Alcohols-buliding-blocks

Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines was written by Ye, Hao;Wu, Linhui;Zhang, Minrui;Jiang, Guomin;Dai, Hong;Wu, Xin-Xing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application In Synthesis of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones was written by Ma, Xiaochen;Zuo, Ziqing;Liu, Guixia;Huang, Zheng. And the article was included in ACS Omega in 2017.SDS of cas: 120121-01-9 This article mentions the following:

Nonracemic (oxazolinyl)pyridinylimine manganese complexes I (R = i-Pr, Ph₂CH; R¹ = H, Me; R² = PhCH₂, i-Pr, t-Bu) were prepared as catalysts for the enantioselective hydrosilylation of aralkyl ketones. In the presence of I (R = Ph₂CH; R¹ = Me; R² = t-Bu), aralkyl ketones such as 4-R³C₆H₄COMe (R³ = Cl, i-Bu, t-Bu, cyclohexyl, n-Pr, MeO, Br, I, H) with Ph₃SiH and NaBHEt₃ in toluene to yield nonracemic benzylic alcs. such as (R)-4-R³C₆H₄CH(OH)Me (R³ = Cl, i-Bu, t-Bu, cyclohexyl, n-Pr, MeO, Br, I, H) in 48-99% yields and 66:34-96.5:3.5 er. The structure of I路2 CH₂Cl₂ (R = Ph₂CH; R¹ = Me; R² = t-Bu) was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9SDS of cas: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Regulation of mechanical properties of diene rubber cured by oxa-Michael Reaction via manipulating network structure was written by Zhang, Xuhui;Tang, Zhenghai;Guo, Baochun. And the article was included in Polymer in 2018.Recommanded Product: 4074-88-8 This article mentions the following:

As diene rubber products are generally fabricated with complicated curing package involving toxic additives, the exploration of alternative green curing chem. for diene rubber is of great importance. In this contribution, we demonstrate a curing chem. based on oxa-Michael reaction for diene rubber to achieve the combination of simple curing system and tunable mech. properties. Specifically, pendent hydroxyls are introduced onto the solution-polymerized styrene-butadiene rubber (SSBR) via thiol-ene click reaction and the modified SSBR is effectively cured by various acrylates without the use of any addnl. additives. The mech. behaviors of vulcanizates can be widely regulated by manipulating the network structures, which is tuned by curing temperature, hydroxyl content of SSBR, content and functionality of acrylates. The correlation between mech. properties and network structure is accordingly achieved, which provides essential basis for the future application of the diene rubbers cured by oxa-Michael reaction. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Physical constants of substituted acetophenones was written by Guzman-Lopez, Enrique;Rosas, Noe;Walls, Fernando. And the article was included in Boletin del Instituto de Quimica de la Universidad Nacional Autonoma de Mexico in 1970.Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone This article mentions the following:

An attempt to prepare perezone and the 2 pipitzols gave a mixture of 2-(4-methyl-2,5-dimethoxyphenyl)-6-methyl-1,5-heptadiene and 2-(4-methyl-2,5-dimethoxyphenyl)-6-methyl-2,5-heptadiene, and 12 substituted acetophenones, and 5 related products. Their ir, uv, and NMR spectra were described. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of synthesis conditions on the non-uniformity of nanofiltration membrane pore size distribution was written by Zhang, Ting;Fu, Ruo-Yu;Wang, Kun-Peng;Gao, Ya-Wei;Li, Hong-Rui;Wang, Xiao-Mao;Xie, Yuefeng F.;Hou, Li’an. And the article was included in Journal of Membrane Science in 2022.SDS of cas: 149-32-6 This article mentions the following:

The uniformity of membrane pore sizes, which is essentially determined by the membrane synthesis conditions, significantly affects the rejection performance of nanofiltration (NF) membranes. In this study, we applied two modeling methods, i.e., the DSPM (Donnan Steric Pore Model) and the log-normal distribution methods, for the determination of the average membrane pore size and pore size uniformity of lab-made NF membranes. The synthesis conditions included concentration of monomers (e.g., piperazine and trimesoyl chloride), (thermal) curing temperature and time, and activation solvent type and duration. Results showed that both high piperazine (PIP) concentration (鈮?.5 wt%) and curing temperature (鈮?0掳C) could enhance the membrane pore size uniformity. Although the average membrane pore size calculated by the DSPM method was higher than that by the log-normal distribution method, they significantly correlated. It appears that the log-normal distribution method could more directly characterize membrane pore size uniformity. Obviously, the pore uniformity of NF membranes affected the rejection of small mols., such as trace organic compounds These insights provided a theor. foundation for the characterization of membrane pore size distribution with more accuracy and the fabrication of membranes with higher pore size uniformity. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6SDS of cas: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrosilyl group-directed iridium-catalyzed peri-selective C-H borylation of ring-fused (hetero)arenes was written by Sumida, Yuto;Harada, Ryu;Sumida, Tomoe;Hashizume, Daisuke;Hosoya, Takamitsu. And the article was included in Chemistry Letters in 2018.COA of Formula: C16H20B2N2O2 This article mentions the following:

The iridium-catalyzed direct C-H borylation of ring-fused (hetero)arenes afforded borylated products in a peri-selective manner, directed by a proximal hydrosilyl group. Further selective transformations of the boryl and silyl groups enabled the synthesis of various multisubstituted (hetero)arenes, such as 1,8-disubstituted naphthalenes and 3,4-diarylindole. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6COA of Formula: C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation Using Unsymmetrical Vicinal Diamine-Based Ligands: Dramatic Substituent Effect on Catalyst Efficiency was written by Zhang, Bo;Wang, Hui;Lin, Guo-Qiang;Xu, Ming-Hua. And the article was included in European Journal of Organic Chemistry in 2011.Application of 120121-01-9 This article mentions the following:

The use of unsym. vicinal diamines as ligands for Ru-catalyzed asym. transfer hydrogenation is described. With a SmI₂-mediated cross-coupling protocol, a series of enantiomerically pure unsym. vicinal diamines were readily prepared and examined in the asym. transfer hydrogenation. It was found that an aromatic substituent on the carbon bearing the -NHTs group and a bulky alkyl substituent on the other side, are both very important for the effectiveness of the ligand, suggesting that the substituent has a dramatic effect on the catalyst efficiency. With ligand I, excellent enantioselectivities that are comparable to N-tosyl-1,2-diphenylethane-1,2-diamine (TsDPEN) were achieved. The results provide some helpful information on the mechanism of Ru-catalyzed asym. transfer hydrogenation. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Application of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, Characterization, and Application in HeLa Cells of an NIR Light Responsive Doxorubicin Delivery System Based on NaYF₄:Yb,Tm@SiO₂-PEG Nanoparticles was written by Alonso-Cristobal, Paulino;Oton-Fernandez, Olalla;Mendez-Gonzalez, Diego;Diaz, J. Fernando;Lopez-Cabarcos, Enrique;Barasoain, Isabel;Rubio-Retama, Jorge. And the article was included in ACS Applied Materials & Interfaces in 2015.Synthetic Route of C7H7NO4 This article mentions the following:

Herein, we present a phototriggered drug delivery system based on light responsive nanoparticles, which is able to release doxorubicin upon NIR light illumination. The proposed system is based on upconversion fluorescence nanoparticles of 尾-NaYF₄:Yb,Tm@SiO₂-PEG with a mean diameter of 52 卤 2.5 nm that absorb the NIR light and emit UV light. The UV radiation causes the degradation of photodegradable ortho-nitrobenzyl alc. derivates, which are attached on one side to the surface of the nanoparticles and on the other to doxorubicin. This degradation triggers the doxorubicin release. This drug delivery system has been tested “in vitro” with HeLa cells. The results of this study demonstrated that this system caused negligible cytotoxicity when they were not illuminated with NIR light. In contrast, under NIR light illumination, the HeLa cell viability was conspicuously reduced. These results demonstrated the suitability of the proposed system to control the release of doxorubicin via an external NIR light stimulus. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Synthetic Route of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An iron variant of the Noyori hydrogenation catalyst for the asymmetric transfer hydrogenation of ketones was written by Huo, Shangfei;Wang, Qingwei;Zuo, Weiwei. And the article was included in Dalton Transactions in 2020.COA of Formula: C8H9ClO This article mentions the following:

The design of a new iron catalyst for the asym. transfer hydrogenation of ketones R¹C(O)R² [R¹ = Ph, naphthalen-2-yl, 2,3-dihydro-1H-inden-5-yl, etc.; R² = Me, Et, dimethoxymethyl, (dimethylamino)methyl] was reported. This type of iron catalyst combines the structural characteristics of the Noyori hydrogenation catalyst (an axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl fragment and the metal-ligand bifunctional motif) and an ene(amido) group SA,RP,SS/SA,RP,RR-I (Ar = Ph, 4-methoxyphenyl) that can activate the iron center. After activation by 8 equiv of potassium tert-butoxide, (SA,RP,SS)-I (Ar = Ph (II)) and (SA,RP,SS)-I (Ar = 4-methoxyphenyl) are active but nonenantioselective catalysts for the transfer hydrogenation of acetophenone and 伪,尾-unsaturated aldehydes R³CHO (R³ = 2,6-dimethylhepta-1,5-dien-1-yl, 2-phenylethenyl) are kept at room temperature in isopropanol. A maximum turnover number of 14480 was observed for (SA,RP,SS) (II) in the reduction of acetophenone. The right combination of the stereochem. of the axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl group and the carbon-centered chiral amine-imine moiety in (SA,RP,RR)-I (Ar = 4-methoxyphenyl) afforded an enantioselective catalyst for the preparation of chiral alcs. R¹/R³CH(R²/H)OH with moderate to good yields and a broad functional group tolerance. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production of (R)-1-phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum was written by ilbeyaz, Kani;Taskin, Mesut;Kurbanoglu, Esabi B.;Kurbanoglu, Namudar I.;Kilic, Hamdullah. And the article was included in Chirality in 2010.COA of Formula: C8H9FO This article mentions the following:

A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)-alcs. Among these strains, isolate Trichothecium roseum EBK-18 was highly effective in the production of (R)-alcs. with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)-1-phenylethanol is reported. Chirality 2010. 漏 2009 Wiley-Liss, Inc. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4COA of Formula: C8H9FO).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C8H9FO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts