacus sp. nov., isolated from hypersaline Lake Pengyanco on the Tibetan Plateau was written by Lu, Huibin;Xing, Peng;Zhai, Lei;Li, Huabing;Wu, Qinglong. And the article was included in International Journal of Systematic and Evolutionary Microbiology in 2020.Product Details of 10030-85-0 This article mentions the following:

A Gram-stain-neg., catalase- and oxidase-pos., aerobic, rod-shaped, motile strain (PYC7WT) was isolated from Lake Pengyanco on the Tibetan Plateau. Comparisons based on 16S rRNA gene sequences showed that strain PYC7WT belongs to the genus Halomonas, with Halomonas malpeensis YU-PRIM-29T and Halomonas johnsoniae T68687T as its closest neighbors (96.8 and 96.6% 16S rRNA gene sequence similarity, resp.), and only 93.1% 16S rRNA gene sequence similarity to Halomonas elongata ATCC 33173T. The predominant respiratory quinone of strain PYC7WT is Q-9, with Q-8 as a minor component. The major fatty acids are C18:1 ω6c and / or C18:1 ω7c, C16:0, C16:1 ω6c and/or C16:1 ω7c, and C12:0 3OH. The polar lipids of strain PYC7WT include phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, phosphatidylinositol and two unidentified phospholipids. Genome sequencing revealed a genome size of 4.79 Mbp and a G+C content of 62.9 mol%. DNA-DNA hybridization values of strain PYC7WT showed 45, 30 and 38% relatedness with Halomonas johnsoniae DSM 21197T, Halomonas hamiltonii DSM 21196T and Halomonas stevensii DSM 21198T, resp. Combining phenotypic, biochem., genotypic and DNA-DNA hybridization data, we propose that strain PYC7WT represents a novel species within the genus Halomonas and to have the name Halomonas montanilacus sp. nov.; PYC7WT (=CICC 24506T= KCTC 62529T) is the type strain. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Product Details of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis was written by Komm, Barry S.;Chines, Arkadi A.. And the article was included in Maturitas in 2012.Formula: C24H23ClO2 This article mentions the following:

Several selective estrogen receptor modulators are in clin. development for postmenopausal osteoporosis. Bazedoxifene has shown significant reductions in vertebral and non-vertebral (in higher-risk women) fracture risk, with no evidence of breast or endometrial stimulation. Lasofoxifene has demonstrated significant reductions in vertebral and non-vertebral fracture risk, but has been associated with endometrial/uterine effects. Both selective estrogen receptor modulators were generally safe and well tolerated but have been associated with some “class effects” (e.g., hot flushes, venous thromboembolic events). A tissue selective estrogen complex partnering bazedoxifene with conjugated estrogens is under clin. investigation for the treatment of menopausal symptoms and osteoporosis prevention. Future directions in selective estrogen receptor modulator research include ospemifene and RAD 1901. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva was written by Li, Rongfeng;Yu, Huahua;Yue, Yang;Liu, Song;Xing, Rong’e;Chen, Xiaolin;Li, Pengcheng. And the article was included in Chinese Journal of Oceanology and Limnology in 2017.Recommanded Product: 10030-85-0 This article mentions the following:

Sea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China. Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides. To investigate the bioactivities of the polysaccharides from sea cucumber H. fuscogliva, we prepared the sulfated polysaccharides (HfP) from sea cucumber H. fuscogliva using a protease hydrolysis method. Antioxidant activities of HfP were investigated, including hydroxyl radical scavenging activity and superoxide radical scavenging activity. And, the anticoagulant activities of HfP were studied, including the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT). The average mol. weight was 1 867.1 Da, with a sulfate content of 20.7%. In addition, the molar ratio of monosaccharide composition of HfP was Man: Rha: Glc A: Glc: Gal: Xyl: Fuc=0.083 6: 0.437: 0.134: 0: 1.182: 0.748: 1. It had a strong antioxidant activity, the hydroxyl and superoxide radical scavenging activity EC 50 of HfP was 3.74 and 0.037 mg/mL, resp. It also showed a good anticoagulant activity in our study. The APTT of HfP was much higher than that of heparin sodium, and the PT and TT of HfP was close to that of heparin sodium at a low concentration Therefore, HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Recommanded Product: 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH was written by Cheng, Ying-Ni;Wu, Hsyueh-Liang;Wu, Ping-Yu;Shen, Ying-Ying;Uang, Biing-Jiun. And the article was included in Chemistry – An Asian Journal in 2012.Synthetic Route of C8H9ClO This article mentions the following:

An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcs., which may undergo further chem. transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcs. with excellent enantioselectvities has been achieved in the presence of 0.1-0.5 mol % of the camphor-derived chiral ligand (-)-2-exo-morpholinoisobornane-10-thiol (MITH) at room temperature or at 0°. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photopolymer resins for luminescent three-dimensional printing was written by Wang, Fei;Chong, Yiting;Wang, Fu Ke;He, Chaobin. And the article was included in Journal of Applied Polymer Science in 2017.Application of 4074-88-8 This article mentions the following:

Liquid resins based three-dimensional (3D) printing techniques such as stereolithog. (SLA) and digital light processing (DLP) show higher resolution and accuracy than other printing techniques, but their applications were impeded by the limited materials selection and lack of functions. We here reported the preparation of luminescent resins for DLP-based 3D printing. Homogeneous dispersion of the fluorescent dyes was achieved by small acrylate mols. screening, and the cure depth studies was used to optimize both resin composition and printing parameters setting. In addition, we showed that the optical anal. of absorption and emission spectra is an important tool to reduce the complex mutual-interference of the light absorption of dye, photoinitiator and photo-absorber in the printable resin. We also developed the mater batch technique to tune the emitting colors in the whole visible range, together with white emitting. By using the developed resins, different 3D structures with different emitting colors were successfully printed by DLP technique. These results will further widen the applications of the liquid resins-based 3D printing techniques, and these luminescent resins show highly potential applications in education, lighting, UV converters, and so on. © 2017 Wiley Periodicals, Inc.J. Appl. Polym. Sci. 2017, 134, 44988. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Harnessing light to create functional, three-dimensional polymeric materials: multitasking initiation systems as the critical key to success was written by Tomal, Wiktoria;Krok, Dominika;Chachaj-Brekiesz, Anna;Lepcio, Petr;Ortyl, Joanna. And the article was included in Additive Manufacturing in 2021.Recommanded Product: 4074-88-8 This article mentions the following:

Nowadays, the lack of suitable photoinitiators (PI) and photoinitiating systems (PISs) represents the utmost challenge in 3D-VAT printing. High photoinitiating efficiency is needed for example in the presence of nanofillers such as carbon nanotubes (CNTs) which absorb and scatter light. Many prominent PISs contains iodonium salt as an initiator and a second component as a photosensitizer. This study addresses the high demand for innovative PISs with improved photoinitiating efficiency by a complete cycle of research: from the synthesis of new biphenyl derivatives, through their employment as photosensitizers of iodonium salt for light-induced cationic, free-radical, and hybrid polymerization processes, to the representative application in 3D printing processes such as digital light processing (DLP) or laser printing. The ultimate performance of the newly synthesized compounds was tested by preparing 3D-printable photosensitive nanocomposite resins filled with CNTs as a nanoscale filler. Their photopolymerization kinetics as well as the effect of the CNT concentration on the crosslinking were analyzed via real-time FTIR and photo-rheol. The printouts were observed with optical microscopy and SEM. In addition, the key printing parameters were determined, i.e. E_c (critical energy to initiate polymerization) and D_p (penetration depth of curing light). Our results evidence the capability of the synthesized compounds to take part in the photoinitiating systems of complex and demanding 3D printing applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts