Alcohols-buliding-blocks

Mortezaee, Keywan; Najafi, Masoud; Farhood, Bagher; Ahmadi, Amirhossein; Shabeeb, Dheyauldeen; Musa, Ahmed E. published the artcile< Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol anticancer agent cancer; Resveratrol; chemotherapy; molecular targeted therapy; neoplasm; radiation; radiotherapy; tumor microenvironment..

A review. Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clin. studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clin. studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clin. translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

Current Cancer Drug Targets published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mendoza-Pedroza, Jose de Jesus; Sanchez-Ramirez, Eduardo; Segovia-Hernandez, Juan Gabriel; Hernandez, Salvador; Orjuela, Alvaro published the artcile< Recovery of alcohol industry wastes: Revaluation of fusel oil through intensified processes>, Name: 2-Ethylhexan-1-ol, the main research area is alc industry waste fusel oil recovery.

Fusel oil is a mixture obtained as a side cut during ethanol distillation, mainly composed of i-amyl alc., water, ethanol, isobutanol, and other alcs. Currently, fusel separation into the constitutive alcs. is accomplished by batch or continuous distillation involving different columns in an energy-intensive process. Moreover, fusel oil presents a particular thermodn. behavior projected in several azeotropes, making the purification of fusel oil a challenging process. In this work is proposed a novel distillation scheme to purify isoamyl alc. from other fusel alcs. by using a dividing wall column scheme. In order to determine the benefits of using such intensified technol., a comparison with the conventional scheme was carried out. In order to accurately represent the thermodn. equilibrium, data for phase equilibrium was needed to the correctly design of the purification process. Both, the traditional distillation scheme and the dividing wall column were modeled using Aspen Plus and optimized by using a hybrid stochastic algorithm. Results indicate that the dividing wall column is not only more efficient in term of energy intensity (2785 kJ/kg Amyl alc.) against (3497 kJ/Kg Amyl alc.) the conventional scheme, but also it offers large economic savings compared with the conventional scheme (27% savings).

Chemical Engineering and Processing published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Name: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Shu; Wang, Mengya; Qiang, Zhe; Song, Jianchun; Wang, Yue; Fan, Yuchi; You, Zhengwei; Liao, Yaozu; Zhu, Meifang; Ye, Changhuai published the artcile< Multi-functional and highly conductive textiles with ultra-high durability through 'green' fabrication process>, Computed Properties of 87-73-0, the main research area is green conductive GA chitosan polyamide SWCNT composite coated textile.

Conductive textiles with mech. flexibility, long-term durability and stability under harsh conditions are highly desired for potential applications in wearable electronics and devices. One challenge associated with the development of such materials is their fabrication method, which requires to be low-cost, scalable, and environmental-friendly. Herein, we developed a full “”green”” route to fabricate machine-washable conductive textiles by coating textiles with a novel crosslinked and conductive polymer composite coating, using single-walled carbon nanotubes (SWNTs) and bio-mass derived glucaric acid/chitosan (GA-chitosan) organic salt aqueous solution with dip-coating or spray-coating. The crosslinked SWNTs/GA-chitosan polyamide coatings exhibit a high elec. conductivity of up to 7.4 x 102 S/m and high water/organic solvents resistance. The conductive textiles can achieve an exceptional Joule heating performance driven by moderate voltage and exhibit a high electromagnetic interference shielding efficiency of approx. 30 dB at X-band under optimized formulation. The high adhesive energy between the polymer composite coatings and textile substrates enables the ultra-high durability and stability of textiles, confirmed by mech. deformation, rubbing, and washing tests. This simple and organic solvent-free processing method provides an environmentally friendly, cost-effective fabrication approach, holding great promise for large-scale production of multifunctional conductive wearable textiles for EMI shielding and/or personal heating applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Carbon nanotubes (single walled). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kwon, Yu-Jin; Jang, Su-Nyeong; Liu, Kwang-Hyeon; Jung, Dong-Hyuk published the artcile< Effect of Korean red ginseng on cholesterol metabolites in postmenopausal women with hypercholesterolemia: a pilot randomized controlled trial>, SDS of cas: 434-16-2, the main research area is Korean red ginseng cholesterol postmenopause hypercholesterolemia; Korean red ginseng; cholesterol metabolism; menopause; sterols; women.

Korean red ginseng (KRG) is known to exert beneficial effects on cardiovascular health. Meanwhile, reduced estrogen at menopause has been shown to have various adverse impacts on cardiovascular risk factors, including blood lipids. The aim of this pilot study was to investigate the effect of KRG on cholesterol metabolites, which are surrogate markers of cholesterol absorption and biosynthesis, in postmenopausal women with hypercholesterolemia. The present study is an exploratory study which used data from a 4-wk, double-blinded, placebo-controlled clin. pilot study in 68 postmenopausal women with hypercholesterolemia. Patients received KRG (2 g) or placebo (2 g) once daily. The primary endpoints were changes in the levels of nine sterols. Serum sterols were analyzed using liquid chromatog.-mass spectrometry (LC-MS)/MS anal. Among the sterols, reduction in cholesterol level were significantly larger in the KRG group than in the placebo group (the changes: -148.3 ± 261.1 nmol/mL in the ginseng group vs. -23.0 ± 220.5 nmol/mL in the placebo group, p = 0.039). Addnl., changes in 7-hydroxycholesterol (7-OHC) were significantly larger in the KRG group than in the placebo group (the changes: -0.05 ± 0.09 nmol/mL in the ginseng group vs. -0.002 ± 0.1 nmol/mL in the placebo group, p = 0.047). Oxysterols, cholesterol derivates, have been known to play a role in chronic inflammation diseases such as cardiovascular diseases. KRG improves sterol metabolism by decreasing cholesterol and 7-OHC levels in postmenopausal women with hypercholesterolemia.

Nutrients published new progress about Bicycling. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koolivand, Mostafa; Nikoorazm, Mohsen; Ghorbani-Choghamarani, Arash; Tahmasbi, Bahman published the artcile< Cu-citric acid metal-organic framework: Synthesis, characterization and catalytic application in Suzuki-Miyaura cross-coupling reaction and oxidation of sulfides>, Safety of 2-(Phenylthio)ethanol, the main research area is copper citrate metal organic framework preparation catalyst; Suzuki Miyaura cross coupling oxidation sulfide catalyst copper citrate.

Citric acid with three carboxylic groups was used as an outstanding chelating agent was utilized for the preparation of Cu-citric acid metal-organic framework (Cu-CA-MOF). The prepared MOF was characterized by FT-IR, XRD, EDS, AAS, SEM, WDX and BET anal. N2 adsorption-desorption isotherms indicated acceptable BET surface area for Cu-CA-MOF. SEM images were shown that Cu-CA-MOF has geometric polyhedral shapes. Also, catalytic activity of Cu-CA-MOF successfully examined for the Suzuki-Miyaura cross-coupling reaction and chemoselective oxidation of sulfides to sulfoxides.

Applied Organometallic Chemistry published new progress about Adsorption. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< [(PPh3)2NiCl2]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines>, Category: alcohols-buliding-blocks, the main research area is aryl amine methanol nickel catalyst alkylation reaction; arylmethylamine preparation; aminobenzyl alc ethanone nickel catalyst dehydrogenation heterocyclization; quinoline preparation.

Com. available [(PPh3)2NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcs. to deliver diverse secondary amines, including the drug intermediates chloropyramine and mepyramine in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy was also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hoseini, Asma; Namazi, Gholamreza; Farrokhian, Alireza; Reiner, Zeljko; Aghadavod, Esmat; Bahmani, Fereshteh; Asemi, Zatollah published the artcile< The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease>, Application of C14H12O3, the main research area is diet supplement diabetes mellitus coronary heart disease resveratrol.

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 wk. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β -1.09μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β -0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Addnl., resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β -0.21μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD. Food & Function published new progress about Acetylation. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liang, Ying; Li, Yi; Sun, Aidong; Liu, Xianjin published the artcile< Chemical compound identification and antibacterial activity evaluation of cinnamon extracts obtained by subcritical n-butane and ethanol extraction>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is chem compound identification antibacterial activity evaluation cinnamon extract obtained; subcritical butane ethanol extraction; GC‐MS; HPLC‐MS; antibacterial activity; cinnamon; subcritical extraction.

Four important Cinnamomum species in China including C. cassia, C. loureiroi, C. wilsonii, and C. burmannii were chosen to be extracted by subcritical n-butane and ethanol. The chem. compounds of extracts were identified by GC-MS and HPLC-MS, and the antibacterial activities were evaluated by agar-well diffusion assay and twofold microdilution broth method. There were 47 compounds identified in n-butane extracts and 11 compounds in ethanol extracts totally. The major compounds in n-butane extracts varied significantly among different Cinnamomum species, and (E)-cinnamaldehyde and coumarin were major compounds for C. cassia with area percentage of 74.32%; (E)-cinnamaldehyde and a-copaene for C. loureiroi with area percentage of 67.83%; linalool, (E)-cinnamaldehyde, and citral for C. wilsonii with area percentage of 58.74%; and eugenol, (E)-cinnamaldehyde, and coumarin for C. burmannii with area percentage of 76.43%. The maximum compounds in ethanol extracts were (E)-cinnamaldehyde and (Z)-cinnamaldehyde, and others varied among the Cinnamomum species. All cinnamon extracts showed antibacterial activities that n-butane extracts were much more sensitive than ethanol extracts The inhibition zone for N-butane extracts against Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella anatum was from 18.98 to 37.45 mm while for ethanol extracts from 7.11 to 10.11 mm. The min. bactericidal concentrations for n-butane extracts were ranged from 0.31 to 2.50 mg/mL and for ethanol extracts ranged from 20.00 to 160.00 mg/mL. N-butane extracts of C. cassia and C. loureiroi processed much higher antibacterial activities than C. wilsonii and C. burmannii. N-butane extracts of C. cassia and C. loureiroi have the potential to be used as food biopreservative.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qu, Xianfeng; Chen, Xiao; Shi, Qingqing; Wang, Xiaofei; Wang, Dongguo; Yang, Li published the artcile< Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol beclin1 interleukin6 ischemia reperfusion injury diabetic myocardium; diabetes; ischemia/reperfusion injury; resveratrol autophagy.

The rising incidence and complications of diabetes constitutes a major public health issue. The mortality rate of diabetes-induced myocardial ischemia/reperfusion (I/R) injury is significantly elevated. Resveratrol (RSV) is a naturally occurring polyphenol considered to be a potent cardioprotective compound The aim of the present study was to explore the function and mol. mechanism of RSV on diabetes-induced myocardial I/R injury. Left anterior descending coronary artery ligation was performed to stimulate myocardial I/R injury in streptozotocin-induced diabetic rats. Heart elec. activity was monitored through an ECG to confirm successful models. The myocardial infarct volume was detected via 2,3,5-triphenyltetrazolium chloride staining. Western blotting was employed to examine the levels of autophagy markers. It was found that the injection of RSV mitigated the ischemia- or I/R injury-induced myocardial damage on hemodynamic function and infarct size, but the autophagy inhibitor 3-methyladenine significantly blocked the function of RSV. Furthermore, the application of RSV significantly enhanced the expression of Beclin-1 and LC-3II but inhibited the serum levels of tumor necrosis factor-α and interleukin-6. These findings revealed an alleviating effect of RSV on diabetes-induced myocardial I/R injury and provided new evidence for the successful application of RSV on the diabetic myocardium.

Experimental and Therapeutic Medicine published new progress about Autophagy. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An, Taeyang; Lee, Yan published the artcile< Nucleophilic Substitution at the Guanidine Carbon Center via Guanidine Cyclic Diimide Activation>, Category: alcohols-buliding-blocks, the main research area is guanidine carbon center preparation; amine guanidine cyclic diimide nucleophilic substitution; alc guanidine cyclic diimide nucleophilic substitution.

Despite the electron-deficient nature of the guanidine carbon centers R1NHC(NH2)=NH+R2Cl- (R1 = n-Bu, Ph, cyclohexyl, etc.; R2 = Ph, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, etc.) and R1NHC(O)NHC(O)(CH2)2C(O)OR2, nucleophilic reactions at these sites have been underdeveloped due to the resonance stabilization of the guanidine group. A guanidine C-N bond substitution strategy entailing the formation of guanidine cyclic diimide (GCDI) structures I, which effectively destabilize the resonance structure of the guanidine group was proposed. In the presence of acid additives, the guanidine carbon center of GCDIs I undergoes nucleophilic substitution reactions with various amines R2NH2 and alcs. R2OH.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts