Category: alcohols-buliding-blocks

Khodja, Maroua published the artcileTuning nanotubular structures by templateless electropolymerization with thieno[3,4-b]thiophene-based monomers with different substituents and water content, Synthetic Route of 2240-88-2, the publication is Journal of Colloid and Interface Science (2020), 19-27, database is CAplus and MEDLINE.

Here, templateless electropolymerization is employed to produce nanotubular structures from various thieno[3,4-b]thiophene-based monomers that differ in substituent structure and size, as well as the linker connecting the thieno[3,4-b]thiophene core and substituent. The formation of densely packed vertically aligned are obtained from monomers with a pyrene substituent and when a significant amount of water (CH₂Cl₂ + H₂O) is included in the solvent. The geometrical parameters of the nanotubes are highly dependent on the electopolymn. method. A significant amount of air is trapped within the structure of the densely packed open nanotubes obtained with Qs = 100 mC cm^-2 causing an increase in water contact angle (θ_w) up to 82.6° (intermediate state between the Wenzel and the Cassie-Baxter state), and θ_w can become even more hydrophobic by further modifying the deposition method or the electrolyte.

Journal of Colloid and Interface Science published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Lingxiao published the artcileHydrogen-Free Production of 4-Alkylphenols from Lignin via Self-Reforming-Driven Depolymerization and Hydrogenolysis, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2020), 10(24), 15197-15206, database is CAplus.

Lignin is constructed from methoxylated phenylpropanoid with plenty of hydroxy and methoxy groups. Its conversion to valuable products is extremely attractive but especially challenging without addnl. hydrogen sources. Herein we report a hydrogen-free production of 4-alkylphenols directly from native lignin via self-reforming-driven depolymerization and hydrogenolysis over Pt/NiAl₂O₄. This is the first example of acquiring 4-alkylphenols from native lignin. Using this strategy, high yields of 4-alkylphenols, 17.3 wt %, were obtained from birch lignin. Reaction pathway and mechanism studies revealed that this strategy initiates from the reforming of aliphatic hydroxys, followed by the cleavage of C-O linkages, and ends via demethoxylation over Pt/NiAl₂O₄. Moreover, the subsequent aqueous phase reforming of the as-formed methanol accelerates the whole process. This strategy realizes the one-pot production of 4-alkylphenols from lignin by fully utilizing the structural hydrogen in lignin and H₂O, providing a low-cost and safe method of lignin valorization.

ACS Catalysis published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Weiwei published the artcileStudy on the efficacy and safety of ambroxol combined with methylprednisolone in patients with acute lung injury, Product Details of C13H19Br2ClN2O, the publication is BioMed Research International (2021), 5771101, database is CAplus and MEDLINE.

There is no better treatment method towards paraquat-induced acute lung injury (ALI) at present. Ambroxol combined with methylprednisolone exhibits a significant improvement effect on ALI treatment, whereas their mechanism in ALI is still unclear. 64 Patients with ALI caused by paraquat poisoning brought to author’s hospital from Jan. 2015 to Jan. 2018 were selected. They were separated into a combined treatment group (CTG) and a routine treatment group (RTG) on the basis of different treatment methods. The survival of patients was observed after 7 days of treatment. Arterial blood gas, oxygen partial pressure (PaO₂), partial pressure of carbon dioxide (PaCO₂), oxygenation index (PaO₂/FiO₂), patient’s spontaneous respiratory rate (RR), tidal volume (VT), and pos. end-expiratory pressure (PEEP) were observed before and after treatment for 7 days. Interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) were analyzed. The differences of indexes between the dead patients and the survivors were observed, and the potential predictive value of death was analyzed. After treatment, the indexes of patients were significantly improved in both groups compared with those before therapy. Further comparison showed that the improvement of PaO₂, PaCO₂, and PaO₂/FiO₂ in CTG was obviously higher than that in RTG (p < 0.05). The improvement of RR, PEEP, and VT in CTG was obviously higher than that in RTG (p < 0.05). The decreased degree of IL-6 and TNF-α in CTG was higher than that in RTG (p < 0.05). The 7-day mortality rate of 64 patients was 39.06%, and there was no obvious difference in the 7-day survival rate in both groups (p = 0.649). IL-6 and TNF-α were expected to be potential prediction indexes of paraquat-induced ALI. Ambroxol combined with methylprednisolone significantly improved the oxygen partial pressure and oxygenation index of patients with paraquat-induced ALI and inhibited the inflammatory response of patients.

BioMed Research International published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H26O2, Product Details of C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alder, Kurt published the artcileSubstituting additions. IX. Substituting addition and diene synthesis with methylenecyclobutane, Safety of 1-Methylcyclobutan-1-ol, the publication is Chemische Berichte (1952), 556-65, database is CAplus.

cf. C.A. 44, 2927i. The substituting addition of maleic anhydride (I) to methylenecyclobutane (II), which is similar to the addition of I to methylenecyclohexane and -pentane, is studied. Heating an intimate mixture of 400 g. pentaerythrityl tetrabromide and 410 g. Zn dust in 600 cc. H₂O slowly to 85° with stirring and adding over a period of 2 hrs. 300 cc. MeOH in small portions give 70-85% II, b. 41-2°. Heating 25 cc. II and 50 g. I in 50 cc. dry C₆H₆ in a bomb tube 30 hrs. at 190-5°, washing the reaction product with Me₂CO into a beaker, and allowing the solvent to evaporate cause the crystallization of 35% adduct (III), consisting of 1 mol. II and 2 mols. I, m. 170-1°, which, on standing in the open air, changes to a tetracarboxylic acid (IV), m. 165-6°. On catalytic hydrogenation of 1 g. IV in AcOEt with PtO₂, the saturated tetracarboxylic acid, m. 193°, is formed. Heating 1.5 g. III and 1.4 g. S 2.5 hrs. at 240-5°, dissolving the reaction products in Na₂CO₃, oxidizing with KMnO₄, destroying the excess KMnO₄ with NaHSO₃, washing with ether, acidifying, evaporating the filtered solution in vacuo to dryness, and extracting the residue with hot Me₂CO give a tetracarboxylic acid (V) of Va as an oil. Oxidation of V with concentrated HNO₃ on a water bath and, finally, in a bomb tube at 165° gives trimellitic acid (VI), m. 221°, which, heated above its m.p. and sublimed, gives the anhydride, m. 161°. Distilling the residue of the mother liquor of III in vacuo gives 3 g. of a fraction, b₁₃ 155-60°, which, dissolved in Na₂CO₃, filtered, acidified, and extracted with ether, gives the dicarboxylic acid (VII), of VIIa, an adduct of 1 mol. isoprene and 1 mol. I, m. 155°. When hydrogenated in AcOEt in the presence of PtO₂, VII gives 4-methylcyclohexane-1,2-dicarboxylic acid, m. 165°. Heating 1 g. VII with 0.35 g. S 2.5 hrs. at 230-5° and then heating the reaction product with concentrated HNO₃, finally 6 hrs. in a bomb tube at 160°, give VI. The formation of VII is the result of a rearrangement of II via CH₂.CH₂.CH:CMe to CH₂:CHCMe:CH₂. Heating 20 cc. II and 35 cc. freshly distilled CH₂:CHCO₂H in 40 cc. dry C₆H₆ 30 hrs. at 200° and fractionally distilling in vacuo the reaction product from 2 runs give 45% distillate (VIII), b₁₃ 120-45°. Shaking VIII with ether and dilute KOH, acidifying the alk. solution with HCl, and extracting with ether give 18 g. of an acid mixture which, redistilled, b₁₃ 130-8°. It is separated into 7.2 g. crystalline 4-methyl-Δ³-tetrahydrobenzoic acid (IX), m. 100° (anilide, prepared via its Me ester, long needles, m. 154°; hydrazide, long silky nedles, m. 151-2°), and 7.9 g. of an oily adduct (X), CH₂.CMe:CH.CH₂.CH₂.CHCO₂H. Hydrogenating IX with PtO₂ in AcOEt and treating the Me ester, prepared with CH₂N₂, with PhNH₂ give the anilide of the saturated acid, C₁₄H₁₉ON, long needles, m. 130-1°. Ozonization of 2.5 g. IX in 100 cc. AcOEt with O containing 3-4% O₃ and reduction of the reaction product with PtO₂ and a few drops MeOH give MeCOCH₂CH₂CH(CO₂H)CH₂CO₂H, hard crystals, m. 122-3° (semicarbazone, m. 178°). Heating 1 g. IX with 4 cc. concentrated H₂SO₄ 15 min. on a boiling water bath and pouring the mixture on ice give p-MeC₆H₄CO₂H, m. 178°, in good yield. Heating 1.4 g. IX 2.5 hrs. at 230-5° with 0.64 g. S, dissolving the reaction product in Na₂CO₃, treating it with KMnO₄, decolorizing with NaHSO₃, and acidifying give p-C₆H₄(CO₂H)₂ (di-Me ester, m. 140°). Heating 1.4 g. X 2.5 hrs. at 230-5° with 0.64 g. S gives m-MeC₆H₄CO₂H, m. 110°, which, oxidized with KMnO₄, gives m-C₆H₄(CO₂H)₂ (di-Me ester m. 68°). Distillation of the residue of the washed ether solution obtained in the working up of VIII gives 10 g. 1-hydroxy-1-methylcyclobutane (XI) acrylate (XII), b₁₃ 125°, which (8 g.), refluxed 6 hrs. with concentrated KOH-MeOH, gives XI, b. 117-20° (phenylurethan m. 139°). Ozonization of XII gives HCHO. Acidification of the alk. solution gives 1.5 g. IX. Heating 20 cc. II and 20 cc. AcOH 48 hrs. at 200°, diluting the mixture with H₂O, and distilling the washed (dilute Na₂CO₃, H₂O) oil give 9 g. of a mixture, b. 140-200°. Saponification with KOH-MeOH of the fraction, b. 130-60°, gives XI. Refluxing 4 g. of the fraction, b. 170-85°, 4 hrs. with 2 g. I in a little ether, distilling off the ether and unreacted reagents, and dissolving the residue in hot concentrated Na₂CO₂H give the Na salt of an adduct of I with α-terpinene, as fatty shiny scales. Heating the free acid above its m.p. gives the anhydride, m. 62-3°.

Chemische Berichte published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Safety of 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marques, Michael A. published the artcileToward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides, Safety of Thiophen-3-ol, the publication is Helvetica Chimica Acta (2002), 85(12), 4485-4517, database is CAplus.

Crescent-shaped polyamides composed of aromatic amino acids, i.e., 1-methyl-1H-imidazole Im, 1-methyl-1H-pyrrole Py, and 3-hydroxy-1H-pyrrole Hp, bind in the minor groove of DNA as 2:1 and 1:1 ligand/DNA complexes. DNA-Sequence specificity can be attributed to shape-selective recognition and the unique corners or pairs of corners presented by each heterocycle(s) to the edges of the base pairs on the floor of the minor groove. Here we examine the relationship between heterocycle structure and DNA-sequence specificity for a family of five-membered aromatic amino acids. By means of quant. DNase-I footprinting, the recognition behavior of polyamides containing eight different aromatic amino acids, i.e., 1-methyl-1H-pyrazole Pz, 1H-pyrrole Nh, 5-methylthiazole Nt, 4-methylthiazole Th, 3-methylthiophene Tn, thiophene Tp, 3-hydroxythiophene Ht, and furan Fr, were compared with the polyamides containing the parent-ring amino acids Py, Im, and Hp for their ability to discriminate between the four Watson-Crick base pairs in the DNA minor groove. Anal. of the data and mol. modeling showed that the geometry inherent to each heterocycle plays a significant role in the ability of polyamides to differentiate between DNA sequences. Binding appears sensitive to changes in curvature complementarity between the polyamide and DNA. The Tn/Py pair affords a modest 3-fold discrimination of T · A vs. A · T and suggests that an S-atom in the thiophene ring prefers to lie opposite T not A.

Helvetica Chimica Acta published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Safety of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cai, Kun published the artcileChanges in Phenolic Profiles and Inhibition Potential of Macrophage Foam Cell Formation during Noni (Morinda citrifolia Linn.) Fruit Juice Fermentation, COA of Formula: C8H8O3, the publication is Fermentation (2022), 8(5), 201, database is CAplus.

The dynamic changes in phenolic composition and antioxidant activity, and the potential effect on foam cell formation and cholesterol efflux during noni (Morinda citrifolia Linn.) fruit juice fermentation were investigated in this study. The composition of phenolic compounds was significantly different at various fermentation times. Rutin, quercetin, and isoquercitrin were the major phenolics in fermented noni fruit juice based on a quant. anal. of representative phenolics. The contents of caffeic acid, 2,4-dihydroxybenzoic acid, p-coumaric acid, rutin, and quercetin tended to increase, while those of isoquercitrin decreased during the fermentation process. Fermented noni juice extracts showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), hydroxyl radical scavenging activity, and ferric reducing antioxidant power. Notably, the highest antioxidant activity was observed after 28 days of fermentation Furthermore, the treatment of fermented noni juice extracts was shown to reduce foam cell formation, intracellular cholesterol level, and the cholesterol esterification ratio. A correlation anal. indicated a strong pos. relationship between the phenolic composition, antioxidant activity, and the ratio of cholesterol ester and total cholesterol. This study may provide a theor. basis for the quality improvement and standardized production of fermented noni fruit juice, thus promoting the development of the noni food industry.

Fermentation published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Mei published the artcileNovel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants, Application of 2-Morpholinoethanol, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1196-1204, database is CAplus and MEDLINE.

Flexible heterocyclic moieties as the P2 ligands of HIV-1 protease inhibitors may be adapted to the minimally distorted active site of mutations easily and enhance activity against DRV-resistant HIV-1 variants. Herein, the design, synthesis, and biol. evaluation of a new series of inhibitors containing morpholine derivatives as the P2 ligands were described, among which, carbamate inhibitor I and carbamido inhibitor II exhibited almost 4- and 2-fold superior activity with enzyme Ki of 0.092 nM and 0.21 nM, as well as antiviral IC50 values of 0.41 nM and 0.95 nM, resp., compared to DRV. Besides, they exhibited excellent activity with inhibition of 94% and 91%, resp. Furthermore, they also showed appreciable antiviral activity against DRV-resistant HIV-1 variants.

ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H6BrF3S, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dem’yanov, I. N. published the artcileVinyltrimethylene and its Derivatives, Category: alcohols-buliding-blocks, the publication is Zhurnal Russkago Fiziko-Khimicheskago Obshchestva (1913), 176-84, database is CAplus.

The alc. (a) obtained by shaking vinyltrimethylene (b) with H₂SO₄ (Gustavson, J. prakt. Chem., [2] 54, 104), not being oxidizable to an aldehyde or ketone, is doubtless tertiary; it b₇₅₅, 117.5-8.5° m. -5°, d₄²² 0.889, n₄²² 1.4315. Of the 2 formulas of (a), and preference is given to the 2nd. By converting (a) into an iodide (b₂₂ 50°) and treating the latter with Zn + AcOH a mixture of a hydrocarbon C₅H₁₀ (c) and the acetate of (a) was obtained. (c) b₇₅₃ 34-5°, d₀⁰ 0.6973, d₄⁰ 0.6805, n_D¹⁷ 1.3814; its formula is supposed to be. A hydrocarbon almost identical with (c) is more readily obtainable by reducing (b) with H + Pt black. The acetate of (c) b. 130-2.5°, d₄²⁰ 0.9351, n_D²⁰ 1.419.

Zhurnal Russkago Fiziko-Khimicheskago Obshchestva published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Horakova, Eva published the artcileSynthesis and in vitro evaluation of novel N-cycloalkylcarbamates as potential cholinesterase inhibitors, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Monatshefte fuer Chemie (2017), 148(12), 2143-2153, database is CAplus.

Abstract: This present paper describes the preparation and characterization of a series of O-substituted N-cycloalkylcarbamate derivatives These compounds were tested as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All studied carbamates exhibited moderate inhibitory activity of both cholinesterases with values of IC₅₀ in the range of 36.1-78.6 μM for AChE and 9.8-215.4 μM for BChE, resp. These values are comparable with those values of inhibition obtained with the established drug rivastigmine. The cytotoxicity of all carbamates was evaluated using standard in vitro test with Jurkat cells. Many of the studied carbamates can be considered as promising compounds for potential medicinal applications with regard to their inhibitory activity as well as negligible cytotoxicity. Graphical abstract: [Figure not available: see fulltext.].

Monatshefte fuer Chemie published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cortes-Arriagada, Diego published the artcileInsights into the luminescent properties of anionic cyclometalated iridium(III) complexes with ligands derived from natural products, Formula: C8H5F3O3, the publication is International Journal of Quantum Chemistry (2018), 118(17), n/a, database is CAplus.

In the search of remarkable anionic electroluminescent semiconductors to be applied in energy conversion devices such as Light Emitting Electrochem. Cells, we report the electronic, photophys., and charge injection/transfer properties of a series of cyclometalated iridium(III) complexes through a DFT/TD-DFT procedure. The proposed semiconductors involve bidentated ligands based on natural products (salicylic acid and boldine), and phenylpyridine and phenylpyrazole as the cyclometalating units. The proposed compounds emit in the range of 446 to 571 nm, where the boldine based compounds have red-shifted emissions compared to their analogs with salicylic acid. Blue phosphors were obtained by the use of phenylpyrazole units; however, the ligand field is weak in these cases compared to the ligand field exerted by the phenylpyridine ligands. The latter allows the accessibility to the radiationless states for emitters below 495 nm as a result of the increased stability of the metal centered excited states; consequently, the luminescent quantum yield could be decreased. Conversely, the semiconductors with phenylpyridine units show a restricted accessibility to radiationless processes, which could result in emitters with a high luminescent quantum yield and low non-radiative constants Finally, the proposed anionic semiconductors show a better balance between hole/electron transfer rate compared to related cationic Ir(III) complexes; while, the easier hole-electron injection is favored for semiconductors with salicylic acid and phenylpyridine units.

International Journal of Quantum Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts