Category: alcohols-buliding-blocks

Hecht, Stephen S. published the artcileA study of chemical carcinogenesis. II. Synthesis of N-nitrosamino aldehydes, HPLC of Formula: 4543-95-7, the publication is Tetrahedron Letters (1976), 593-6, database is CAplus.

The alcs. RNHCHR1(CH2)3OH (I; R = Pr, Me, PhCH2, R1 = H) were prepared from Cl(CH2)4OH and the corresponding amine; I (R = Me, R1 = 3-pyridyl) was prepared by condensation of Et nicotinate with butyrolactone to give dihydro-3-(3-pyridoyl)-2-(3H)-furanone, which was successively hydrolyzed, decarboxylated, and treated with NaBH3CN and MeNH2. Nitrosation of I with NaNO2 gave RN(N:O)CHR1(CH2)3OH which was oxidized with dicyclohexylcarbodiimide in DMSO to give RN(N:O)CHR1(CH2)2CHO. The aldehydes were mixtures of Z- and E-isomers.

Tetrahedron Letters published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, HPLC of Formula: 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsai, Yan-Ting published the artcileSelective C_α Alcohol Oxidation of Lignin Substrates Featuring a β-O-4 Linkage by a Dinuclear Oxovanadium Catalyst via Two-Electron Redox Processes, SDS of cas: 70110-65-5, the publication is European Journal of Inorganic Chemistry (2019), 2019(43), 4637-4646, database is CAplus.

Developing highly efficient catalyst systems to transform lignin biomass into value-added chem. feedstocks is imperative for using lignin as renewable alternatives to fossil fuels. Recently, the pre-activated strategy involving the selective oxidation of C_α alc. of lignin substrates containing (β-O-4) linkage mode significantly increases the depolymerization efficiency of native aspen lignin from 10-20 to 60 weight-%. the authors reported the synthesis of a dinuclear oxovanadium complex 2 that is capable of selectively oxidizing the C_α alc. (80-100% selectivity) of various dimeric lignin substrates under a mild condition. Further study of catalytic mechanism revealed that two V=O motifs of complex 2 could serve as proton abstraction sites for both C_α and C_γ alc. of dimeric lignin substrates, resp. The dinuclear vanadium intermediate 4 demonstrates the ability to uptake two electrons resulting from the oxidation of C_α alc. and yields two corresponding mononuclear V^IV intermediate 5. The mononuclear V^IV intermediate 5 exhibits a characteristic 8-line EPR spectrum and possesses one unpaired electron determined by the Evans method. The established structure-reactivity relations will be able to shed light on the future directions for rational design of highly efficient catalysts for selective oxidation of lignin biomass.

European Journal of Inorganic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C10H8N4, SDS of cas: 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pei, Zhonghua published the artcileExploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates, Quality Control of 73303-88-5, the publication is Molecular Pharmaceutics (2018), 15(9), 3979-3996, database is CAplus and MEDLINE.

A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation (disulfide cleavage) in vitro in the presence of either glutathione (GSH) or cysteine (Cys). A good correlation was observed between in vitro GSH stability and in vitro cytotoxicity toward tumor cell lines. The prodrug-containing compounds were typically more potent against cells with relatively high intracellular GSH levels (e.g., KPL-4 cells). Several antibody-drug conjugates (ADCs) were subsequently constructed from PBD dimers that incorporated selected disulfide-based prodrugs. Such HER2 conjugates exhibited potent antiproliferation activity against KPL-4 cells in vitro in an antigen-dependent manner. However, the disulfide prodrugs contained in the majority of such entities were surprisingly unstable toward whole blood from various species. One HER2-targeting conjugate that contained a thiophenol-derived disulfide prodrug was an exception to this stability trend. It exhibited potent activity in a KPL-4 in vivo efficacy model that was approx. three-fold weaker than that displayed by the corresponding parent ADC. The same prodrug-containing conjugate demonstrated a three-fold improvement in mouse tolerability properties in vivo relative to the parent ADC, which did not contain the prodrug.

Molecular Pharmaceutics published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Quality Control of 73303-88-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yasin Tabatabaei Dakhili, S. published the artcileRecombinant silicateins as model biocatalysts in organosiloxane chemistry, Category: alcohols-buliding-blocks, the publication is Proceedings of the National Academy of Sciences of the United States of America (2017), 114(27), E5285-E5291, database is CAplus and MEDLINE.

The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers. The enzymes’ kinetic parameters were obtained by a high-throughput colorimetric assay based on the hydrolysis of 4-nitrophenyl silyl ethers. These assays showed unambiguous catalysis with k_cat/K_m values on the order of 2-50 min^-1 μM^-1. Condensation reactions were also demonstrated by the generation of silyl ethers from their corresponding silanols and alcs. Notably, when presented with a substrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the latter group, in clear contrast to nonenzymic silylations. Furthermore, the silicateins are able to catalyze transetherifications, where the silyl group from one silyl ether may be transferred to a recipient alc. Despite close sequence homol. to the protease cathepsin L, the silicateins seem to exhibit no significant protease or esterase activity when tested against analogous substrates. Overall, these results suggest the silicateins are promising candidates for future elaboration into efficient and selective biocatalysts for organosiloxane chem.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4H6N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Botero, David published the artcileComparative study of pyrantel pamoate, bephenium hydroxynaphthoate, and tetrachloroethylene in the treatment of Necator americanus infections, HPLC of Formula: 3818-50-6, the publication is American Journal of Tropical Medicine and Hygiene (1972), 22(1), 45-52, database is CAplus and MEDLINE.

A study of 105 patients with the hookworm N. americanus infections was undertaken to compare the new anthelmintic pyrantel pamoate (I-pamoate) [22204-24-6] and 2 commonly used drugs bephenium hydroxynaphthoate [3818-50-6] and tetrachloroethylene [127-18-4]. I, in a dose of 10 mg/day, orally, for 3 days, had action comparable or superior to the other drugs against the hookworm. In addition, I caused an almost 100% cure rate in patients infected with Ascaris lumbricoides, and caused a slight decrease in egg count in patients infected with Trichuris trichiura. I was tolerated well and no toxic effects were observed by hematol. and biochem. examination

American Journal of Tropical Medicine and Hygiene published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Dominguez, Raul published the artcileFood and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study, Related Products of alcohols-buliding-blocks, the publication is Molecular Nutrition & Food Research (2021), 65(23), 2100606, database is CAplus and MEDLINE.

Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. The article studies the long-term prospective Three-City Cohort, which consists of two sep. nested case-control sample sets from different geog. regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychol. tests (Mini-Mental State Examination, Benton Visual Retention Test, Isaac’s Set Test, Trail-Making Test part A, and Trail-Making Test part B). The food-related and microbiota-derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large-scale quant. metabolomics anal. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol-rich foods, and cognitive decline, as well as a neg. association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alc. These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.

Molecular Nutrition & Food Research published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vlckova, Hana Kocova published the artcileFeaturing ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma, Product Details of C8H8O3, the publication is Journal of Separation Science (2021), 44(9), 1893-1903, database is CAplus and MEDLINE.

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments

Journal of Separation Science published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C13H26N2, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Minero, Claudio published the artcileRole of adsorption in photocatalyzed reactions of organic molecules in aqueous titania suspensions, Formula: C22H38O2, the publication is Langmuir (1992), 8(2), 481-6, database is CAplus.

The photocatalyzed transformation of chem. compounds strongly adsorbed on a particle surface was investigated in the presence of different photoactive and “inert” supports. For several compounds, such as dioctylquinol and chrysene, the rate of degradation is only slightly affected by the initial adsorption onto nonphotocatalytic materials (SiO₂, Al₂O₃) when irradiated in a slurry with added micrometer size TiO₂ particles. A rapid exchange of the substrate between the different inorganic supports was exptl. observed and explains the photocatalytic results. Decafluorobiphenyl (DFBP), which adsorbs tenaciously on Al₂O₃, degrades slowly when irradiated in the presence of TiO₂ particles. Measurements confirm that DFPB is poorly exchanged from alumina to TiO₂. Comparison with the results obtained using colloidal TiO₂ or silica particles, and with the behavior of pentafluorophenol, under otherwise identical conditions, suggests that the photogenerated oxidizing species does not migrate far from the photogenerated active centers and that the degradation process occurs at the surface or within a few monolayers around the photocatalytic particles.

Langmuir published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fernández de Arriba, A published the artcileInhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid., Synthetic Route of 328-90-5, the publication is Molecular pharmacology (1999), 55(4), 753-60, database is MEDLINE.

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.

Molecular pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Arriba, Alberto Fernandez published the artcileInhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid, HPLC of Formula: 328-90-5, the publication is Molecular Pharmacology (1999), 55(4), 753-760, database is CAplus.

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E₂ (PGE₂) production (IC₅₀ = 0.16, 0.18, 0.39, and > 10 mM, resp.). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE₂ production (ID₅₀ = 18.9 and 11.4 mg/kg p.o., resp.) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-κB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE₂ synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathol. situations in which genes under nuclear factor-κB control are up-regulated.

Molecular Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts