Category: alcohols-buliding-blocks

Jana, Rahul Dev published the artcileDioxygen Activation and Mandelate Decarboxylation by Iron(II) Complexes of N4 Ligands: Evidence for Dioxygen-Derived Intermediates from Cobalt Analogues, Application In Synthesis of 90-64-2, the publication is Inorganic Chemistry (2022), 61(27), 10461-10476, database is CAplus and MEDLINE.

The isolation, characterization, and dioxygen reactivity of monomeric [(TPA)M^II(mandelate)]⁺ (M = Fe, 1; Co, 3) and dimeric [(BPMEN)₂M₂^II(μ-mandelate)₂]²⁺ (M = Fe, 2; Co, 4) (TPA = tris(2-pyridylmethyl)amine and BPMEN = N¹,N²-dimethyl-N¹,N²-bis(pyridin-2-yl-methyl)ethane-1,2-diamine) complexes are reported. The iron(II)- and cobalt(II)-mandelate complexes react with dioxygen to afford benzaldehyde and benzoic acid in a 1:1 ratio. In the reactions, one oxygen atom from dioxygen is incorporated into benzoic acid, but benzaldehyde does not derive any oxygen atom from dioxygen. While no O₂-derived intermediate is observed with the iron(II)-mandelate complexes, the analogous cobalt(II) complexes react with dioxygen at a low temperature (-80°) to generate the corresponding cobalt(III)-superoxo species (S), a key intermediate implicated in the initiation of mandelate decarboxylation. At -20°, the cobalt(II)-mandelate complexes bind dioxygen reversibly giving μ-1,2-peroxo-dicobalt(III)-mandelate species (P). The geometric and electronic structures of the O₂-derived intermediates (S and P) were established by computational studies. The intermediates S and P upon treatment with a protic acid undergo decarboxylation to afford benzaldehyde (50%) with a concomitant formation of the corresponding μ-1,2-peroxo-μ-mandelate-dicobalt(III) (P1) species. The crystal structure of a peroxide species isolated from the cobalt(II)-carboxylate complex [(TPA)Co^II(MPA)]⁺ (5) (MPA = 2-methoxyphenylacetate) supports the composition of P1. The observations of the dioxygen-derived intermediates from cobalt complexes and their electronic structure analyses not only provide information about the nature of active species involved in the decarboxylation of mandelate but also shed light on the mechanistic pathway of two-electron vs. four-electron reduction of dioxygen.

Inorganic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dhiman, Mahak published the artcileOrganosilane oxidation with a half million turnover number using fibrous nanosilica supported ultrasmall nanoparticles and pseudo-single atoms of gold, Name: Triisopropylsilanol, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2017), 5(5), 1935-1940, database is CAplus.

The combination of ultrasmall nanoparticles and pseudo-single atoms of gold (Au) and fibrous nanosilica (KCC-1) functionalized with 3-aminopropyltriethoxysilane (APTS) enabled the design of KCC-1-APTS/Au nanocatalysts with very high turnover numbers (TONs). KCC-1-APTS/Au catalyzed the oxidation of organosilanes to silanols, with a TON of approx. half a million (591 000 for dimethylphenyl silane as a model substrate). Addnl., the figure-of-merit (FOM), which provides an integrated view of the rate of the reaction, the energy required, the reaction scale and the recyclability of the catalysts, was 633 mmol h^-1 K^-1. KCC-1-APTS/Au also catalyzed two addnl. challenging reactions, the alcoholysis of silane and the hydrosilylation of aldehydes, with very high TONs. These characteristics make KCC-1-APTS/Au a versatile nanocatalyst.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dhiman, Mahak published the artcileOrganosilane oxidation with a half million turnover number using fibrous nanosilica supported ultrasmall nanoparticles and pseudo-single atoms of gold, Synthetic Route of 597-52-4, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2017), 5(5), 1935-1940, database is CAplus.

The combination of ultrasmall nanoparticles and pseudo-single atoms of gold (Au) and fibrous nanosilica (KCC-1) functionalized with 3-aminopropyltriethoxysilane (APTS) enabled the design of KCC-1-APTS/Au nanocatalysts with very high turnover numbers (TONs). KCC-1-APTS/Au catalyzed the oxidation of organosilanes to silanols, with a TON of approx. half a million (591 000 for dimethylphenyl silane as a model substrate). Addnl., the figure-of-merit (FOM), which provides an integrated view of the rate of the reaction, the energy required, the reaction scale and the recyclability of the catalysts, was 633 mmol h^-1 K^-1. KCC-1-APTS/Au also catalyzed two addnl. challenging reactions, the alcoholysis of silane and the hydrosilylation of aldehydes, with very high TONs. These characteristics make KCC-1-APTS/Au a versatile nanocatalyst.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Synthetic Route of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Zhi-Qiang published the artcilePreparation of porous carbon spheres from 2-keto-L-gulonic acid mother liquor by oxidation and activation for electric double-layer capacitor application, Quality Control of 526-98-7, the publication is Journal of Colloid and Interface Science (2018), 20-27, database is CAplus and MEDLINE.

A strategy is proposed for the increase of sp. surface area (SSA) of porous carbon sphere (PCS) by oxidation and activation. 2-keto-L-gulonic acid mother liquor (GAML) as a high-pollution waste has a relatively high value of reutilization. For its high value-added utilization, GAML is used as the precursor for preparation of PCS as carbon-based electrode materials for elec. double-layer capacitor. PCS is prepared by hydrothermal carbonization, carbonization and KOH activation, and Fe(NO₃)₃ 9H₂O is used as an oxidizing agent during carbonization. The as-prepared PCS has excellent porosity and high SSA of 2478 m² g^-1. Meanwhile, the pore structure of PCS can be controlled by the adjustment of carbonization parameters (carbonization temperature and the loading of Fe(NO₃)₃ 9H₂O). Besides, the SSA and specific capacitance of PCS can be increased remarkably when Fe(NO₃)₃ 9H₂O is added in carbonization. The specific capacitance of PCS can reach 303.7 F g^-1 at 40 mA g^-1. PCSs as electrode material have superior electrochem. stability. After 8000 cycles, the capacitance retention is 98.3% at 2 A g^-1. The elec. double-layer capacitance of PCS is improved when CS is carbonized with Fe(NO₃)₃ 9H₂O, and the economic and environmental benefits are achieved by the effective recycle of GAML.

Journal of Colloid and Interface Science published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Zhi-Qiang published the artcilePreparation of porous carbon sphere from waste sugar solution for electric double-layer capacitor, Formula: C6H10O7, the publication is Journal of Power Sources (2017), 249-258, database is CAplus.

Waste sugar solution (WSS), which contains abundant 2-keto-L-gulonic acid, is harmful to the environment if discharged directly. For value-added use of the waste resource, a novel process is developed for preparation of porous C spheres by hydrothermal carbonization (HTC) of WSS followed by KOH activation. Addnl., the possible preparation mechanism of C spheres is proposed. The effects of hydrothermal and activation parameters on the properties of the C sphere are also studied. The C sphere is applied to elec. double-layer capacitor and its electrochem. performance is studied. The C sphere obtained by HTC at 180° for 12 h with the WSS/deionized H₂O volume ratio of 2/3 possess the highest specific capacitance under identical activation conditions. The specific capacitance of the C spheres can reach 296.1 F g^-1 at a c.d. of 40 mA g^-1. Besides, excellent cycle life and good capacitance retention (89.6%) are observed at 1.5 A g^-1 after 5000 cycles. This study not only provides a facile and potential method for the WSS treatment, but also achieves the high value-added recycling of WSS for the preparation of porous C spheres with superior electrochem. properties.

Journal of Power Sources published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Zuobing published the artcileCharacterization of the key aroma compounds in three world-famous black teas, Application In Synthesis of 106-25-2, the publication is European Food Research and Technology (2022), 248(9), 2237-2252, database is CAplus.

The volatile compounds of three world-famous black teas (Darjeeling, DJL, Keemun, KM, and Ceylon, CL) were extracted by stir bar sorptive extraction (SBSE), and analyzed by gas chromatog.-olfactometry (GC-O), gas chromatog.-mass spectrometry (GC-MS). The results indicated that 78, 76, and 69 volatile compounds were detected in the three tea infusions. And 9 sulfur compounds in black teas were identified by gas chromatog.-flame photometric detection (GC-FPD). In addition, a total of 42 aroma compounds were perceived and 38 compounds were identified as important aroma compounds due to their high odor activity values (OAVs), such as 3-methylbutanal (OAV: 24-82), linalool (OAV: 24-64), geraniol (OAV: 2-97), β-ionone (OAV: 54-122), and cis-jasmone (OAV: 2-119). According to the results of aroma recombination and omission experiments, 2-methylbutanal, linalool, Me salicylate and β-cyclocitral were confirmed to be the key aroma compounds in Darjeeling black tea, 3-methylbutanal, hexanal, β-myrcene, and Me salicylate were the key aroma compounds in Keemun, while β-ionone, linalool, 2-methylbutanal, and salicylaldehyde were the key aroma compounds in Ceylon black tea.

European Food Research and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C11H16BNO3, Application In Synthesis of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zong, Fang published the artcileEfficacy of carboprost tromethamine combined with leonurus japonicus for prevention of postpartum hemorrhage in high-risk pregnant women: A protocol for systematic review and meta-analysis, Related Products of alcohols-buliding-blocks, the publication is Medicine (Philadelphia, PA, United States) (2021), 100(30), e26792, database is CAplus and MEDLINE.

No well-designed and systematic evaluation of the efficacy and safety of leonurus japonicus injection (LJI) in combination with carboprost tromethamine has been found. Therefore, we undertook a meta-anal. to assess the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage in high-risk pregnant women to provide new evidence-based medical evidence for clin. treatment. This systematic review and meta-anal. would be performed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The following databases including EMBASE, MEDICINE, Wanfang, China National Knowledge Infrastructure database, and Cochrane central controlled trial registries were searched by 2 reviewers from inception to July 2021. Mesh and keyword search terms were “motherwort,” “Yimucao,” “leonurus japonicas,””carboprost tromethamine,” and “postpartum hemorrhage”. Any cohort studies that assessed the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage would be included. P05 was set as the level of significance. The review would add to the existing literature by showing compelling evidence and improved guidance in clinic settings.

Medicine (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wen, Xin published the artcilePreparation of a novel two-dimensional carbon material and enhancing Pb(II) removal by tri-isopropanolamine, Recommanded Product: Triisopropanolamine, the publication is Desalination and Water Treatment (2018), 253-262, database is CAplus.

A novel tri-isopropanolamine functionalized graphene oxide (TI-GO) adsorbent was synthesized by one-step reaction at 358K. Then the prepared TI-GO was characterized by SEM-EDS, FTIR, Raman spectra, TG, BET and XPS. The characterization results indicated the TI-GO has been synthesized successfully and it interact with Pb(II) ions through its nitrogen and oxygen-containing functional groups. Batch adsorption experiments were applied to evaluate the optimized conditions of adsorption. The results indicated that the TI-GO can reach equilibrium adsorption in 30 min and get maximum adsorption capacity at 293 K, pH 5.0. Besides, the adsorption kinetic and adsorption isotherm research indicated that the adsorption of TI-GO fit pseudo-second-order (PSO) kinetic and Langmuir adsorption isotherm model. In addition, the maximum adsorption capacity evaluated by Langmuir adsorption isotherm equation is 1478 mg/g.

Desalination and Water Treatment published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C37H30ClIrOP2, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zaksauskas, Audrius published the artcileMethyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX, Quality Control of 4410-99-5, the publication is International Journal of Molecular Sciences (2022), 23(1), 130, database is CAplus and MEDLINE.

Among the twelve catalytically active carbonic anhydrase isoenzymes present in the human body, the CAIX is highly overexpressed in various solid tumors. Many attempts have been made to design chem. compounds that would exhibit high affinity and selective binding to CAIX over the remaining eleven catalytically active CA isoenzymes to limit undesired side effects. Herein, a series of compounds, Me 5-sulfamoyl-benzoates, which bear a primary sulfonamide group, a well-known marker of CA inhibitors is designed and their affinities for all twelve CA isoenzymes has been determined. Variations of substituents on the benzenesulfonamide ring led to compound Me 2-bromo-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate, which exhibited an extremely high observed binding affinity to CAIX; the K_d was 0.12 nM. The intrinsic dissociation constant, where the binding-linked protonation reactions have been subtracted, reached 0.08 pM. The compound also exhibited more than 100-fold selectivity over the remaining CA isoenzymes. The X-ray crystallog. structure of compound Me 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate bound to CAIX showed the structural position, while several structures of compounds bound to other CA isoenzymes showed structural reasons for compound selectivity towards CAIX. Since this series of compounds possess physicochem. properties suitable for drugs, they may be developed for anticancer therapeutic purposes.

International Journal of Molecular Sciences published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H6BF3O3, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Winterton, Sarah E. published the artcileDiscovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase, Product Details of C11H8O3, the publication is Journal of Medicinal Chemistry (2018), 61(12), 5199-5221, database is CAplus and MEDLINE.

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an anal. of the structure-activity relationships related to metabolic activation and SCD inhibition.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H21BO2Si, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts