Alcohols-buliding-blocks

Metal salts as new catalysts for mild and efficient aminolysis of oxiranes was written by Chini, Marco;Crotti, Paolo;Macchia, Franco. And the article was included in Tetrahedron Letters in 1990.Reference of 40571-86-6 This article mentions the following:

A new, simple, efficient, inexpensive method for aminolysis of 1,2-epoxides, by means of metal salts, is described. The reactions proceed under mild conditions in MeCN to afford 尾-amino alcs. with complete antistereoselectivity and generally high regioselectivity. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Reference of 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Longitudinal two-dimensional gas chromatography mass spectrometry as a non-destructive at-line monitoring tool during cell manufacturing identifies volatile features correlative to cell product quality was written by Jimenez, Angela C.;Heist, Christopher A.;Navaei, Milad;Yeago, Carolyn;Roy, Krishnendu. And the article was included in Cytotherapy in 2022.Recommanded Product: 3391-86-4 This article mentions the following:

Cell therapies have emerged as a potentially transformative therapeutic modality in many chronic and incurable diseases. However, inherent donor and patient variabilities, complex manufacturing processes, lack of well-defined critical quality attributes and unavailability of in-line or at-line process or product anal. technologies result in significant variance in cell product quality and clin. trial outcomes. New approaches for overcoming these challenges are needed to realize the potential of cell therapies. Here the authors developed an untargeted two-dimensional gas chromatog. mass spectrometry-based method for non-destructive longitudinal at-line monitoring of cells during manufacturing to discover correlative volatile biomarkers of cell proliferation and end product potency. Specifically, using mesenchymal stromal cell cultures as a model, the authors demonstrated that GCxGC-MS of the culture medium headspace can effectively discriminate between media types and tissue sources. Headspace GCxGC-MS identified specific volatile compounds that showed a strong correlation with cell expansion and product functionality quantified by indoleamine-2,3-dioxygenase and T-cell proliferation/suppression assays. Addnl., the authors discovered increases in specific volatile metabolites when cells were treated with inflammatory stimulation. This work establishes GCxGC-MS as an at-line process anal. technol. for cell manufacturing that could improve culture robustness and may be used to non-destructively monitor culture state and correlate with end product function. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of polar groups of polystyrenes on the self-assembly of breath figure arrays was written by Zhou, Di;Wu, Bai-Heng;Yang, Wen-Wu;Li, Xiao;Zhu, Liang-Wei;Xu, Zhi-Kang;Wan, Ling-Shu. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

The breath figure (BF) process has been widely used to prepare patterned porous films. The mechanism remains to be further elucidated, especially how polymer architectures affect the stability of water droplets and the pore structure. Polystyrenes (PS) was functionalized with a series of polar groups both in chain middle and chain end, which was synthesized by using difunctional atom transfer radical polymerization (ATRP) initiators with the combination of nucleophilic substitution of the end bromine. It is found that PS with polar groups, which help to reduce interfacial tension, tends to form regular patterns at low concentration and to generate multilayered pores. The coalescence resistance measurement was performed to characterize the stabilization of water droplets from polymers by precipitation The results show opposite trend with the results of the BF process, indicating a minor role played by polymer precipitation on microdroplets stabilization. We reveal that addition of only an oxyethyl group in the chain middle of PS contributes to the formation of ordered patterns. This study helps to shed light on the impact of polymer architectures on the self-assembly behavior in the BF process. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic 伪-Amination of Stabilized Enolates was written by Poeira, Diogo L.;Negrao, Ana Claudia R.;Faustino, Helio;Coelho, Jaime A. S.;Gomes, Clara S. B.;Gois, Pedro M. P.;Marques, M. Manuel B.. And the article was included in Organic Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A new family of hypervalent iodine reagents containing transferable primary amine groups is described. The benziodoxolone-based reagents were synthesized on a gram-scale through operationally simple reactions in up to quant. yields. These bench-stable solids were characterized by X-ray anal. and successfully employed in the 伪-amination of indanone-based 尾-ketoesters in up to 83% yield. Mechanistic studies indicate a substitution mechanism involving an electrophilic amine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni(cod)(duroquinone)-Catalyzed C-N Cross-Coupling for the Synthesis of N,N-Diarylsulfonamides was written by You, Tian;Li, Junqi. And the article was included in Organic Letters in 2022.SDS of cas: 68716-49-4 This article mentions the following:

A C-N cross-coupling reaction of weakly nucleophilic N-arylsulfonamides and aryl bromides to access N,N-diarylsulfonamides RR¹NSO₂R² [R = n-Bu, Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄; R¹ = Ph, 4-ClC₆H₄, 3-furyl, etc.; R² = cyclopropyl, 4-MeC₆H₄, 4-PhC₆H₄, etc.] using Ni(cod)(DQ) as a catalyst without addnl. ligands was reported. The process was compatible with electron-deficient and electron-rich aryl and heteroaryl bromides and could be applied to the derivatization of an N-arylsulfonamide pharmaceutical compound In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4SDS of cas: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Propolis extract combined with oregano essential oil applied to lima bean seeds against Sclerotinia sclerotiorum was written by Cibanal, Irene Laura;Fernandez, Leticia Andrea;Rodriguez, Silvana Andrea;Pellegrini, Cecilia Noemi;Gallez, Liliana Maria. And the article was included in European Journal of Plant Pathology in 2022.Recommanded Product: 499-75-2 This article mentions the following:

In this study, propolis extract (EPE) and oregano essential oil (OEO), both natural products with different bioactive compounds, were evaluated in vitro and in vivo against Sclerotinia sclerotiorum. This phytopathogen is important worldwide as it can contaminate seeds and infect seedlings of many species. Antifungal susceptibility assays on culture media revealed that EPE and OEO were highly active against this phytopathogen, both individually and combined. EPE showed a fungistatic dose-dependent effect, acting mainly through diffusion, while OEO completely prevented mycelial growth at very low concentrations, with a combination of vapor and diffusion activity. Interestingly, OEO was more effective than EPE, as their min. inhibitory concentrations were 0.39渭l/mL and 5渭l/mL, resp. Combinations of EPE and OEO showed, depending on the doses, additive or synergistic antifungal effects. In the in vivo trial, dilutions of EPE and OEO made in sterile distilled water (SDW) were tested through a pathosystem with lima bean seeds and S. sclerotiorum. Seeds soaked in formulations with 40% EPE + 12% OEO + 48% SDW, and 20% EPE + 6% OEO + 74% SDW reduced disease incidence of 40% and 60% resp., significantly decreased severity, with a min. phytotoxic effect. This study strengthens previous work showing the antifungal action of EPE and OEO against S. sclerotiorum, and, as a main goal, highlights their potential for the development of biofungicides to protect lima bean seeds. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors was written by Allegretti, Marcello;Bertini, Riccardo;Cesta, Maria Candida;Bizzarri, Cinzia;Di Bitondo, Rosa;Di Cioccio, Vito;Galliera, Emanuela;Berdini, Valerio;Topai, Alessandra;Zampella, Giuseppe;Russo, Vincenzo;Di Bello, Nicoletta;Nano, Giuseppe;Nicolini, Luca;Locati, Massimo;Fantucci, Piercarlo;Florio, Saverio;Colotta, Francesco. And the article was included in Journal of Medicinal Chemistry in 2005.Formula: C16H16O3 This article mentions the following:

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2). (R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL8-induced human PMNs chemotaxis. The authors report here mol. modeling studies showing a putative interaction site of 1 in the TM region of CXCR1. The binding model was confirmed by alanine scanning mutagenesis and photoaffinity labeling experiments The mol. model driven medicinal chem. optimization of 1 led to a new class of potent and specific inhibitors of CXCL8 biol. activity. Among these, repertaxin was selected as a clin. candidate drug for prevention of postischemia reperfusion injury. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Acaricidal activity of carvacrol and thymol on acaricide-resistant Rhipicephalus microplus (Acari: Ixodidae) populations and combination with cypermethrin: Is there cross-resistance and synergism? was written by Novato, Tatiane Pinheiro;Milhomem, Marlise Neves;Marchesini, Paula Barroso Cruz;Coutinho, Ana Lucia;Silva, Isabela Santos;de Souza Perinotto, Wendell Marcelo;de Azevedo Prata, Marcia Cristina;Ferreira, Lorena Lopes;Lopes, Welber Daniel Zanetti;Costa-Junior, Livio Martins;de Oliveira Monteiro, Caio Marcio. And the article was included in Veterinary Parasitology in 2022.COA of Formula: C10H14O This article mentions the following:

This study evaluated the acaricidal activity of thymol and carvacrol on Rhipicephalus microplus populations with different resistance profiles and investigated the synergistic effect of combinations of these monoterpenes with cypermethrin. The adult immersion test (AIT) was used to characterize the susceptibility of tick populations (45 field populations) to synthetic acaricides: deltamethrin, amitraz and chlorfenvinphos. The larval packet test (LPT) was used to determine the LC₅₀ values for thymol (25 tick populations) and carvacrol (20 tick populations). The susceptible strain Porto Alegre (POA) was used as a reference for calculating the resistance ratio (RR). Subsequently, larval immersion tests (LIT) were performed with combinations of cypermethrin with thymol or carvacrol to assess a synergistic effect. In the AIT, deltamethrin showed efficacy > 90% in one (2.2%) population tested (mean: 12.1 and 11.1 for populations 1-25 and 26-40, resp.), whereas amitraz and chlorfenvinphos showed efficacy > 90% for two (4.4%) populations (mean: 61.3 and 47.3 for populations 1-25 and 26-40, resp.) and eight (17.7%) populations (mean: 69.7 and 59.7 for populations 1-25 and 26-40, resp.). In the LPT, the LC₅₀ values for thymol and carvacrol varied from 0.67 to 2.12 mg/mL and 0.55-3.21 mg/mL, with an average LC₅₀ for populations of 1.49 and 1.75 mg/mL, resp. For thymol, no resistance was observed in any of the populations, values of RR₅₀ > 1.5. There was no correlation between the LC₅₀ values for thymol and the efficacy of the chem. acaricides tested. Regarding carvacrol, for only one tick population had the value of RR₅₀ > 1.5, indicating an incipient resistance. No correlation was observed between the LC₅₀ values for carvacrol and the efficacy of tested acaricides. The combination of thymol and carvacrol with cypermethrin showed a synergistic effect in the resistant population (Jaguar – thymol 4.19 and carvacrol 3.67), and no synergistic interaction were showed in the susceptible population. Answering the questions we conclude that: 1 – The comparison between the LC₅₀ values for thymol and carvacrol in field populations and the susceptible strain POA suggests the absence of cross-resistance (ticks and terpenes), and the differences between the LC₅₀ values for thymol and carvacrol in the different R. microplus populations are inherent to the characteristics of each population tested; 2 – the combination of thymol or carvacrol with cypermethrin showed a synergistic effect with different activity according to the population of ticks. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2COA of Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stereoselective oxidation of racemic 1-arylethanols by basil cultured cells of Ocimum basilicum cv. Purpurascens was written by Itoh, Ken-ichi;Nakamura, Kaoru;Utsukihara, Takamitsu;Sakamaki, Hiroshi;Horiuchi, C. Akira. And the article was included in Biotechnology Letters in 2008.Synthetic Route of C8H9ClO This article mentions the following:

The biotransformation of racemic 1-phenylethanol (30 mg) with plant cultured cells of basil (Ocimum basilicum cv. Purpurascens, 5 g wet wt) by shaking 120 rpm at 25掳C for 7 days in the dark gave (R)-(+)-1-phenylethanol and acetophenone in 34 and 24% yields, resp. The biotransformation can be applied to other 1-arylethanols and basil cells oxidized the (S)-alcs. to the corresponding ketones remaining the (R)-alcs. in excellent ee. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suspect screening based on market data of polar halogenated micropollutants in river water affected by wastewater was written by Menger, Frank;Ahrens, Lutz;Wiberg, Karin;Gago-Ferrero, Pablo. And the article was included in Journal of Hazardous Materials in 2021.Application of 1777-82-8 This article mentions the following:

Wastewater treatment plants (WWTPs) are known point sources of contaminants of emerging concern (CECs) to the aquatic environment, but current knowledge is mostly limited to well-known chem. structures. In this study, we sought to identify unknown CECs polluting the aquatic environment through a novel suspect screening approach for organohalogens, i.e. organic halogenated mols. often toxic and resistant to transformation and characterised as persistent organic pollutants (POPs). Surface water samples were collected with passive samplers in the Fyris River catchment (Uppsala, Sweden), analyzed using liquid chromatog. high-resolution mass spectrometry (LC-HRMS) and screened for organohalogens using a suspect screening approach based on market data obtained from a regulatory authority. Thirteen suspects from very different application areas were confirmed or tentatively identified with high confidence, including seven previously unknown structures (diflufenican, chlorzoxazone, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, 2,4-disulfamyl-5-trifluoromethylaniline, 5-amino-2-chlorotoluene-4-sulfonic acid, perfluoropentane-1-sufonic acid, (2-chlorophenyl)(hydroxy)methanesulfonic acid). Spatiotemporal occurrence patterns were detected, which helped to understand the usage pattern of the chems. and pinpoint potential pollution sources, e.g. specific WWTPs in the catchment. Several of the newly identified structures had virtually no information publicly available and were detected years after their last registered use, which highlights the knowledge gaps and concerns about POPs. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts