Alcohols-buliding-blocks

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15518-10-2, name is 3-Amino-2-methylpropan-1-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 3-Amino-2-methylpropan-1-ol

EXAMPLE I N-(2-Hydroxy-1,1-dimethylethyl)-2,4,5-trifluorobenzamide A solution of 19.4 g (110 mmol) of 2,4,5-trifluorobenzoic acid (JP 58,150,543 (Cl. C07C69) Sept. 7, 1983). 15.2 g (120 mmol) of oxalyl chloride and 250 ml of dichloromethane was treated with four drops of DMF, and the mixture was stirred at room temperature for four hours. The mixture was concentrated to a oil and was redissolved in 100 ml of dichloromethane. This solution was added dropwise to a solution of 19.6 g (240 mmol) of 3-amino-2-methyl-1-propanol in 200 ml of dichloromethane at 5 C., and the reaction mixture was stirred at room temperature overnight. The solids were filtered, and the filtrate was washed with 5% sodium bicarbonate, 1N hydrochloric acid, and water. The organic layer was dried over magnesium sulfate and concentrated to give 24.5 g of the title compound, mp 114-116 C.

With the rapid development of chemical substances, we look forward to future research findings about 15518-10-2.

Reference:
Patent; Warner-Lambert Company; US4920120; (1990); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(3-Fluorophenyl)ethanol

1 [0036] Aldehyde 14 can be prepared as shown in Scheme 3. 2-(3- Fluorophenyl)ethanol can be oxidized with Dess-Martin periodinane to give 15.Reductive amination with N-(2-hydroxyethyl)benzyl amine gives 16. Hydrogenolysis, Boc protection, and Dess-Martin oxidation gives 14 in excellent yields.Scheme 3. Synthesis of aldehyde 14 used in the synthesis of 1

With the rapid development of chemical substances, we look forward to future research findings about 52059-53-7.

Reference:
Patent; NORTHWESTERN UNIVERSITY; YANG, Sun; MEYSKENS, Frank, L.; SILVERMAN, Richard, B.; JI, Haitao; XUE, Fengtian; POULOS, Thomas, L.; WO2012/97121; (2012); A2;,
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Synthetic Route of 870-72-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 870-72-4, name is Hydroxymethanesulfonic Acid Sodium Salt. This compound has unique chemical properties. The synthetic route is as follows.

(S)-(-)-(5,7-Difluoro-1,2,3,4-tetrahydronaphth-2-yl)(cyanomethyl)amine. The amine hydrochloride 8a (50.27 g, 229 mmol) was treated with a solution of NaOH (10.0 g. 250 mmol) in water (150 mL), followed by a few additional pellets of NaOH sufficient to obtain a solution. Further water (300 mL) was added and the mixture placed in a 50 C bath and treated with formaldehyde sodium bisulfite complex (30.8 g, 230 mmol). After the mixture had been stirred for 30 min, KCN (15.0 g, 230 mmol) was added. The reaction mixture was stirred for a further 1 h at 80 C, cooled to room temperature, and extracted with EtOAc to give an oil (51.3 g) which solidified. TLC (5% MeOH-CH2Cl2) showed ca. 10-15% of starting amine remained. Chromatography on silica gave the nitrile product (39.4 g) and starting free amine (7.12 g), which quickly forms the carbonate in air. Recycling this amine gave an additional 5.35 g of product. Combined yield (44.8 g, 202 mmol; 87.5%): mp 73.1-76.5 C; [alpha]25D -58.0 (c = 1.63, CHCl3); 1H NMR (CDCl3) delta 1.50 (br s, 1H), 1.70 (m, 1H), 2.05 (m, 1H), 2.55-3.04 (m, 4H), 3.22 (m, 1H), 3.70 (s, 2H), 6.62 (m, 2H); MS m/z 222 (M+). Anal. Calcd for C12H12F2N2: C, 64.85; H, 5.44; N, 12.60. Found: C, 65.07; H, 5.47; N, 12.44. The spectra for the (R)-enantiomer 9b are identical: mp 64.4-73.6 C; [alpha]25D +52.3 (c =2.12, CHCl3). Anal. Calcd for C12H12F2N2: C, 64.85; H, 5.44; N, 12.60. Found: C, 65.14; H, 5.54; N, 12.53.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt.

Reference:
Patent; Biotie Therapies, Inc.; WOIWODE, Tom; MORAN, Mark; PICKFORD, Lesley; (73 pag.)EP2182804; (2017); B1;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.COA of Formula: C6H14O3

A. Preparation of 1-Allyloxy-2-(2′-ethoxyethoxy) ethanol (4A) All procedures were the same as for preparation of 1A except that diethylene glycol monoethyl ether (39.0 mL, 0.288 mmoles) was used. After filtering the sodium bromide precipitate and concentrating the filtrate, the product was chromatographed on silica gel (eluents: toluene, 15% ethyl acetate in toluene, then 50% ethyl acetate in toluene) and then purified by fractional distillation to produce an 80% yield of colorless liquid, b.p. 78-79 C. at 0.2 torr. 1 H NMR:delta1.02 (t, J=7.0 Hz, –O–C–CH3); 3.28 (q, J=6.5 Hz, –O–CH2 C); 3.30 [m, W1/2 =4 Hz (CH2 CH2 O)2 ]; 3.77 (d, J=5.0 Hz, CH2 allyloxy); 4.69-5.22 (m, CH2 vinyl); 5.29-6.02 (m, CH vinyl).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; Northeastern University; US4778909; (1988); A;,
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Electric Literature of 627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 3,4-Dihydropyran (DHP, 15 mmol) was added slowly to a stirred solution of bromohydrin (10 mmol) and p-toluenesulfonic acid (1 mmol) in dichloromethane (20 mL) on ice bath. After stirring at room temperature overnight, the reaction mixture was diluted with water and extracted with dichloromethane. The organic layer was washed with brine and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography to afford 1-5 as a light yellow oil. 2-(3-Bromopropoxy)tetrahydro-2H-pyran (1). Yield 94.2%. 1H NMR spectrum, delta, ppm: 1.37-1.55 m (4H), 1.57-1.65 m (1H), 1.70-1.78 m (1H), 2.01-2.10 m (2H), 3.37-3.49 m (4H), 3.73-3.83 m (2H), 4.49-4.55 m (1H). 13C NMR spectrum, deltaC, ppm: 19.4, 25.4, 30.5, 30.6, 32.8, 62.1, 64.8, 98.7.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Article; Zhang; Dong; Meng; Huang; Li; Russian Journal of General Chemistry; vol. 88; 11; (2018); p. 2388 – 2393; Zh. Obshch. Khim.;,
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Electric Literature of 33420-52-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33420-52-9, name is 2,2-Difluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Trifluoromethanesulfonic anhydride (3.29 ml, 19.5 mmol) was added dropwise to a solution of 2,2-difluoropropan-1-ol (1.7 g, 18 mmol) in DCM (40 mL) at -10 C. (salt/ice bath). 2,6-Dimethylpyridine (2.5 mL, 21 mmol) was then added, and the reaction was stirred for 1 hour under these conditions. The reaction was then washed with water (*2), and the organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure (vacuum ?200 mbars) to afford 2,2-difluoropropyl trifluoromethanesulfonate (2.1 g, 52%) as a red oil. 1H NMR (400 MHz, CHLOROFORM-d, 27 C.) 4.48 (2H, t), 1.73 (3H, t).

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; BARLAAM, Bernard Christophe; O’DONOVAN, Daniel Hillebrand; HUGHES, Samantha Jayne; MOSS, Thomas Andrew; NISSINK, Johannes Wilhelmus Maria; SCOTT, James Stewart; YANG, Bin; (148 pag.)US2018/111931; (2018); A1;,
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Electric Literature of 756520-66-8 ,Some common heterocyclic compound, 756520-66-8, molecular formula is C8H7Cl2FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of triphenyl phosphine (8. 2 G, 0. 03 mol) and DEAD (13. 65 mL of a 40% solution in toluene) in THF (200 mL) at 0 C was added a solution of 1- (2, 6-DICHLORO-3-FLUORO-PHENYL)- ethanol (4. 55 G, 0. 021 mol) and 3-hydroxy-nitropyridine (3. 35 G, 0. 023 mol) in THF (200 mL). The resulting bright orange solution was stirred under a nitrogen atmosphere at ambient temperature for 4 hours at which point all starting materials had been consumed. The solvent was removed, and the crude material was dry loaded onto silica gel, and eluted with ethyl acetate-hexanes (20 : 80) to yield 3- (2, 6-DICHLORO-3-FLUORO-BENZYLOXY)-2-NITRO-PYRIDINE (6. 21 G, 0. 021 mol, 98%) as a pink SOLID. 1H NMR (CDCl3, 300 MHz) 1. 8-1. 85 (d, 3H), 6. 0-6. 15 (q, 1H), 7. 0-7. 1 (t, 1H), 7. 2-7. 21 (d, 1H), 7. 25-7. 5 (m, 2H), 8. 0-8. 05 (d, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUGEN, INC.; WO2004/76412; (2004); A2;,
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Adding a certain compound to certain chemical reactions, such as: 83647-43-2, (3-Bromo-2-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 83647-43-2, blongs to alcohols-buliding-blocks compound. Product Details of 83647-43-2

To a solution of 20.00 g (99.47 mmol, 1.0 eq) of (3-bromo-2-methyl-phenyl)methanol 1A and 24.26 g (198.94 mmol, 2.0 eq) of phenylboronic acid in 156 mL of toluene and 52mL of EtOH, were added 812.3 mg (0.995 mmol, 0.01 eq) of Pd(dppf)Cl2.CH2Cl2 and 25.07g (2 M, 149.21 mL, 3.0 eq) of NaHCC under nitrogen gas. The mixture was stirred at 80C for 12 hours. The mixture was separated, and the aqueous phase was extracted with 2 x 400 mL of ethyl acetate (EtOAc). The combined organic phase was washed with 2 x 200 mL of brine, dried over Na2SC>4, filtered and the solvent was concentrated. The residue was purified by column eluted with petroleum ether/ethyl acetate = 25/1-10/1 to give crude product (25 g) as a yellow solid. The solid was smashed in 100 mL of petroleum ether, and the suspension was filtered to give 15.00 g (74.62%) of (2-methyl-[l,l’-biphenyl]-3-yl)methanol as a white solid. lH NMR (400 MHz, CDC13): delta 7.40-7.31 (m, 4H) 7.25-7.22 (m, 3H) 4.75-4.74 (m, 2H) 2.21 (m, 3H) 1.62~1.59(m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,83647-43-2, (3-Bromo-2-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; BI, Yingzhi; DORSEY, Bruce D.; MOORE, Christopher Brooks; (75 pag.)WO2018/200571; (2018); A1;,
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Electric Literature of 52059-53-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

A mixture of 2-(3-fluorophenyl)ethan-1-ol (0.031 g, 0.223 mmol, 5 equiv), 60%NaH (8.90 mg, 0.223 mmol, 5 equiv), and isopropyl (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin- 1 -yl)-6?-fluoro-6-methyl- [3,3 ?-bipyridinj -5-yl)acetate (0.021 g, 0.045 mmol, 1 equiv) in THF (1.5 mL) was stirred at ambient temperature for 1 h. Upon complete addition, 5 M NaOH (0.089 mL, 0.445 mmol, 10 equiv) was added and the mixture was heated at 80 C for 2 h. The reaction was allowed to cool to ambienttemperature, filtered, and purified by preparative reverse phase HPLC to provide the product (10 mg, 40%). ?H NMR (500 MHz, DMSO-d6) 8.18 – 7.97 (m, 2H), 7.73 – 7.60 (m, 1H), 7.40 – 7.29 (m, 1H), 7.21 – 6.94 (m, 3H), 6.93 – 6.83 (m, 1H), 5.86 – 5.75 (m, 1H), 4.62 -4.50 (m, 2H), 3.14 -3.02 (m, 1H), 1.38 – 1.24 (m, 3H), 1.18 – 1.02 (m, 1OH),0.91 – 0.70 (m, 6H). LCMS (M+1): 550.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52059-53-7, 2-(3-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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