Category: alcohols-buliding-blocks

Lim, Soobin published the artcileCobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation, Synthetic Route of 23351-09-9, the publication is Organic Letters (2020), 22(18), 7387-7392, database is CAplus and MEDLINE.

Transition-metal-catalyzed transformations of the C-F bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein the authors report a practical Co-catalyzed silylation of aryl fluorides that uses a cheap electrophilic Si source with Mg. This method is compatible with various Si sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic Si source.

Organic Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Synthetic Route of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Payne, China M. published the artcile5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions, HPLC of Formula: 622-40-2, the publication is RSC Advances (2019), 9(53), 30736-30740, database is CAplus and MEDLINE.

Norbornenone derivative, obtained from the reaction of 2,5-dimethyl-3,4-diphenylcyclopentadienone dimer with bromomaleic anhydride, provided an excellent base-triggered source of carbon monoxide for palladium-catalyzed carbonylation reactions. Aminocarbonylation, ketoamide synthesis, and Suzuki-Miyaura reactions of aryl iodides carried out in a two-chamber reaction vessel gave good to excellent yields of carbonylated products.

RSC Advances published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, HPLC of Formula: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Jinwoong published the artcileComputer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor, Product Details of C6H13NO2, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 1314-1320, database is CAplus and MEDLINE.

BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irresp. of RAS, resulting in melanoma-like cancer. Over the years, small mols. targeting BRAFV600E have been discovered to be very effective melanoma drugs, but they are known to cause the BRAF paradox. Recently, it was shown that this paradox is caused by the heterodimer phenomenon of BRAF/CRAF. Here, we suggest one method by which paradoxical activation can be avoided by selectively inhibiting BRAFV600E and CRAF but not wild-type BRAF. From previous report of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl) aryl amide as a selective inhibitor of BRAFV600E and CRAF, we present compounds that offer enhanced selectivity and efficacy with the aid of mol. modeling.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Product Details of C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xiushang published the artcileSynthesis and characterization of dibenzo[hi,st]ovalene as a highly fluorescent polycyclic aromatic hydrocarbon and its π-extension to circumpyrene, Formula: C8H5F3O3, the publication is Yuki Gosei Kagaku Kyokaishi (2020), 78(11), 1094-1104, database is CAplus.

This account described the synthetic approaches to dibenzo[hi,st]ovalene (DBOV) as a novel PAH with a combination of armchair and zigzag edges and the elucidation of its unique optoelectronic and photophys. properties, such as strong red emission with a fluorescence quantum yield of up to 0.89 and stimulated emission. Furthermore, DBOV demonstrated the so-called fluorescence blinking that enables its application as a fluorophore in single-mol. localization microscopy, which is one of the modern superresoln. fluorescence microscopy methods. The self-assembly of a DBOV derivative bearing two 3,4,5-tris(dodecyloxy)phenyl groups was also investigated, showing the formation of helical columnar stacks. On the other hand, the regioselective bromination of DBOV was achieved, allowing the postsynthetic functionalization and modulation of the optoelectronic properties. Moreover, π-extension of the DBOV at the bay regions led to circumpyrene, the largest circumarene synthesized to date.

Yuki Gosei Kagaku Kyokaishi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C6H5NO, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tu, Ya-lin published the artcileDiscovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is RSC Advances (2016), 6(63), 58516-58520, database is CAplus.

A series of lipoic acid (LA) and 4-phenyl-1H-pyrazole hybrids as bifunctional Rho-associated kinase (ROCK) inhibitors were designed, synthesized and evaluated. Compound 15 is identified to be a novel potent bifunctional ROCK inhibitor with antioxidant activity and neuroprotection.

RSC Advances published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C11H12O4, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Wenbo published the artcileSynthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Journal of Organic Chemistry (2019), 84(9), 5655-5666, database is CAplus and MEDLINE.

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde di-Et acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zema, Zelalem Anja published the artcileTuning the CO₂ absorption and physicochemical properties of K⁺ chelated dual functional ionic liquids by changing the structure of primary alkanolamine ligands, Application of 2-Aminobutan-1-ol, the publication is Journal of Molecular Liquids (2021), 117983, database is CAplus.

To reveal the effects of the alkyl substitutions at alpha (α) or beta (β) position adjacent to amino group of primary alkanolamine ligands on CO₂ absorption and physicochem. properties of metal chelated dual functional ionic liquids (DFILs), four DFILs were prepared by reacting potassium imidazole salt (KIm) with alkanolamine ligands, including 2-amino-2-methyl-1-propanol (AMP), 2-amino-1-butanol (AMB), DL-1-amino-2-propanol (DLAMP), and monoethanolamine (MEA). CO₂ absorption behavior and mechanism of DFILs were studied, and d. (ρ), speed of sound (u), and viscosity (η) of DFILs were measured to correlate with the CO₂ absorption performance. DFT calculations were employed to explore the influence of the interactions between K⁺ and alkanolamine on the CO₂ absorption and physicochem. properties of DFILs. The results show that CO₂ capacity at 333.2 K is as follows: [K(AMP)₂][Im] > [K(AMB)₂][Im] > [K(DLAMP)₂][Im] > [K(MEA)₂][Im], indicating that the introduction of alkyl group at α or β position of alkanolamines can enhance CO₂ capacity, and the effect of the α position is more significant than the β position. Both ρ and u follow the order: [K(AMP)₂][Im] < [K(AMB)₂][Im] < [K(DLAMP)₂][Im] < [K(MEA)₂][Im], while η is in the reverse order. Moreover, the saturated CO₂ capacity of DFILs has an approx. linear relation with the thermal expansion coefficient DFT calculations show that the presence of the alkyl group at α or β position of alkanolamines reduces the Mulliken charge of N and O atom, thereby weakening the cation coordination interaction between K⁺ with ligand, resulting in the decrease in ρ and u of DFILs. Moreover, the decrease in the Mulliken charge of N and O atom in alkanolamine leads to the increase of chelated cation-[Im]^– interaction, thereby increasing η of DFILs. Consequently, [K(AMP)₂][Im] exhibits higher CO₂ capacity and good reversibility, due to the fact that CO₂ can react with the chelated cation and [Im]^– simultaneously. The present study provides a new method for effectively regulating the performance of DFILs.

Journal of Molecular Liquids published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H15NO6S, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guan, Weixiang published the artcileHighly Dispersed Rh/NbO_x Invoking High Catalytic Performances for the Valorization of Lignin Monophenols and Lignin Oil into Aromatics, HPLC of Formula: 645-56-7, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(9), 3529-3541, database is CAplus.

As fossil fuels are constantly depleted, valorization of lignocellulosic biomass into valuable aromatic compounds is of great significance but exceedingly challenging. In this work, the structure and catalytic performance of various Rh/Nb₂O₅ catalysts were studied in detail via the catalytic hydrodeoxygenation of a representative lignin monophenol compound 2-methoxy-4-propylphenol. The best catalytic performance was obtained over Rh/Nb₂O₅-400 (Nb₂O₅ calcined at 400°C) with an exceptional 98% yield of propylbenzene under 0.5 MPa H₂, which was mainly due to the cooperation between highly dispersed Rh metals and NbO_x species, in which Rh was responsible for dissociation of H₂ and NbO_x for breaking of C-O bonds at the metal-support interface. Besides, the lignin oil obtained in depolymerization of raw pine wood was directly used as the substrate in the catalytic hydrodeoxygenation reaction over the Rh/Nb₂O₅-400 catalyst under 0.5 MPa H₂. Encouragingly, the liquid products were identified and found that lignin oil was completely converted into C₆-C₁₀ hydrocarbons (>99% selectivity) with an 80.1 mol % yield of aromatics The results achieved in this work highlighted that high-value utilization of lignocellulosic biomass feedstocks to produce aromatic chems. and liquid fuels could be achieved over Rh/Nb₂O₅ under a low hydrogen pressure.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, HPLC of Formula: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chong, Curtis R. published the artcileA clinical drug library screen identifies astemizole as an antimalarial agent, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Nature Chemical Biology (2006), 2(8), 415-416, database is CAplus and MEDLINE.

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery the authors created a library of 2687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Nature Chemical Biology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Dawei published the artcileAn efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO₂ under microwave irradiation, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Monatshefte fuer Chemie (2016), 147(9), 1605-1614, database is CAplus.

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, ¹H NMR, and ¹³C NMR spectroscopy. Solid support SiO₂ possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO₂. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.

Monatshefte fuer Chemie published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C6H6N2O, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts