Alcohols-buliding-blocks

Sattarinezhad, A.; Roozbeh, J.; Shirazi Yeganeh, B.; Omrani, G. R.; Shams, M. published the artcile< Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial>, SDS of cas: 501-36-0 , the main research area is resveratrol antioxidant albuminuria diabetic nephropathy; Albuminuria; Diabetes complications; Diabetes mellitus; Diabetic nephropathy; Resveratrol.

Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN.In this randomized, double-blind, placebo-controlled clin. trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500 mg/day) or placebo for 90 days. Losartan (12.5 mg/day) was also administered to all participants. Primary outcomes were urinary albumin/creatinine ratio, estimated glomerular filtration rate (eGFR) and serum creatinine levels. Secondary outcomes were oxidative stress markers, and anthropometric and biochem. measures. Mean urine albumin/creatinine ratio was significantly reduced in the resveratrol group vs placebo (-46.4 mg/g, 95% CI: -64.5 to -28.3 vs 29.9 mg/g, 95% CI: 4.9 to 54.9; P < 0.001), whereas eGFR (1.7 mL/min/1.73 m2, 95% CI: -3.4 to 6.8 vs -4.0, 95% CI: -8.2 to 0.2; P = 0.08) and serum creatinine (-0.3 mg/dL, 95% CI: -0.1 to 0.1 vs 0.1 mg/dL, 95% CI: -0.0 to 0.1; P = 0.13) were unchanged. Serum antioxidant enzymes were significantly increased with resveratrol. After adjusting for confounding variables, the effect of resveratrol in reducing urinary albumin excretion was still significant (P < 0.001). Regression anal. revealed that every 1-cm decrease in waist circumference and 1-μmol/L increase in nitric oxide (NO) was associated with 9.4 mg/g and 4.0 mg/g reductions, resp., of urine albumin/creatinine ratio. This clin. trial has shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN (ClinicalTrials.gov: NCT02704494). Diabetes & Metabolism published new progress about Albuminuria. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Masri, Harbi Tomah; Almejled, Akram Ali published the artcile< Hg(II) and Ru(II) complexes of mono- and dichalcogenides of bis(diphenylphosphino)amine chelating ligands: Synthesis, characterization and catalytic activity in transfer hydrogenation of acetophenone derivatives>, Application In Synthesis of 403-41-8, the main research area is ruthenium aminobisphosphino iodo carbonyl complex catalyst preparation crystal structure; transfer hydrogenatio catalyst ruthenium aminobisphosphino iodo carbonyl complex.

Reactions of C10H7-1-N(PPh2)2 (1) and C10H7-1-N(P(Se)Ph2)2 (2) ligands with mercury(II)iodide in equimolar ratio gave cis-[HgI2{-κ2P,P}] (3) and cis-[HgI2{-κ2Se,Se}] (4). Also, refluxing of monooxidized thioyl and selenoyl bis(phosphino)amine ligands C10H7-1-N(P(E)Ph2)(PPh2) (E = S (5), Se (6)) with [Ru(CO)3Cl2]2 dimer afforded cis-[Ru(CO)2Cl2{-κ2P,S}] (7) and cis-[Ru(CO)2Cl2{-κ2P,Se}] (8). Complexes , , and were identified and characterized by multinuclear NMR (1H, 13C, 31P and 77Se NMR) and IR spectroscopy. The mol. structure of was determined by single x-ray crystallog. is the first structurally characterized example of this kind of κ2P,S -bidentate ligand. The novel ruthenium(II) complexes and show high catalytic activity in the transfer hydrogenation of acetophenone derivatives to 1-phenylethanol derivatives in the presence of 2-propanol as the hydrogen source.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Chalcogenides Role: RCT (Reactant), RACT (Reactant or Reagent) (di-). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Utsukihara, Takamitsu; Horiuchi, C. Akira published the artcile< Production of chiral aromatic alcohol by acetophenone and 1-arylethanol derivatives using vegetables>, Computed Properties of 403-41-8, the main research area is Ducus Solanum chiral aromatic alc acetophenone arylethanol.

We have studied the biotransformation of acetophenone derivatives (1a-1f) and 1-arylethanol derivatives (2a-2e, 2g, 2h) using various vegetables. It is found that the reduction of acetophenone derivatives (1a-1f) using carrot (Ducus carota) gives (S)-1-arylethanols with high enantioselectivity. On the other hand, biooxidation of 1-arylethanols (2a-2e, 2g, 2h) using potato (Solanum tuberosum) is oxidized to give (R)-1-arylethanols as major product with high stereoselectivity. Carrot (D. carota) is the best catalyst for this reduction and shows a good reaction yield and enantioselectivity. On the other hand, it is found that the racemic alcs. are converted into the corresponding (R)-alcs. with high ee using Japanese potato (S. tuberosum) as catalyst. The availability of the enzymic system using various vegetables is convenient and an eco-friendly system.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allium cepa. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Caijuan; Li, Guoxun; Mu, Yu; Wu, Wenxi; Cao, Bixuan; Wang, Zixuan; Yu, Hainan; Guan, Peipei; Han, Li; Li, Liya; Huang, Xueshi published the artcile< Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is jamunone analog preparation antitumor triple neg breast cancer.

Twenty-three natural jamunone analogs along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the Me group on chromanone affected the selectivity of mols. against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (I; JM) was screened as the most effective anti-triple-neg. breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R. published the artcile< Liver cell enlargement in rats given hydroxymethylpyrroles analogous to pyrrolizidine alkaloid metabolites, followed later by the hepatotoxin dimethylnitrosamine>, Electric Literature of 52160-51-7, the main research area is hydroxymethylpyrrole DMN liver.

Male rats aged 4-5 wk were given single doses of pyrrolic alcs. having alkylating properties similar to those of pyrrolizidine alkaloid metabolites, followed several days later by 1 of the hepatotoxins, DMN [62-75-9], thioacetamide (TA) [62-55-5] or CCl4 [56-23-5]. After 24-32 days the livers of animals given the pyrroles 1-methyl-2,3-bis(hydroxymethyl)pyrrole (I) [53365-77-8] or 1-phenyl-5-methyl-2,3-bis(hydroxymethyl)pyrrole (II) [68384-87-2] and then DMN, contained enlarged parenchymal cells (megalocytes) similar to those seen in chronic pyrrolizidine alkaloid poisoning. At this time such abnormal cells were not found in rats given any of the other pyrroles followed by DMN, or compound I and then TA or CCl4.

Toxicology Letters published new progress about Liver. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Electric Literature of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alhamed, Samiyah; Alnakhli, Jawzah; Boadi, William; Beni, Ryan published the artcile< Triphenylmethanol conjugates of triptorelin as anti-lipid peroxidation prodrugs>, Electric Literature of 76-84-6, the main research area is triphenylmethanol triptorelin antilipid peroxidation.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable mols. that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% – 30% for the treated samples of synthesized conjugates compared to their resp. control phys. mixtures These data suggest that TRP-TPMs derivatives can be used to improve the biol. activity of TRP.

Open Journal of Medicinal Chemistry published new progress about Lipid peroxidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Rohit; Abbat, Sheenu; Mudududdla, Ramesh; Vishwakarma, Ram A.; Bharatam, Prasad V.; Bharate, Sandip B. published the artcile< ortho-Quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes>, Formula: C8H6O5, the main research area is quinone methide TFA generation water trapping lactam styrene.

A simple and efficient trifluoroacetic acid mediated protocol for ortho-amidomethylation of phenols in aqueous medium was described. Developed protocol has a good substrate scope, involves mild reaction conditions, and products are obtained in good yields. The quantum chem. calculations were performed in implicit solvent (water) conditions, which helped in tracing the reaction mechanism and getting insights on the possible reaction pathway, which involves the N-C bond formation and simultaneous hydrogen transfer to give final product. The applicability of this protocol for 1-pot synthesis of flavans from phenols, formaldehyde and styrene also was demonstrated.

Tetrahedron Letters published new progress about Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adhikary, Subhasis D.; Mandal, Debaprasad published the artcile< Polyoxometalate catalyzed imine synthesis: Investigation of mechanistic pathways>, Application In Synthesis of 5344-90-1, the main research area is preparation crystal structure zinc tungsten polyoxometalate complex; thermal decomposition zinc tungsten polyoxometalate complex; zinc tungsten polyoxometalate complex catalyst imine synthesis; imine preparation.

The syntheses of imines by oxidative coupling of primary alcs. and amines were achieved by using 2 mol% polyoxometalate (POM) Na12[WZn3(H2O)2(ZnW9O34)2] (Zn-WZn3) catalyst in the presence of t-BuOK and di-oxygen with excellent conversion (up to 100%) and selectivity (up to 100%). Non-noble metal-based POM catalyst in the presence of base represents a new reaction protocol for the selective synthesis of imine from both aromatic and aliphatic primary amines with functional group tolerance. Control experiment shows the formation of di-oxygen bind Zn-WZn3 activated species. The electron-d. of POM is mostly situated on the surface oxygen atoms of W-O-W bonds which can engage the alc. OH group and helps for the imine selectivity in the second step of imine synthesis.

Tetrahedron published new progress about Crystal structure. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hou, Chih-Yao; Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung published the artcile< The effects of resveratrol in the treatment of metabolic syndrome>, Reference of 501-36-0 , the main research area is resveratrol metabolic syndrome review; high-fat diet; metabolic syndrome; resveratrol; resveratrol derivatives.

A review. Resveratrol, also known as 3,5,4′-trihydroxystilbene, is a natural polyphenol that occurs as a phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, peanuts, and other oilseeds. This compound has a variety of effects on human health and diseases. This review summarizes the mounting evidence that resveratrol is helpful in treating metabolic syndrome and related disorders. Resveratrol can be provided either early as a reprogramming agent or later as part of treatment. A few of the main mechanisms underlying the beneficial effects of resveratrol on metabolic syndrome are outlined. This review also discusses the potential of resveratrol derivatives as a complementary or alternative medicine. In conclusion, resveratrol could be a useful regimen for the prevention and treatment of metabolic syndrome and its related conditions.

International Journal of Molecular Sciences published new progress about Cardiovascular disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iftikhar, Rabeeya; Ansari, Asma; Siddiqui, Nadir Naveed; Hussain, Fayaz; Aman, Afsheen published the artcile< Structural elucidation and cytotoxic analysis of a fructan based biopolymer produced extracellularly by Zymomonas mobilis KIBGE-IB14>, Synthetic Route of 492-62-6, the main research area is Zymomonas levan cytotoxicity fibroblast biomedical application; Chemical characterization; Cytotoxicity; Exopolysaccharide; Levan; NIH/3T3 Cell line.

Fructan based biopolymers have been extensively characterized and explored for their potential applications. Linear chained biopolymers, like levan-type fructan, have gained attention because they have exhibited unconventional stretchable and unbendable properties along with biodegradable and biocompatible nature. Current study deals with the chem. characterization and cytotoxic anal. of fructose based exopolysaccharide that was extracellularly produced by an indigenously isolated bacterial species (Zymomonas mobilis KIBGE-IB14). Maximum yield of exopolysaccharide (44.7 gL-1) was attained after 72 h of incubation at 30°C under shaking conditions (180 rpm) when the culture medium was supplemented with 150.0 gL-1 of sucrose as a sole carbon source. This exopolysaccharide displayed high water solubility index (96.0%) with low water holding capacity (17.0%) and an intrinsic viscosity of about 0.447 dL g-1. This biopolymer exhibited a characteristic linear homopolysaccharide structure of levan when characterized using Fourier Transform IR (FTIR), NMR (NMR) spectroscopy (1H, 13C, TOCSY and NOESY) while, Atomic Force Microscopy (AFM) revealed its pointed and thorny structure. The decomposition temperature of levan was approx. 245°C as revealed by Thermal Gravimetric Anal. (TGA). X-Ray Diffraction (XRD) results revealed its amorphous nature with crystalline phase. Cytotoxicity of different concentrations of levan was investigated against mouse fibroblast cell lines by measuring their cellular metabolic activity and it was noticed that a higher concentration of levan (2.0 mg ml-1) permitted the normal cell growth of NIH/3T3 cell lines. This non-cytotoxic and biocompatible nature suggests that this levan has the capability to be utilized in food and drug-based formulations as it exhibited biomedical potential.

Carbohydrate Research published new progress about Biocompatibility. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts