Alcohols-buliding-blocks

Electric Literature of 17100-58-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 4-bromo-l-(bromomethyl)-2-methylbenzene; Hydrobromic acid (cone, 2 eq.) was added to a stirred solution of the alcohol from step 1 (1 eq.) in acetic acid (0.22M). The mixture was stirred at 50 C for 12 h, cooled down to room temperature, poured in water and extracted with Et2O. The organic extract was washed with water, aqueous sodium hydrogen carbonate (3x), brine, dried over MgSO4, filtered and concentrated to afford the desired benzyl bromide as a light yellow solid.

According to the analysis of related databases, 17100-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/23964; (2009); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

2-(2-Bromophenyl)propene (6b) was synthesized in a similar way by dehydration of 65.00 g (0.33 mol) of compound 5b with 49.50 g (0.36 mol) of phthalic anhydride. The oily crude product, 49.50 g, was distilled under reduced pressure. Yield 46.50 g (77%), purity 98% (GLC), bp 64-65C (1 mm), d420 = 1.5365,nD20 = 1.5595; MRD 47.50, calcd. 47.46; published data [21]: bp 55-65C (0.9 mm), nD27 = 1.553. IR spectrum,nu, cm-1: 3090, 1648, 910 (C=CH2), 740 (C-Br).1H NMR spectrum, delta, ppm: 2.07 m (3H, CH3), 4.95 mand 5.23 m (2H, =CH2), 7.03-7.37 m (3H, Harom),7.58 d (1H, 3-H, J = 7 Hz). 13C NMR spectrum, deltaC,ppm: 145.5 (C1), 128.1 (C2), 129.5 (C3, C4), 126.9(C5), 132.8 (C6), 121.7 (C7), 116.0 (C8), 23.5 (CH3).Found, %: C 54.51; H 4.40; Br 40.35. C9H9Br. Calculated,%: C 54.85; H 4.60; Br 40.55.

With the rapid development of chemical substances, we look forward to future research findings about 7073-69-0.

Reference:
Article; Fedorov; Fedorova; Sheverdov; Pavlov; Eremkin; Russian Journal of Organic Chemistry; vol. 52; 6; (2016); p. 806 – 812; Zh. Org. Khim.; vol. 52; 6; (2016); p. 806 – 812,7;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. Formula: C13H20O4

2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (1.0 g, 4.16 mmol) and carbon tetrabromide (1.40 g, 4.2 mmol) were dissolved in dichloromethane under an argon atmosphere. The flask was placed in a water bath and triphenylphosphine (1.10 g, 4.2 mmol) in dichloromethane (10 ml_) was added drop-wise over 15 minutes. After stirring for an additional 2 hours at room temperature, the solution was concentrated and the product was purified by flash column chromatography on silica gel (30 g), eluting with a mixture of heptanes/ethyl acetate (3:1 ). The experiment generated ((2-(2-(2- bromoethoxy)ethoxy)ethoxy)methyl)benzene 5 (1 .0 g, 80% yield) as a colorless liquid. 1H NMR (300 MHz, CDCI3): 7.60-7.40 (m, 5H), 4.56 (s, 2H), 3.79 (t, 2H, J = 6.3 Hz), 3.72-3.55 (m, 8H), 3.44 (t, 2H, J = 6.3 Hz). 13C (75 MHz, CDCI3): 138.24, 128.37, 127.74, 127.61 , 73.34, 71.32, 70.83, 70.76, 70.66, 69.55, 30.55.

The synthetic route of 55489-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RODOS BIOTARGET GMBH; AUGUSTUS BIOTARGET, INC.; SCOLARO, Michael, J.; SULLIVAN, Sean, M.; GIESELER, Robert, K.; HOZSA, Constantin; FURCH, Marcus; (68 pag.)WO2017/17148; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2568-33-4, 3-Methylbutane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H12O2, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C5H12O2

Example 2OC; N-r(2Z)-3-butviri.31thiazolor4.5-clpyridin-2(3H)-ylidenel-2-(3-hvdroxy-3-methylbutoxy)-5-(trifluoromethyl)benzamide; 3-Methylbutane-l,3-diol (42 mg, 0.4 mmol) in THF (1 mL) was treated with NaH (60%) (16 mg, 0.4 mmol) at room temperature for 20 min. To the above mixture, which was cooled to 0-5 0C, was added the product from Example 2OB (80 mg, 0.2 mmol) in THF (1 mL). After 20 min. the reaction mixture was quenched with saturated aqueous NaHCO3 (20 mL) and extracted with ethyl acetate (2 x 30 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography using an Analogix Intelliflash280 (SiO2, 0-100 % ethyl acetate in hexanes) to afford 87 mg (90 %) of the title compound. 1H NMR (500 MHz, CDCl3) delta ppm 1.04 (t, J=7.32 Hz, 3 H) 1.36 (s, 6 H) 1.47 – 1.55 (m, 2 H) 1.88 – 1.96 (m, 2 H) 2.13 (t, J=5.80 Hz, 2 H) 4.35 (t, J=5.80 Hz, 2 H) 4.54 (t, J=7.63 Hz, 2 H) 5.12 (brs, 1 H) 7.11 (d, J=8.54 Hz, 1 H) 7.61 (d, J=5.19 Hz, 1 H) 7.74 (dd, J=8.54, 2.14 Hz, 1 H) 8.49 (d, J=5.19 Hz, 1 H) 8.68 (s, 1 H) 8.72 (s, 1 H); MS (ESI+) m/z 482 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; FROST, Jennifer, M.; LATSHAW, Steven, P.; DART, Michael, J.; CARROLL, William, A.; PEREZ-MEDRANO, Arturo; KOLASA, Teodozyj; PATEL, Meena; NELSON, Derek, W.; LI, Tongmei; PEDDI, Sridhar; WANG, Xueqing; LUI, Bo; WO2010/71783; (2010); A1;,
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Electric Literature of 29171-20-8, Adding some certain compound to certain chemical reactions, such as: 29171-20-8, name is 3,7-Dimethyloct-6-en-1-yn-3-ol,molecular formula is C10H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29171-20-8.

EXAMPLE 3 Manufacture of 4-methyl-4-(4-methyl-3-pentenyl)-5-methylene-1,3-dioxolan-2-one According to the methodology described in Example 1, but with a heating period of 8 hours at 20 bar (2000 kPa) and 80¡ã C., and starting from 68.51 g (0.45 mol) of 3,7-dimethyl-oct-1-yn-6-en-3-ol (dehydrolinalool) there are obtained 69.41 g (97.79percent content) of 4-methyl-4-(4-methyl-3-pentenyl)-5-methylene-1,3-dioxolan-2-one; the yield is 76.9percent based on the dehydrolinalool used.

According to the analysis of related databases, 29171-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Roche Vitamins Inc.; US5817838; (1998); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C13H20O4

General procedure: Methanesulfonyl chloride (1.5 equiv.) was added drop-wise to astirred solution of alcohol (1 equiv.) and Et3N (1.5 equiv.) in anhydrousDCM (30 mL) at 0 C under nitrogen. The reaction wasallowed to warm to room temperature, and stirred for 2 h. Thereaction mixture was poured into methanol (10 mL), and concentratedin vacuo. The reaction mixture was then diluted with diethylether (20 mL), washed with water (3 20 mL) and brine(3 20 mL). The combined organic extracts were then dried overanhydrous MgSO4, filtered, and concentrated in vacuo. The residuewas dissolved in DMF (25 mL), sodium azide (3 equiv.) was added, and the mixture was stirred at 60 C for 16 h. The reaction mixturewas concentrated in vacuo, and The reaction mixture was thendiluted with diethyl ether (50 mL), washed with water (3 20 mL)and brine (3 30 mL), dried over anhydrous MgSO4, filtered, andconcentrated in vacuo, to give a residue which was purified by flashchromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55489-58-2, 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol.

Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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Synthetic Route of 26021-57-8 , The common heterocyclic compound, 26021-57-8, name is 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 209.1 mg of 2-ethylbenzene-1 ,4-diamine dihydrochloride (1 mmol) and 151.1 mg of 3-aminophenol (1 mmol) in 2 ml of ethanol and 1 ml of water is adjusted to a pH of 9.5 with 20% aqueous ammonia solution. 0.21 ml of 30% aqueous hydrogen peroxide solution is then added. The reaction medium is stirred at room temperature for 5 hours. The precipitate formed is filtered off, rinsed with water-ethanol and then dried under vacuum. 148 mg of a mixture of isomers of 2-(4-amino-2 or 3-ethylphenylamino)-5-(2- hydroxyethylamino)[1 ,4]benzoquinone, compound (1 ) are isolated in the form of a green- brown powder. MS (ES+): [M+H] = 302.

The synthetic route of 26021-57-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; L’OREAL; SABELLE, Stephane; LEDUC, Madeleine; WO2014/191354; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 111-90-0, blongs to alcohols-buliding-blocks compound. SDS of cas: 111-90-0

To a solution of 3 (0.5 g, 1.78 mmol), DMAP (0.22 g, 1.78 mmol), and diethylene glycol monoethyl ether (0.24 g, 1.78 mmol) in dichloromethane (15 mL) was added portionwise EDCI (0.34 g, 1.78 mmol) at room temperature. After stirring for 2 hrs, the product was extracted with ether (45 mL). The ether solution was washed with water (50 mL), a solution of 1N HCl (10 mL), and water (40 mL), dried over MgSO4, and concentrated. The residue was purified with silica gel column chromatography eluting with ethyl acetate to give compound 8 (0.18 g) as an oil in 25% yield. 1H NMR delta (CDCl3) 1.21 (3H, t, J = 6.9 Hz), 1.75 (6H, brs) 1.84 (2H, quint, J = 6.9 Hz), 1.95 (6H, brs), 2.05 (3H, brs), 2.38 (2H, t, J = 6.9 Hz), 3.18 (2H, q, J = 6.9 Hz), 3.53 (2H, q, , J = 6.9 Hz), 3.61 (2H, t, J = 6.9 Hz), 3.67 (2H, t, J = 6.9 Hz), 3.74 (2H, t, J = 6.9 Hz), 4.25 (2H, t, J = 6.9 Hz), 4.47 (1H, s), 4.62 (1H, s). LC-MS (ESI) m/z calcd for C21H36N2O5 [M + H]+ 397.26, found [M + H]+ 397.32.

The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kim, In-Hae; Nishi, Kosuke; Kasagami, Takeo; Morisseau, Christophe; Liu, Jun-Yan; Tsai, Hsing-Ju; Hammock, Bruce D.; Bioorganic and medicinal chemistry letters; vol. 22; 18; (2012); p. 5889 – 5892,4;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 114686-85-0, name is 2-(2,3-Dichlorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(2,3-Dichlorophenyl)ethanol

A mixture of 2-(2,3-dichlorophenyl)ethanol (0.50 g), NaHCO3 (0.438 g) and Dess-Martin periodinane (1.22 g) in dichloromethane (10 mL) and water (46 mL) was stirred for 1 hour. The mixture was quenched with aqueous NaHCO3 and saturated aqueous Na2S2O3 and extracted with dichloromethane. The extract was dried (Na2SO4), filtered and concentrated. The concentrate was purified on silica gel with an Intelliflash-280 purification system with hexanes/ethyl acetate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 114686-85-0, 2-(2,3-Dichlorophenyl)ethanol.

Reference:
Patent; Sheppard, George S.; Wang, Gary T.; Palazzo, Fabio; Bell, Randy L.; Mantei, Robert A.; Wang, Jieyi; Hubbard, Robert D.; Kawai, Megumi; Erickson, Scott A.; BaMaung, Nwe; Fidanze, Steve D.; US2007/203143; (2007); A1;,
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Electric Literature of 5020-41-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5020-41-7, 2-(3-Methoxyphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
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