Category: alcohols-buliding-blocks

Spell, Mark L. published the artcileA Visible-Light-Promoted O-Glycosylation with a Thioglycoside Donor, Quality Control of 85618-21-9, the publication is Angewandte Chemie, International Edition (2016), 55(22), 6515-6519, database is CAplus and MEDLINE.

Visible-light irradiation of 4-p-methoxyphenyl-3-butenylthioglucoside donors in the presence of Umemoto’s reagent and alc. acceptors serves as a mild approach to O-glycosylation. Visible-light photocatalysts are not required for activation, and alkyl- and arylthioglycosides not bearing the p-methoxystyrene are inert to these conditions. Exptl. and computational evidence for an intervening electron donor-acceptor complex, which is necessary for reactivity, is provided. Yields with primary, secondary, and tertiary alc. acceptors range from moderate to high. Complete β-selectivity can be attained through neighboring-group participation.

Angewandte Chemie, International Edition published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C8H7N3, Quality Control of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Saxena, A. K. published the artcileModelling the binding affinity of steroids to zebrafish sex hormone-binding globulin, Synthetic Route of 1139-46-4, the publication is SAR and QSAR in Environmental Research (2014), 25(5), 407-421, database is CAplus and MEDLINE.

The circulating endogenous steroids are transported in the bloodstream. These are bound to a highly specific sex hormone-binding globulin (SHBG) and in lower affinity to proteins such as the corticosteroid-binding protein and albumin in vertebrates, including fish. It is generally believed that the glycoprotein SHBG protects these steroids from rapid metabolic degradation and thus intervenes in its availability at the target tissues. Endocrine disrupters binding to SHBG affect the normal activity of natural steroids. Since xenobiotics are primarily released in the aquatic environment, there is a need to evaluate the binding affinity of xenosteroid mimics on fish SHBG, especially in zebrafish (Danio rerio), a small freshwater fish originating in India and widely employed in ecotoxicol., toxicol., and genetics. In this context, a zebrafish SHBG (zfSHBG) homol. model was developed using the human SHBG (hSHBG) receptor structure as template. It was shown that interactions with amino acids Ser-36, Asp-59 and Thr-54 were important for binding affinity. A ligand-based pharmacophore model was also developed for both zfSHBG and hSHBG inhibitors that differentiated binders from non-binders, but also demonstrated structural requirements for zfSHBG and hSHBG ligands. The study provides insights into the mechanism of action of endocrine disruptors in zebrafish as well as providing a useful tool for identifying anthropogenic compounds inhibiting zfSHBG.

SAR and QSAR in Environmental Research published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Synthetic Route of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chowdhury, Amiya K. Roy published the artcileR.S.(P), a new isolate from the root of Rauwolfia serpentina, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Medical Journal (1964), 58(12), 241-52, database is CAplus.

The pharmacol. actions of a nonalkaloidal fraction isolated from the root of R. serpentina are given. This fraction, R.S.(P), was less potent than reserpine but equipotent to Rauwolfia total extract (1%) in lowering the blood pressure in anesthetized cats. In suitable doses it increased the pentobarbital sleeping time, reduced the spontaneous motility, postponed Metrazol convulsion and lethality, and affected the conditioned behavior in rats (maze test). Coordinated muscular movements were least affected, except when very high doses were used. Electroencephalogram studies in unanesthetized rabbits revealed considerable slowing of the brain wave pattern with the calming and quieting effect on the animals. Sometimes behavioral nonreactivity was seen. The drug appeared to have a central site of action. Its action differed from that of reserpine in many respects. It may possibly be used as an antihypertensive and anticonvulsant or sedative agent.

Indian Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eswaramoorthy, Senthil Kumar published the artcileAtomically Precise Palladium Nanoclusters with 21 and 38 Pd Atoms Protected by Phenylethanethiol, Application In Synthesis of 4410-99-5, the publication is Journal of Physical Chemistry C (2022), 126(1), 444-450, database is CAplus.

Monolayer thiolate-protected nanoclusters (MPCs) are extensively studied due to their distinctive properties. The at. precision in MPCs, especially in gold MPCs, is determined through mass spectrometry, which leads to the accurate identification of metal-ligand composition The total structure determination of gold and silver MPCs using ScXRD revolutionized the field by providing insights into the structural arrangement at an at. level. The synthesis of atomically precise MPCs using other metals like palladium (Pd) to study and compare properties is tedious and complex. In one end, larger size monodisperse Pd nanoparticles (NPs) were synthesized and studied for various catalytic properties. Meanwhile, on the other end, a small-mol. tiara-like Pd-thiolate complex was reported. However, at. precise Pd MPCs in the middle and its detailed studies are not yet explored. Here, we report the synthesis and identification of atomically precise phenylethanethiol-protected Pd₂₁(SCH₂CH₂Ph)₁₈ and Pd₃₈(SCH₂CH₂Ph)₂₁S₂ Pd nanoclusters. The size distribution is confirmed using matrix-assisted laser desorption ionization mass spectra (MALDI-MS), and electrospray ionization mass spectrometry (ESI-MS) confirms the composition through the isotopically resolved peak. The XPS spectra elucidate the cluster formation in smaller size.

Journal of Physical Chemistry C published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Braddock, D. Christopher published the artcileMethyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Organic Letters (2022), 24(5), 1175-1179, database is CAplus and MEDLINE.

Methyltrimethoxysilane [MTM, CH₃Si(OMe)₃] was demonstrated an effective, inexpensive, and safe reagent for direct amidation of carboxylic acids with amines. Two simple workup procedures that provided the pure amide product R¹C(O)N(R²)R³ [R¹ = Ph, Bn, 4-IC₆H₄, etc.; R² = Me, Et, Ph, etc.; R³ = H, Me, Et, MeO; R²R³ = (CH₂)₅, O(CH₂)₄]without the need for further purification was developed. First employed an aqueous base-mediated annihilation of MTM. Second involved simple product crystallization from the reaction mixture provides a low process mass intensity direct amidation protocol.

Organic Letters published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lacroix, Pauline M. published the artcileHPLC and NMR methods for the quantitation of the (R)-enantiomer in (-)-(S)-timolol maleate drug raw materials, Recommanded Product: 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Chirality (1994), 6(6), 484-91, database is CAplus.

HPLC and ¹N-NMR methods for the quantitation of the (R)-enantiomer in (-)-(S)-timolol maleate were developed and validated. The HPLC method requires a 25 cm × 4.6 nm 5 μm Chiracel OD-H (cellulose tris-3,5-dimethylphenylcarbamate) column, a mobile phase of 0.2% (volume/volume) diethylamine and 4% (volume/volume) isopropanol in hexane at a flow rate of 1 mL/min and UV detection at 297 nm. A system suitability test was devised to verify the separation of the (R)- and (S)-enantiomers of timolol from other drug-related impurities. The NMR method requires the use of a high-field NMR spectrometer (> 360 MHz) and a chiral solvating agent, (-)-(R)-2,2,2-trifluoro-1-(9-anthrylethanol)(R-TFAE). The limits of quantitation were 0.5% and 0.2% (m/m) for HPLC and NMR, resp. The methods were applied to the determination of the (R)-enantiomer in eight lots of raw material. The results for the two methods were in very good agreement, with results ranging from 0.1 to 4.1% (m/m) by HPLC and none detected to 4.3% (m/m) by NMR. The USP method for sp. rotation was found to be unsuitable for detecting the presence of low levels of the (R)-enantiomer in (-)-(S)-timolol maleate.

Chirality published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Recommanded Product: 4-Morpholino-1,2,5-thiadiazol-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutter, Marc published the artcile1,2,3-Trimethoxypropane and Glycerol Ethers as Biosource Solvents from Glycerol. Synthesis by Solvent-Free Phase-Transfer Catalysis and Utilization as an Alternative Solvent in Chemical Transformations, Quality Control of 70445-33-9, the publication is ChemCatChem (2013), 5(10), 2893-2904, database is CAplus.

1,2,3-Trimethoxypropane, 1-alkoxy-2,3-dimethoxypropane and 1-aryloxy-2,3-dimethoxypropane were prepared in good yields and selectivity by a solid-liquid phase-transfer catalysis in the presence of an inorganic base and an ammonium salt as a phase-transfer catalyst with no addnl. solvent. No heating was required and the synthesis of the target compounds was achieved easily under atm. pressure on a 150 g scale. For the preparation of 1,2,3-trimethoxypropane, the conversion of glycerol was complete and the selectivity for the expected glycerol tri-Me ether was above 95%. This product was used as a solvent in organic reactions such as a transesterification between glycerol and vegetable oil, organometallic reactions (Grignard- and Barbier-type reactions), carbon-carbon coupling reactions (Suzuki, Sonogashira, Heck) and in etherification reactions by dehydrogenative alkylation. The solvent showed interesting properties for the solubilization of polymers.

ChemCatChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C6H12Br2, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutter, Marc published the artcileSelective Synthesis of 1-O-Alkyl(poly)glycerol Ethers by Catalytic Reductive Alkylation of Carboxylic Acids with a Recyclable Catalytic System, SDS of cas: 70445-33-9, the publication is ChemSusChem (2012), 5(12), 2397-2409, database is CAplus and MEDLINE.

(Poly)glycerol monoethers were synthesized in good yield and selectivity by the catalytic reductive alkylation of glycerol, diglycerol, and triglycerol with readily available, cheap and/or bio-sourced carboxylic acids. The reaction was catalyzed by 1 mol % of Pd/C under 50 bar H₂ using an acid ion-exchange resin as a recyclable cocatalyst. The catalytic system was recycled several times, and a mechanism is proposed for this transformation.

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C10H9ClN2O, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hernandez, Marita published the artcileEffect of 4-trifluoromethyl derivatives of salicylate on nuclear factor κB-dependent transcription in human astrocytoma cells, Quality Control of 328-90-5, the publication is British Journal of Pharmacology (2001), 132(2), 547-555, database is CAplus and MEDLINE.

The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the expression of several proteins displaying proinflammatory activities the regulation of which is associated to the transcription factor NF-κB, was assayed in the human astrocytoma cell line 1321N1. Tumor necrosis factor-α (TNF-α) activated NF-κB as judged from both the appearance of κB-binding activity in the nuclear extracts, the degradation of IκB proteins in the cell lyzates, and the activation of IκB kinases using an immunocomplex kinase assay with glutathione S-transferase (GST)-IκB proteins as substrates. HTB up to 3 mM did not inhibit the nuclear translocation of NK-κB/Rel proteins as judged from electrophoretic mobility-shift assays; however, HTB inhibited the degradation of IκBβ without significantly affecting the degradation of both IκBα and IκBε. In keeping with their inhibitory effect on IκBβ degradation in the cell lyzates, both HTB and triflusal inhibited the phosphorylation of GST-IκBβ elicited by TNF-α, without affecting the phosphorylation of GST-IκBα. The effect of both HTB and triflusal on κB-dependent trans-activation was studied by assaying the expression of both cyclo-oxygenase-2 (COX-2) and vascular cell adhesion mol.-1 (VCAM-1). HTB and triflusal inhibited in a dose-dependent manner the expression of COX-2 and VCAM-1 mRNA and the induction of COX-2 protein at therapeutically relevant concentrations These findings show the complexity of the biochem. mechanisms underlying the activation of NF-κB in the different cell types and extend the anti-inflammatory effects of HTB and triflusal to neural cells.

British Journal of Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Quality Control of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goulart, Enio G. published the artcileAnthemintic drugs. Their ovicidal and larvicidal actions, Category: alcohols-buliding-blocks, the publication is Revista Brasileira de Medicina (1974), 31(11), 791-4, database is CAplus.

Of 9 chemotherapeutic anthelmintics tested in vitro against eggs and larvae of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma caninum, pyrantel pamoate [22204-24-6] and tetrachloroethylene [127-18-4] (10 and 100 mg each) inhibited development of A. caninum; similar results were obtained with 1 mg tetramisole-HCl (I-HCl) [5086-74-8] and thiabendazole (II) [148-79-8]. Stilbazium iodide [3784-99-4], pyrvinium pamoate [3546-41-6], and bephenium hydroxynaphthoate [3818-50-6] showed anthelmintic activity which was directly related to the concentrations None of the compounds tested showed embryogenic blocking activity against A. lumbricoides or T. trichiura. Prophylactic treatments of contaminated soil or organic fertilizer are apparently ineffective.

Revista Brasileira de Medicina published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts