Category: alcohols-buliding-blocks

Cheng, Xiang published the artcileStructural characterization of a heteropolysaccharide from fruit of Chaenomelese speciosa (Sweet) Nakai and its antitumor activity, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Chaenomelese fruit heteropolysaccharide antitumor; Antitumor; Chaenomeles Speciosa (Sweet) Nakai; Heteropolysaccharide; Structural characteristics.

The present study aimed at investigating the structural features and antitumor properties of a novel heteropolysaccharide (CSP-W-2) obtained from the fruit of Chaenomeles Speciosa (Sweet) Nakai. CSP-W-2 demonstrate that they mainly contain glucose, galactose, arabinose, mannose, xylose in a ratio of 3.7: 3.2: 1.7: 0.9: 0.4, with the mol. weight of 8.7 kDa. Its backbone is predominantly composed of 1,4 linked β-D-Galp, 1,4 linked α-D-Glcp, 1,4 linked β-D-Glcp, and 1,4,6-β-D-Glcp, addnl. some branches contained 1,5 linked α-L-Araf, 1,4 linked β-D-Glcp, 1,3 linked α-L-Araf, and T linked β-D-Manp according to the results of partial acid hydrolysis anal., methylation anal., IR and NMR spectra. The antitumor properties study results demonstrated that CSP-W-2 had an inhibitory effect on HepG2 growth by enhancing the nucleus shrinkage and apoptosis. These findings indicate that CSP-W-2 had antitumor potential in the treatment of human liver tumor.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Juan published the artcileRelationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures, SDS of cas: 59-23-4, the main research area is Astragalus polysaccharide structure antitumor temperature; Antitumor activity; Astragalus membranaceus polysaccharides; Structural characterization.

This study investigated the effects of different temperatures on structural characterization and antitumor activity of polysaccharides from Astragalus membranaceus. APS4 and APS90 were extracted at 4°C and 90°C, resp., and purified by Sephadex G-200 column. APS4-90 were obtained from APS4 after treatment at 90°C for 6 h. MTT results showed that APS4 possessed the highest inhibitory effects on MGC-803, A549 and HepG2 cells. HPGPC anal. showed that the average mol. weights of these polysaccharides were approx. 1.5 × 106 Da, while the asym. peak of APS4-90 suggested heat degradation and configuration changes of APS4. GC, NMR and methylation results showed that these three polysaccharides had similar monosaccharide components (mainly contain glucose), and their backbones were composed of (1→2)-α-D-Glcp. However, APS4 showed higher content of (1→2,6)-α-D-Glcp compared to APS4-90 and APS90, which indicated that higher branched degree would be responsible for the stronger in vitro antitumor activity in APS4. These results were also confirmed by sp. rotation and SEM anal. Our study suggested that APS4 had the potential application for cancer treatment.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Datta, Hemanta Kumar published the artcileStructural elucidation of a heteropolysaccharide from the wild mushroom Marasmiellus palmivorus and its immune-assisted anticancer activity, Related Products of alcohols-buliding-blocks, the main research area is Marasmiellus heteropolysaccharide structure immunity anticancer activity; Anticancer activity; Heteropolysaccharide; Immunomodulation; Macrofungi; Marasmiellus palmivorus; Structure.

The biol. activity of macrofungal polysaccharides (MFPS) depends on their structural features and is a topic of keen interest for researchers since long time. We report a water-soluble macrofungal heteropolysaccharide (MFPS1) with a molar weight of ∼145,000 g/mol, obtained through alkali extraction, of the wild mushroom, Marasmiellus palmivorus, with significant immunomodulatory properties. In cancer, after the induction of metastasis, the anticancer immune system becomes unresponsive. By studying cytokine secretion and immune phenotyping, it was observed that MFPS1 reactivated the anticancer immune surveillance system. MFPS1 executed T-cell maturation and activation via M1Φ; and also stimulated natural killer (NK) cell and B-cell population. The entire immune activation pathway corroborates its anticancer activity. The RP-HPLC anal. of hydrolyzed MFPS1 showed arabinose, glucose, galactose, and mannose as monosaccharide units. The proposed structure of repeating unit was established from methylation anal., 1D- and 2D NMR study, HR-MS and MALDI-TOF MS anal.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zichao published the artcileEfficient biosynthesis of anticancer polysaccharide by a mutant Chaetomium globosum ALE20 via non-sterilized fermentation, Formula: C6H12O6, the main research area is fermentation Chaetomium globosum polysaccharide batch fermentation; Adaptive laboratory evolution; Anticancer polysaccharide; Methanol-resistant strain.

The sterilization process, due to its immense energy consumption, high facilities investment, and loss of raw materials by caramelization, during industrial production has drawn much attention. In this study, a methanol-resistant mutant strain, Chaetomium globosum ALE20, was obtained following 20 cycles of adaptive laboratory evolution process. The titer of anticancer polysaccharide (GCP-M) from C. globosum ALE20 reached 9.2 g/L with glycerol as sole carbon source using non-sterilized and fed-batch fermentation strategy. This titer represents a 200% increase compared with the 3.3 g/L attained with batch fermentation The GCP-M monosaccharide was comprised of galactose, glucose, mannose and glucuronic acid, in a molar ratio of 3.83:66.37:3.26:1.95, resp., and its weight-average mol. weight and polydispersity were 3.796 × 104 Da and 1.060, resp. This work presents an ideal alternative and safer fermentation process without sterilization, and a useful approach for enhancing industrial production

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cho, Er-Chieh published the artcileRing size changes in the development of class I HDAC inhibitors, Category: alcohols-buliding-blocks, the main research area is thienylbenzamide anticancer SAR HDAC inhibitor docking; HDAC; Thienylbenzamides; colon cancer; ring transformation.

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides which display the structure-activity relationships of class I HDAC inhibitors. All the synthesized compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound Compounds and inhibit HCT116 cells by activation of the apoptosis pathway.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jing published the artcileCross-Linked Reverse Vesicle as a General and Effective Vehicle for Hydrophobic Drugs, Quality Control of 7575-23-7, the main research area is crosslinking drug carrier antitumor.

It is well-known that vesicles serve as an excellent delivery platform for hydrophilic drugs. However, there is still a lack of a general and effective platform for hydrophobic drug loading. We herein disclose that water-soluble cross-linked reverse vesicles (cRVs) constructed from anionic surfactant 1, a counterpart of normal vesicles, would be excellent vehicles for hydrophobic drugs, the drug loading content (DLC) for which arrived up to 21.1%, 19.8%, and 25.8%, resp., for three anticancer drugs, paclitaxel, camptothecin, and carmofur. This represents a general drug carrier with high drug loading content for various hydrophobic drugs without the assistance of other external forces. In addition to drug loading superiority, the cRVs were also characterized by robust stability, specific stimulus response, easy postfunctionalization, and good biocompatibility and thus are promising candidates for drug delivery systems.

Langmuir published new progress about Antitumor agents. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Xiong-Jie published the artcileA pH-responsive fluorescence probe and photosensitiser based on a tetraamino silicon(IV) phthalocyanine, Recommanded Product: N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, the main research area is pH responsive fluorescence probe photosensitizer tetraaminosilicon phthalocyanine.

A novel tetraamino silicon(IV) phthalocyanine has been prepared, of which the fluorescence emission and reactive oxygen species generation efficiency are greatly enhanced at lower pH in the range of ∼5-7, making it a promising pH-controlled and tumor-selective fluorescence probe and photosensitizer for photodynamic therapy.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antitumor agents. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Recommanded Product: N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chan published the artcileNovel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study, HPLC of Formula: 111-87-5, the main research area is SN38 PA liposome anticancer; CPT-11; SN38; biodistribution; lipophilic prodrug; long-circulating liposome; pharmacodynamics; pharmacokinetics.

Background: Many novel drug delivery systems have been extensively studied to exploit the full therapeutic potential of SN38, which is one of the most potent antitumor analogs of camptothecins (CPTs), whose clin. application is seriously hindered by poor water solubility, low plasmatic stability, and severe toxicity, but results are always unsatisfactory. Methods: In this study, combining the advantages of prodrug and nanotechnol., a lipophilic prodrug of SN38, SN38-PA, was developed by conjugating palmitic acid to SN38 via ester bond at C10 position, and then the lipophilic prodrug was encapsulated into a long-circulating liposomal carrier by film dispersion method. Results: The SN38-PA liposomes were characterized as follows: an average particle size of 80.13 nm, an average zeta potential of -33.53 mv, and the entrapment efficiency of 99%. Compared with CPT-11, SN38-PA liposome was more stable in close lactone form, more efficient in conversion rate to SN38, and more potent in cytotoxicity against tumor cells. Pharmacokinetic study showed that SN38-PA liposome had significantly enhanced plasma half-life (t1/2) value of SN38 and increased area under the curve (AUC) of SN38, which was 7.5-fold higher than that of CPT-11. Biodistribution study showed that SN38-PA liposome had more active metabolite SN38 in each tissue. Finally, the pharmacodynamic study showed that SN38-PA liposome had higher antitumor effect with the antitumor inhibition rate of 1.61 times than that of CPT-11. Conclusion: These encouraging data merit further investigation on this novel SN38-PA liposome.

International Journal of Nanomedicine published new progress about Antitumor agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Song, Zilan published the artcileStructure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists, Application of 2,2-Dimethoxyethanamine, the main research area is amidobenzimidazole analog STING agonist SAR immunooncol.

Activation of the stimulator of interferon gene (STING) has emerged as an exciting immuno-oncol. therapeutic strategy; however, the first-generation STING agonists, cyclic dinucleotide (CDN) analogs, have suffered from many disadvantages and failed in clin. trials. Therefore, non-CDN small-mol. STING agonists are urgently needed. In view of the unique structure of the high potency of dimeric amidobenzimidazole STING agonist 5, a structural elaboration was conducted by modifying several structural hotspots of this scaffold. Triazole 40 was identified as a new potent STING activator, possessing EC50 values of 0.24 and 39.51μM for h- and m-STING, resp. This compound has a slightly better pharmacokinetic profile and is >20-fold more aqueously soluble than 5. It activated the STING signaling dramatically by directly binding and stabilizing all h-STING isoforms and m-STING. In vivo, intermittent administration of 40 (I) was found to have significant antitumor efficacy with good tolerance in two mouse tumor models.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Application of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liao, Deng-wei published the artcileCharacterization and antitumor activities of polysaccharides obtained from ginger (Zingiber officinale) by different extraction methods, SDS of cas: 59-23-4, the main research area is Zingiber colon breast cervical cancer cell polysaccharide antitumor; Antitumor activity; Ginger polysaccharide; Structure characterization.

Three different extraction technologies including hot water extraction (HWE), enzyme assisted extraction (EAE) and ultrasonic cell grinder extraction (UCGE) were employed to extract crude ginger polysaccharides (GPs) under their resp. best parameters, then crude GPs were purified by DEAE cellulose-52 and Sephadex G-200 size-exclusion chromatog. in that order. Five GPs fractions (HGP, EGP1, EGP2, UGP1, and UGP2, resp.) were obtained. The differences of five GPs in chem. composition, characterization and antitumor activities were further compared. The mol. weights were different in five GPs, varying from 11.81 to 1831.75 kDa. Mannose and glucose as the main monosaccharide and the glycosidic linkage of →4)-α-D-Glc(1→ and -α-Manp-(1→ existed in both five GPs. While EGP2 and UGP1 possessed specific structure of →6)-β-D-Galp-(1→ and UGP1 contained more sulfate group. Moreover, UGP1 exhibited strong inhibitory effect on three tumor cells especially the colon cancer. The inhibition rates of UGP1 on H1975, HCT116 and MCF-7 were 23.339 ± 2.285%, 56.843 ± 2.405% and 21.061 ± 1.920% resp. The study indicated GPs extracted by UCGE could reserve more active structure and inhibit colon cancer more significantly.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts