Category: alcohols-buliding-blocks

Deldaele, Christopher published the artcileRoom-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides, Formula: C8H19NO2, the publication is ChemCatChem (2016), 8(7), 1319-1328, database is CAplus.

An efficient and highly practical procedure was reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides were readily aminated at room temperature The reaction proceeded well regardless of the electronic properties of the starting aryl iodide and the amination products were obtained without the need for purification by column chromatog. in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination was extended to the amination of complex aryl iodides at room temperature

ChemCatChem published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryczaj, Klaudia published the artcilePotentially harmful substances in moisturizers, COA of Formula: C11H24O3, the publication is Journal of Allergy and Clinical Immunology (2021), 148(2), 653-654, database is CAplus and MEDLINE.

A review. Despite the promising results of preliminary studies and hope for preventing atopic dermatitis (AD) and food allergy (FA) in high-risk infants by emollient application from their first days of life, further analyses failed to confirm the validity of such an approach. Haptens are low-mol.-weight chems. that may cause irritant or allergic contact dermatitis or subclin. skin barrier function changes. In 13 of the 17 emollients, at least 1 hapten was identified. The haptens found in the preparations were as follows: lanolin, iso-Pr myristate, phenoxyethanol, benzyl alc., sorbitan oleate, sorbitan sesquioleate, tocopheryl acetate, tocopherol, sorbic acid, propylene glycol, panthenol, ethylhexyl glycerin, cetearyl alc., cetyl alc., and stearyl alc. Thus, it is possible that chronic use of moisturizers containing haptens may lead to a vicious cycle of inflammation and skin barrier disruption that requires repeated applications of products

Journal of Allergy and Clinical Immunology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ilic, Milos published the artcileTowards dual antithrombotic compounds – Balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is European Journal of Medicinal Chemistry (2013), 329-340, database is CAplus and MEDLINE.

Enantiomers of 2,3-dihydro-1,4-benzodioxine derivatives possessing both thrombin and fibrinogen GPIIb/IIIa binding inhibitory activities were prepared from (R)- and (S)-glycidol as potential dual antithrombotic compounds The influence of chirality and substitution pattern on thrombin inhibition and on inhibition of fibrinogen binding to GPIIb/IIIa was analyzed. Docking studies were used in an attempt to rationalize the results. The (S)-isomers of both 2,3-dihydro-1,4-benzodioxine regioisomers at positions 6 and 7 were found to be better thrombin inhibitors than the corresponding (R)-enantiomers, whereas we observed that stereochem. does not display a consistent influence on fibrinogen GPIIb/IIIa binding inhibitory activity. Compound 11b, the (S)-isomer of the 6-substituted regioisomer, possessed the best balanced dual activity, with K_i(thrombin) = 1.67 ± 0.27 μM and IC_{50(GPIIb/IIIa)} = 0.665 ± 0.26 μM, raising the hope that merging anticoagulant and platelet antiaggregatory activities in the same mol. could lead to successful multitarget antithrombotic agents.

European Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chams, Amani published the artcileDirect growth of polymer brushes from an electrodeposited conducting poly(dithienylpyrrole) layer functionalized with ATRP initiating moieties, Synthetic Route of 23351-09-9, the publication is Journal of Electroanalytical Chemistry (2013), 20-30, database is CAplus.

A new strategy for growing polymer brushes using surface-initiated atom transfer radical polymerization (SI-ATRP) from a thin functionalized conducting-polymer layer is reported. Three new heterocyclic monomers based on thiophene and/or pyrrole bearing an ATRP-initiator have been synthesized. Electrochem. behavior and electrodeposition of these monomers was carried out by both potentiodynamic (CV) and potentiostatic (CA) methods. Remarkably, the use of a tricyclic (2,5-dithienyl)pyrrole-based monomer allowed the formation of a conducting film at a relatively low oxidation potential (onset ∼0.65 V/SCE). Electroactivity characterization showed that conducting, stable and adherent thin polymer layer was formed. The charge-transfer agent was subsequently engaged in SI-ATRP to grow polymethacrylate brushes directly from the conducting functionalized surface. Both the functionalized conducting polymer layer and the resulting tethered polymer brushes were characterized using XPS and SEM (SEM). This study confirms that polymethacrylate brushes can efficiently grow directly from a functionalized conducting-polymer thin layer by using a conventional SI-ATRP procedure.

Journal of Electroanalytical Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Synthetic Route of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dalton, David R. published the artcileBromohydrin formation in aqueous dimethyl sulphoxide; electronic and steric effects, Application In Synthesis of 2588-77-4, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1971), 85-9, database is CAplus.

The role of electronic and steric effects in the stereospecific trans-addition of HOBr to olefins, with moist Me2SO as solvent-reactant and N-bromosuccinimide as the source of Br, was examined In the absence of severe steric restrictions, the electronic effects were observed to direct the addition in a Markovnikov sense. Highly hindered olefins and those wherein the electron d. at the C:C double bond is severely depleted by electron-withdrawing substituents fail to react. Similar systems which have shown a susceptibility to carbonium ion rearrangements in analogous reactions fail to yield, for the most part, rearranged products. The intermediate is deemed best represented by a bromonium ion, symmetrical or nonsymmetrical, depending upon the structure of the starting olefin. If the addition of HOBr is retarded owing to electronic or steric effects, considerable amounts of dibromide accompany bromohydrin.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Application In Synthesis of 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coles, G. C. published the artcileMechanism of action of the anthelmintic levamisole, SDS of cas: 3818-50-6, the publication is General Pharmacology (1975), 6(4), 309-13, database is CAplus.

In a solution of levamisole-HCl (I) [16595-80-5], the small round worm Nippostrongylus brasiliensis became paralyzed, but recovered on being left in the solution Both the rates of paralysis and recovery increased with increasing concentration of I. A small percentage of Ascaris suum also resumed movement in I, and were then protected against the effects of the anthelmintics bephenium hydroxynaphthoate [3818-50-6], methyridine [114-91-0], and pyrantel tartrate [33401-94-4]. The autonomic blocking agents mecamylamine and pempidine blocked I contractions in normal A. suum, and the results suggested that all 4 anthelmintics acted in a similar way.

General Pharmacology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bastien, Dominic published the artcileFragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3182-3192, database is CAplus and MEDLINE.

The continuously increasing use of trimethoprim as a common antibiotic for medical use and for prophylactic application in terrestrial and aquatic animal farming has increased its prevalence in the environment. This has been accompanied by increased drug resistance, generally in the form of alterations in the drug target, dihydrofolate reductase (DHFR). The most highly resistant variants of DHFR are known as type II DHFR, among which R67 DHFR is the most broadly studied variant. We report the first attempt at designing specific inhibitors to this emerging drug target by fragment-based design. The detection of inhibition in R67 DHFR was accompanied by parallel monitoring of the human DHFR, as an assessment of compound selectivity. By those means, small aromatic mols. of 150-250 g/mol (fragments) inhibiting R67 DHFR selectively in the low millimolar range were identified. More complex, sym. bis-benzimidazoles and a bis-carboxyphenyl were then assayed as fragment-based leads, which procured selective inhibition of the target in the low micromolar range (K_i = 2-4 μM). The putative mode of inhibition is discussed according to mol. modeling supported by in vitro tests.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wakamiya, Yuma published the artcileTotal Synthesis of Amphidinol 3: A General Strategy for Synthesizing Amphidinol Analogues and Structure-Activity Relationship Study, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Journal of the American Chemical Society (2020), 142(7), 3472-3478, database is CAplus and MEDLINE.

Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce natural product due to the presence of numerous stereogenic centers on the acyclic carbon chain. Since the absolute configuration was partially determined on the basis of insufficient evidence, the originally proposed structure has been revised three times. Although recent progress on structure determination by computational anal. is remarkable, total synthesis is still the most reliable way to confirm structures. The first total synthesis of AM3 was achieved via expeditious assembly of three components in five steps, confirming the revised structure of AM3 after more than 20 years since its first discovery. The established synthetic route would be a general strategy for synthesizing amphidinol congeners. An artificial and simplified analog of AM3, which elicited antifungal activity comparable to that of AM3, was designed and synthesized. This is the first example of a biol. active artificial analog possessing a shorter polyol moiety, providing insight on the antifungal mode-of-action.

Journal of the American Chemical Society published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C23H43NP2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diez, Stefan J. published the artcileCrystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates, HPLC of Formula: 86-48-6, the publication is Crystal Growth & Design (2018), 18(6), 3263-3268, database is CAplus.

A crystal growth technique, interfacial cocrystn., is demonstrated to be a simple and effective method for preparing multi-component crystal forms. The technique is based on the generation of a liquid-liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Lei published the artcileExperimental and Theoretical Studies of Quadrupolar Oligothiophene-Cored Chromophores Containing Dimesitylboryl Moieties as π-Accepting End-Groups: Syntheses, Structures, Fluorescence, and One- and Two-Photon Absorption, Computed Properties of 239075-02-6, the publication is Chemistry – A European Journal (2014), 20(42), 13618-13635, database is CAplus and MEDLINE.

Quadrupolar oligothiophene chromophores composed of four to five thiophene rings with two terminal (E)-dimesitylborylvinyl groups (4 V-5 V), and five thiophene rings with two terminal aryldimesitylboryl groups (5 B), and an analog of 5 V with a central EDOT ring (5 VE), were synthesized via Pd-catalyzed cross-coupling reactions in high yields (66-89 %). Crystal structures of 4 V, 5 B, bithiophene 2 V, and five thiophene-derived intermediates are reported. Chromophores 4 V, 5 V, 5 B and 5 VE have photoluminescence quantum yields of 0.26-0.29, which are higher than those of the shorter analogs 1 V-3 V (0.01-0.20), and short fluorescence lifetimes (0.50-1.05 ns). Two-photon absorption (TPA) spectra were measured for 2 V-5 V, 5 B and 5 VE in the range 750-920 nm. The measured TPA cross-sections for the series 2 V-5 V increase steadily with length up to a maximum of 1930 GM. We compare the TPA properties of 2 V-5 V with the related compounds 5 B and 5 VE, giving insight into the structure-property relation for this class of chromophore. DFT and TD-DFT results, including calculated TPA spectra, complement the exptl. findings and contribute to their interpretation. A comparison to other related thiophene and dimesitylboryl compounds indicates that our design strategy is promising for the synthesis of efficient dyes for two-photon-excited fluorescence applications.

Chemistry – A European Journal published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts