Category: alcohols-buliding-blocks

Yu, Jintao published the artcileCopper-catalyzed aerobic oxidation of silanes to silanols, Computed Properties of 597-52-4, the publication is Changzhou Daxue Xuebao, Ziran Kexueban (2016), 28(1), 43-47, database is CAplus.

The Cu(OAc)₂-catalyzed selective hydrolytic oxidation of silanes toward the silanols using water as the oxidant was achieved. All the products were characterized by ¹H NMR, ¹³C NMR and GCMS. Compared with other methods, this silane hydrolysis protocol is featured with the solvent-free mild reaction conditions using H₂O as clean oxidant with good substrate compatibility. This work provides a new approach toward the synthesis of silanols.

Changzhou Daxue Xuebao, Ziran Kexueban published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C15H12O6, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jianjun published the artcileTotal Synthesis of (-)-Melanthioidine by Copper-Mediated Cyclodimerization, Product Details of C9H11NO4, the publication is Organic Letters (2016), 18(15), 3542-3545, database is CAplus and MEDLINE.

An efficient asym. total synthesis of the dimeric macrocyclic diaryl ether phenethyltetrahydroisoquinoline alkaloid (-)-melanthioidine is reported. Key steps of the synthesis include an efficient Noyori asym. transfer hydrogenation to access the enantioenriched phenethyltetrahydroisoquinoline monomeric subunit and a copper-mediated cyclodimerization to form the two diaryl ether linkages with concomitant macrocyclization.

Organic Letters published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C6H16OSi, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Donnelly, Liam J. published the artcileC-H Borylation Catalysis of Heteroaromatics by a Rhenium Boryl Polyhydride, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is ACS Catalysis (2021), 11(12), 7394-7400, database is CAplus.

Transition metal complexes bearing metal-boron bonds are of particular relevance to catalytic C-H borylation reactions, with iridium polyboryl and polyhydrido-boryl complexes the current benchmark catalysts for these transformations. Herein, we demonstrate that polyhydride boryl phosphine rhenium complexes are accessible and catalyze the C-H borylation of heteroaromatic substrates. Reaction of [K(DME)(18-c-6)][ReH₄(Bpin)(η²-HBpin)(κ²-H₂Bpin)] 1 with 1,3-bis(diphenylphosphino)propane (dppp) produced [K(18-c-6)][ReH₄(η²-HBpin)(dppp)] 2 through substitution of two equivalent of HBpin, and protonation of 2 formed the neutral complex [ReH₆(Bpin)(dppp)] 3. Combined X-ray crystallog. and DFT studies show that 2 is best described as a σ-borane complex, whereas 3 is a boryl complex. Significantly, the boryl complex 3 acted as a catalyst for the C(sp²)-H borylation of a variety of heteroarenes (14 examples including furan, thiophene, pyrrole and indole derivatives) and displayed similar reactivity to the iridium analogs.

ACS Catalysis published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Murphy, Ann published the artcileChemically stabilized trypsin used in dipeptide synthesis, Application In Synthesis of 70539-42-3, the publication is Biotechnology and Bioengineering (1998), 58(4), 364-373, database is CAplus and MEDLINE.

Bovine pancreatic trypsin was treated with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester), such that approx. 8 out of 14 lysines per trypsin mol. were modified. This derivative (EG trypsin) was more stable than native between 30° and 70°: T₅₀ values were 59° and 46°, resp. EG trypsin’s half-life of 25 min at 55° was fivefold greater than native’s. EG trypsin had a decreased rate of autolysis and retained more activity in aqueous mixtures of 1,4-dioxan, DMF, dimethylsulfoxide, and acetonitrile. EG trypsin had lower K_m values for both amide and ester substrates; its k_cat values for two amides (PhCO-Arg-NHC₆H₄NO₂-4 and Cbz-Gly-Gly-Arg-NMC; NMC = 7-amino-4-methylcoumarin) increased, whereas its k_cat value for an ester (Cbz-Lys-SCOPh) decreased slightly. The specific activity (k_cat/K_m) of EG trypsin was increased for both amide and ester substrates. EG trypsin gave higher yields and reaction rates than the native trypsin in kinetically controlled synthesis of PhCO-Arg-Leu-NH₂ in acetonitrile and in t-butanol. Highest peptide yields occurred with EG trypsin in 95% acetonitrile, where 90% of the substrate was converted to product. No peptide synthesis occurred in 95% DMF with either form of trypsin.

Biotechnology and Bioengineering published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application In Synthesis of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

O’Brien, Anne Marie published the artcileChemical stabilization of recombinant horseradish peroxidase, Product Details of C18H20N2O12, the publication is Biotechnology Techniques (1996), 10(12), 905-910, database is CAplus.

Unglycosylated recombinant horseradish peroxidase (HRP C°) had a half life of 21 min at 65° compared with only 5 min for the plant enzyme (HRP). The half life of HRP C^* at 65° increased by 5-fold following modification with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester). Tolerance to 60% 1,4-dioxan also increased while tolerance to 30% DMF was unchanged.

Biotechnology Techniques published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Product Details of C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gestin, J. F. published the artcileIntroduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab’)₂ fragments of anti-carcinoembryonic antigen antibody–I. A new reproducible synthetic method, Category: alcohols-buliding-blocks, the publication is Nuclear Medicine and Biology (1993), 20(6), 755-62, database is CAplus and MEDLINE.

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of ¹¹¹In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab’)₂ fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with ¹¹¹In with good retention of immunoreactivity.

Nuclear Medicine and Biology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gotz, Tobias published the artcileMolecular Scissors for Tailor-Made Modification of Siloxane Scaffolds, Related Products of alcohols-buliding-blocks, the publication is Chemistry – A European Journal (2022), 28(2), e202103531, database is CAplus and MEDLINE.

The controlled design of functional oligosiloxanes is an important topic in current research. A consecutive Si-O-Si bond cleavage/formation using siloxanes that are substituted with 1,2-diaminobenzene derivatives acting as mol. scissors is presented. The method allows to cut at certain positions of a siloxane scaffold forming a cyclic diaminosilane or -siloxane intermediate and then to introduce new functional siloxy units. The procedure could be extended to a direct one-step cleavage of chlorooligosiloxanes. Both siloxane formation and cleavage proceed with good to excellent yields, high regioselectivity, and great variability of the siloxy units. Control of the selectivity is achieved by the choice of the amino substituent. Insight into the mechanism was provided by low temperature NMR studies and the isolation of a lithiated intermediate.

Chemistry – A European Journal published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Esguerra, Kenneth Virgel N. published the artcileA biomimetic catalytic aerobic functionalization of phenols, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2014), 53(23), 5877-5881, database is CAplus and MEDLINE.

A biomimetic approach that converts phenolic C-H bonds into C-O, C-N, and C-S bonds at the sole expense of reducing O₂ to water (H₂O) was reported. This method hinges on a regio- and chemoselective Cu-catalyzed aerobic oxygenation to provide orthoquinones. Orthoquinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koohmareh, Gholam Ali published the artcileSynthesis, characterization, and optical properties of poly[2-(4-(2,2′-bithiophen-5-yl)phenyl)-4-(4-alkoxyphenyl)-6-phenylpyridine|s, Related Products of alcohols-buliding-blocks, the publication is Designed Monomers and Polymers (2014), 17(5), 401-415, database is CAplus.

Two new copolymers, P₁ and P₂, composed of 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridine and bithiophene units, have been synthesized via Suzuki cross-coupling reactions. 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridines were synthesized starting from condensation reaction of 4-bromoacetophenone and 4-hydroxy benzaldehyde, and subsequent alkoxylation of hydroxyl groups. All of the polymers and intermediates were characterized using FTIR and NMR spectroscopies. The synthesized polymers exhibit good solubility in common organic solvents. The maximum absorption peak for P₁ and P₂ was 430 and 420 nm, resp. The optical band gap energy of the polymers was determined by absorption onset and found to be 2.17 eV for P₁ and 2.13 eV for P₂.

Designed Monomers and Polymers published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Zechao published the artcileDesign, Synthesis, and Characterization of Binaphthalene Precursors as Photoactivated DNA Interstrand Cross-Linkers, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2018), 83(16), 8815-8826, database is CAplus and MEDLINE.

Most recently, alkylation via photo-generated carbocations has been identified as a novel mechanism for photo-induced DNA interstrand crosslink (ICL) formation by bifunctional aryl compounds However, most compounds showed a low efficiency for DNA crosslinking. Here, the authors have developed a series of new 1,1′-binaphthalene analogs that efficiently form DNA ICLs upon 350 nm irradiation via generated 2-naphthalenylmethyl cations. The DNA crosslinking efficiency depends on the substituents at the position-4 of the naphthalene moiety as well as the leaving groups. Compounds with NO2, Ph, H, Br, or OMe substituents led to 2-4 times higher DNA ICL yields than those with a boronate ester group. Compounds having tri-Me ammonium salt as a leaving group showed slightly better crosslinking efficiency than those with bromo as a leaving group. Some of these compounds showed a better crosslinking efficiency than that of traditional alkylating agents, such as nitrogen mustard analogs or quinone methide precursors. These highly efficient photo-activated carbocation precursors allow determination and characterization of the adducts formed between the photo-generated naphthalenyl cations and four natural nucleosides, indicating that the alkylation sites for these naphthalene analogs are dG, dA, and dC.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts